Myo6 ELISA Kit for Mouse(Mus musculus) | EIAab.comMyo6 ELISA Kit for Mouse(Mus musculus)

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Myo6 (Gene name),

Myosin-VI (Protein name ), MYO6_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

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Gene name:

Myo6(Sv);

Protein name:

Myosin-VI;

Alternative:

Unconventional myosin-6;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Homodimer. Binding to calmodulin through a unique insert, not found in other myosins, located in the neck region between the motor domain and the IQ domain appears to contribute to the directionality reversal. This interaction occurs only if the C-terminal lobe of calmodulin is occupied by calcium. Interaction with F-actin/ACTN1 occurs only at the apical brush border domain of the proximal tubule cells (By similarity). Interacts with DAB2. In vitro, the C-terminal globular tail binds a C-terminal region of DAB2. Interacts with CFTR. Forms a complex with CFTR and DAB2 in the apical membrane of epithelial cells. Interacts with OPTN.

Function:

Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Myosin 6 is a reverse-direction motor protein that moves towards the minus-end of actin filaments. Has slow rate of actin-activated ADP release due to weak ATP binding. Functions in a variety of intracellular processes such as vesicular membrane trafficking and cell migration. Required for the structural integrity of the Golgi apparatus via the p53-dependent pro-survival pathway. Appears to be involved in a very early step of clathrin-mediated endocytosis in polarized epithelial cells. May act as a regulator of F-actin dynamics. May play a role in transporting DAB2 from the plasma membrane to specific cellular targets. Required for structural integrity of inner ear hair cells.

Subcellular Location:

Golgi apparatus trans-Golgi network membrane Peripheral membrane protein Golgi apparatus Nucleus Cytoplasm perinuclear region Membrane clathrin-coated pit Cell projection ruffle Cytoplasmic vesicle Also present in endocyctic vesicles, and membrane ruffles. Translocates from membrane ruffles, endocytic vesicles and cytoplasm to Golgi apparatus, perinuclear membrane and nucleus through induction by p53 and p53-induced DNA damage. Recruited into membrane ruffles from cell surface by EGF-stimulation. Colocalizes with DAB2 in clathrin-coated pits/vesicles. Colocalizes with OPTN at the Golgi complex and in vesicular structures close to the plasma membrane.

Protein Attributes:

Sequence length:

1265

Sequence:

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1265:

ARPTYATAML | QNLLK

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

Q64331

UniGene:

Mm.4040

String:

Q64331

Pfam:

PF00063

Uniprot:

Q64331

FOR

ELISA Kit for Mouse Myosin-VI

CLIA Kit for Mouse Myosin-VI

Polyclonal Antibody for Mouse Myosin-VI

Monoclonal Antibody for Mouse Myosin-VI

Protein for Mouse Myosin-VI

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"The mouse Snell's waltzer deafness gene encodes an unconventional myosin required for structural integrity of inner ear hair cells."
Avraham K.B. , Hasson T. , Steel K.P. , Kingsley D.M. , Russell L.B. , Mooseker M.S. , Copeland N.G. , Jenkins N.A.
Nat. Genet.11:369-375(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANT SNELL'S WALTZER
tissue: Brain.
2.

"DOC-2/DAB2 is the binding partner of myosin VI."
Inoue A. , Sato O. , Homma K. , Ikebe M.
Biochem. Biophys. Res. Commun.292:300-307(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH DAB2;POSSIBLE FUNCTION

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