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Index > Protein center > NOS3(Gene name) > Human
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  • NOS3 (Gene name),
  • Nitric oxide synthase, endothelial (Protein name ),  NOS3_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Related Databases
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  • Gene name:
    NOS3;
    Protein name:
    Nitric oxide synthase, endothelial;
    Alternative:
    EC-NOS;Constitutive NOS(cNOS);NOS type III(NOSIII);Endothelial NOS(eNOS);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Homodimer. Interacts with NOSIP and NOSTRIN.
    Function:
    Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets.
    Subcellular Location:
    Cell membrane Membrane caveola Cytoplasm cytoskeleton Golgi apparatus Specifically associates with actin cytoskeleton in the G2 phase of the cell cycle; which is favored by interaction with NOSIP and results in a reduced enzymatic activity.
    Protein Attributes:
    Sequence length:
    1203
    Sequence:
    50:
    MGNLKSVAQE | PGPPCGLGLG | LGLGLCGKQG | PATPAPEPSR | APASLLPPAP | 
    100:
    EHSPPSSPLT | QPPEGPKFPR | VKNWEVGSIT | YDTLSAQAQQ | DGPCTPRRCL | 
    150:
    GSLVFPRKLQ | GRPSPGPPAP | EQLLSQARDF | INQYYSSIKR | SGSQAHEQRL | 
    200:
    QEVEAEVAAT | GTYQLRESEL | VFGAKQAWRN | APRCVGRIQW | GKLQVFDARD | 
    250:
    CRSAQEMFTY | ICNHIKYATN | RGNLRSAITV | FPQRCPGRGD | FRIWNSQLVR | 
    300:
    YAGYRQQDGS | VRGDPANVEI | TELCIQHGWT | PGNGRFDVLP | LLLQAPDEPP | 
    350:
    ELFLLPPELV | LEVPLEHPTL | EWFAALGLRW | YALPAVSNML | LEIGGLEFPA | 
    400:
    APFSGWYMST | EIGTRNLCDP | HRYNILEDVA | VCMDLDTRTT | SSLWKDKAAV | 
    450:
    EINVAVLHSY | QLAKVTIVDH | HAATASFMKH | LENEQKARGG | CPADWAWIVP | 
    500:
    PISGSLTPVF | HQEMVNYFLS | PAFRYQPDPW | KGSAAKGTGI | TRKKTFKEVA | 
    550:
    NAVKISASLM | GTVMAKRVKA | TILYGSETGR | AQSYAQQLGR | LFRKAFDPRV | 
    600:
    LCMDEYDVVS | LEHETLVLVV | TSTFGNGDPP | ENGESFAAAL | MEMSGPYNSS | 
    650:
    PRPEQHKSYK | IRFNSISCSD | PLVSSWRRKR | KESSNTDSAG | ALGTLRFCVF | 
    700:
    GLGSRAYPHF | CAFARAVDTR | LEELGGERLL | QLGQGDELCG | QEEAFRGWAQ | 
    750:
    AAFQAACETF | CVGEDAKAAA | RDIFSPKRSW | KRQRYRLSAQ | AEGLQLLPGL | 
    800:
    IHVHRRKMFQ | ATIRSVENLQ | SSKSTRATIL | VRLDTGGQEG | LQYQPGDHIG | 
    850:
    VCPPNRPGLV | EALLSRVEDP | PAPTEPVAVE | QLEKGSPGGP | PPGWVRDPRL | 
    900:
    PPCTLRQALT | FFLDITSPPS | PQLLRLLSTL | AEEPREQQEL | EALSQDPRRY | 
    950:
    EEWKWFRCPT | LLEVLEQFPS | VALPAPLLLT | QLPLLQPRYY | SVSSAPSTHP | 
    1000:
    GEIHLTVAVL | AYRTQDGLGP | LHYGVCSTWL | SQLKPGDPVP | CFIRGAPSFR | 
    1050:
    LPPDPSLPCI | LVGPGTGIAP | FRGFWQERLH | DIESKGLQPT | PMTLVFGCRC | 
    1100:
    SQLDHLYRDE | VQNAQQRGVF | GRVLTAFSRE | PDNPKTYVQD | ILRTELAAEV | 
    1150:
    HRVLCLERGH | MFVCGDVTMA | TNVLQTVQRI | LATEGDMELD | EAGDVIGVLR | 
    1200:
    DQQRYHEDIF | GLTLRTQEVT | SRIRTQSFSL | QERQLRGAVP | WAFDPPGSDT | 
    1203:
    NSP
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    SMR:
    KEGG:
    Pfam:
    String:
    UniGene:
    MIM:
    Uniprot:
     
    FOR
    ELISA Kit for Human Nitric oxide synthase, endothelial
    Cat.:
    E0815r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human Nitric oxide synthase, endothelial
    Cat.:
    E0815h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human Nitric oxide synthase, endothelial
    Cat.:
    E0815d
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human Nitric oxide synthase, endothelial
    Cat.:
    E0815p
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human Nitric oxide synthase, endothelial
    Cat.:
    E0815m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human Nitric oxide synthase, endothelial
    Cat.:
    E0815b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Nitric oxide synthase, endothelial
    Cat.:
    U0815h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Nitric oxide synthase, endothelial
    Cat.:
    U0815r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Nitric oxide synthase, endothelial
    Cat.:
    U0815d
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Nitric oxide synthase, endothelial
    Cat.:
    U0815p
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Nitric oxide synthase, endothelial
    Cat.:
    U0815m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Nitric oxide synthase, endothelial
    Cat.:
    U0815b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human Nitric oxide synthase, endothelial
    Cat.:
    P0815Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Nitric oxide synthase, endothelial
    Cat.:
    P0815Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Nitric oxide synthase, endothelial
    Polyclonal Antibody for Human Nitric oxide synthase, endothelial
    Cat.:
    P0815Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Nitric oxide synthase, endothelial
    Polyclonal Antibody for Human Nitric oxide synthase, endothelial
    Monoclonal Antibody for Human Nitric oxide synthase, endothelial
    Monoclonal Antibody for Human Nitric oxide synthase, endothelial
    Monoclonal Antibody for Human Nitric oxide synthase, endothelial
    Monoclonal Antibody for Human Nitric oxide synthase, endothelial
    Monoclonal Antibody for Human Nitric oxide synthase, endothelial
    Monoclonal Antibody for Human Nitric oxide synthase, endothelial
    Protein for Human Nitric oxide synthase, endothelial
    Protein for Human Nitric oxide synthase, endothelial
    Protein for Human Nitric oxide synthase, endothelial
    Protein for Human Nitric oxide synthase, endothelial
    Protein for Human Nitric oxide synthase, endothelial
    Protein for Human Nitric oxide synthase, endothelial

    R&D Technical Data
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    s
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    Precision
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    Intra-assay Precision (Precision within an assay):Three samples of known concentration were tested twenty times on one plate to assess intra-assay precision.

    Intra-Assay CV: ≤3.9%

    Inter-assay Precision (Precision between assays):Three samples of known concentration were tested in five separate assays to assess inter-assay precision.

    Inter-Assay CV: ≤7.7%

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    Recovery
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    Recovery was determined by spiking various levels of ACE into serum and plasma .

    Sample Type

    Average(%)

    Recovery Range(%)

    Serum

    99

    91-103

    Plasma

    98

    93-106

     

     

     

     

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    Linearity
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    The linearity of the kit was assayed by testing samples spiked with appropriate concentration of ACE and their serial dilutions. The results were demonstrated by the percentage of calculated concentration to the expected.  

     

    Sample

    1:2

    1:4

    1:8

    1:16

    serum(n=5)

    92-105%

    90-101%

    95-105%

    92-109%

    Saliva(n=3)

    89-95%

    93105%

    89-94%

    90-106%

    heparin plasma(n=5)

    93-104%

     

    94-110%

    101-111%

    91-110%

     

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    Citations
    References
    1. 1.
      "Cloning and expression of a cDNA encoding human endothelium-derived relaxing factor/nitric oxide synthase."
      Janssens S.P. , Shimouchi A. , Quertermous T. , Bloch D.B. , Bloch K.D.
      J. Biol. Chem.267:14519-14522(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    2. 2.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM
    3. 3.
      "Molecular cloning and characterization of human endothelial nitric oxide synthase."
      Marsden P.A. , Schappert K.T. , Chen H.S. , Flowers M. , Sundell C.L. , Wilcox J.N. , Lamas S. , Michel T.
      FEBS Lett.307:287-293(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    4. 4.
      "Structure and chromosomal localization of the human constitutive endothelial nitric oxide synthase gene."
      Marsden P.A. , Heng H.H.Q. , Scherer S.W. , Stewart R.J. , Hall A.V. , Shi X.-M. , Tsui L.-C. , Schappert K.T.
      J. Biol. Chem.268:17478-17488(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    5. 5.
      "Gene structure, polymorphism and mapping of the human endothelial nitric oxide synthase gene."
      Nadaud S.A. , Bonnardeaux A. , Lathrop M. , Soubrier F.
      Biochem. Biophys. Res. Commun.198:1027-1033(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
      tissue: Placenta.
    6. 6.
      "Cloning and structural characterization of the human endothelial nitric-oxide-synthase gene."
      Miyahara K. , Kawamoto T. , Sase K. , Yui Y. , Toda K. , Yang L.X. , Hattori R. , Aoyama T. , Yamamoto Y. , Doi Y. , Ogoshi S. , Hashimoto K. , Kawai C. , Sasayama S. , Shizuta Y.
      Eur. J. Biochem.223:719-726(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    7. 7.
      "Alternative splicing in intron 13 of the human eNOS gene: a potential mechanism for regulating eNOS activity."
      Lorenz M. , Hewing B. , Hui J. , Zepp A. , Baumann G. , Bindereif A. , Stangl V. , Stangl K.
      FASEB J.21:1556-1564(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS ENOS13B AND ENOS13C);ALTERNATIVE SPLICING;FUNCTION (ISOFORM ENOS13C);VARIANT ASP-298
    8. 8.
      Liao J.K.
      Submitted (1993-12) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
      tissue: Umbilical vein.
    9. 9.
      "The role of phosphatidylinositol-3-oh kinase in platelet-derived nitric oxide release and platelet disaggregation."
      Zhang Y. , Freedman J.E.
      Submitted (2001-07) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      tissue: Platelet.
    10. 10.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT ASP-298
      tissue: Hippocampus.
      tissue: Trachea.
    11. 11.
      Totoki Y. , Toyoda A. , Takeda T. , Sakaki Y. , Tanaka A. , Yokoyama S.
      Submitted (2005-04) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Spleen.
    12. 12.
      SeattleSNPs variation discovery resource
      Submitted (2002-06) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS GLN-112; ASP-298; MET-827; MET-885 AND LEU-982
    13. 13.
      NHLBI resequencing and genotyping service (RS&G)
      Submitted (2007-12) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    14. 14.
      "The DNA sequence of human chromosome 7."
      Hillier L.W. , Fulton R.S. , Fulton L.A. , Graves T.A. , Pepin K.H. , Wagner-McPherson C. , Layman D. , Maas J. , Jaeger S. , Walker R. , Wylie K. , Sekhon M. , Becker M.C. , O'Laughlin M.D. , Schaller M.E. , Fewell G.A. , Delehaunty K.D. , Miner T.L. , more...
      Nature424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    15. 15.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    16. 16.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT ASP-298
      tissue: Placenta.
    17. 17.
      "Isolation and chromosomal localization of the human endothelial nitric oxide synthase (NOS3) gene."
      Robinson L.J. , Weremowicz S. , Morton C.C. , Michel T.
      Genomics19:350-357(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-53
      tissue: Placenta.
    18. 18.
      "Expression of constitutive endothelial nitric oxide synthase in human blood platelets."
      Sase K. , Michel T.
      Life Sci.57:2049-2055(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 411-528 (ISOFORM 1/ENOS13C)
      tissue: Platelet.
    19. 19.
      "Purification and characterization of the constitutive nitric oxide synthase from human placenta."
      Garvey E.P. , Tuttle J.V. , Covington K. , Merrill B.M. , Wood E.R. , Baylis S.A. , Charles I.G.
      Arch. Biochem. Biophys.311:235-241(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 167-175; 531-540; 835-845; 876-881; 886-898; 1001-1005 AND 1068-1080;TISSUE SPECIFICITY
      tissue: Placenta.
    20. 20.
      "NOSIP, a novel modulator of endothelial nitric oxide synthase activity."
      Dedio J. , Koenig P. , Wohlfart P. , Schroeder C. , Kummer W. , Mueller-Esterl W.
      FASEB J.15:79-89(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH NOSIP;ENZYME REGULATION;SUBCELLULAR LOCATION
    21. 21.
      "NOSTRIN: a protein modulating nitric oxide release and subcellular distribution of endothelial nitric oxide synthase."
      Zimmermann K. , Opitz N. , Dedio J. , Renne C. , Mueller-Esterl W. , Oess S.
      Proc. Natl. Acad. Sci. U.S.A.99:17167-17172(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH NOSTRIN;ENZYME REGULATION;SUBCELLULAR LOCATION
    22. 22.
      "Endothelial thrombomodulin induces Ca2+ signals and nitric oxide synthesis through epidermal growth factor receptor kinase and calmodulin kinase II."
      David-Dufilho M. , Millanvoye-Van Brussel E. , Topal G. , Walch L. , Brunet A. , Rendu F.
      J. Biol. Chem.280:35999-36006(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT THR-495 AND SER-1177
    23. 23.
      "NOSTRIN functions as a homotrimeric adaptor protein facilitating internalization of eNOS."
      Icking A. , Matt S. , Opitz N. , Wiesenthal A. , Mueller-Esterl W. , Schilling K.
      J. Cell Sci.118:5059-5069(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
    24. 24.
      "Cell cycle-regulated inactivation of endothelial NO synthase through NOSIP-dependent targeting to the cytoskeleton."
      Schleicher M. , Brundin F. , Gross S. , Mueller-Esterl W. , Oess S.
      Mol. Cell. Biol.25:8251-8258(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
    25. 25.
      "CDK5 phosphorylates eNOS at Ser-113 and regulates NO production."
      Lee C.-H. , Wei Y.-W. , Huang Y.-T. , Lin Y.-T. , Lee Y.-C. , Lee K.-H. , Lu P.-J.
      J. Cell. Biochem.110:112-117(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-114;MUTAGENESIS OF SER-114
    26. 26.
      "Structural characterization of nitric oxide synthase isoforms reveals striking active-site conservation."
      Fischmann T.O. , Hruza A. , Niu X.D. , Fossetta J.D. , Lunn C.A. , Dolphin E. , Prongay A.J. , Reichert P. , Lundell D.J. , Narula S.K. , Weber P.C.
      Nat. Struct. Biol.6:233-242(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS)
    27. 27.
      "Conformational changes in nitric oxide synthases induced by chlorzoxazone and nitroindazoles: crystallographic and computational analyses of inhibitor potency."
      Rosenfeld R.J. , Garcin E.D. , Panda K. , Andersson G. , Aberg A. , Wallace A.V. , Morris G.M. , Olson A.J. , Stuehr D.J. , Tainer J.A. , Getzoff E.D.
      Biochemistry41:13915-13925(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.96 ANGSTROMS) OF 67-480
    28. 28.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.44 ANGSTROMS) OF 66-492
    29. 29.
      "A missense Glu298Asp variant in the endothelial nitric oxide synthase gene is associated with coronary spasm in the Japanese."
      Yoshimura M. , Yasue H. , Nakayama M. , Shimasaki Y. , Sumida H. , Sugiyama S. , Kugiyama K. , Ogawa H. , Ogawa Y. , Saito Y. , Miyamoto Y. , Nakao K.
      Hum. Genet.103:65-69(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT SUSCEPTIBILITY TO CORONARY SPASM ASP-298
    30. 30.
      "In-vivo effects of Glu298Asp endothelial nitric oxide synthase polymorphism."
      Sofowora G. , Dishy V. , Xie H.G. , Imamura H. , Nishimi Y. , Morales C.R. , Morrow J.D. , Kim R.B. , Stein C.M. , Wood A.J.
      Pharmacogenetics11:809-814(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT SUSCEPTIBILITY TO CORONARY SPASM ASP-298
    31. 31.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS [LARGE SCALE ANALYSIS] CYS-474 AND GLN-602
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