NOTCH2 ELISA Kit for Human(Homo sapiens) | EIAab.comNOTCH2 ELISA Kit for Human(Homo sapiens)

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NOTCH2 (Gene name),

Neurogenic locus notch homolog protein 2 (Protein name ), NOTC2_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

NOTCH2;

Protein name:

Neurogenic locus notch homolog protein 2(Notch 2;hN2);

Alternative:

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Heterodimer of a C-terminal fragment N(TM) and an N-terminal fragment N(EC) which are probably linked by disulfide bonds (By similarity). Interacts with MAML1, MAML2 and MAML3 which act as transcriptional coactivators for NOTCH2. Interacts with RELA/p65.

Function:

Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). Involved in bone remodeling and homeostasis. In collaboration with RELA/p65 enhances NFATc1 promoter activity and positively regulates RANKL-induced osteoclast differentiation.

Subcellular Location:

Notch 2 intracellular domain Nucleus Following proteolytical processing NICD is translocated to the nucleus.

Protein Attributes:

Sequence length:

2471

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2471:

GQRGPGTHMS | EPPHNNMQVY | A

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Hs.487360

SMR:

Q04721

String:

Q04721

Pfam:

PF00023

Pfam:

PF12796

MIM:

102500

KEGG:

hsa:4853

STRING:

9606.ENSP00000256646

Uniprot:

Q04721

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ELISA Kit for Human Notch 2

Cat.:

E2420r

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96T

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ELISA Kit for Human Notch 2

Cat.:

E2420h

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Manual:

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96T

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ELISA Kit for Human Notch 2

Cat.:

E2420m

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MSDS:

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Packing:

96T

CLIA Kit for Human Notch 2

Cat.:

U2420r

Price:

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MSDS:

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Packing:

96T

CLIA Kit for Human Notch 2

Cat.:

U2420h

Price:

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Manual:

Looking for manual.

MSDS:

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Packing:

96T

Range:

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CLIA Kit for Human Notch 2

Cat.:

U2420m

Price:

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MSDS:

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Packing:

96T

Polyclonal Antibody for Human Notch 2

Cat.:

P2420Rb-h

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Notch 2

Cat.:

P2420Rb-m

Price:

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Notch 2

Cat.:

P2420Rb-r

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human Notch 2

Protein for Human Notch 2

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Complete human notch 2 (hN2) cDNA sequence."
Blaumueller C.M. , Mann R.S.
Submitted (2000-11) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
tissue: Brain.
2.

"Human Notch2, a novel member of cell-fate determining NOTCH family."
Correa R.G. , Camargo A.A. , Moreira E.S. , Simpson A.J.G.
Submitted (2000-10) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
tissue: Mammary tumor.
3.

"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G. , Barlow K.F. , McLay K.E. , Kaul R. , Swarbreck D. , Dunham A. , Scott C.E. , Howe K.L. , Woodfine K. , Spencer C.C.A. , Jones M.C. , Gillson C. , Searle S. , Zhou Y. , Kokocinski F. , McDonald L. , Evans R. , Phillips K. , more...
Nature441:315-321(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
4.

"Partial sequence of EGF-like repeat domain of human Notch2 mRNA."
Lemasson I. , Devaux C. , Mesnard J.-M.
Submitted (1996-11) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 967-1229
tissue: T-cell.
5.

"Human homologs of a Drosophila enhancer of split gene product define a novel family of nuclear proteins."
Stifani S. , Blaumueller C.M. , Redhead N.J. , Hill R.E. , Artavanis-Tsakonas S.
Nat. Genet.2:119-127(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1810-2447
tissue: Brain.
6.

"Intracellular cleavage of Notch leads to a heterodimeric receptor on the plasma membrane."
Blaumueller C.M. , Qi H. , Zagouras P. , Artavanis-Tsakonas S.
Cell90:281-291(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEOLYTIC PROCESSING
7.

"Human ligands of the Notch receptor."
Gray G.E. , Mann R.S. , Mitsiadis E. , Henrique D. , Carcangiu M.-L. , Banks A. , Leiman J. , Ward D. , Ish-Horowitz D. , Artavanis-Tsakonas S.
Am. J. Pathol.154:785-794(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION OF LIGANDS
8.

"MAML1, a human homologue of Drosophila mastermind, is a transcriptional co-activator for NOTCH receptors."
Wu L. , Aster J.C. , Blacklow S.C. , Lake R. , Artavanis-Tsakonas S. , Griffin J.D.
Nat. Genet.26:484-489(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MAML1
9.

"Identification of a family of mastermind-like transcriptional coactivators for mammalian notch receptors."
Wu L. , Sun T. , Kobayashi K. , Gao P. , Griffin J.D.
Mol. Cell. Biol.22:7688-7700(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MAML2 AND MAML3
10.

"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
Olsen J.V. , Blagoev B. , Gnad F. , Macek B. , Kumar C. , Mortensen P. , Mann M.
Cell127:635-648(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
11.

"Asparaginyl hydroxylation of the Notch ankyrin repeat domain by factor inhibiting hypoxia-inducible factor."
Coleman M.L. , McDonough M.A. , Hewitson K.S. , Coles C. , Mecinovic J. , Edelmann M. , Cook K.M. , Cockman M.E. , Lancaster D.E. , Kessler B.M. , Oldham N.J. , Ratcliffe P.J. , Schofield C.J.
J. Biol. Chem.282:24027-24038(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH HIF1AN
12.

"A quantitative atlas of mitotic phosphorylation."
Dephoure N. , Zhou C. , Villen J. , Beausoleil S.A. , Bakalarski C.E. , Elledge S.J. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1716; THR-1802; SER-1804; THR-1808; SER-1845; SER-2070; SER-2081 AND THR-2097;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
13.

"Interaction with factor inhibiting HIF-1 defines an additional mode of cross-coupling between the Notch and hypoxia signaling pathways."
Zheng X. , Linke S. , Dias J.M. , Zheng X. , Gradin K. , Wallis T.P. , Hamilton B.R. , Gustafsson M. , Ruas J.L. , Wilkins S. , Bilton R.L. , Brismar K. , Whitelaw M.L. , Pereira T. , Gorman J.J. , Ericson J. , Peet D.J. , Lendahl U. , more...
Proc. Natl. Acad. Sci. U.S.A.105:3368-3373(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: HYDROXYLATION BY HIF1AN
14.

"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1778 AND SER-1845;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Leukemic T-cell.
15.

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1778;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
16.

"Truncating mutations in the last exon of NOTCH2 cause a rare skeletal disorder with osteoporosis."
Isidor B. , Lindenbaum P. , Pichon O. , Bezieau S. , Dina C. , Jacquemont S. , Martin-Coignard D. , Thauvin-Robinet C. , Le Merrer M. , Mandel J.L. , David A. , Faivre L. , Cormier-Daire V. , Redon R. , Le Caignec C.
Nat. Genet.43:306-308(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INVOLVEMENT IN HJCYS
17.

"Mutations in NOTCH2 cause Hajdu-Cheney syndrome, a disorder of severe and progressive bone loss."
Simpson M.A. , Irving M.D. , Asilmaz E. , Gray M.J. , Dafou D. , Elmslie F.V. , Mansour S. , Holder S.E. , Brain C.E. , Burton B.K. , Kim K.H. , Pauli R.M. , Aftimos S. , Stewart H. , Kim C.A. , Holder-Espinasse M. , Robertson S.P. , Drake W.M. , more...
Nat. Genet.43:303-305(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INVOLVEMENT IN HJCYS;TISSUE SPECIFICITY
18.

"Structural basis for autoinhibition of Notch."
Gordon W.R. , Vardar-Ulu D. , Histen G. , Sanchez-Irizarry C. , Aster J.C. , Blacklow S.C.
Nat. Struct. Mol. Biol.14:295-300(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 1426-1677;DISULFIDE BONDS
19.

"NOTCH2 mutations cause Alagille syndrome, a heterogeneous disorder of the notch signaling pathway."
McDaniell R. , Warthen D.M. , Sanchez-Lara P.A. , Pai A. , Krantz I.D. , Piccoli D.A. , Spinner N.B.
Am. J. Hum. Genet.79:169-173(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT ALGS2 TYR-444

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