MUC1 ELISA Kit for Human(Homo sapiens) | EIAab.comMUC1 ELISA Kit for Human(Homo sapiens)

Search Protein-oriented Product center.

For antibodies, ELISA/CLIA, proteins... Product center

Tips

Index > Protein center > MUC1(Gene name) > Human

MUC1 (Gene name),

Mucin-1 (Protein name ), MUC1_HUMAN from NCBI database.

top

General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

Feedback

Gene name:

MUC1(PUM);

Protein name:

Mucin-1(MUC-1);

Alternative:

Tumor-associated epithelial membrane antigen(EMA);Carcinoma-associated mucin(CA 15-3);Tumor-associated mucin(Breast carcinoma-associated antigen DF3);H23AG;Episialin;Peanut-reactive urinary mucin(PUM);PEMT;Tumor-associated epithelial membrane antigen(EMA);Polymorphic epithelial mucin(PEM);Tumor-associated mucin(PEM);

CD:

CD227;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

The alpha subunit forms a tight, non-covalent heterodimeric complex with the proteolytically-released beta-subunit. Interaction, via the tandem repeat region, with domain 1 of ICAM1 is implicated in cell migration and metastases. Isoform 1 binds directly the SH2 domain of GRB2, and forms a MUC1/GRB2/SOS1 complex involved in RAS signaling. The cytoplasmic tail (MUC1CT) interacts with several proteins such as SRC, CTNNB1 and ERBs. Interaction with the SH2 domain of CSK decreases interaction with GSK3B. Interacts with CTNNB1/beta-catenin and JUP/gamma-catenin and promotes cell adhesion. Interaction with JUP/gamma-catenin is induced by heregulin. Binds PRKCD, ERBB2, ERBB3 and ERBB4. Heregulin (HRG) stimulates the interaction with ERBB2 and, to a much lesser extent, the interaction with ERBB3 and ERBB4. Interacts with P53 in response to DNA damage. Interacts with KLF4. Interacts with estrogen receptor alpha/ESR1, through its DNA-binding domain, and stimulates its transcription activity. Binds ADAM17.

Function:

The beta subunit contains a C-terminal domain which is involved in cell signaling, through phosphorylations and protein-protein interactions. Modulates signaling in ERK, SRC and NF-kappa-B pathways. In activated T-cells, influences directly or indirectly the Ras/MAPK pathway. Promotes tumor progression. Regulates TP53-mediated transcription and determines cell fate in the genotoxic stress response. Binds, together with KLF4, the PE21 promoter element of TP53 and represses TP53 activity.

Subcellular Location:

Mucin-1 subunit beta Cell membrane Cytoplasm Nucleus On EGF and PDGFRB stimulation, transported to the nucleus through interaction with CTNNB1, a process which is stimulated by phosphorylation. On HRG stimulation, colocalizes with JUP/gamma-catenin at the nucleus.

Protein Attributes:

Sequence length:

1255

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

700:

750:

800:

850:

900:

950:

1000:

1050:

1100:

1150:

1200:

1250:

1255:

TSANL

3D Structure:

N/A

Predicted Eptitope:

Please Sign in.

Vaild Sequence:

Please Sign in.

Related Databases

Pfam:

PF01390

UniGene:

Hs.89603

KEGG:

hsa:4582

SMR:

P15941

MIM:

113720

String:

P15941

Uniprot:

P15941

FOR

ELISA Kit for Human MUC-1

Cat.:

E0413h

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

Please sign in first.

ELISA Kit for Human MUC-1

Cat.:

E0413m

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

Please sign in first.

ELISA Kit for Human MUC-1

Cat.:

E0413b

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Human MUC-1

Cat.:

U0413b

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Human MUC-1

Cat.:

U0413m

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

Please sign in first.

CLIA Kit for Human MUC-1

Cat.:

U0413h

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

Polyclonal Antibody for Human MUC-1

Cat.:

P0413Rb-m

Price:

Please sign in first.

Packing:

40ug/0.2ml

Polyclonal Antibody for Human MUC-1

Cat.:

P0413Rb-h

Price:

Please sign in first.

Packing:

40ug/0.2ml

Monoclonal Antibody for Human MUC-1

Protein for Human MUC-1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Cloning and sequencing of a human pancreatic tumor mucin cDNA."
Lan M.S. , Batra S.K. , Qi W.-N. , Metzgar R.S. , Hollingsworth M.A.
J. Biol. Chem.265:15294-15299(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue: Pancreatic carcinoma.
2.

"Episialin, a carcinoma-associated mucin, is generated by a polymorphic gene encoding splice variants with alternative amino termini."
Ligtenberg M.J.L. , Vos H.L. , Gennissen A.M.C. , Hilkens J.
J. Biol. Chem.265:5573-5578(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2)
3.

"Molecular cloning and expression of human tumor-associated polymorphic epithelial mucin."
Gendler S.J. , Lancaster C.A. , Taylor-Papadimitriou J. , Duhig T. , Peat N. , Burchell J. , Pemberton L. , Lalani E.-N. , Wilson D.
J. Biol. Chem.265:15286-15293(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue: Mammary carcinoma.
4.

"Structure and expression of the human polymorphic epithelial mucin gene: an expressed VNTR unit."
Lancaster C.A. , Peat N. , Duhig T. , Wilson D. , Taylor-Papadimitriou J. , Gendler S.J.
Biochem. Biophys. Res. Commun.173:1019-1029(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1)
5.

"Human epithelial tumor antigen cDNA sequences. Differential splicing may generate multiple protein forms."
Wreschner D.H. , Hareuveni M. , Tsarfaty I. , Smorodinsky N. , Horev J. , Zaretsky J. , Kotkes P. , Weiss M. , Lathe R. , Dion A. , Keydar I.
Eur. J. Biochem.189:463-473(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5)
tissue: Mammary carcinoma.
6.

"A transcribed gene, containing a variable number of tandem repeats, codes for a human epithelial tumor antigen. cDNA cloning, expression of the transfected gene and over-expression in breast cancer tissue."
Hareuveni M. , Tsarfaty I. , Zaretsky J. , Kotkes P. , Horev J. , Zrihan S. , Weiss M. , Green S. , Lathe R. , Keydar I. , Wreschner D.H.
Eur. J. Biochem.189:475-486(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
tissue: Mammary carcinoma.
7.

"Isolation and characterization of an expressed hypervariable gene coding for a breast-cancer-associated antigen."
Tsarfaty I. , Hareuveni M. , Horev J. , Zaretsky J. , Weiss M. , Jeltsch J.-M. , Garnier J.-M. , Lathe R. , Keydar I. , Wreschner D.H.
Gene93:313-318(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1)
8.

"Characterization and molecular cloning of a novel MUC1 protein, devoid of tandem repeats, expressed in human breast cancer tissue."
Zrihan-Licht S. , Vos H.L. , Baruch A. , Elroy-Stein O. , Sagiv D. , Keydar I. , Hilkens J. , Wreschner D.H.
Eur. J. Biochem.224:787-795(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM Y)
9.

"Comparison of MUC-1 mucin expression in epithelial and non-epithelial cancer cell lines and demonstration of a new short variant form (MUC-1/Z)."
Oosterkamp H.M. , Scheiner L. , Stefanova M.C. , Lloyd K.O. , Finstad C.L.
Int. J. Cancer72:87-94(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 6; Y AND 8);TISSUE SPECIFICITY
10.

"A novel protein derived from the MUC1 gene by alternative splicing and frameshifting."
Levitin F. , Baruch A. , Weiss M. , Stiegman K. , Hartmann M.L. , Yoeli-Lerner M. , Ziv R. , Zrihan-Licht S. , Shina S. , Gat A. , Lifschitz B. , Simha M. , Stadler Y. , Cholostoy A. , Gil B. , Greaves D. , Keydar I. , Zaretsky J. , more...
J. Biol. Chem.280:10655-10663(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM ZD)
11.

"Human mucin MUC1 RNA undergoes different types of alternative splicing resulting in multiple isoforms."
Zhang L. , Vlad A. , Milcarek C. , Finn O.J.
Cancer Immunol. Immunother.62:423-435(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 6; E2; J13; M6; S2; T10; Y-LSP AND ZD);ALTERNATIVE SPLICING;VARIANT MET-1117
12.

"Cloning of a new potential secreted short variant form of MUC1 mucin in epithelial cancer cell line."
Zhang L.X. , Li C.H. , Sun L.Y. , Yue W.
Submitted (2001-02) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 9)
tissue: Carcinoma.
13.

"Soluble expression of peptide containing MUC1/Y-specific epitope in Escherichia coli and preparation of the antibody."
Zhang L.X. , Li C.H. , Sun L.Y. , Wang M. , Lu H.J.
Sheng Wu Gong Cheng Xue Bao19:337-342(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM Y);VARIANT MET-1117
tissue: Cervix carcinoma.
14.

"Cloning of a new MUC1 short variant mRNA F from HeLa cells."
Zhang L.X. , Lu H.J.
Submitted (2003-06) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM F)
15.

"Cloning of a new MUC1 short variant mRNA S2 from HeLa cells."
Zhang L.X. , Lu H.J.
Submitted (2003-06) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM S2)
16.

"Isolation of MUC1 isoforms from MCF7 cells."
Zhang L. , Finn O.J.
Submitted (2007-06) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM M6)
17.

NIEHS SNPs program
Submitted (2003-11) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS MET-1117 AND ASN-1142
18.

"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G. , Barlow K.F. , McLay K.E. , Kaul R. , Swarbreck D. , Dunham A. , Scott C.E. , Howe K.L. , Woodfine K. , Spencer C.C.A. , Jones M.C. , Gillson C. , Searle S. , Zhou Y. , Kokocinski F. , McDonald L. , Evans R. , Phillips K. , more...
Nature441:315-321(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
19.

Mural R.J. , Istrail S. , Sutton G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
20.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS Y AND Y-LSP)
21.

"A highly immunogenic region of a human polymorphic epithelial mucin expressed by carcinomas is made up of tandem repeats."
Gendler S.J. , Taylor-Papadimitriou J. , Duhig T. , Rothbard J. , Burchell J.
J. Biol. Chem.263:12820-12823(1988) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PARTIAL NUCLEOTIDE SEQUENCE [MRNA]
22.

"Sequence analysis of the 5' region of the human DF3 breast carcinoma-associated antigen gene."
Abe M. , Siddiqui J. , Kufe D.
Biochem. Biophys. Res. Commun.165:644-649(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-160 (ISOFORM 2)
23.

"Preoperative diagnosis of thyroid papillary carcinoma by reverse transcriptase polymerase chain reaction of the MUC1 gene."
Weiss M. , Baruch A. , Keydar I. , Wreschner D.H.
Int. J. Cancer66:55-59(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-109 (ISOFORM 2)
tissue: Thyroid.
24.

"Mucin mRNA expression in lung adenocarcinoma cell lines and tissues."
Yu C.J. , Yang P.C. , Shew J.Y. , Hong T.M. , Yang S.C. , Lee Y.C. , Lee L.N. , Luh K.T. , Wu C.W.
Oncology53:118-126(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-89
tissue: Lung.
25.

Buluwela L. , Liu Q. , Luqmani Y.A. , Gomm J.J. , Coombes R.C.
Submitted (1992-10) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-46 (ISOFORMS 3 AND 4)
tissue: Mammary carcinoma.
26.

"Identification of MUC1 proteolytic cleavage sites in vivo."
Parry S. , Silverman H.S. , McDermott K. , Willis A. , Hollingsworth M.A. , Harris A.
Biochem. Biophys. Res. Commun.283:715-720(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 24-33; 28-37 AND 1098-1107;PROTEOLYTIC PROCESSING
27.

"The MUC1 SEA module is a self-cleaving domain."
Levitin F. , Stern O. , Weiss M. , Gil-Henn C. , Ziv R. , Prokocimer Z. , Smorodinsky N.I. , Rubinstein D.B. , Wreschner D.H.
J. Biol. Chem.280:33374-33386(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 1098-1111;PROTEOLYTIC CLEAVAGE;MUTAGENESIS OF SER-1098
28.

"High density O-glycosylation on tandem repeat peptide from secretory MUC1 of T47D breast cancer cells."
Mueller S. , Alving K. , Peter-Katalinic J. , Zachara N. , Gooley A.A. , Hanisch F.-G.
J. Biol. Chem.274:18165-18172(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF TANDEM REPEAT;IDENTIFICATION BY MASS SPECTROMETRY;GLYCOSYLATION
29.

"Tyrosine phosphorylation of the MUC1 breast cancer membrane proteins. Cytokine receptor-like molecules."
Zrihan-Licht S. , Baruch A. , Elroy-Stein O. , Keydar I. , Wreschner D.H.
FEBS Lett.356:130-136(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION
30.

"Association of the DF3/MUC1 breast cancer antigen with Grb2 and the Sos/Ras exchange protein."
Pandey P. , Kharbanda S. , Kufe D.
Cancer Res.55:4000-4003(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN A COMPLEX WITH SOS1 AND GRB2;INTERACTION WITH GRB2 AND SOS1;PHOSPHORYLATION
31.

"Studies on the order and site specificity of GalNAc transfer to MUC1 tandem repeats by UDP-GalNAc: polypeptide N-acetylgalactosaminyltransferase from milk or mammary carcinoma cells."
Stadie T.R. , Chai W. , Lawson A.M. , Byfield P.G. , Hanisch F.G.
Eur. J. Biochem.229:140-147(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION AT THR-131 AND THR-139;IDENTIFICATION BY MASS SPECTROMETRY
32.

"Interaction of the DF3/MUC1 breast carcinoma-associated antigen and beta-catenin in cell adhesion."
Yamamoto M. , Bharti A. , Li Y. , Kufe D.
J. Biol. Chem.272:12492-12494(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CTNNB1 AND JUP;FUNCTION
33.

"Localization of O-glycosylation sites on glycopeptide fragments from lactation-associated MUC1. All putative sites within the tandem repeat are glycosylation targets in vivo."
Mueller S. , Goletz S. , Packer N.H. , Gooley A.A. , Lawson A.M. , Hanisch F.-G.
J. Biol. Chem.272:24780-24793(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION WITHIN TANDEM REPEAT
34.

"Developmental expression of mucin genes in the human gastrointestinal system."
Reid C.J. , Harris A.
Gut42:220-226(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DEVELOPMENTAL STAGE
35.

"Localization of O-glycosylation sites of MUC1 tandem repeats by QTOF ESI mass spectrometry."
Hanisch F.G. , Green B.N. , Bateman R. , Peter-Katalinic J.
J. Mass Spectrom.33:358-362(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION AT THR-131 AND THR-139;IDENTIFICATION BY MASS SPECTROMETRY
36.

"Interaction of glycogen synthase kinase 3beta with the DF3/MUC1 carcinoma-associated antigen and beta-catenin."
Li Y. , Bharti A. , Chen D. , Gong J. , Kufe D.
Mol. Cell. Biol.18:7216-7224(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH GSK3B AND CTNNB1;PHOSPHORYLATION AT SER-1227;MUTAGENESIS OF SER-1223 AND SER-1227
37.

"The breast cancer-associated MUC1 gene generates both a receptor and its cognate binding protein."
Baruch A. , Hartmann M.-L. , Yoeli M. , Adereth Y. , Greenstein S. , Stadler Y. , Skornik Y. , Zaretsky J. , Smorodinsky N.I. , Keydar I. , Wreschner D.H.
Cancer Res.59:1552-1561(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION (ISOFORM Y);MUTAGENESIS OF ASP-1116
38.

"MUC1 mucin core protein binds to the domain 1 of ICAM-1."
Hayashi T. , Takahashi T. , Motoya S. , Ishida T. , Itoh F. , Adachi M. , Hinoda Y. , Imai K.
Digestion 63 Suppl.1:87-92(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ICAM1
39.

"Mucin MUC1 is seen in cell surface protrusions together with ezrin in immunoelectron tomography and is concentrated at tips of filopodial protrusions in MCF-7 breast carcinoma cells."
Bennett R. Jr. , Jaervelae T. , Engelhardt P. , Kostamovaara L. , Sparks P. , Carpen O. , Turunen O. , Vaheri A.
J. Histochem. Cytochem.49:67-77(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
40.

"The c-Src tyrosine kinase regulates signaling of the human DF3/MUC1 carcinoma-associated antigen with GSK3 beta and beta-catenin."
Li Y. , Kuwahara H. , Ren J. , Wen G. , Kufe D.
J. Biol. Chem.276:6061-6064(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SRC; GSK3B AND CTNNB1;PHOSPHORYLATION AT TYR-1229;MUTAGENESIS OF TYR-1229
41.

"Identification and topology of variant sequences within individual repeat domains of the human epithelial tumor mucin MUC1."
Engelmann K. , Baldus S.E. , Hanisch F.-G.
J. Biol. Chem.276:27764-27769(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: POLYMORPHISM WITHIN THE REPEAT
42.

"The epidermal growth factor receptor regulates interaction of the human DF3/MUC1 carcinoma antigen with c-Src and beta-catenin."
Li Y. , Ren J. , Yu W. , Li Q. , Kuwahara H. , Yin L. , Carraway K.L. III , Kufe D.
J. Biol. Chem.276:35239-35242(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH EGFR;PHOSPHORYLATION AT TYR-1229 BY EGFR;MUTAGENESIS OF TYR-1191; TYR-1203; TYR-1209; TYR-1218 AND TYR-1229
43.

"Protein kinase C delta regulates function of the DF3/MUC1 carcinoma antigen in beta-catenin signaling."
Ren J. , Li Y. , Kufe D.
J. Biol. Chem.277:17616-17622(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT THR-1224;INTERACTION WITH PRKCD;FUNCTION;MUTAGENESIS OF SER-1223; THR-1224 AND SER-1227
44.

"Identification of four sites of stimulated tyrosine phosphorylation in the MUC1 cytoplasmic tail."
Wang H. , Lillehoj E.P. , Kim K.C.
Biochem. Biophys. Res. Commun.310:341-346(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT TYR-1203; TYR-1212; TYR-1229 AND TYR-1243
45.

"DF3/MUC1 signaling in multiple myeloma cells is regulated by interleukin-7."
Li Y. , Chen W. , Ren J. , Yu W.H. , Li Q. , Yoshida K. , Kufe D.
Cancer Biol. Ther.2:187-193(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH LYN;PHOSPHORYLATION
46.

"MUC1 cytoplasmic domain coactivates Wnt target gene transcription and confers transformation."
Huang L. , Ren J. , Chen D. , Li Y. , Kharbanda S. , Kufe D.
Cancer Biol. Ther.2:702-706(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CTNNB1;FUNCTION;MUTAGENESIS OF TYR-1229
47.

"Tumor necrosis factor-alpha converting enzyme/ADAM 17 mediates MUC1 shedding."
Thathiah A. , Blobel C.P. , Carson D.D.
J. Biol. Chem.278:3386-3394(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ADAM17;CLEAVAGE
48.

"Nuclear association of the cytoplasmic tail of MUC1 and beta-catenin."
Wen Y. , Caffrey T.C. , Wheelock M.J. , Johnson K.R. , Hollingsworth M.A.
J. Biol. Chem.278:38029-38039(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CTNNB1;SUBCELLULAR LOCATION
49.

"Heregulin targets gamma-catenin to the nucleolus by a mechanism dependent on the DF3/MUC1 oncoprotein."
Li Y. , Yu W.-H. , Ren J. , Chen W. , Huang L. , Kharbanda S. , Loda M. , Kufe D.
Mol. Cancer Res.1:765-775(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ERBB2; ERBB3 AND ERBB4;SUBCELLULAR LOCATION;MUTAGENESIS OF 1187-ARG--LYS-1189
50.

"MUC1 membrane trafficking is modulated by multiple interactions."
Kinlough C.L. , Poland P.A. , Bruns J.B. , Harkleroad K.L. , Hughey R.P.
J. Biol. Chem.279:53071-53077(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH AP1S2 AND GRB2;SUBCELLULAR LOCATION;MUTAGENESIS OF TYR-1191; TYR-1203; TYR-1229 AND TYR-1243
51.

"Human MUC1 oncoprotein regulates p53-responsive gene transcription in the genotoxic stress response."
Wei X. , Xu H. , Kufe D.
Cancer Cell7:167-178(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TP53;FUNCTION
52.

"MUC1 oncoprotein blocks glycogen synthase kinase 3beta-mediated phosphorylation and degradation of beta-catenin."
Huang L. , Chen D. , Liu D. , Yin L. , Kharbanda S. , Kufe D.
Cancer Res.65:10413-10422(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH GSK3B;PHOSPHORYLATION;FUNCTION
53.

Kinlough C.L. , Poland P.A. , Bruns J.B. , Harkleroad K.L. , Hughey R.P.
J. Biol. Chem.280:28827-28827(2005)

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM
54.

"Transmembrane and secreted MUC1 probes show trafficking-dependent changes in O-glycan core profiles."
Engelmann K. , Kinlough C.L. , Muller S. , Razawi H. , Baldus S.E. , Hughey R.P. , Hanisch F.-G.
Glycobiology15:1111-1124(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE OF CARBOHYDRATES;IDENTIFICATION BY MASS SPECTROMETRY;SUBCELLULAR LOCATION
55.

"MUC1 (CD227) interacts with lck tyrosine kinase in Jurkat lymphoma cells and normal T cells."
Mukherjee P. , Tinder T.L. , Basu G.D. , Gendler S.J.
J. Leukoc. Biol.77:90-99(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH LCK;PHOSPHORYLATION;FUNCTION;TISSUE SPECIFICITY
56.

"Recycling of MUC1 is dependent on its palmitoylation."
Kinlough C.L. , McMahan R.J. , Poland P.A. , Bruns J.B. , Harkleroad K.L. , Stremple R.J. , Kashlan O.B. , Weixel K.M. , Weisz O.A. , Hughey R.P.
J. Biol. Chem.281:12112-12122(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PALMITOYLATION AT CYS-1184 AND CYS-1186;SUBCELLULAR LOCATION;INTERACTION WITH AP1S1 AND AP1S2;MUTAGENESIS OF CYS-1184; CYS-1186; TYR-1203 AND 1187-ARG--LYS-1189
57.

"MUC1 oncoprotein stabilizes and activates estrogen receptor alpha."
Wei X. , Xu H. , Kufe D.
Mol. Cell21:295-305(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ESR1
58.

"MUC1 inhibits cell proliferation by a beta-catenin-dependent mechanism."
Lillehoj E.P. , Lu W. , Kiser T. , Goldblum S.E. , Kim K.C.
Biochim. Biophys. Acta1773:1028-1038(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CTNNB1;SUBCELLULAR LOCATION;FUNCTION
59.

"Human mucin 1 oncoprotein represses transcription of the p53 tumor suppressor gene."
Wei X. , Xu H. , Kufe D.
Cancer Res.67:1853-1858(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH KLF4;FUNCTION
60.

"Platelet-derived growth factor receptor beta-mediated phosphorylation of MUC1 enhances invasiveness in pancreatic adenocarcinoma cells."
Singh P.K. , Wen Y. , Swanson B.J. , Shanmugam K. , Kazlauskas A. , Cerny R.L. , Gendler S.J. , Hollingsworth M.A.
Cancer Res.67:5201-5210(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT TYR-1203; TYR-1218 AND TYR-1229;MUTAGENESIS OF TYR-1203 AND TYR-1218;SUBCELLULAR LOCATION;IDENTIFICATION BY MASS SPECTROMETRY
61.

"MUC1 is a novel regulator of ErbB1 receptor trafficking."
Pochampalli M.R. , el Bejjani R.M. , Schroeder J.A.
Oncogene26:1693-1701(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH EGFR;FUNCTION
62.

"CA 15-3: uses and limitation as a biomarker for breast cancer."
Duffy M.J. , Evoy D. , McDermott E.W.
Clin. Chim. Acta411:1869-1874(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MARKER IN BREAST CANCER
63.

"Mutations causing medullary cystic kidney disease type 1 lie in a large VNTR in MUC1 missed by massively parallel sequencing."
Kirby A. , Gnirke A. , Jaffe D.B. , Baresova V. , Pochet N. , Blumenstiel B. , Ye C. , Aird D. , Stevens C. , Robinson J.T. , Cabili M.N. , Gat-Viks I. , Kelliher E. , Daza R. , DeFelice M. , Hulkova H. , Sovova J. , Vylet'al P. , more...
Nat. Genet.45:299-303(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN MCKD1
64.

"N-glycosylation of the MUC1 mucin in epithelial cells and secretions."
Parry S. , Hanisch F.G. , Leir S.H. , Sutton-Smith M. , Morris H.R. , Dell A. , Harris A.
Glycobiology16:623-634(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 1041-1097 AND 1098-1152 OF WILD TYPE AND MUTANT ALA-1098;IDENTIFICATION BY MASS SPECTROMETRY;STRUCTURE OF CARBOHYDRATES;AUTOCATALYTIC CLEAVAGE

Product Feedback Wall

* Email:
*Comments: