Nuclear receptor subfamily 1 group I member 2 (Protein name
), NR1I2_HUMAN from NCBI database.
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General Annotation
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Antigen Annotation
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Predicted Eptitope
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Vaild Sequence
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Gene name:
NR1I2(PXR);
Protein name:
Nuclear receptor subfamily 1 group I member 2;
Alternative:
Orphan nuclear receptor PXR;Orphan nuclear receptor PAR1;Steroid and xenobiotic receptor(SXR);Pregnane X receptor;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Heterodimer with RXR. Interacts with NCOA1.
Function:
Nuclear receptor that binds and is activated by variety of endogenous and xenobiotic compounds. Transcription factor that activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, drugs and endogenous compounds. Activated by the antibiotic rifampicin and various plant metabolites, such as hyperforin, guggulipid, colupulone, and isoflavones. Response to specific ligands is species-specific. Activated by naturally occurring steroids, such as pregnenolone and progesterone. Binds to a response element in the promoters of the CYP3A4 and ABCB1/MDR1 genes.
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Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1A);FUNCTION
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Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS 1A AND 3);FUNCTION;VARIANTS SER-27; ARG-36 AND GLN-122
5.
"Identification of a novel protein isoform of the human nuclear hormone receptor PXR/SXR and localization to chromosome 3q12.1 -13.3." Heard D.J.
,
Holloway J.
,
Hansen C.
,
Tommerup N.
,
Aagaard L.
,
Vissing H.
Submitted (1998-07) to the EMBL/GenBank/DDBJ databases
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Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1A; 1B; 1C; 2A; 2B AND 2C);VARIANT THR-12
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Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS LYS-18; SER-27 AND THR-370
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Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1A)
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Cited for: SUBCELLULAR LOCATION;MUTAGENESIS OF 66-ARG-ARG-67 AND 91-ARG-ARG-92;NUCLEAR LOCALIZATION SIGNAL
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Cited for: X-RAY CRYSTALLOGRAPHY (2.52 ANGSTROMS) OF 130-434
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Cited for: X-RAY CRYSTALLOGRAPHY (2.15 ANGSTROMS) OF 130-434 IN COMPLEX WITH HYPERFORIN;FUNCTION;INTERACTION WITH NCOA1
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Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 130-434 IN COMPLEX WITH THE CHOLESTEROL-LOWERING COMPOUND SR12813 AND NCOA1
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Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 130-431 IN COMPLEX WITH RIFAMPICIN
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Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 142-434 IN COMPLEX WITH T0901317 AND NCOA1;INTERACTION WITH NCOA1
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Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 130-434 IN COMPLEX WITH COLUPULONE;FUNCTION
Vaild Sequence:
