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Index > Protein center > MVP(Gene name) > Human
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  • MVP (Gene name),
  • Major vault protein (Protein name ),  MVP_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Gene name:
    MVP(LRP);
    Protein name:
    Major vault protein(MVP);
    Alternative:
    Lung resistance-related protein;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    The vault ribonucleoprotein particle is a huge (400 A x 670 A) cage structure of 12.9 MDa. It consists of a dimer of half-vaults, with each half-vault comprising 39 identical major vault protein (MVP) chains, PARP4 and one or more vault RNAs (vRNAs). Interacts with TEP1. Interacts with PTEN and activated MAPK1. The phosphorylated protein interacts with the SH2 domains of PTPN11 and SRC. Interacts with APEX1. May interact with ZNF540.
    Function:
    Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. Down-regulates INFG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases.
    Subcellular Location:
    Cytoplasm Nucleus nuclear pore complex 5% found in the nuclear pore complex. Translocates from the nucleus to the cytoplasm upon EGF treatment.
    Protein Attributes:
    Sequence length:
    893
    Sequence:
    50:
    MATEEFIIRI | PPYHYIHVLD | QNSNVSRVEV | GPKTYIRQDN | ERVLFAPMRM | 
    100:
    VTVPPRHYCT | VANPVSRDAQ | GLVLFDVTGQ | VRLRHADLEI | RLAQDPFPLY | 
    150:
    PGEVLEKDIT | PLQVVLPNTA | LHLKALLDFE | DKDGDKVVAG | DEWLFEGPGT | 
    200:
    YIPRKEVEVV | EIIQATIIRQ | NQALRLRARK | ECWDRDGKER | VTGEEWLVTT | 
    250:
    VGAYLPAVFE | EVLDLVDAVI | LTEKTALHLR | ARRNFRDFRG | VSRRTGEEWL | 
    300:
    VTVQDTEAHV | PDVHEEVLGV | VPITTLGPHN | YCVILDPVGP | DGKNQLGQKR | 
    350:
    VVKGEKSFFL | QPGEQLEQGI | QDVYVLSEQQ | GLLLRALQPL | EEGEDEEKVS | 
    400:
    HQAGDHWLIR | GPLEYVPSAK | VEVVEERQAI | PLDENEGIYV | QDVKTGKVRA | 
    450:
    VIGSTYMLTQ | DEVLWEKELP | PGVEELLNKG | QDPLADRGEK | DTAKSLQPLA | 
    500:
    PRNKTRVVSY | RVPHNAAVQV | YDYREKRARV | VFGPELVSLG | PEEQFTVLSL | 
    550:
    SAGRPKRPHA | RRALCLLLGP | DFFTDVITIE | TADHARLQLQ | LAYNWHFEVN | 
    600:
    DRKDPQETAK | LFSVPDFVGD | ACKAIASRVR | GAVASVTFDD | FHKNSARIIR | 
    650:
    TAVFGFETSE | AKGPDGMALP | RPRDQAVFPQ | NGLVVSSVDV | QSVEPVDQRT | 
    700:
    RDALQRSVQL | AIEITTNSQE | AAAKHEAQRL | EQEARGRLER | QKILDQSEAE | 
    750:
    KARKELLELE | ALSMAVESTG | TAKAEAESRA | EAARIEGEGS | VLQAKLKAQA | 
    800:
    LAIETEAELQ | RVQKVRELEL | VYARAQLELE | VSKAQQLAEV | EVKKFKQMTE | 
    850:
    AIGPSTIRDL | AVAGPEMQVK | LLQSLGLKST | LITDGSTPIN | LFNTAFGLLG | 
    893:
    MGPEGQPLGR | RVASGPSPGE | GISPQSAQAP | QAPGDNHVVP | VLR
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    KEGG:
    MIM:
    Pfam:
    String:
    UniGene:
    SMR:
    Uniprot:
     
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    References
    1. 1.
      "The drug resistance-related protein LRP is the human major vault protein."
      Scheffer G.L. , Wijngaard P.L.J. , Flens M.J. , Izquierdo M.A. , Slovak M.L. , Pinedo H.M. , Meijer C.J.L.M. , Clevers H.C. , Scheper R.J.
      Nat. Med.1:578-582(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    2. 2.
      Scheffer G.L.
      Submitted (2002-03) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SEQUENCE REVISION TO C-TERMINUS
    3. 3.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Eye.
    4. 4.
      "Cloning and initial analysis of the human multidrug resistance-related MVP/LRP gene promoter."
      Lange C. , Walther W. , Schwabe H. , Stein U.
      Biochem. Biophys. Res. Commun.278:125-133(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-169
    5. 5.
      "A small upstream open reading frame causes inhibition of human major vault protein expression from a ubiquitous mRNA splice variant."
      Holzmann K. , Ambrosch I. , Elbling L. , Micksche M. , Berger W.
      FEBS Lett.494:99-104(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] OF 1-65
      tissue: Lung cancer.
    6. 6.
      Quadroni M. , Potts A. , Barblan J. , Bienvenut W.V.
      Submitted (2005-01) to the UniProtKB
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 2-9; 68-82 AND 462-474;CLEAVAGE OF INITIATOR METHIONINE;ACETYLATION AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY
      tissue: Melanoma.
    7. 7.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ASSOCIATION WITH TEP1
    8. 8.
      "PTEN associates with the vault particles in HeLa cells."
      Yu Z. , Fotouhi-Ardakani N. , Wu L. , Maoui M. , Wang S. , Banville D. , Shen S.-H.
      J. Biol. Chem.277:40247-40252(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PTEN
    9. 9.
      "The major vault protein is a novel substrate for the tyrosine phosphatase SHP-2 and scaffold protein in epidermal growth factor signaling."
      Kolli S. , Zito C.I. , Mossink M.H. , Wiemer E.A.C. , Bennett A.M.
      J. Biol. Chem.279:29374-29385(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT TYROSINE RESIDUES;IDENTIFICATION BY MASS SPECTROMETRY;INTERACTION WITH PTPN11;SUBCELLULAR LOCATION;FUNCTION
    10. 10.
      "A novel human zinc finger protein ZNF540 interacts with MVP and inhibits transcriptional activities of the ERK signal pathway."
      Xiang Z. , Yuan W. , Luo N. , Wang Y. , Tan K. , Deng Y. , Zhou X. , Zhu C. , Li Y. , Liu M. , Wu X. , Li Y.
      Biochem. Biophys. Res. Commun.347:288-296(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ZNF540
    11. 11.
      "Crosstalk between Src and major vault protein in epidermal growth factor-dependent cell signalling."
      Kim E. , Lee S. , Mian M.F. , Yun S.U. , Song M. , Yi K.-S. , Ryu S.H. , Suh P.-G.
      FEBS J.273:793-804(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH SRC;TYROSINE PHOSPHORYLATION;SUBCELLULAR LOCATION;IDENTIFICATION BY MASS SPECTROMETRY
    12. 12.
      "The major vault protein is responsive to and interferes with interferon-gamma-mediated STAT1 signals."
      Steiner E. , Holzmann K. , Pirker C. , Elbling L. , Micksche M. , Sutterluety H. , Berger W.
      J. Cell Sci.119:459-469(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION;FUNCTION
    13. 13.
      "Regulatory role of human AP-endonuclease (APE1/Ref-1) in YB-1-mediated activation of the multidrug resistance gene MDR1."
      Chattopadhyay R. , Das S. , Maiti A.K. , Boldogh I. , Xie J. , Hazra T.K. , Kohno K. , Mitra S. , Bhakat K.K.
      Mol. Cell. Biol.28:7066-7080(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH APEX1
    14. 14.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    15. 15.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    16. 16.
      "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
      Bienvenut W.V. , Sumpton D. , Martinez A. , Lilla S. , Espagne C. , Meinnel T. , Giglione C.
      Mol. Cell. Proteomics11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    17. 17.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    18. 18.
      "Solution structure of a two-repeat fragment of major vault protein."
      Kozlov G. , Vavelyuk O. , Minailiuc O. , Banville D. , Gehring K. , Ekiel I.
      J. Mol. Biol.356:444-452(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 113-221;INTERACTION WITH PARP4
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