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Index > Protein center > MYH2(Gene name) > Human
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  • MYH2 (Gene name),
  • Myosin-2 (Protein name ),  MYH2_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    MYH2(MYHSA2);
    Protein name:
    Myosin-2;
    Alternative:
    Myosin heavy chain 2a(MyHC-2a);Myosin heavy chain 2;Myosin heavy chain, skeletal muscle, adult 2;Myosin heavy chain IIa(MyHC-IIa);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Muscle myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2).
    Function:
    Muscle contraction. Required for cytoskeleton organization.
    Subcellular Location:
    Cytoplasm myofibril Thick filaments of the myofibrils.
    Protein Attributes:
    Sequence length:
    1941
    Sequence:
    50:
    MSSDSELAVF | GEAAPFLRKS | ERERIEAQNR | PFDAKTSVFV | AEPKESFVKG | 
    100:
    TIQSREGGKV | TVKTEGGATL | TVKDDQVFPM | NPPKYDKIED | MAMMTHLHEP | 
    150:
    AVLYNLKERY | AAWMIYTYSG | LFCVTVNPYK | WLPVYKPEVV | TAYRGKKRQE | 
    200:
    APPHIFSISD | NAYQFMLTDR | ENQSILITGE | SGAGKTVNTK | RVIQYFATIA | 
    250:
    VTGEKKKEEI | TSGKIQGTLE | DQIISANPLL | EAFGNAKTVR | NDNSSRFGKF | 
    300:
    IRIHFGTTGK | LASADIETYL | LEKSRVVFQL | KAERSYHIFY | QITSNKKPEL | 
    350:
    IEMLLITTNP | YDYPFVSQGE | ISVASIDDQE | ELMATDSAID | ILGFTNEEKV | 
    400:
    SIYKLTGAVM | HYGNLKFKQK | QREEQAEPDG | TEVADKAAYL | QSLNSADLLK | 
    450:
    ALCYPRVKVG | NEYVTKGQTV | EQVSNAVGAL | AKAVYEKMFL | WMVARINQQL | 
    500:
    DTKQPRQYFI | GVLDIAGFEI | FDFNSLEQLC | INFTNEKLQQ | FFNHHMFVLE | 
    550:
    QEEYKKEGIE | WTFIDFGMDL | AACIELIEKP | MGIFSILEEE | CMFPKATDTS | 
    600:
    FKNKLYDQHL | GKSANFQKPK | VVKGKAEAHF | ALIHYAGVVD | YNITGWLEKN | 
    650:
    KDPLNETVVG | LYQKSAMKTL | AQLFSGAQTA | EGEGAGGGAK | KGGKKKGSSF | 
    700:
    QTVSALFREN | LNKLMTNLRS | THPHFVRCII | PNETKTPGAM | EHELVLHQLR | 
    750:
    CNGVLEGIRI | CRKGFPSRIL | YADFKQRYKV | LNASAIPEGQ | FIDSKKASEK | 
    800:
    LLASIDIDHT | QYKFGHTKVF | FKAGLLGLLE | EMRDDKLAQL | ITRTQARCRG | 
    850:
    FLARVEYQRM | VERREAIFCI | QYNIRSFMNV | KHWPWMKLFF | KIKPLLKSAE | 
    900:
    TEKEMATMKE | EFQKIKDELA | KSEAKRKELE | EKMVTLLKEK | NDLQLQVQAE | 
    950:
    AEGLADAEER | CDQLIKTKIQ | LEAKIKEVTE | RAEDEEEINA | ELTAKKRKLE | 
    1000:
    DECSELKKDI | DDLELTLAKV | EKEKHATENK | VKNLTEEMAG | LDETIAKLTK | 
    1050:
    EKKALQEAHQ | QTLDDLQAEE | DKVNTLTKAK | IKLEQQVDDL | EGSLEQEKKL | 
    1100:
    RMDLERAKRK | LEGDLKLAQE | SIMDIENEKQ | QLDEKLKKKE | FEISNLQSKI | 
    1150:
    EDEQALGIQL | QKKIKELQAR | IEELEEEIEA | ERASRAKAEK | QRSDLSRELE | 
    1200:
    EISERLEEAG | GATSAQIEMN | KKREAEFQKM | RRDLEEATLQ | HEATAATLRK | 
    1250:
    KHADSVAELG | EQIDNLQRVK | QKLEKEKSEM | KMEIDDLASN | VETVSKAKGN | 
    1300:
    LEKMCRTLED | QLSELKSKEE | EQQRLINDLT | AQRGRLQTES | GEFSRQLDEK | 
    1350:
    EALVSQLSRG | KQAFTQQIEE | LKRQLEEEIK | AKNALAHALQ | SSRHDCDLLR | 
    1400:
    EQYEEEQESK | AELQRALSKA | NTEVAQWRTK | YETDAIQRTE | ELEEAKKKLA | 
    1450:
    QRLQAAEEHV | EAVNAKCASL | EKTKQRLQNE | VEDLMLDVER | TNAACAALDK | 
    1500:
    KQRNFDKILA | EWKQKCEETH | AELEASQKEA | RSLGTELFKI | KNAYEESLDQ | 
    1550:
    LETLKRENKN | LQQEISDLTE | QIAEGGKRIH | ELEKIKKQVE | QEKCELQAAL | 
    1600:
    EEAEASLEHE | EGKILRIQLE | LNQVKSEVDR | KIAEKDEEID | QLKRNHIRIV | 
    1650:
    ESMQSTLDAE | IRSRNDAIRL | KKKMEGDLNE | MEIQLNHANR | MAAEALRNYR | 
    1700:
    NTQGILKDTQ | IHLDDALRSQ | EDLKEQLAMV | ERRANLLQAE | IEELRATLEQ | 
    1750:
    TERSRKIAEQ | ELLDASERVQ | LLHTQNTSLI | NTKKKLETDI | SQMQGEMEDI | 
    1800:
    LQEARNAEEK | AKKAITDAAM | MAEELKKEQD | TSAHLERMKK | NMEQTVKDLQ | 
    1850:
    LRLDEAEQLA | LKGGKKQIQK | LEARVRELEG | EVESEQKRNA | EAVKGLRKHE | 
    1900:
    RRVKELTYQT | EEDRKNILRL | QDLVDKLQAK | VKSYKRQAEE | AEEQSNTNLA | 
    1941:
    KFRKLQHELE | EAEERADIAE | SQVNKLRVKS | REVHTKVISE | E
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    String:
    MIM:
    UniGene:
    SMR:
    KEGG:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Human Myosin-2
    Cat.:
    E0755h
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human Myosin-2
    Cat.:
    E0755b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human Myosin-2
    Cat.:
    E0755p
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human Myosin-2
    Cat.:
    E0755d
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Myosin-2
    Cat.:
    U0755p
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Myosin-2
    Cat.:
    U0755b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Myosin-2
    Cat.:
    U0755h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Myosin-2
    Cat.:
    U0755d
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human Myosin-2
    Polyclonal Antibody for Human Myosin-2
    Polyclonal Antibody for Human Myosin-2
    Cat.:
    P0755Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Myosin-2
    Monoclonal Antibody for Human Myosin-2
    Monoclonal Antibody for Human Myosin-2
    Monoclonal Antibody for Human Myosin-2
    Monoclonal Antibody for Human Myosin-2
    Protein for Human Myosin-2
    Protein for Human Myosin-2
    Protein for Human Myosin-2
    Protein for Human Myosin-2

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Comparative sequence analysis of the complete human sarcomeric myosin heavy chain family: implications for functional diversity."
      Weiss A. , Schiaffino S. , Leinwand L.A.
      J. Mol. Biol.290:61-75(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      tissue: Skeletal muscle.
    2. 2.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Skeletal muscle.
    3. 4.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
      tissue: Cerebellum.
    4. 5.
      "Type IIx myosin heavy chain transcripts are expressed in type IIb fibers of human skeletal muscle."
      Smerdu V. , Karsch-Mizrachi I. , Campione M. , Leinwand L. , Schiaffino S.
      Am. J. Physiol.267:C1723-C1728(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1711-1941 (ISOFORM 1)
      tissue: Skeletal muscle.
    5. 6.
      "Characterization of human skeletal muscle fibres according to the myosin heavy chains they express."
      Ennion S. , Sant'ana Pereira J. , Sargeant T. , Young A. , Goldspink G.
      J. Muscle Res. Cell Motil.16:35-43(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1823-1941 (ISOFORM 1)
      tissue: Skeletal muscle.
    6. 7.
      "HGAL, a lymphoma prognostic biomarker, interacts with the cytoskeleton and mediates the effects of IL-6 on cell migration."
      Lu X. , Chen J. , Malumbres R. , Cubedo Gil E. , Helfman D.M. , Lossos I.S.
      Blood110:4268-4277(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH GCSAM
    7. 8.
      "Autosomal dominant myopathy: missense mutation (Glu-706 --> Lys) in the myosin heavy chain IIa gene."
      Martinsson T. , Oldfors A. , Darin N. , Berg K. , Tajsharghi H. , Kyllerman M. , Wahlstroem J.
      Proc. Natl. Acad. Sci. U.S.A.97:14614-14619(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT IBM3 LYS-706
    8. 9.
      "Mutations and sequence variation in the human myosin heavy chain IIa gene (MYH2)."
      Tajsharghi H. , Darin N. , Rekabdar E. , Kyllerman M. , Wahlstroem J. , Martinsson T. , Oldfors A.
      Eur. J. Hum. Genet.13:617-622(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS ILE-970 AND VAL-1061
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