Gene name:
MTUS1 (ATBP;ATIP;GK1;KIAA1288;MTSG1) ;
Protein name:
Microtubule-associated tumor suppressor 1 ;
Alternative:
Angiotensin-II type 2 receptor-interacting protein ;AT2 receptor-binding protein ;Mitochondrial tumor suppressor 1 ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Homodimer. Interacts with AGTR2. Interacts with PTPN6 (By similarity). Isoform 1 associates with microtubules.
Function:
Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation. Isoform 1 inhibits breast cancer cell proliferation, delays the progression of mitosis by prolonging metaphase and reduces tumor growth.
Subcellular Location:
Isoform 1
Cytoplasm
cytoskeleton
centrosome
Cytoplasm
cytoskeleton
spindle
Localizes with the mitotic spindle during mitosis and with the intercellular bridge during cytokinesis.
Protein Attributes:
50:
MTDDNSDDKI | EDELQTFFTS | DKDGNTHAYN | PKSPPTQNSS | ASSVNWNSAN |
100:
PDDMVVDYET | DPAVVTGENI | SLSLQGVEVF | GHEKSSSDFI | SKQVLDMHKD |
150:
SICQCPALVG | TEKPKYLQHS | CHSLEAVEGQ | SVEPSLPFVW | KPNDNLNCAG |
200:
YCDALELNQT | FDMTVDKVNC | TFISHHAIGK | SQSFHTAGSL | PPTGRRSGST |
250:
SSLSYSTWTS | SHSDKTHARE | TTYDRESFEN | PQVTPSEAQD | MTYTAFSDVV |
300:
MQSEVFVSDI | GNQCACSSGK | VTSEYTDGSQ | QRLVGEKETQ | ALTPVSDGME |
350:
VPNDSALQEF | FCLSHDESNS | EPHSQSSYRH | KEMGQNLRET | VSYCLIDDEC |
400:
PLMVPAFDKS | EAQVLNPEHK | VTETEDTQMV | SKGKDLGTQN | HTSELILSSP |
450:
PGQKVGSSFG | LTWDANDMVI | STDKTMCMST | PVLEPTKVTF | SVSPIEATEK |
500:
CKKVEKGNRG | LKNIPDSKEA | PVNLCKPSLG | KSTIKTNTPI | GCKVRKTEII |
550:
SYPRPNFKNV | KAKVMSRAVL | QPKDAALSKV | TPRPQQTSAS | SPSSVNSRQQ |
600:
TVLSRTPRSD | LNADKKAEIL | INKTHKQQFN | KLITSQAVHV | TTHSKNASHR |
650:
VPRTTSAVKS | NQEDVDKASS | SNSACETGSV | SALFQKIKGI | LPVKMESAEC |
700:
LEMTYVPNID | RISPEKKGEK | ENGTSMEKQE | LKQEIMNETF | EYGSLFLGSA |
750:
SKTTTTSGRN | ISKPDSCGLR | QIAAPKAKVG | PPVSCLRRNS | DNRNPSADRA |
800:
VSPQRIRRVS | SSGKPTSLKT | AQSSWVNLPR | PLPKSKASLK | SPALRRTGST |
850:
PSIASTHSEL | STYSNNSGNA | AVIKYEEKPP | KPAFQNGSSG | SFYLKPLVSR |
900:
AHVHLMKTPP | KGPSRKNLFT | ALNAVEKSRQ | KNPRSLCIQP | QTAPDALPPE |
950:
KTLELTQYKT | KCENQSGFIL | QLKQLLACGN | TKFEALTVVI | QHLLSEREEA |
1000:
LKQHKTLSQE | LVNLRGELVT | ASTTCEKLEK | ARNELQTVYE | AFVQQHQAEK |
1050:
TERENRLKEF | YTREYEKLRD | TYIEEAEKYK | MQLQEQFDNL | NAAHETSKLE |
1100:
IEASHSEKLE | LLKKAYEASL | SEIKKGHEIE | KKSLEDLLSE | KQESLEKQIN |
1150:
DLKSENDALN | EKLKSEEQKR | RAREKANLKN | PQIMYLEQEL | ESLKAVLEIK |
1200:
NEKLHQQDIK | LMKMEKLVDN | NTALVDKLKR | FQQENEELKA | RMDKHMAISR |
1250:
QLSTEQAVLQ | ESLEKESKVN | KRLSMENEEL | LWKLHNGDLC | SPKRSPTSSA |
1270:
IPLQSPRNSG | SFPSPSISPR |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Bovine
Rat
Human
Mouse
ELISA Kit for Human Microtubule-associated tumor suppressor 1
ELISA Kit for Human Microtubule-associated tumor suppressor 1
ELISA Kit for Human Microtubule-associated tumor suppressor 1
ELISA Kit for Human Microtubule-associated tumor suppressor 1
CLIA Kit for Human Microtubule-associated tumor suppressor 1
CLIA Kit for Human Microtubule-associated tumor suppressor 1
CLIA Kit for Human Microtubule-associated tumor suppressor 1
CLIA Kit for Human Microtubule-associated tumor suppressor 1
Polyclonal Antibody for Human Microtubule-associated tumor suppressor 1
Polyclonal Antibody for Human Microtubule-associated tumor suppressor 1
Polyclonal Antibody for Human Microtubule-associated tumor suppressor 1
Polyclonal Antibody for Human Microtubule-associated tumor suppressor 1
Monoclonal Antibody for Human Microtubule-associated tumor suppressor 1
Monoclonal Antibody for Human Microtubule-associated tumor suppressor 1
Monoclonal Antibody for Human Microtubule-associated tumor suppressor 1
Monoclonal Antibody for Human Microtubule-associated tumor suppressor 1
Protein for Human Microtubule-associated tumor suppressor 1
Protein for Human Microtubule-associated tumor suppressor 1
Protein for Human Microtubule-associated tumor suppressor 1
Protein for Human Microtubule-associated tumor suppressor 1
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);TISSUE SPECIFICITY;SUBCELLULAR LOCATION
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3);FUNCTION;TISSUE SPECIFICITY;SUBCELLULAR LOCATION
3.
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Europe PMC ]
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Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3);ALTERNATIVE SPLICING (ISOFORMS 1; 5 AND 6);SUBUNIT;TISSUE SPECIFICITY
tissue :
Lung .
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more...
Nat. Genet.36:40-45(2004)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3; 6 AND 7);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 875-1270 (ISOFORM 1)
tissue :
Brain .
tissue :
Fetal brain .
tissue :
Placenta .
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"The full-ORF clone resource of the German cDNA consortium."
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BMC Genomics8:399-399(2007)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 266-1270 (ISOFORM 5)
tissue :
Salivary gland .
tissue :
Uterus .
6.
"DNA sequence and analysis of human chromosome 8."
Nusbaum C.
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Mikkelsen T.S.
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more...
Nature439:331-335(2006)
[
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[
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[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
7.
Mural R.J.
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more...
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA];VARIANT ARG-148
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3);VARIANTS ARG-148 AND THR-1063
tissue :
Ovary .
tissue :
Skin .
tissue :
Testis .
9.
"Differential expression in normal trophoblast and gestational tumors."
Abadie P.A.
,
Genti-Raimondi S.
Submitted (2003-08) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 1-891 (ISOFORM 2);VARIANTS ARG-148 AND ARG-575
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 26-1270 (ISOFORM 1)
tissue :
Brain .
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : TISSUE SPECIFICITY
12.
"Structural organization and expression of human MTUS1, a candidate 8p22 tumor suppressor gene encoding a family of angiotensin II AT2 receptor-interacting proteins, ATIP."
Di Benedetto M.
,
Bieche I.
,
Deshayes F.
,
Vacher S.
,
Nouet S.
,
Collura V.
,
Seitz I.
,
Louis S.
,
Pineau P.
,
Amsellem-Ouazana D.
,
Couraud P.-O.
,
Strosberg A.D.
,
Stoppa-Lyonnet D.
,
Lidereau R.
,
Nahmias C.
Gene380:127-136(2006)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ALTERNATIVE SPLICING;TISSUE SPECIFICITY
13.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : TISSUE SPECIFICITY
14.
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Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
15.
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Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
16.
"8p22 MTUS1 gene product ATIP3 is a novel anti-mitotic protein underexpressed in invasive breast carcinoma of poor prognosis."
Rodrigues-Ferreira S.
,
Di Tommaso A.
,
Dimitrov A.
,
Cazaubon S.
,
Gruel N.
,
Colasson H.
,
Nicolas A.
,
Chaverot N.
,
Molinie V.
,
Reyal F.
,
Sigal-Zafrani B.
,
Terris B.
,
Delattre O.
,
Radvanyi F.
,
Perez F.
,
Vincent-Salomon A.
,
Nahmias C.
PLoS ONE4:E7239-E7239(2009)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
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Cited for : FUNCTION;ASSOCIATION WITH MICROTUBULES;SUBCELLULAR LOCATION;INDUCTION
17.
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Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1264 AND SER-1268;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Leukemic T-cell .
18.
"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V.
,
Vermeulen M.
,
Santamaria A.
,
Kumar C.
,
Miller M.L.
,
Jensen L.J.
,
Gnad F.
,
Cox J.
,
Jensen T.S.
,
Nigg E.A.
,
Brunak S.
,
Mann M.
Sci. Signal.3:RA3-RA3(2010)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1224 AND SER-1268;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
19.
"Mutation analysis of the 8p22 candidate tumor suppressor gene ATIP/MTUS1 in hepatocellular carcinoma."
Di Benedetto M.
,
Pineau P.
,
Nouet S.
,
Berhouet S.
,
Seitz I.
,
Louis S.
,
Dejean A.
,
Couraud P.-O.
,
Strosberg A.D.
,
Stoppa-Lyonnet D.
,
Nahmias C.
Mol. Cell. Endocrinol.252:207-215(2006)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
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Cited for : VARIANTS HCC LYS-75; SER-563; HIS-873 AND ARG-1201;VARIANTS ARG-148; MET-425; THR-453; ARG-575; THR-911 AND GLN-1105
20.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANTS ARG-148 AND THR-453;VARIANT HNSCC SER-186;TISSUE SPECIFICITY