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Index > Protein center > NR1I2(Gene name) > Human
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  • NR1I2 (Gene name),
  • Nuclear receptor subfamily 1 group I member 2 (Protein name ),  NR1I2_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    NR1I2(PXR);
    Protein name:
    Nuclear receptor subfamily 1 group I member 2;
    Alternative:
    Orphan nuclear receptor PXR;Orphan nuclear receptor PAR1;Steroid and xenobiotic receptor(SXR);Pregnane X receptor;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Heterodimer with RXR. Interacts with NCOA1.
    Function:
    Nuclear receptor that binds and is activated by variety of endogenous and xenobiotic compounds. Transcription factor that activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, drugs and endogenous compounds. Activated by the antibiotic rifampicin and various plant metabolites, such as hyperforin, guggulipid, colupulone, and isoflavones. Response to specific ligands is species-specific. Activated by naturally occurring steroids, such as pregnenolone and progesterone. Binds to a response element in the promoters of the CYP3A4 and ABCB1/MDR1 genes.
    Subcellular Location:
    Nucleus
    Protein Attributes:
    Sequence length:
    434
    Sequence:
    50:
    MEVRPKESWN | HADFVHCEDT | ESVPGKPSVN | ADEEVGGPQI | CRVCGDKATG | 
    100:
    YHFNVMTCEG | CKGFFRRAMK | RNARLRCPFR | KGACEITRKT | RRQCQACRLR | 
    150:
    KCLESGMKKE | MIMSDEAVEE | RRALIKRKKS | ERTGTQPLGV | QGLTEEQRMM | 
    200:
    IRELMDAQMK | TFDTTFSHFK | NFRLPGVLSS | GCELPESLQA | PSREEAAKWS | 
    250:
    QVRKDLCSLK | VSLQLRGEDG | SVWNYKPPAD | SGGKEIFSLL | PHMADMSTYM | 
    300:
    FKGIISFAKV | ISYFRDLPIE | DQISLLKGAA | FELCQLRFNT | VFNAETGTWE | 
    350:
    CGRLSYCLED | TAGGFQQLLL | EPMLKFHYML | KKLQLHEEEY | VLMQAISLFS | 
    400:
    PDRPGVLQHR | VVDQLQEQFA | ITLKSYIECN | RPQPAHRFLF | LKIMAMLTEL | 
    434:
    RSINAQHTQR | LLRIQDIHPF | ATPLMQELFG | ITGS
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    SMR:
    MIM:
    Pfam:
    String:
    UniGene:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Human Nuclear receptor subfamily 1 group I member 2
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    E10641m
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    ELISA Kit for Human Nuclear receptor subfamily 1 group I member 2
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    E10641h
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    ELISA Kit for Human Nuclear receptor subfamily 1 group I member 2
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    E10641r
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    CLIA Kit for Human Nuclear receptor subfamily 1 group I member 2
    Cat.:
    U10641h
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    MSDS:
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    96T
    Range:
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    CLIA Kit for Human Nuclear receptor subfamily 1 group I member 2
    Cat.:
    U10641m
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    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Nuclear receptor subfamily 1 group I member 2
    Cat.:
    U10641r
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    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human Nuclear receptor subfamily 1 group I member 2
    Polyclonal Antibody for Human Nuclear receptor subfamily 1 group I member 2
    Polyclonal Antibody for Human Nuclear receptor subfamily 1 group I member 2
    Cat.:
    P10641Rb-h
    Price:
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    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Nuclear receptor subfamily 1 group I member 2
    Monoclonal Antibody for Human Nuclear receptor subfamily 1 group I member 2
    Monoclonal Antibody for Human Nuclear receptor subfamily 1 group I member 2
    Protein for Human Nuclear receptor subfamily 1 group I member 2
    Protein for Human Nuclear receptor subfamily 1 group I member 2
    Protein for Human Nuclear receptor subfamily 1 group I member 2

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    References
    1. 1.
      "SXR, a novel steroid and xenobiotic-sensing nuclear receptor."
      Blumberg B. , Sabbagh W. Jr. , Juguilon H. , Bolado J. Jr. , van Meter C.M. , Ong E.S. , Evans R.M.
      Genes Dev.12:3195-3205(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1A)
    2. 2.
      "The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions."
      Lehmann J.M. , McKee D.D. , Watson M.A. , Willson T.M. , Moore J.T. , Kliewer S.A.
      J. Clin. Invest.102:1016-1023(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1A);FUNCTION
      tissue: Liver.
    3. 3.
      "Identification of a human nuclear receptor defines a new signaling pathway for CYP3A induction."
      Bertilsson G. , Heidrich J. , Svensson K. , Asman M. , Jendeberg L. , Sydow-Baeckman M. , Ohlsson R. , Postlind H. , Blomquist P. , Berkenstam A.
      Proc. Natl. Acad. Sci. U.S.A.95:12208-12213(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1A AND 3)
      tissue: Liver.
    4. 4.
      "The human pregnane X receptor: genomic structure and identification and functional characterization of natural allelic variants."
      Zhang J. , Kuehl P. , Green E.D. , Touchman J.W. , Watkins P.B. , Daly A. , Hall S.D. , Maurel P. , Relling M. , Brimer C. , Yasuda K. , Wrighton S.A. , Hancock M. , Kim R.B. , Strom S. , Thummel K. , Russell C.G. , Hudson J.R. Jr. , more...
      Pharmacogenetics11:555-572(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS 1A AND 3);FUNCTION;VARIANTS SER-27; ARG-36 AND GLN-122
    5. 5.
      "Identification of a novel protein isoform of the human nuclear hormone receptor PXR/SXR and localization to chromosome 3q12.1 -13.3."
      Heard D.J. , Holloway J. , Hansen C. , Tommerup N. , Aagaard L. , Vissing H.
      Submitted (1998-07) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1A; 1B; 1C; 2A; 2B AND 2C);VARIANT THR-12
      tissue: Liver.
    6. 6.
      Wang X. , Li J. , Deng X. , Chen J. , Huang M.
      Submitted (2006-08) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    7. 7.
      SeattleSNPs variation discovery resource
      Submitted (2007-05) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS LYS-18; SER-27 AND THR-370
    8. 8.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1A)
      tissue: Hepatoma.
    9. 9.
      "Nuclear receptor response elements mediate induction of intestinal MDR1 by rifampin."
      Geick A. , Eichelbaum M. , Burk O.
      J. Biol. Chem.276:14581-14587(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    10. 10.
      "Molecular mechanism of nuclear translocation of an orphan nuclear receptor, SXR."
      Kawana K. , Ikuta T. , Kobayashi Y. , Gotoh O. , Takeda K. , Kawajiri K.
      Mol. Pharmacol.63:524-531(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;MUTAGENESIS OF 66-ARG-ARG-67 AND 91-ARG-ARG-92;NUCLEAR LOCALIZATION SIGNAL
    11. 11.
      "Human CYP3A4 and murine Cyp3A11 are regulated by equol and genistein via the pregnane X receptor in a species-specific manner."
      Li Y. , Ross-Viola J.S. , Shay N.F. , Moore D.D. , Ricketts M.L.
      J. Nutr.139:898-904(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    12. 12.
      "The human nuclear xenobiotic receptor PXR: structural determinants of directed promiscuity."
      Watkins R.E. , Wisely G.B. , Moore L.B. , Collins J.L. , Lambert M.H. , Williams S.P. , Willson T.M. , Kliewer S.A. , Redinbo M.R.
      Science292:2329-2333(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.52 ANGSTROMS) OF 130-434
    13. 13.
      "2.1 A crystal structure of human PXR in complex with the St. John's wort compound hyperforin."
      Watkins R.E. , Maglich J.M. , Moore L.B. , Wisely G.B. , Noble S.M. , Davis-Searles P.R. , Lambert M.H. , Kliewer S.A. , Redinbo M.R.
      Biochemistry42:1430-1438(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.15 ANGSTROMS) OF 130-434 IN COMPLEX WITH HYPERFORIN;FUNCTION;INTERACTION WITH NCOA1
    14. 14.
      "Coactivator binding promotes the specific interaction between ligand and the pregnane X receptor."
      Watkins R.E. , Davis-Searles P.R. , Lambert M.H. , Redinbo M.R.
      J. Mol. Biol.331:815-828(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 130-434 IN COMPLEX WITH THE CHOLESTEROL-LOWERING COMPOUND SR12813 AND NCOA1
    15. 15.
      "Structural disorder in the complex of human pregnane X receptor and the macrolide antibiotic rifampicin."
      Chrencik J.E. , Orans J. , Moore L.B. , Xue Y. , Peng L. , Collins J.L. , Wisely G.B. , Lambert M.H. , Kliewer S.A. , Redinbo M.R.
      Mol. Endocrinol.19:1125-1134(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 130-431 IN COMPLEX WITH RIFAMPICIN
    16. 16.
      "Crystal structure of the PXR-T1317 complex provides a scaffold to examine the potential for receptor antagonism."
      Xue Y. , Chao E. , Zuercher W.J. , Willson T.M. , Collins J.L. , Redinbo M.R.
      Bioorg. Med. Chem.15:2156-2166(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 142-434 IN COMPLEX WITH T0901317 AND NCOA1;INTERACTION WITH NCOA1
    17. 17.
      "Structural basis of human pregnane X receptor activation by the hops constituent colupulone."
      Teotico D.G. , Bischof J.J. , Peng L. , Kliewer S.A. , Redinbo M.R.
      Mol. Pharmacol.74:1512-1520(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 130-434 IN COMPLEX WITH COLUPULONE;FUNCTION
    18. 18.
      "Eleven novel single nucleotide polymorphisms in the NR1I2 (PXR) gene, four of which induce non-synonymous amino acid alterations."
      Koyano S. , Kurose K. , Ozawa S. , Saeki M. , Nakajima Y. , Hasegawa R. , Komamura K. , Ueno K. , Kamakura S. , Nakajima T. , Saito H. , Kimura H. , Goto Y. , Saitoh O. , Katoh M. , Ohnuma T. , Kawai M. , Sugai K. , more...
      Drug Metab. Pharmacokinet.17:561-565(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS CYS-98; GLN-148; TRP-381 AND VAL-403
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