GRIN1 ELISA Kit for Human(Homo sapiens) | EIAab.comGRIN1 ELISA Kit for Human(Homo sapiens)

Search Protein-oriented Product center.

For antibodies, ELISA/CLIA, proteins... Product center

Tips

Index > Protein center > GRIN1(Gene name) > Human

GRIN1 (Gene name),

Glutamate [NMDA] receptor subunit zeta-1 (Protein name ), NMDZ1_HUMAN from NCBI database.

top

General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

Feedback

Gene name:

GRIN1(NMDAR1);

Protein name:

Glutamate [NMDA] receptor subunit zeta-1(GluN1);

Alternative:

N-methyl-D-aspartate receptor subunit NR1(NMD-R1);N-methyl-D-aspartate receptor subunit NR1(NMD-R1);

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Forms heteromeric channel of a zeta subunit (GRIN1), a epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D) and a third subunit (GRIN3A or GRIN3B); disulfide-linked. Found in a complex with GRIN2A or GRIN2B, GRIN3A or GRIN3B and PPP2CB. Interacts with DLG4 and MPDZ (By similarity). Interacts with LRFN1 and LRFN2 (By similarity). Interacts with GCOM1.

Function:

NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. This protein plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. It mediates neuronal functions in glutamate neurotransmission. Is involved in the cell surface targeting of NMDA receptors.

Subcellular Location:

Cell membrane Multi-pass membrane protein Cell junction synapse postsynaptic cell membrane Cell junction synapse postsynaptic cell membrane postsynaptic density Enriched in post-synaptic plasma membrane and post-synaptic densities.

Protein Attributes:

Sequence length:

938

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

700:

750:

800:

850:

900:

938:

STGGGRGALQ | NQKDTVLPRR | AIEREEGQLQ | LCSRHRES

3D Structure:

N/A

Predicted Eptitope:

Please Sign in.

Vaild Sequence:

Please Sign in.

Related Databases

Pfam:

PF01094

KEGG:

hsa:2902

UniGene:

Hs.558334

String:

Q05586

MIM:

138249

SMR:

Q05586

Uniprot:

Q05586

FOR

ELISA Kit for Human GluN1

Cat.:

E0336h

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

Please sign in first.

ELISA Kit for Human GluN1

Cat.:

E0336r

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

Please sign in first.

ELISA Kit for Human GluN1

Cat.:

E0336m

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

ELISA Kit for Human GluN1

Cat.:

E0336d

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Human GluN1

Cat.:

U0336d

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Human GluN1

Cat.:

U0336m

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Human GluN1

Cat.:

U0336r

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

Please sign in first.

CLIA Kit for Human GluN1

Cat.:

U0336h

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

Please sign in first.

Polyclonal Antibody for Human GluN1

Cat.:

P0336Rb-m

Price:

Please sign in first.

Packing:

40ug/0.2ml

Polyclonal Antibody for Human GluN1

Cat.:

P0336Rb-r

Price:

Please sign in first.

Packing:

40ug/0.2ml

Polyclonal Antibody for Human GluN1

Cat.:

P0336Rb-h

Price:

Please sign in first.

Packing:

40ug/0.2ml

Polyclonal Antibody for Human GluN1

Monoclonal Antibody for Human GluN1

Protein for Human GluN1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Cloning and sequence analysis of cDNAs encoding human hippocampus N-methyl-D-aspartate receptor subunits: evidence for alternative RNA splicing."
Foldes R.L. , Rampersad V. , Kamboj R.K.
Gene131:293-298(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);NUCLEOTIDE SEQUENCE [MRNA] OF 11-938 (ISOFORM 3);NUCLEOTIDE SEQUENCE [MRNA] OF 300-938 (ISOFORM 2)
tissue: Brain.
2.

"Molecular cloning and chromosomal localization of the key subunit of the human N-methyl-D-aspartate receptor."
Karp S.J. , Masu M. , Eki T. , Ozawa K. , Nakanishi S.
J. Biol. Chem.268:3728-3733(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3)
3.

"Molecular cloning, functional expression, and pharmacological characterization of an N-methyl-D-aspartate receptor subunit from human brain."
Planells-Cases R. , Sun W. , Ferrer-Montiel A.V. , Montal M.
Proc. Natl. Acad. Sci. U.S.A.90:5057-5061(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue: Brain.
4.

"Cloning and structure of the gene encoding the human N-methyl-D-aspartate receptor (NMDAR1)."
Zimmer M. , Fink T.M. , Franke Y. , Lichter P. , Spiess J.
Gene159:219-223(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
5.

"Cloning and localization of exon 5-containing isoforms of the NMDAR1 subunit in human and rat brains."
Nash N.R. , Heilman C.J. , Rees H.D. , Levey A.I.
J. Neurochem.69:485-493(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 6 AND 7);VARIANTS MET-540 AND SER-682
6.

"DNA sequence and analysis of human chromosome 9."
Humphray S.J. , Oliver K. , Hunt A.R. , Plumb R.W. , Loveland J.E. , Howe K.L. , Andrews T.D. , Searle S. , Hunt S.E. , Scott C.E. , Jones M.C. , Ainscough R. , Almeida J.P. , Ambrose K.D. , Ashwell R.I.S. , Babbage A.K. , Babbage S. , Bagguley C.L. , more...
Nature429:369-374(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
7.

"Cloning and sequence analysis of additional splice variants encoding human N-methyl-D-aspartate receptor (hNR1) subunits."
Foldes R.L. , Rampersad V. , Kamboj R.K.
Gene147:303-304(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 332-922 (ISOFORM 4);NUCLEOTIDE SEQUENCE [MRNA] OF 86-259 (ISOFORM 5)
tissue: Cerebellum.
tissue: Hippocampus.
8.

"Inducible expression of neuronal glutamate receptor channels in the NT2 human cell line."
Younkin D.P. , Tang C.-M. , Hardy M. , Reddy U.R. , Shi Q.-Y. , Pleasure S.J. , Lee V.M.-Y. , Pleasure D.
Proc. Natl. Acad. Sci. U.S.A.90:2174-2178(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 364-464 (ISOFORMS 1/2/3)
9.

"Regulation of NMDA receptor phosphorylation by alternative splicing of the C-terminal domain."
Tingley W.G. , Roche K.W. , Thompson A.K. , Huganir R.L.
Nature364:70-73(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION BY PKC
10.

"Appropriate NR1-NR1 disulfide-linked homodimer formation is requisite for efficient expression of functional, cell surface N-methyl-D-aspartate NR1/NR2 receptors."
Papadakis M. , Hawkins L.M. , Stephenson F.A.
J. Biol. Chem.279:14703-14712(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERCHAIN DISULFIDE BOND
11.

"GRINL1A colocalizes with N-methyl D-aspartate receptor NR1 subunit and reduces N-methyl D-aspartate toxicity."
Roginski R.S. , Goubaeva F. , Mikami M. , Fried-Cassorla E. , Nair M.R. , Yang J.
NeuroReport19:1721-1726(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MYZAP
12.

"Structures of the M2 channel-lining segments from nicotinic acetylcholine and NMDA receptors by NMR spectroscopy."
Opella S.J. , Marassi F.M. , Gesell J.J. , Valente A.P. , Kim Y. , Oblatt-Montal M. , Montal M.
Nat. Struct. Biol.6:374-379(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 599-621
13.

"Excess of de novo deleterious mutations in genes associated with glutamatergic systems in nonsyndromic intellectual disability."
Hamdan F.F. , Gauthier J. , Araki Y. , Lin D.T. , Yoshizawa Y. , Higashi K. , Park A.R. , Spiegelman D. , Dobrzeniecka S. , Piton A. , Tomitori H. , Daoud H. , Massicotte C. , Henrion E. , Diallo O. , Shekarabi M. , Marineau C. , Shevell M. , more...
Am. J. Hum. Genet.88:306-316(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS MRD8 SER-560 INS AND LYS-662;CHARACTERIZATION OF VARIANTS MRD8 SER-560 INS AND LYS-662

Product Feedback Wall

* Email:
*Comments: