Protein name:
Muscle, skeletal receptor tyrosine-protein kinase ;
Alternative:
Muscle-specific tyrosine-protein kinase receptor (MuSK;Muscle-specific kinase receptor) ;
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Monomer. Homodimer (Probable). Interacts with DOK7. Interaction with DOK7 promotes activation by tyrosine phosphorylation. Interacts with PDZRN3; this interaction is enhanced by agrin. Interacts with RNF31.
Function:
Receptor tyrosine kinase that is a key mediator of agrin's action and is involved in neuromuscular junction (NMJ) organization.
Subcellular Location:
Cell membrane
Single-pass type I membrane protein
Protein Attributes:
50:
MRELVNIPLL | QMLTLVAFSG | TEKLPKAPVI | TTPLETVDAL | VEEVATFMCA |
100:
VESYPQPEIS | WTRNKILIKL | FDTRYSIREN | GQLLTILSVE | DSDDGIYCCI |
150:
ANNGVGGAVE | SCGALQVKMK | PKITRPPINV | KIIEGLKAVL | PCTTMGNPKP |
200:
SVSWIKGDNA | LRENSRIAVL | ESGSLRIHNV | QKEDAGQYRC | VAKNSLGTAY |
250:
SKLVKLEVEV | FARILRAPES | HNVTFGSFVT | LRCTAIGIPV | PTISWIENGN |
300:
AVSSGSIQES | VKDRVIDSRL | QLFITKPGLY | TCIATNKHGE | KFSTAKAAAT |
350:
VSIAEWSKSQ | KDSQGYCAQY | RGEVCDAVLA | KDALVFFNTS | YRDPEDAQEL |
400:
LIHTAWNELK | AVSPLCRPAA | EALLCNHLFQ | ECSPGVVPTP | MPICREYCLA |
450:
VKELFCAKEW | QAMEGKAHRG | LYRSGMHLLP | VPECSKLPSM | HRDPTACTRL |
500:
PYLDYKKENI | TTFPSITSSR | PSADIPNLPA | STSSFAVSPA | YSMTVIISIV |
550:
SSFALFALLT | IATLYCCRRR | KEWKNKKRES | TAVTLTTLPS | ELLLDRLHPN |
600:
PMYQRMPLLL | NPKLLSLEYP | RNNIEYVRDI | GEGAFGRVFQ | ARAPGLLPYE |
650:
PFTMVAVKML | KEEASADMQA | DFQREAALMA | EFDNPNIVKL | LGVCAVGKPM |
700:
CLLFEYMAYG | DLNEFLRSMS | PHTVCSLSHS | DLSTRARVSS | PGPPPLSCAE |
750:
QLCIARQVAA | GMAYLSERKF | VHRDLATRNC | LVGETMVVKI | ADFGLSRNIY |
800:
SADYYKADGN | DAIPIRWMPP | ESIFYNRYTT | ESDVWAYGVV | LWEIFSYGLQ |
850:
PYYGMAHEEV | IYYVRDGNIL | ACPENCPLEL | YNLMRLCWSK | LPADRPSFCS |
868:
IHRILQRMCE | RAEGTVGV
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
Chicken
Rat
ELISA Kit for Mouse Muscle, skeletal receptor tyrosine-protein kinase
ELISA Kit for Mouse Muscle, skeletal receptor tyrosine-protein kinase
ELISA Kit for Mouse Muscle, skeletal receptor tyrosine-protein kinase
ELISA Kit for Mouse Muscle, skeletal receptor tyrosine-protein kinase
CLIA Kit for Mouse Muscle, skeletal receptor tyrosine-protein kinase
CLIA Kit for Mouse Muscle, skeletal receptor tyrosine-protein kinase
CLIA Kit for Mouse Muscle, skeletal receptor tyrosine-protein kinase
CLIA Kit for Mouse Muscle, skeletal receptor tyrosine-protein kinase
Polyclonal Antibody for Mouse Muscle, skeletal receptor tyrosine-protein kinase
Polyclonal Antibody for Mouse Muscle, skeletal receptor tyrosine-protein kinase
Polyclonal Antibody for Mouse Muscle, skeletal receptor tyrosine-protein kinase
Polyclonal Antibody for Mouse Muscle, skeletal receptor tyrosine-protein kinase
Monoclonal Antibody for Mouse Muscle, skeletal receptor tyrosine-protein kinase
Monoclonal Antibody for Mouse Muscle, skeletal receptor tyrosine-protein kinase
Monoclonal Antibody for Mouse Muscle, skeletal receptor tyrosine-protein kinase
Monoclonal Antibody for Mouse Muscle, skeletal receptor tyrosine-protein kinase
Protein for Mouse Muscle, skeletal receptor tyrosine-protein kinase
Protein for Mouse Muscle, skeletal receptor tyrosine-protein kinase
Protein for Mouse Muscle, skeletal receptor tyrosine-protein kinase
Protein for Mouse Muscle, skeletal receptor tyrosine-protein kinase
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2)
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 3 AND 4);DEVELOPMENTAL STAGE;TISSUE SPECIFICITY
tissue :
Myoblast .
3.
"The receptor tyrosine kinase MuSK is required for neuromuscular junction formation in vivo."
DeChiara T.M.
,
Bowen D.C.
,
Valenzuela D.M.
,
Simmons M.V.
,
Poueymirou W.T.
,
Thomas S.
,
Kinetz E.
,
Compton D.L.
,
Rojas E.
,
Park J.S.
,
Smith C.
,
DiStefano P.S.
,
Glass D.J.
,
Burden S.J.
,
Yancopoulos G.D.
Cell85:501-512(1996)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : DISRUPTION PHENOTYPE;FUNCTION IN NEUROMUSCULAR JUNCTION DEVELOPMENT
4.
"Agrin acts via a MuSK receptor complex."
Glass D.J.
,
Bowen D.C.
,
Stitt T.N.
,
Radziejewski C.
,
Bruno J.
,
Ryan T.E.
,
Gies D.R.
,
Shah S.
,
Mattsson K.
,
Burden S.J.
,
DiStefano P.S.
,
Valenzuela D.M.
,
DeChiara T.M.
,
Yancopoulos G.D.
Cell85:513-523(1996)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION OF AGRIN AS LIGAND;IDENTIFICATION OF THE AGRIN RECEPTOR COMPLEX;PHOSPHORYLATION
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION IN ACETYLCHOLINE RECEPTOR CLUSTERING
6.
"Regulation of AChR clustering by Dishevelled interacting with MuSK and PAK1."
Luo Z.G.
,
Wang Q.
,
Zhou J.Z.
,
Wang J.
,
Luo Z.
,
Liu M.
,
He X.
,
Wynshaw-Boris A.
,
Xiong W.C.
,
Lu B.
,
Mei L.
Neuron35:489-505(2002)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH DVL1 AND PAK1
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION IN TRANSCRIPTION REGULATION
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION IN RAC1 ACTIVATION;FUNCTION IN PHOSPHORYLATION OF FNTA;INTERACTION WITH FNTA
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH RNF31
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION IN ACETYLCHOLINE RECEPTOR CLUSTERING
11.
"Casein kinase 2-dependent serine phosphorylation of MuSK regulates acetylcholine receptor aggregation at the neuromuscular junction."
Cheusova T.
,
Khan M.A.
,
Schubert S.W.
,
Gavin A.C.
,
Buchou T.
,
Jacob G.
,
Sticht H.
,
Allende J.
,
Boldyreff B.
,
Brenner H.R.
,
Hashemolhosseini S.
Genes Dev.20:1800-1816(2006)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ENZYME REGULATION;PHOSPHORYLATION AT SER-680 AND SER-697 BY CK2;INTERACTION WITH CSNK2B
12.
"The muscle protein Dok-7 is essential for neuromuscular synaptogenesis."
Okada K.
,
Inoue A.
,
Okada M.
,
Murata Y.
,
Kakuta S.
,
Jigami T.
,
Kubo S.
,
Shiraishi H.
,
Eguchi K.
,
Motomura M.
,
Akiyama T.
,
Iwakura Y.
,
Higuchi O.
,
Yamanashi Y.
Science312:1802-1805(2006)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH DOK7;PHOSPHORYLATION AT TYR-553;MUTAGENESIS OF TYR-553
13.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH PDZRN3;UBIQUITINATION
14.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION;INTERACTION WITH LRP4
15.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH NSF
16.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH DNAJA3;SUBCELLULAR LOCATION
17.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH CAV3
18.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS) OF 544-556 IN COMPLEX WITH DOK7;INTERACTION WITH DOK7;PHOSPHORYLATION AT TYR-553