Protein name:
Cell surface glycoprotein MUC18 ;
Alternative:
Melanoma cell adhesion molecule ;Gicerin ;Melanoma-associated antigen MUC18 ;
CD:
CD146 ;
Organism:
Mouse (Mus musculus).
General Annotation
Function:
Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2, and a transient increase in the intracellular calcium concentration.
Subcellular Location:
Membrane
Single-pass type I membrane protein
Protein Attributes:
50:
MGLPKLVCVF | LFAACCCCRR | AAGVPGEEKQ | PVPTPDLVEA | EVGSTALLKC |
100:
GPSRASGNFS | QVDWFLIHKE | RQILIFRVHQ | GKGQREPGEY | EHRLSLQDSV |
150:
ATLALSHVTP | HDERMFLCKS | KRPRLQDHYV | ELQVFKAPEE | PTIQANVVGI |
200:
HVDRQELREV | ATCVGRNGYP | IPQVLWYKNS | LPLQEEENRV | HIQSSQIVES |
250:
SGLYTLKSVL | SARLVKEDKD | AQFYCELSYR | LPSGNHMKES | KEVTVPVFYP |
300:
AEKVWVEVEP | VGLLKEGDHV | TIRCLTDGNP | QPHFTINKKD | PSTGEMEEES |
350:
TDENGLLSLE | PAEKHHSGLY | QCQSLDLETT | ITLSSDPLEL | LVNYVSDVQV |
400:
NPTAPEVQEG | ESLTLTCEAE | SNQDLEFEWL | RDKTGQLLGK | GPVLQLNNVR |
450:
REAGGRYLCM | ASVPRVPGLN | RTQLVSVGIF | GSPWMALKER | KVWVQENAVL |
500:
NLSCEASGHP | QPTISWNVNG | SATEWNPDPQ | TVVSTLNVLV | TPELLETGAE |
550:
CTASNSLGSN | TTTIVLKLVT | LTTLIPDSSQ | TTGLSTLTVS | PHTRANSTST |
600:
EKKLPQPESK | GVVIVAVIVC | TLVLAVLGAA | LYFFYKKGKL | PCGRSGKQEI |
648:
TLPPTRKSEF | VVEVKSDKLP | EEMALLQGSN | GDKRAPGDQG | EKYIDLRH
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
Rat
ELISA Kit for Mouse Cell surface glycoprotein MUC18
ELISA Kit for Mouse Cell surface glycoprotein MUC18
ELISA Kit for Mouse Cell surface glycoprotein MUC18
CLIA Kit for Mouse Cell surface glycoprotein MUC18
CLIA Kit for Mouse Cell surface glycoprotein MUC18
CLIA Kit for Mouse Cell surface glycoprotein MUC18
Polyclonal Antibody for Mouse Cell surface glycoprotein MUC18
Polyclonal Antibody for Mouse Cell surface glycoprotein MUC18
Polyclonal Antibody for Mouse Cell surface glycoprotein MUC18
Monoclonal Antibody for Mouse Cell surface glycoprotein MUC18
Monoclonal Antibody for Mouse Cell surface glycoprotein MUC18
Monoclonal Antibody for Mouse Cell surface glycoprotein MUC18
Protein for Mouse Cell surface glycoprotein MUC18
Protein for Mouse Cell surface glycoprotein MUC18
Protein for Mouse Cell surface glycoprotein MUC18
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2)
strain :
BALB/c .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
strain :
FVB/N-3 .
tissue :
Mammary tumor .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 561-648 (ISOFORMS 1 AND 2)
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : TISSUE SPECIFICITY;ROLE IN MELANOMA
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-58 AND ASN-510