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Index > Protein center > CYB5R4(Gene name) > Human
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  • CYB5R4 (Gene name),
  • Cytochrome b5 reductase 4 (Protein name ),  NB5R4_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    CYB5R4(NCB5OR);
    Protein name:
    Cytochrome b5 reductase 4;
    Alternative:
    N-terminal cytochrome b5 and cytochrome b5 oxidoreductase domain-containing protein;Flavohemoprotein b5/b5R(b5+b5R);cb5/cb5R;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    NADH-cytochrome b5 reductase involved in endolasmic reticulum stress response pathway. Plays a critical role in protecting pancreatic beta-cells against oxidant stress, possibly by protecting the cell from excess buildup of reactive oxygen species (ROS). Reduces a variety of substrates in vitro, such as cytochrome c, feericyanide and methemoglobin.
    Subcellular Location:
    Endoplasmic reticulum Soluble protein.
    Protein Attributes:
    Sequence length:
    521
    Sequence:
    50:
    MLNVPSQSFP | APRSQQRVAS | GGRSKVPLKQ | GRSLMDWIRL | TKSGKDLTGL | 
    100:
    KGRLIEVTEE | ELKKHNKKDD | CWICIRGFVY | NVSPYMEYHP | GGEDELMRAA | 
    150:
    GSDGTELFDQ | VHRWVNYESM | LKECLVGRMA | IKPAVLKDYR | EEEKKVLNGM | 
    200:
    LPKSQVTDTL | AKEGPSYPSY | DWFQTDSLVT | IAIYTKQKDI | NLDSIIVDHQ | 
    250:
    NDSFRAETII | KDCLYLIHIG | LSHEVQEDFS | VRVVESVGKI | EIVLQKKENT | 
    300:
    SWDFLGHPLK | NHNSLIPRKD | TGLYYRKCQL | ISKEDVTHDT | RLFCLMLPPS | 
    350:
    THLQVPIGQH | VYLKLPITGT | EIVKPYTPVS | GSLLSEFKEP | VLPNNKYIYF | 
    400:
    LIKIYPTGLF | TPELDRLQIG | DFVSVSSPEG | NFKISKFQEL | EDLFLLAAGT | 
    450:
    GFTPMVKILN | YALTDIPSLR | KVKLMFFNKT | EDDIIWRSQL | EKLAFKDKRL | 
    500:
    DVEFVLSAPI | SEWNGKQGHI | SPALLSEFLK | RNLDKSKVLV | CICGPVPFTE | 
    521:
    QGVRLLHDLN | FSKNEIHSFT | A
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    SMR:
    Pfam:
    KEGG:
    UniGene:
    MIM:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Human Cytochrome b5 reductase 4
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    CLIA Kit for Human Cytochrome b5 reductase 4
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    CLIA Kit for Human Cytochrome b5 reductase 4
    Cat.:
    U10148b
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    Packing:
    96T
    CLIA Kit for Human Cytochrome b5 reductase 4
    Cat.:
    U10148m
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Cytochrome b5 reductase 4
    Cat.:
    U10148h
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    MSDS:
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    Packing:
    96T
    Polyclonal Antibody for Human Cytochrome b5 reductase 4
    Cat.:
    P10148Rb-h
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Cytochrome b5 reductase 4
    Cat.:
    P10148Rb-r
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Cytochrome b5 reductase 4
    Polyclonal Antibody for Human Cytochrome b5 reductase 4
    Cat.:
    P10148Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Cytochrome b5 reductase 4
    Monoclonal Antibody for Human Cytochrome b5 reductase 4
    Monoclonal Antibody for Human Cytochrome b5 reductase 4
    Monoclonal Antibody for Human Cytochrome b5 reductase 4
    Protein for Human Cytochrome b5 reductase 4
    Protein for Human Cytochrome b5 reductase 4
    Protein for Human Cytochrome b5 reductase 4
    Protein for Human Cytochrome b5 reductase 4

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    References
    1. 1.
      SeattleSNPs variation discovery resource
      Submitted (2008-02) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS HIS-140; ALA-267 AND SER-316
    2. 2.
      "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J. , Palmer S.A. , Sims S.K. , Edwards C.A. , Ashurst J.L. , Wilming L. , Jones M.C. , Horton R. , Hunt S.E. , Scott C.E. , Gilbert J.G.R. , Clamp M.E. , Bethel G. , Milne S. , Ainscough R. , Almeida J.P. , Ambrose K.D. , Andrews T.D. , more...
      Nature425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    3. 3.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Testis.
    4. 4.
      "Identification of a cytochrome b-type NAD(P)H oxidoreductase ubiquitously expressed in human cells."
      Zhu H. , Qiu H. , Yoon H.-W. , Huang S. , Bunn H.F.
      Proc. Natl. Acad. Sci. U.S.A.96:14742-14747(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 33-521;SUBCELLULAR LOCATION;HEME-BINDING;FAD-BINDING;TISSUE SPECIFICITY
    5. 5.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    6. 6.
      "Study of the individual cytochrome b5 and cytochrome b5 reductase domains of Ncb5or reveals a unique heme pocket and a possible role of the CS domain."
      Deng B. , Parthasarathy S. , Wang W. , Gibney B.R. , Battaile K.P. , Lovell S. , Benson D.R. , Zhu H.
      J. Biol. Chem.285:30181-30191(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.25 ANGSTROMS) OF 51-137;HEME-BINDING SITES
    7. 7.
      "Variation in NCB5OR: studies of relationships to type 2 diabetes, maturity-onset diabetes of the young, and gestational diabetes mellitus."
      Andersen G. , Wegner L. , Rose C.S. , Xie J. , Zhu H. , Larade K. , Johansen A. , Ek J. , Lauenborg J. , Drivsholm T. , Borch-Johnsen K. , Damm P. , Hansen T. , Bunn H.F. , Pedersen O.
      Diabetes53:2992-2997(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS ARG-187 AND ARG-223
    8. 8.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
    9. 9.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS [LARGE SCALE ANALYSIS] TYR-371 AND MET-390
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