Gene name:
Grin1 (Glurz1) ;
Protein name:
Glutamate [NMDA] receptor subunit zeta-1 (GluN1) ;
Alternative:
N-methyl-D-aspartate receptor subunit NR1 (NMD-R1) ;N-methyl-D-aspartate receptor subunit NR1 (NMD-R1) ;
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Forms heteromeric channel of a zeta subunit (GRIN1), a epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D) and a third subunit (GRIN3A or GRIN3B); disulfide-linked. Found in a complex with GRIN2A or GRIN2B and GRIN3B. Found in a complex with GRIN2A or GRIN2B, GRIN3A and PPP2CB. Interacts with DLG4 and MPDZ (By similarity). Interacts with LRFN1 and LRFN2 (By similarity). Interacts with GCOM1.
Function:
NMDA receptor subtype of glutamate-gated ion channels possesses high calcium permeability and voltage-dependent sensitivity to magnesium. Modulated by glycine. This protein plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. It mediates neuronal functions in glutamate neurotransmission. Is involved in the cell surface targeting of NMDA receptors.
Subcellular Location:
Cell membrane
Multi-pass membrane protein
Cell junction
synapse
postsynaptic cell membrane
Cell junction
synapse
postsynaptic cell membrane
postsynaptic density
Enriched in post-synaptic plasma membrane and post-synaptic densities.
Protein Attributes:
50:
MSTMHLLTFA | LLFSCSFARA | ACDPKIVNIG | AVLSTRKHEQ | MFREAVNQAN |
100:
KRHGSWKIQL | NATSVTHKPN | AIQMALSVCE | DLISSQVYAI | LVSHPPTPND |
150:
HFTPTPVSYT | AGFYRIPVLG | LTTRMSIYSD | KSIHLSFLRT | VPPYSHQSSV |
200:
WFEMMRVYNW | NHIILLVSDD | HEGRAAQKRL | ETLLEERESK | AEKVLQFDPG |
250:
TKNVTALLME | ARDLEARVII | LSASEDDAAT | VYRAAAMLNM | TGSGYVWLVG |
300:
EREISGNALR | YAPDGIIGLQ | LINGKNESAH | ISDAVGVVAQ | AVHELLEKEN |
350:
ITDPPRGCVG | NTNIWKTGPL | FKRVLMSSKY | ADGVTGRVEF | NEDGDRKFAN |
400:
YSIMNLQNRK | LVQVGIYNGT | HVIPNDRKII | WPGGETEKPR | GYQMSTRLKI |
450:
VTIHQEPFVY | VKPTMSDGTC | KEEFTVNGDP | VKKVICTGPN | DTSPGSPRHT |
500:
VPQCCYGFCV | DLLIKLARTM | NFTYEVHLVA | DGKFGTQERV | NNSNKKEWNG |
550:
MMGELLSGQA | DMIVAPLTIN | NERAQYIEFS | KPFKYQGLTI | LVKKEIPRST |
600:
LDSFMQPFQS | TLWLLVGLSV | HVVAVMLYLL | DRFSPFGRFK | VNSEEEEEDA |
650:
LTLSSAMWFS | WGVLLNSGIG | EGAPRSFSAR | ILGMVWAGFA | MIIVASYTAN |
700:
LAAFLVLDRP | EERITGINDP | RLRNPSDKFI | YATVKQSSVD | IYFRRQVELS |
750:
TMYRHMEKHN | YESAAEAIQA | VRDNKLHAFI | WDSAVLEFEA | SQKCDLVTTG |
800:
ELFFRSGFGI | GMRKDSPWKQ | NVSLSILKSH | ENGFMEDLDK | TWVRYQECDS |
850:
RSNAPATLTF | ENMAGVFMLV | AGGIVAGIFL | IFIEIAYKRH | KDARRKQMQL |
900:
AFAAVNVWRK | NLQDRKSGRA | EPDPKKKATF | RAITSTLASS | FKRRRSSKDT |
938:
STGGGRGALQ | NQKDTVLPRR | AIEREEGQLQ | LCSRHRES
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Rat
Mouse
Dog
ELISA Kit for Mouse GluN1
ELISA Kit for Mouse GluN1
ELISA Kit for Mouse GluN1
ELISA Kit for Mouse GluN1
Polyclonal Antibody for Mouse GluN1
Polyclonal Antibody for Mouse GluN1
Polyclonal Antibody for Mouse GluN1
Polyclonal Antibody for Mouse GluN1
Monoclonal Antibody for Mouse GluN1
Monoclonal Antibody for Mouse GluN1
Monoclonal Antibody for Mouse GluN1
Monoclonal Antibody for Mouse GluN1
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
2.
"Lineage-specific biology revealed by a finished genome assembly of the mouse."
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Europe PMC ]
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Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain :
C57BL/6J .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
tissue :
Eye .
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION IN A COMPLEX WITH GRIN2A OR GRIN2B AND GRIN3B
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : SUBCELLULAR LOCATION;IDENTIFICATION IN A COMPLEX WITH GRIN2A OR GRIN2B AND GRIN3B
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH MYZAP
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"Loss of sorting nexin 27 contributes to excitatory synaptic dysfunction by modulating glutamate receptor recycling in Down's syndrome."
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Nat. Med.19:473-480(2013)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH SNX27