Protein name:
Major vault protein (MVP) ;
Alternative:
Lung resistance-related protein ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
The vault ribonucleoprotein particle is a huge (400 A x 670 A) cage structure of 12.9 MDa. It consists of a dimer of half-vaults, with each half-vault comprising 39 identical major vault protein (MVP) chains, PARP4 and one or more vault RNAs (vRNAs). Interacts with TEP1. Interacts with PTEN and activated MAPK1. The phosphorylated protein interacts with the SH2 domains of PTPN11 and SRC. Interacts with APEX1. May interact with ZNF540.
Function:
Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. Down-regulates INFG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases.
Subcellular Location:
Cytoplasm
Nucleus
nuclear pore complex
5% found in the nuclear pore complex. Translocates from the nucleus to the cytoplasm upon EGF treatment.
Protein Attributes:
50:
MATEEFIIRI | PPYHYIHVLD | QNSNVSRVEV | GPKTYIRQDN | ERVLFAPMRM |
100:
VTVPPRHYCT | VANPVSRDAQ | GLVLFDVTGQ | VRLRHADLEI | RLAQDPFPLY |
150:
PGEVLEKDIT | PLQVVLPNTA | LHLKALLDFE | DKDGDKVVAG | DEWLFEGPGT |
200:
YIPRKEVEVV | EIIQATIIRQ | NQALRLRARK | ECWDRDGKER | VTGEEWLVTT |
250:
VGAYLPAVFE | EVLDLVDAVI | LTEKTALHLR | ARRNFRDFRG | VSRRTGEEWL |
300:
VTVQDTEAHV | PDVHEEVLGV | VPITTLGPHN | YCVILDPVGP | DGKNQLGQKR |
350:
VVKGEKSFFL | QPGEQLEQGI | QDVYVLSEQQ | GLLLRALQPL | EEGEDEEKVS |
400:
HQAGDHWLIR | GPLEYVPSAK | VEVVEERQAI | PLDENEGIYV | QDVKTGKVRA |
450:
VIGSTYMLTQ | DEVLWEKELP | PGVEELLNKG | QDPLADRGEK | DTAKSLQPLA |
500:
PRNKTRVVSY | RVPHNAAVQV | YDYREKRARV | VFGPELVSLG | PEEQFTVLSL |
550:
SAGRPKRPHA | RRALCLLLGP | DFFTDVITIE | TADHARLQLQ | LAYNWHFEVN |
600:
DRKDPQETAK | LFSVPDFVGD | ACKAIASRVR | GAVASVTFDD | FHKNSARIIR |
650:
TAVFGFETSE | AKGPDGMALP | RPRDQAVFPQ | NGLVVSSVDV | QSVEPVDQRT |
700:
RDALQRSVQL | AIEITTNSQE | AAAKHEAQRL | EQEARGRLER | QKILDQSEAE |
750:
KARKELLELE | ALSMAVESTG | TAKAEAESRA | EAARIEGEGS | VLQAKLKAQA |
800:
LAIETEAELQ | RVQKVRELEL | VYARAQLELE | VSKAQQLAEV | EVKKFKQMTE |
850:
AIGPSTIRDL | AVAGPEMQVK | LLQSLGLKST | LITDGSTPIN | LFNTAFGLLG |
893:
MGPEGQPLGR | RVASGPSPGE | GISPQSAQAP | QAPGDNHVVP | VLR
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
Bovine
Rat
Chicken
Polyclonal Antibody for Human MVP
Polyclonal Antibody for Human MVP
Polyclonal Antibody for Human MVP
Polyclonal Antibody for Human MVP
Polyclonal Antibody for Human MVP
Monoclonal Antibody for Human MVP
Monoclonal Antibody for Human MVP
Monoclonal Antibody for Human MVP
Monoclonal Antibody for Human MVP
Monoclonal Antibody for Human MVP
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
2.
Scheffer G.L.
Submitted (2002-03) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : SEQUENCE REVISION TO C-TERMINUS
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue :
Eye .
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-169
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] OF 1-65
tissue :
Lung cancer .
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 2-9; 68-82 AND 462-474;CLEAVAGE OF INITIATOR METHIONINE;ACETYLATION AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY
tissue :
Melanoma .
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ASSOCIATION WITH TEP1
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH PTEN
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION AT TYROSINE RESIDUES;IDENTIFICATION BY MASS SPECTROMETRY;INTERACTION WITH PTPN11;SUBCELLULAR LOCATION;FUNCTION
10.
"A novel human zinc finger protein ZNF540 interacts with MVP and inhibits transcriptional activities of the ERK signal pathway."
Xiang Z.
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Yuan W.
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Luo N.
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Wang Y.
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Tan K.
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Deng Y.
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Li Y.
Biochem. Biophys. Res. Commun.347:288-296(2006)
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PubMed ]
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Europe PMC ]
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Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH ZNF540
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;INTERACTION WITH SRC;TYROSINE PHOSPHORYLATION;SUBCELLULAR LOCATION;IDENTIFICATION BY MASS SPECTROMETRY
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INDUCTION;FUNCTION
13.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH APEX1
14.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
15.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
16.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
17.
"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P.
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Proc. Natl. Acad. Sci. U.S.A.109:12449-12454(2012)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
18.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : STRUCTURE BY NMR OF 113-221;INTERACTION WITH PARP4