Protein name:
Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2 ;
Alternative:
N-heparan sulfate sulfotransferase 2 (N-HSST 2) ;Glucosaminyl N-deacetylase/N-sulfotransferase 2 (NDST-2) ;
Organism:
Human (Homo sapiens).
General Annotation
Function:
Essential bifunctional enzyme that catalyzes both the N-deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA dissacharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Plays a role in determining the extent and pattern of sulfation of heparan sulfate.
Subcellular Location:
Golgi apparatus membrane
Single-pass type II membrane protein
Protein Attributes:
50:
MLQLWKVVRP | ARQLELHRLI | LLLIAFSLGS | MGFLAYYVST | SPKAKEPLPL |
100:
PLGDCSSGGA | AGPGPARPPV | PPRPPRPPET | ARTEPVVLVF | VESAYSQLGQ |
150:
EIVAILESSR | FRYSTELAPG | RGDMPTLTDN | THGRYVLVIY | ENLLKYVNLD |
200:
AWSRELLDRY | CVEYGVGIIG | FFRAHEHSLL | SAQLKGFPLF | LHSNLGLRDY |
250:
QVNPSAPLLH | LTRPSRLEPG | PLPGDDWTIF | QSNHSTYEPV | LLASLRPAEP |
300:
AVPGPVLRRA | RLPTVVQDLG | LHDGIQRVLF | GHGLSFWLHK | LIFVDAVAYL |
350:
TGKRLCLDLD | RYILVDIDDI | FVGKEGTRMK | VADVEALLTT | QNKLRTLVPN |
400:
FTFNLGFSGK | FYHTGTEEED | AGDDMLLKHR | KEFWWFPHMW | SHMQPHLFHN |
450:
RSVLADQMRL | NKQFALEHGI | PTDLGYAVAP | HHSGVYPIHT | QLYEAWKSVW |
500:
GIQVTSTEEY | PHLRPARYRR | GFIHNGIMVL | PRQTCGLFTH | TIFYNEYPGG |
550:
SRELDRSIRG | GELFLTVLLN | PISIFMTHLS | NYGNDRLGLY | TFESLVRFLQ |
600:
CWTRLRLQTL | PPVPLAQKYF | ELFPQERSPL | WQNPCDDKRH | KDIWSKEKTC |
650:
DRLPKFLIVG | PQKTGTTAIH | FFLSLHPAVT | SSFPSPSTFE | EIQFFNSPNY |
700:
HKGIDWYMDF | FPVPSNASTD | FLFEKSATYF | DSEVVPRRGA | ALLPRAKIIT |
750:
VLTNPADRAY | SWYQHQRAHG | DPVALNYTFY | QVISASSQTP | LALRSLQNRC |
800:
LVPGYYSTHL | QRWLTYYPSG | QLLIVDGQEL | RTNPAASMES | IQKFLGITPF |
850:
LNYTRTLRFD | DDKGFWCQGL | EGGKTRCLGR | SKGRRYPDMD | TESRLFLTDF |
883:
FRNHNLELSK | LLSRLGQPVP | SWLREELQHS | SLG
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
Bovine
ELISA Kit for Human Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2
ELISA Kit for Human Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2
ELISA Kit for Human Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2
CLIA Kit for Human Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2
CLIA Kit for Human Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2
CLIA Kit for Human Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2
Polyclonal Antibody for Human Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2
Polyclonal Antibody for Human Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2
Polyclonal Antibody for Human Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2
Monoclonal Antibody for Human Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2
Monoclonal Antibody for Human Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2
Monoclonal Antibody for Human Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2
Protein for Human Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2
Protein for Human Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2
Protein for Human Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2
R&D Technical Data
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Precision
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Recovery
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Linearity
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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1)
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue :
Ovary .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 14-377 (ISOFORM 2)
tissue :
Brain .
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;BIOPHYSICOCHEMICAL PROPERTIES
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION