MYD88 ELISA Kit for Human(Homo sapiens) | EIAab.comMYD88 ELISA Kit for Human(Homo sapiens)

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MYD88 (Gene name),

Myeloid differentiation primary response protein MyD88 (Protein name ), MYD88_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

MYD88;

Protein name:

Myeloid differentiation primary response protein MyD88;

Alternative:

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Homodimer. Also forms heterodimers with TIRAP. Binds to TLR2, TLR4, IRAK1, IRAK2 and IRAK4 via their respective TIR domains. Interacts with IL18R1 (By similarity). Interacts with BMX, IL1RL1 and IRF7. Interacts with LRRFIP1 and LRRFIP2; this interaction positively regulates Toll-like receptor (TLR) signaling in response to agonist. Interacts with FLII. LRRFIP1 and LRRFIP2 compete with FLII for MYD88-binding.

Function:

Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway.

Subcellular Location:

Cytoplasm

Protein Attributes:

Sequence length:

296

Sequence:

50:

100:

150:

200:

250:

296:

RLIPIKYKAM | KKEFPSILRF | ITVCDYTNPC | TKSWFWTRLA | KALSLP

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

KEGG:

hsa:4615

MIM:

602170

UniGene:

Hs.82116

SMR:

Q99836

Pfam:

PF00531

STRING:

9606.ENSP00000379625

String:

Q99836

Uniprot:

Q99836

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ELISA Kit for Human Myeloid differentiation primary response protein MyD88

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E1707h

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ELISA Kit for Human Myeloid differentiation primary response protein MyD88

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E1707m

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ELISA Kit for Human Myeloid differentiation primary response protein MyD88

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E1707r

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ELISA Kit for Human Myeloid differentiation primary response protein MyD88

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E1707p

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96T

ELISA Kit for Human Myeloid differentiation primary response protein MyD88

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E1707c

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ELISA Kit for Human Myeloid differentiation primary response protein MyD88

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E1707b

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96T

CLIA Kit for Human Myeloid differentiation primary response protein MyD88

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U1707m

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96T

CLIA Kit for Human Myeloid differentiation primary response protein MyD88

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U1707h

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96T

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CLIA Kit for Human Myeloid differentiation primary response protein MyD88

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U1707b

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96T

CLIA Kit for Human Myeloid differentiation primary response protein MyD88

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U1707r

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96T

CLIA Kit for Human Myeloid differentiation primary response protein MyD88

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U1707c

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CLIA Kit for Human Myeloid differentiation primary response protein MyD88

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U1707p

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Polyclonal Antibody for Human Myeloid differentiation primary response protein MyD88

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P1707Rb-r

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40ug/0.2ml

Polyclonal Antibody for Human Myeloid differentiation primary response protein MyD88

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P1707Rb-h

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Polyclonal Antibody for Human Myeloid differentiation primary response protein MyD88

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P1707Rb-m

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Monoclonal Antibody for Human Myeloid differentiation primary response protein MyD88

Protein for Human Myeloid differentiation primary response protein MyD88

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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Linearity

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References

1.

"Molecular characterization and modular analysis of human MyD88."
Hardiman G. , Rock F.L. , Balasubramanian S. , Kastelein R.A. , Bazan J.F.
Oncogene13:2467-2475(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);TISSUE SPECIFICITY
tissue: Dendritic cell.
2.

"The cloning and characterization of human MyD88: a member of an IL-1 receptor related family."
Bonnert T.P. , Garka K.E. , Parnet P. , Sonoda G. , Testa J.R. , Sims J.E.
FEBS Lett.402:81-84(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION
tissue: Epidermal carcinoma.
3.

"Natural selection in the TLR-related genes in the course of primate evolution."
Nakajima T. , Ohtani H. , Satta Y. , Uno Y. , Akari H. , Ishida T. , Kimura A.
Immunogenetics60:727-735(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
4.

"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
Submitted (2003-05) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
5.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2; 3; 4 AND 5)
tissue: Umbilical cord blood.
6.

"The DNA sequence, annotation and analysis of human chromosome 3."
Muzny D.M. , Scherer S.E. , Kaul R. , Wang J. , Yu J. , Sudbrak R. , Buhay C.J. , Chen R. , Cree A. , Ding Y. , Dugan-Rocha S. , Gill R. , Gunaratne P. , Harris R.A. , Hawes A.C. , Hernandez J. , Hodgson A.V. , Hume J. , more...
Nature440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
7.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
8.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);NUCLEOTIDE SEQUENCE [MRNA] OF 190-224 (ISOFORM 6)
tissue: Pancreas.
9.

"Interferon-alpha induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6."
Kawai T. , Sato S. , Ishii K.J. , Coban C. , Hemmi H. , Yamamoto M. , Terai K. , Matsuda M. , Inoue J. , Uematsu S. , Takeuchi O. , Akira S.
Nat. Immunol.5:1061-1068(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH IRF7
10.

"Role of a transductional-transcriptional processor complex involving MyD88 and IRF-7 in Toll-like receptor signaling."
Honda K. , Yanai H. , Mizutani T. , Negishi H. , Shimada N. , Suzuki N. , Ohba Y. , Takaoka A. , Yeh W.C. , Taniguchi T.
Proc. Natl. Acad. Sci. U.S.A.101:15416-15421(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;INTERACTION WITH IRF7
11.

"IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST 2 and induces T helper type 2-associated cytokines."
Schmitz J. , Owyang A. , Oldham E. , Song Y. , Murphy E. , McClanahan T.K. , Zurawski G. , Moshrefi M. , Qin J. , Li X. , Gorman D.M. , Bazan J.F. , Kastelein R.A.
Immunity23:479-490(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH IL1RL1
12.

"Smad6 negatively regulates interleukin 1-receptor-Toll-like receptor signaling through direct interaction with the adaptor Pellino-1."
Choi K.C. , Lee Y.S. , Lim S. , Choi H.K. , Lee C.H. , Lee E.K. , Hong S. , Kim I.H. , Kim S.J. , Park S.H.
Nat. Immunol.7:1057-1065(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN COMPLEX WITH IRAK1; IRAK4; TRAF6 AND PELI1
13.

"Etk/BMX, a Btk family tyrosine kinase, and Mal contribute to the cross-talk between MyD88 and FAK pathways."
Semaan N. , Alsaleh G. , Gottenberg J.E. , Wachsmann D. , Sibilia J.
J. Immunol.180:3485-3491(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH BMX
14.

"Modulation of TLR signaling by multiple MyD88-interacting partners including leucine-rich repeat Fli-I-interacting proteins."
Dai P. , Jeong S.Y. , Yu Y. , Leng T. , Wu W. , Xie L. , Chen X.
J. Immunol.182:3450-3460(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH FLII; LRRFIP1 AND LRRFIP2
15.

"AIP1 functions as Arf6-GAP to negatively regulate TLR4 signaling."
Wan T. , Liu T. , Zhang H. , Tang S. , Min W.
J. Biol. Chem.285:3750-3757(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TIRAP
16.

"IKKepsilon-mediated tumorigenesis requires K63-linked polyubiquitination by a cIAP1/cIAP2/TRAF2 E3 ubiquitin ligase complex."
Zhou A.Y. , Shen R.R. , Kim E. , Lock Y.J. , Xu M. , Chen Z.J. , Hahn W.C.
Cell Rep.3:724-733(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH IKBKE
17.

"Structural basis for the multiple interactions of the MyD88 TIR domain in TLR4 signaling."
Ohnishi H. , Tochio H. , Kato Z. , Orii K.E. , Li A. , Kimura T. , Hiroaki H. , Kondo N. , Shirakawa M.
Proc. Natl. Acad. Sci. U.S.A.106:10260-10265(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 148-296;FUNCTION;INTERACTION WITH TIRAP AND IRAK4;MUTAGENESIS OF ARG-196; ASP-197; ARG-217; LYS-282 AND ARG-288;CHARACTERIZATION OF VARIANT MYD88D CYS-196
18.

"Solution NMR structure of human myeloid differentiation primary response (MYD88)."
Northeast structural genomics consortium (NESG)
Submitted (2009-02) to the PDB data bank

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 146-296
19.

"Pyogenic bacterial infections in humans with MyD88 deficiency."
von Bernuth H. , Picard C. , Jin Z. , Pankla R. , Xiao H. , Ku C.-L. , Chrabieh M. , Mustapha I.B. , Ghandil P. , Camcioglu Y. , Vasconcelos J. , Sirvent N. , Guedes M. , Vitor A.B. , Herrero-Mata M.J. , Arostegui J.I. , Rodrigo C. , Alsina L. , more...
Science321:691-696(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS MYD88D PRO-93 AND CYS-196;CHARACTERIZATION OF VARIANTS MYD88D PRO-93 AND CYS-196

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