Musk ELISA Kit for Rat(Rattus norvegicus) | EIAab.comMusk ELISA Kit for Rat(Rattus norvegicus)

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Musk (Gene name),

Muscle, skeletal receptor tyrosine protein kinase (Protein name ), MUSK_RAT from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Musk;

Protein name:

Muscle, skeletal receptor tyrosine protein kinase;

Alternative:

Muscle-specific tyrosine protein kinase receptor(MuSK;Muscle-specific kinase receptor);

Organism:

Rat (Rattus norvegicus).

General Annotation

Sub Unit:

Monomer. Homodimer (Probable). Interacts with DOK7. Interaction with DOK7 promotes activation by tyrosine phosphorylation. Interacts with PDZRN3; this interaction is enhanced by agrin. Interacts with RNF31.

Function:

Receptor tyrosine kinase that is a key mediator of agrin's action and is involved in neuromuscular junction (NMJ) organization.

Subcellular Location:

Cell membrane Single-pass type I membrane protein

Protein Attributes:

Sequence length:

868

Sequence:

50:

100:

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300:

350:

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450:

500:

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600:

650:

700:

750:

800:

850:

868:

IHRILQRMCE | RAEGTVGV

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Rn.10210

Pfam:

PF01392

STRING:

10116.ENSRNOP00000056324

SMR:

Q62838

String:

Q62838

KEGG:

rno:81725

Uniprot:

Q62838

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ELISA Kit for Rat Muscle, skeletal receptor tyrosine protein kinase

Cat.:

E0992h

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Manual:

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Packing:

96T

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ELISA Kit for Rat Muscle, skeletal receptor tyrosine protein kinase

Cat.:

E0992m

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Manual:

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Packing:

96T

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ELISA Kit for Rat Muscle, skeletal receptor tyrosine protein kinase

Cat.:

E0992c

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MSDS:

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Packing:

96T

ELISA Kit for Rat Muscle, skeletal receptor tyrosine protein kinase

Cat.:

E0992r

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MSDS:

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Packing:

96T

CLIA Kit for Rat Muscle, skeletal receptor tyrosine protein kinase

Cat.:

U0992c

Price:

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MSDS:

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Packing:

96T

CLIA Kit for Rat Muscle, skeletal receptor tyrosine protein kinase

Cat.:

U0992m

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MSDS:

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Packing:

96T

CLIA Kit for Rat Muscle, skeletal receptor tyrosine protein kinase

Cat.:

U0992r

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MSDS:

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Packing:

96T

CLIA Kit for Rat Muscle, skeletal receptor tyrosine protein kinase

Cat.:

U0992h

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

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Polyclonal Antibody for Rat Muscle, skeletal receptor tyrosine protein kinase

Cat.:

P0992Rb-r

Price:

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Packing:

40ug/0.2ml

Polyclonal Antibody for Rat Muscle, skeletal receptor tyrosine protein kinase

Cat.:

P0992Rb-m

Price:

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Packing:

40ug/0.2ml

Polyclonal Antibody for Rat Muscle, skeletal receptor tyrosine protein kinase

Cat.:

P0992Rb-h

Price:

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Packing:

40ug/0.2ml

Polyclonal Antibody for Rat Muscle, skeletal receptor tyrosine protein kinase

Monoclonal Antibody for Rat Muscle, skeletal receptor tyrosine protein kinase

Protein for Rat Muscle, skeletal receptor tyrosine protein kinase

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Receptor tyrosine kinase specific for the skeletal muscle lineage: expression in embryonic muscle, at the neuromuscular junction, and after injury."
Valenzuela D.M. , Stitt T.N. , DiStefano P.S. , Rojas E. , Mattsson K. , Compton D.L. , Nunez L. , Park J.S. , Stark J.L. , Gies D.R. , Thomas S. , LeBeau M.M. , Fernald A.A. , Copeland N.G. , Jenkins N.A. , Burden S.J. , Glass D.J. , Yancopoulos G.D.
Neuron15:573-584(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];TISSUE SPECIFICITY;DEVELOPMENTAL STAGE;INDUCTION BY DENERVATION
tissue: Muscle.
2.

"MuSK expressed in the brain mediates cholinergic responses, synaptic plasticity, and memory formation."
Garcia-Osta A. , Tsokas P. , Pollonini G. , Landau E.M. , Blitzer R. , Alberini C.M.
J. Neurosci.26:7919-7932(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN MEMORY FORMATION
3.

"Lrp4 is a receptor for Agrin and forms a complex with MuSK."
Kim N. , Stiegler A.L. , Cameron T.O. , Hallock P.T. , Gomez A.M. , Huang J.H. , Hubbard S.R. , Dustin M.L. , Burden S.J.
Cell135:334-342(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH LRP4
4.

"A mammalian homolog of Drosophila tumorous imaginal discs, Tid1, mediates agrin signaling at the neuromuscular junction."
Linnoila J. , Wang Y. , Yao Y. , Wang Z.Z.
Neuron60:625-641(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH DNAJA3
5.

"The cytoplasmic adaptor protein Dok7 activates the receptor tyrosine kinase MuSK via dimerization."
Bergamin E. , Hallock P.T. , Burden S.J. , Hubbard S.R.
Mol. Cell39:100-109(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH DOK7;ENZYME REGULATION;PHOSPHORYLATION AT TYR-754
6.

"Crystal structure of the MuSK tyrosine kinase: insights into receptor autoregulation."
Till J.H. , Becerra M. , Watty A. , Lu Y. , Ma Y. , Neubert T.A. , Burden S.J. , Hubbard S.R.
Structure10:1187-1196(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.05 ANGSTROMS) OF 560-860
7.

"Crystal structure of the agrin-responsive immunoglobulin-like domains 1 and 2 of the receptor tyrosine kinase MuSK."
Stiegler A.L. , Burden S.J. , Hubbard S.R.
J. Mol. Biol.364:424-433(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.21 ANGSTROMS) OF 22-212;FUNCTION;PHOSPHORYLATION;SUBUNIT;SUBCELLULAR LOCATION;MUTAGENESIS OF MET-48; LEU-83 AND ILE-96;DISULFIDE BONDS
8.

"Crystal structure of the frizzled-like cysteine-rich domain of the receptor tyrosine kinase MuSK."
Stiegler A.L. , Burden S.J. , Hubbard S.R.
J. Mol. Biol.393:1-9(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 313-494;SUBUNIT;DISULFIDE BONDS;GLYCOSYLATION AT ASN-338

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