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Index > Protein center > MTUS1(Gene name) > Human
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  • MTUS1 (Gene name),
  • Microtubule-associated tumor suppressor 1 (Protein name ),  MTUS1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    MTUS1(ATBP;ATIP;GK1;KIAA1288;MTSG1);
    Protein name:
    Microtubule-associated tumor suppressor 1;
    Alternative:
    Angiotensin-II type 2 receptor-interacting protein;AT2 receptor-binding protein;Mitochondrial tumor suppressor 1;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Homodimer. Interacts with AGTR2. Interacts with PTPN6 (By similarity). Isoform 1 associates with microtubules.
    Function:
    Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation. Isoform 1 inhibits breast cancer cell proliferation, delays the progression of mitosis by prolonging metaphase and reduces tumor growth.
    Subcellular Location:
    Isoform 1 Cytoplasm cytoskeleton centrosome Cytoplasm cytoskeleton spindle Localizes with the mitotic spindle during mitosis and with the intercellular bridge during cytokinesis.
    Protein Attributes:
    Sequence length:
    1270
    Sequence:
    50:
    MTDDNSDDKI | EDELQTFFTS | DKDGNTHAYN | PKSPPTQNSS | ASSVNWNSAN | 
    100:
    PDDMVVDYET | DPAVVTGENI | SLSLQGVEVF | GHEKSSSDFI | SKQVLDMHKD | 
    150:
    SICQCPALVG | TEKPKYLQHS | CHSLEAVEGQ | SVEPSLPFVW | KPNDNLNCAG | 
    200:
    YCDALELNQT | FDMTVDKVNC | TFISHHAIGK | SQSFHTAGSL | PPTGRRSGST | 
    250:
    SSLSYSTWTS | SHSDKTHARE | TTYDRESFEN | PQVTPSEAQD | MTYTAFSDVV | 
    300:
    MQSEVFVSDI | GNQCACSSGK | VTSEYTDGSQ | QRLVGEKETQ | ALTPVSDGME | 
    350:
    VPNDSALQEF | FCLSHDESNS | EPHSQSSYRH | KEMGQNLRET | VSYCLIDDEC | 
    400:
    PLMVPAFDKS | EAQVLNPEHK | VTETEDTQMV | SKGKDLGTQN | HTSELILSSP | 
    450:
    PGQKVGSSFG | LTWDANDMVI | STDKTMCMST | PVLEPTKVTF | SVSPIEATEK | 
    500:
    CKKVEKGNRG | LKNIPDSKEA | PVNLCKPSLG | KSTIKTNTPI | GCKVRKTEII | 
    550:
    SYPRPNFKNV | KAKVMSRAVL | QPKDAALSKV | TPRPQQTSAS | SPSSVNSRQQ | 
    600:
    TVLSRTPRSD | LNADKKAEIL | INKTHKQQFN | KLITSQAVHV | TTHSKNASHR | 
    650:
    VPRTTSAVKS | NQEDVDKASS | SNSACETGSV | SALFQKIKGI | LPVKMESAEC | 
    700:
    LEMTYVPNID | RISPEKKGEK | ENGTSMEKQE | LKQEIMNETF | EYGSLFLGSA | 
    750:
    SKTTTTSGRN | ISKPDSCGLR | QIAAPKAKVG | PPVSCLRRNS | DNRNPSADRA | 
    800:
    VSPQRIRRVS | SSGKPTSLKT | AQSSWVNLPR | PLPKSKASLK | SPALRRTGST | 
    850:
    PSIASTHSEL | STYSNNSGNA | AVIKYEEKPP | KPAFQNGSSG | SFYLKPLVSR | 
    900:
    AHVHLMKTPP | KGPSRKNLFT | ALNAVEKSRQ | KNPRSLCIQP | QTAPDALPPE | 
    950:
    KTLELTQYKT | KCENQSGFIL | QLKQLLACGN | TKFEALTVVI | QHLLSEREEA | 
    1000:
    LKQHKTLSQE | LVNLRGELVT | ASTTCEKLEK | ARNELQTVYE | AFVQQHQAEK | 
    1050:
    TERENRLKEF | YTREYEKLRD | TYIEEAEKYK | MQLQEQFDNL | NAAHETSKLE | 
    1100:
    IEASHSEKLE | LLKKAYEASL | SEIKKGHEIE | KKSLEDLLSE | KQESLEKQIN | 
    1150:
    DLKSENDALN | EKLKSEEQKR | RAREKANLKN | PQIMYLEQEL | ESLKAVLEIK | 
    1200:
    NEKLHQQDIK | LMKMEKLVDN | NTALVDKLKR | FQQENEELKA | RMDKHMAISR | 
    1250:
    QLSTEQAVLQ | ESLEKESKVN | KRLSMENEEL | LWKLHNGDLC | SPKRSPTSSA | 
    1270:
    IPLQSPRNSG | SFPSPSISPR | 
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    SMR:
    KEGG:
    MIM:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Human Microtubule-associated tumor suppressor 1
    ELISA Kit for Human Microtubule-associated tumor suppressor 1
    ELISA Kit for Human Microtubule-associated tumor suppressor 1
    ELISA Kit for Human Microtubule-associated tumor suppressor 1
    CLIA Kit for Human Microtubule-associated tumor suppressor 1
    CLIA Kit for Human Microtubule-associated tumor suppressor 1
    CLIA Kit for Human Microtubule-associated tumor suppressor 1
    CLIA Kit for Human Microtubule-associated tumor suppressor 1
    Polyclonal Antibody for Human Microtubule-associated tumor suppressor 1
    Polyclonal Antibody for Human Microtubule-associated tumor suppressor 1
    Polyclonal Antibody for Human Microtubule-associated tumor suppressor 1
    Polyclonal Antibody for Human Microtubule-associated tumor suppressor 1
    Monoclonal Antibody for Human Microtubule-associated tumor suppressor 1
    Monoclonal Antibody for Human Microtubule-associated tumor suppressor 1
    Monoclonal Antibody for Human Microtubule-associated tumor suppressor 1
    Monoclonal Antibody for Human Microtubule-associated tumor suppressor 1
    Protein for Human Microtubule-associated tumor suppressor 1
    Protein for Human Microtubule-associated tumor suppressor 1
    Protein for Human Microtubule-associated tumor suppressor 1
    Protein for Human Microtubule-associated tumor suppressor 1

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    References
    1. 1.
      "Molecular cloning and characterization of two novel genes on chromosome 8p21.3."
      Kinjo T. , Isomura M. , Iwamasa T. , Nakamura Y.
      J. Hum. Genet.45:12-17(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);TISSUE SPECIFICITY;SUBCELLULAR LOCATION
    2. 2.
      "Identification of a new tumor suppressor gene located at chromosome 8p21.3-22."
      Seibold S. , Rudroff C. , Weber M. , Galle J. , Wanner C. , Marx M.
      FASEB J.17:1180-1182(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3);FUNCTION;TISSUE SPECIFICITY;SUBCELLULAR LOCATION
    3. 3.
      "Trans-inactivation of receptor tyrosine kinases by novel angiotensin II AT2 receptor-interacting protein, ATIP."
      Nouet S. , Amzallag N. , Li J.-M. , Louis S. , Seitz I. , Cui T.-X. , Alleaume A.-M. , Di Benedetto M. , Boden C. , Masson M. , Strosberg A.D. , Horiuchi M. , Couraud P.-O. , Nahmias C.
      J. Biol. Chem.279:28989-28997(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3);ALTERNATIVE SPLICING (ISOFORMS 1; 5 AND 6);SUBUNIT;TISSUE SPECIFICITY
      tissue: Lung.
    4. 4.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3; 6 AND 7);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 875-1270 (ISOFORM 1)
      tissue: Brain.
      tissue: Fetal brain.
      tissue: Placenta.
    5. 5.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 266-1270 (ISOFORM 5)
      tissue: Salivary gland.
      tissue: Uterus.
    6. 7.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA];VARIANT ARG-148
    7. 8.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3);VARIANTS ARG-148 AND THR-1063
      tissue: Ovary.
      tissue: Skin.
      tissue: Testis.
    8. 9.
      "Differential expression in normal trophoblast and gestational tumors."
      Abadie P.A. , Genti-Raimondi S.
      Submitted (2003-08) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-891 (ISOFORM 2);VARIANTS ARG-148 AND ARG-575
    9. 10.
      "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T. , Ishikawa K. , Kikuno R. , Hirosawa M. , Nomura N. , Ohara O.
      DNA Res.6:337-345(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 26-1270 (ISOFORM 1)
      tissue: Brain.
    10. 11.
      "Five genes from chromosomal band 8p22 are significantly down-regulated in ovarian carcinoma: N33 and EFA6R have a potential impact on overall survival."
      Pils D. , Horak P. , Gleiss A. , Sax C. , Fabjani G. , Moebus V.J. , Zielinski C. , Reinthaller A. , Zeillinger R. , Krainer M.
      Cancer104:2417-2429(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
    11. 12.
      "Structural organization and expression of human MTUS1, a candidate 8p22 tumor suppressor gene encoding a family of angiotensin II AT2 receptor-interacting proteins, ATIP."
      Di Benedetto M. , Bieche I. , Deshayes F. , Vacher S. , Nouet S. , Collura V. , Seitz I. , Louis S. , Pineau P. , Amsellem-Ouazana D. , Couraud P.-O. , Strosberg A.D. , Stoppa-Lyonnet D. , Lidereau R. , Nahmias C.
      Gene380:127-136(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ALTERNATIVE SPLICING;TISSUE SPECIFICITY
    12. 13.
      "Differential expression in normal-adenoma-carcinoma sequence suggests complex molecular carcinogenesis in colon."
      Lee S. , Bang S. , Song K. , Lee I.
      Oncol. Rep.16:747-754(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
    13. 14.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    14. 15.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    15. 16.
      "8p22 MTUS1 gene product ATIP3 is a novel anti-mitotic protein underexpressed in invasive breast carcinoma of poor prognosis."
      Rodrigues-Ferreira S. , Di Tommaso A. , Dimitrov A. , Cazaubon S. , Gruel N. , Colasson H. , Nicolas A. , Chaverot N. , Molinie V. , Reyal F. , Sigal-Zafrani B. , Terris B. , Delattre O. , Radvanyi F. , Perez F. , Vincent-Salomon A. , Nahmias C.
      PLoS ONE4:E7239-E7239(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;ASSOCIATION WITH MICROTUBULES;SUBCELLULAR LOCATION;INDUCTION
    16. 17.
      "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
      Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1264 AND SER-1268;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Leukemic T-cell.
    17. 18.
      "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
      Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1224 AND SER-1268;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    18. 19.
      "Mutation analysis of the 8p22 candidate tumor suppressor gene ATIP/MTUS1 in hepatocellular carcinoma."
      Di Benedetto M. , Pineau P. , Nouet S. , Berhouet S. , Seitz I. , Louis S. , Dejean A. , Couraud P.-O. , Strosberg A.D. , Stoppa-Lyonnet D. , Nahmias C.
      Mol. Cell. Endocrinol.252:207-215(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS HCC LYS-75; SER-563; HIS-873 AND ARG-1201;VARIANTS ARG-148; MET-425; THR-453; ARG-575; THR-911 AND GLN-1105
    19. 20.
      "Genomic assessments of the frequent loss of heterozygosity region on 8p21.3 approximately p22 in head and neck squamous cell carcinoma."
      Ye H. , Pungpravat N. , Huang B.-L. , Muzio L.L. , Mariggio M.A. , Chen Z. , Wong D.T. , Zhou X.
      Cancer Genet. Cytogenet.176:100-106(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS ARG-148 AND THR-453;VARIANT HNSCC SER-186;TISSUE SPECIFICITY
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