NOX4 ELISA Kit for Human(Homo sapiens) | EIAab.comNOX4 ELISA Kit for Human(Homo sapiens)

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Index > Protein center > NOX4(Gene name) > Human

NOX4 (Gene name),

NADPH oxidase 4 (Protein name ), NOX4_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

NOX4(RENOX);

Protein name:

NADPH oxidase 4;

Alternative:

Kidney superoxide-producing NADPH oxidase;Kidney oxidase-1(KOX-1);Renal NAD(P)H-oxidase;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts with protein disulfide isomerase (By similarity). Interacts with, relocalizes and stabilizes CYBA/p22phox. Interacts with TLR4.

Function:

Constitutive NADPH oxidase which generates superoxide intracellularly upon formation of a complex with CYBA/p22phox. Regulates signaling cascades probably through phosphatases inhibition. May function as an oxygen sensor regulating the KCNK3/TASK-1 potassium channel and HIF1A activity. May regulate insulin signaling cascade. May play a role in apoptosis, bone resorption and lipolysaccharide-mediated activation of NFKB. May produce superoxide in the nucleus and play a role in regulating gene expression upon cell stimulation. Isoform 3 is not functional. Isoform 4 displays an increased activity. Isoform 5 and isoform 6 display reduced activity.

Subcellular Location:

Endoplasmic reticulum membrane Multi-pass membrane protein Cell membrane Multi-pass membrane protein Cell junction focal adhesion Nucleus May localize to plasma membrane and focal adhesions. According to PubMed:15927447, may also localize to the nucleus.

Protein Attributes:

Sequence length:

578

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

578:

SLSKTLHKLS | NQNNSYGTRF | EYNKESFS

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

STRING:

9606.ENSP00000263317

UniGene:

Hs.371036

KEGG:

hsa:50507

String:

Q9NPH5

MIM:

605261

SMR:

Q9NPH5

Pfam:

PF08022

Uniprot:

Q9NPH5

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ELISA Kit for Human NADPH oxidase 4

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E1488h

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96T

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ELISA Kit for Human NADPH oxidase 4

Cat.:

E1488r

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96T

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ELISA Kit for Human NADPH oxidase 4

Cat.:

E1488m

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96T

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CLIA Kit for Human NADPH oxidase 4

Cat.:

U1488h

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Packing:

96T

CLIA Kit for Human NADPH oxidase 4

Cat.:

U1488m

Price:

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MSDS:

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Packing:

96T

CLIA Kit for Human NADPH oxidase 4

Cat.:

U1488r

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Packing:

96T

Polyclonal Antibody for Human NADPH oxidase 4

Cat.:

P1488Rb-h

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40ug/0.2ml

Polyclonal Antibody for Human NADPH oxidase 4

Cat.:

P1488Rb-r

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40ug/0.2ml

Polyclonal Antibody for Human NADPH oxidase 4

Cat.:

P1488Rb-m

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human NADPH oxidase 4

Protein for Human NADPH oxidase 4

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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Linearity

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References

1.

"Identification of renox, an NAD(P)H oxidase in kidney."
Geiszt M. , Kopp J.B. , Varnai P. , Leto T.L.
Proc. Natl. Acad. Sci. U.S.A.97:8010-8014(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);DEVELOPMENTAL STAGE;VARIANT ILE-315
tissue: Kidney.
2.

"Homologs of gp91phox: cloning and tissue expression of Nox3, Nox4, and Nox5."
Cheng G. , Cao Z. , Xu X. , van Meir E.G. , Lambeth J.D.
Gene269:131-140(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);TISSUE SPECIFICITY;DEVELOPMENTAL STAGE;VARIANT ILE-315
tissue: Fetal kidney.
3.

"A novel superoxide-producing NAD(P)H oxidase in kidney."
Shiose A. , Kuroda J. , Tsuruya K. , Hirai M. , Hirakata H. , Naito S. , Hattori M. , Sakaki Y. , Sumimoto H.
J. Biol. Chem.276:1417-1423(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION;TISSUE SPECIFICITY;DEVELOPMENTAL STAGE;VARIANT ILE-315
tissue: Kidney.
4.

"NADPH oxidase-dependent acid production in airway epithelial cells."
Schwarzer C. , Machen T.E. , Illek B. , Fischer H.
J. Biol. Chem.279:36454-36461(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 6);TISSUE SPECIFICITY;VARIANT ILE-315
5.

"Identification of novel Nox4 splice variants with impact on ROS levels in A549 cells."
Goyal P. , Weissmann N. , Rose F. , Grimminger F. , Schaefers H.J. , Seeger W. , Haenze J.
Biochem. Biophys. Res. Commun.329:32-39(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2; 3; 4; 5 AND 6);FUNCTION;SUBCELLULAR LOCATION;GLYCOSYLATION;VARIANT ILE-315
tissue: Lung.
6.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 6 AND 9);VARIANT ILE-315
tissue: Pulmonary artery.
7.

"Human chromosome 11 DNA sequence and analysis including novel gene identification."
Taylor T.D. , Noguchi H. , Totoki Y. , Toyoda A. , Kuroki Y. , Dewar K. , Lloyd C. , Itoh T. , Takeda T. , Kim D.-W. , She X. , Barlow K.F. , Bloom T. , Bruford E. , Chang J.L. , Cuomo C.A. , Eichler E. , FitzGerald M.G. , more...
Nature440:497-500(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
8.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 7);VARIANT ILE-315
tissue: Ovary.
9.

"Reactive oxygen species produced by NAD(P)H oxidase inhibit apoptosis in pancreatic cancer cells."
Vaquero E.C. , Edderkaoui M. , Pandol S.J. , Gukovsky I. , Gukovskaya A.S.
J. Biol. Chem.279:34643-34654(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
10.

"Direct interaction of TLR4 with NAD(P)H oxidase 4 isozyme is essential for lipopolysaccharide-induced production of reactive oxygen species and activation of NF-kappa B."
Park H.S. , Jung H.Y. , Park E.Y. , Kim J. , Lee W.J. , Bae Y.S.
J. Immunol.173:3589-3593(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH TLR4
11.

"The NAD(P)H oxidase homolog Nox4 modulates insulin-stimulated generation of H2O2 and plays an integral role in insulin signal transduction."
Mahadev K. , Motoshima H. , Wu X. , Ruddy J.M. , Arnold R.S. , Cheng G. , Lambeth J.D. , Goldstein B.J.
Mol. Cell. Biol.24:1844-1854(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;ENZYME REGULATION
12.

"NAD(P)H oxidase Nox-4 mediates 7-ketocholesterol-induced endoplasmic reticulum stress and apoptosis in human aortic smooth muscle cells."
Pedruzzi E. , Guichard C. , Ollivier V. , Driss F. , Fay M. , Prunet C. , Marie J.-C. , Pouzet C. , Samadi M. , Elbim C. , O'dowd Y. , Bens M. , Vandewalle A. , Gougerot-Pocidalo M.-A. , Lizard G. , Ogier-Denis E.
Mol. Cell. Biol.24:10703-10717(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INDUCTION;SUBCELLULAR LOCATION;ENZYME REGULATION
13.

"Nox4 is critical for hypoxia-inducible factor 2-alpha transcriptional activity in von Hippel-Lindau-deficient renal cell carcinoma."
Maranchie J.K. , Zhan Y.
Cancer Res.65:9190-9193(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
14.

"NAD(P)H oxidase 4 mediates transforming growth factor-beta1-induced differentiation of cardiac fibroblasts into myofibroblasts."
Cucoranu I. , Clempus R. , Dikalova A. , Phelan P.J. , Ariyan S. , Dikalov S. , Sorescu D.
Circ. Res.97:900-907(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
15.

"The superoxide-producing NAD(P)H oxidase Nox4 in the nucleus of human vascular endothelial cells."
Kuroda J. , Nakagawa K. , Yamasaki T. , Nakamura K. , Takeya R. , Kuribayashi F. , Imajoh-Ohmi S. , Igarashi K. , Shibata Y. , Sueishi K. , Sumimoto H.
Genes Cells10:1139-1151(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;TISSUE SPECIFICITY;ENZYME REGULATION
16.

"Functional analysis of Nox4 reveals unique characteristics compared to other NADPH oxidases."
Martyn K.D. , Frederick L.M. , von Loehneysen K. , Dinauer M.C. , Knaus U.G.
Cell. Signal.18:69-82(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH CYBA;SUBCELLULAR LOCATION;MUTAGENESIS OF ARG-304 AND 575-GLU--SER-578
17.

"NOX4 as an oxygen sensor to regulate TASK-1 activity."
Lee Y.-M. , Kim B.-J. , Chun Y.-S. , So I. , Choi H. , Kim M.-S. , Park J.-W.
Cell. Signal.18:499-507(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;ENZYME REGULATION
18.

"A 28-kDa splice variant of NADPH oxidase-4 is nuclear-localized and involved in redox signaling in vascular cells."
Anilkumar N. , San Jose G. , Sawyer I. , Santos C.X. , Sand C. , Brewer A.C. , Warren D. , Shah A.M.
Arterioscler. Thromb. Vasc. Biol.33:E104-E112(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION (ISOFORM 4);SUBCELLULAR LOCATION (ISOFORM 4)

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