Gene name:
Grin2d (GluN2D) ;
Protein name:
Glutamate [NMDA] receptor subunit epsilon-4 (GluN2D) ;
Alternative:
N-methyl D-aspartate receptor subtype 2D (NMDAR2D) ;N-methyl D-aspartate receptor subtype 2D (NMDAR2D;NR2D) ;
Organism:
Rat (Rattus norvegicus).
General Annotation
Sub Unit:
Forms heteromeric channel of a zeta subunit (GRIN1), a epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D) and a third subunit (GRIN3A or GRIN3B). Interacts with PDZ domains of INADL and DLG4.
Function:
NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine.
Subcellular Location:
Cell membrane
Multi-pass membrane protein
Cell junction
synapse
postsynaptic cell membrane
Multi-pass membrane protein
Protein Attributes:
50:
MRGAGGPRGP | RGPAKMLLLL | ALACASPFPE | EVPGPGAVGG | GTGGARPLNV |
100:
ALVFSGPAYA | AEAARLGPAV | AAAVRSPGLD | VRPVALVLNG | SDPRSLVLQL |
150:
CDLLSGLRVH | GVVFEDDSRA | PAVAPILDFL | SAQTSLPIVA | VHGGAALVLT |
200:
PKEKGSTFLQ | LGSSTEQQLQ | VIFEVLEEYD | WTSFVAVTTR | APGHRAFLSY |
250:
IEVLTDGSLV | GWEHRGALTL | DPGAGEAVLG | AQLRSVSAQI | RLLFCAREEA |
300:
EPVFRAAEEA | GLTGPGYVWF | MVGPQLAGGG | GSGVPGEPLL | LPGGSPLPAG |
350:
LFAVRSAGWR | DDLARRVAAG | VAVVARGAQA | LLRDYGFLPE | LGHDCRTQNR |
400:
THRGESLHRY | FMNITWDNRD | YSFNEDGFLV | NPSLVVISLT | RDRTWEVVGS |
450:
WEQQTLRLKY | PLWSRYGRFL | QPVDDTQHLT | VATLEERPFV | IVEPADPISG |
500:
TCIRDSVPCR | SQLNRTHSPP | PDAPRPEKRC | CKGFCIDILK | RLAHTIGFSY |
550:
DLYLVTNGKH | GKKIDGVWNG | MIGEVFYQRA | DMAIGSLTIN | EERSEIVDFS |
600:
VPFVETGISV | MVARSNGTVS | PSAFLEPYSP | AVWVMMFVMC | LTVVAVTVFI |
650:
FEYLSPVGYN | RSLATGKRPG | GSTFTIGKSI | WLLWALVFNN | SVPVENPRGT |
700:
TSKIMVLVWA | FFAVIFLASY | TANLAAFMIQ | EEYVDTVSGL | SDRKFQRPQE |
750:
QYPPLKFGTV | PNGSTEKNIR | SNYPDMHSYM | VRYNQPRVEE | ALTQLKAGKL |
800:
DAFIYDAAVL | NYMARKDEGC | KLVTIGSGKV | FATTGYGIAL | HKGSRWKRPI |
850:
DLALLQFLGD | DEIEMLERLW | LSGICHNDKI | EVMSSKLDID | NMAGVFYMLL |
900:
VAMGLSLLVF | AWEHLVYWRL | RHCLGPTHRM | DFLLAFSRGM | YSCCSAEAAP |
950:
PPAKPPPPPQ | PLPSPAYPAA | RPPPGPAPFV | PRERAAADRW | RRAKGTGPPG |
1000:
GAAIADGFHR | YYGPIEPQGL | GLGEARAAPR | GAAGRPLSPP | TTQPPQKPPP |
1050:
SYFAIVREQE | PTEPPAGAFP | GFPSPPAPPA | AAAAAVGPPL | CRLAFEDESP |
1100:
PAPSRWPRSD | PESQPLLGGG | AGGPSAGAPT | APPPRRAAPP | PCAYLDLEPS |
1150:
PSDSEDSESL | GGASLGGLEP | WWFADFPYPY | AERLGPPPGR | YWSVDKLGGW |
1200:
RAGSWDYLPP | RGGPAWHCRH | CASLELLPPP | RHLSCSHDGL | DGGWWAPPPP |
1250:
PWAAGPPPRR | RARCGCPRPH | PHRPRASHRA | PAAAPHHHRH | RRAAGGWDFP |
1300:
PPAPTSRSLE | DLSSCPRAAP | TRRLTGPSRH | ARRCPHAAHW | GPPLPTASHR |
1323:
RHRGGDLGTR | RGSAHFSSLE | SEV
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Rat
Mouse
Polyclonal Antibody for Rat GluN2D
Polyclonal Antibody for Rat GluN2D
Polyclonal Antibody for Rat GluN2D
Monoclonal Antibody for Rat GluN2D
Monoclonal Antibody for Rat GluN2D
Monoclonal Antibody for Rat GluN2D
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
"Molecular characterization of the family of the N-methyl-D-aspartate receptor subunits."
Ishii T.
,
Moriyoshi K.
,
Sugihara H.
,
Sakurada K.
,
Kadotani H.
,
Yokoi M.
,
Akazawa C.
,
Shigemoto R.
,
Mizuno N.
,
Masu M.
,
Nakanishi S.
J. Biol. Chem.268:2836-2843(1993)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);NUCLEOTIDE SEQUENCE OF 1265-1356 (ISOFORM 2)
strain :
Sprague-Dawley .
tissue :
Forebrain .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
tissue :
Brain .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
strain :
Sprague-Dawley .
tissue :
Brain .
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH DLG4
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH INADL
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 424-827;DISULFIDE BONDS