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Index > Protein center > NR1H3(Gene name) > Human
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  • NR1H3 (Gene name),
  • Oxysterols receptor LXR-alpha (Protein name ),  NR1H3_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    NR1H3(LXRA);
    Protein name:
    Oxysterols receptor LXR-alpha;
    Alternative:
    Nuclear receptor subfamily 1 group H member 3;Liver X receptor alpha;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Heterodimer of LXRA and RXR.
    Function:
    Orphan receptor. Interaction with RXR shifts RXR from its role as a silent DNA-binding partner to an active ligand-binding subunit in mediating retinoid responses through target genes defined by LXRES. LXRES are DR4-type response elements characterized by direct repeats of two similar hexanuclotide half-sites spaced by four nucleotides. Plays an important role in the regulation of cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8.
    Subcellular Location:
    Nucleus
    Protein Attributes:
    Sequence length:
    447
    Sequence:
    50:
    MSLWLGAPVP | DIPPDSAVEL | WKPGAQDASS | QAQGGSSCIL | REEARMPHSA | 
    100:
    GGTAGVGLEA | AEPTALLTRA | EPPSEPTEIR | PQKRKKGPAP | KMLGNELCSV | 
    150:
    CGDKASGFHY | NVLSCEGCKG | FFRRSVIKGA | HYICHSGGHC | PMDTYMRRKC | 
    200:
    QECRLRKCRQ | AGMREECVLS | EEQIRLKKLK | RQEEEQAHAT | SLPPRASSPP | 
    250:
    QILPQLSPEQ | LGMIEKLVAA | QQQCNRRSFS | DRLRVTPWPM | APDPHSREAR | 
    300:
    QQRFAHFTEL | AIVSVQEIVD | FAKQLPGFLQ | LSREDQIALL | KTSAIEVMLL | 
    350:
    ETSRRYNPGS | ESITFLKDFS | YNREDFAKAG | LQVEFINPIF | EFSRAMNELQ | 
    400:
    LNDAEFALLI | AISIFSADRP | NVQDQLQVER | LQHTYVEALH | AYVSIHHPHD | 
    447:
    RLMFPRMLMK | LVSLRTLSSV | HSEQVFALRL | QDKKLPPLLS | EIWDVHE
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    Pfam:
    UniGene:
    MIM:
    String:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Human Oxysterols receptor LXR-alpha
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    E2044h
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    ELISA Kit for Human Oxysterols receptor LXR-alpha
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    E2044r
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    ELISA Kit for Human Oxysterols receptor LXR-alpha
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    E2044m
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    ELISA Kit for Human Oxysterols receptor LXR-alpha
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    E2044b
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    Packing:
    96T
    CLIA Kit for Human Oxysterols receptor LXR-alpha
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    U2044m
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    Packing:
    96T
    CLIA Kit for Human Oxysterols receptor LXR-alpha
    Cat.:
    U2044h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Oxysterols receptor LXR-alpha
    Cat.:
    U2044r
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    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Oxysterols receptor LXR-alpha
    Cat.:
    U2044b
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    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human Oxysterols receptor LXR-alpha
    Cat.:
    P2044Rb-h
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Oxysterols receptor LXR-alpha
    Cat.:
    P2044Rb-r
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Oxysterols receptor LXR-alpha
    Cat.:
    P2044Rb-m
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Oxysterols receptor LXR-alpha
    Monoclonal Antibody for Human Oxysterols receptor LXR-alpha
    Monoclonal Antibody for Human Oxysterols receptor LXR-alpha
    Monoclonal Antibody for Human Oxysterols receptor LXR-alpha
    Monoclonal Antibody for Human Oxysterols receptor LXR-alpha
    Protein for Human Oxysterols receptor LXR-alpha
    Protein for Human Oxysterols receptor LXR-alpha
    Protein for Human Oxysterols receptor LXR-alpha
    Protein for Human Oxysterols receptor LXR-alpha

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    References
    1. 1.
      "LXR, a nuclear receptor that defines a distinct retinoid response pathway."
      Willy P.J. , Umesono K. , Ong E.S. , Evans R.M. , Heyman R.A. , Mangelsdorf D.J.
      Genes Dev.9:1033-1045(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      tissue: Liver.
    2. 2.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Heart.
    3. 3.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    4. 4.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3)
      tissue: Brain.
      tissue: Placenta.
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