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Index > Protein center > SLC11A2(Gene name) > Human
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  • SLC11A2 (Gene name),
  • Natural resistance-associated macrophage protein 2 (Protein name ),  NRAM2_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    SLC11A2(OK/SW-cl.20;DCT1;DMT1;NRAMP2);
    Protein name:
    Natural resistance-associated macrophage protein 2(NRAMP 2);
    Alternative:
    Divalent metal transporter 1(DMT-1);Divalent cation transporter 1;Solute carrier family 11 member 2;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Forms a complex with NDFIP1 and NEDD4L, in cortical neurons, in response to iron and colbalt exposure; this interaction leads to ubiquitination by NEDD4L and proteasome-dependent degradation. Interacts with NDFIP2.
    Function:
    Important in metal transport, in particular iron. Can also transport manganese, cobalt, cadmium, nickel, vanadium and lead. Involved in apical iron uptake into duodenal enterocytes. Involved in iron transport from acidified endosomes into the cytoplasm of erythroid precursor cells. May play an important role in hepatic iron accumulation and tissue iron distribution.
    Subcellular Location:
    Endosome membrane Multi-pass membrane protein
    Protein Attributes:
    Sequence length:
    568
    Sequence:
    50:
    MVLGPEQKMS | DDSVSGDHGE | SASLGNINPA | YSNPSLSQSP | GDSEEYFATY | 
    100:
    FNEKISIPEE | EYSCFSFRKL | WAFTGPGFLM | SIAYLDPGNI | ESDLQSGAVA | 
    150:
    GFKLLWILLL | ATLVGLLLQR | LAARLGVVTG | LHLAEVCHRQ | YPKVPRVILW | 
    200:
    LMVELAIIGS | DMQEVIGSAI | AINLLSVGRI | PLWGGVLITI | ADTFVFLFLD | 
    250:
    KYGLRKLEAF | FGFLITIMAL | TFGYEYVTVK | PSQSQVLKGM | FVPSCSGCRT | 
    300:
    PQIEQAVGIV | GAVIMPHNMY | LHSALVKSRQ | VNRNNKQEVR | EANKYFFIES | 
    350:
    CIALFVSFII | NVFVVSVFAE | AFFGKTNEQV | VEVCTNTSSP | HAGLFPKDNS | 
    400:
    TLAVDIYKGG | VVLGCYFGPA | ALYIWAVGIL | AAGQSSTMTG | TYSGQFVMEG | 
    450:
    FLNLKWSRFA | RVVLTRSIAI | IPTLLVAVFQ | DVEHLTGMND | FLNVLQSLQL | 
    500:
    PFALIPILTF | TSLRPVMSDF | ANGLGWRIAG | GILVLIICSI | NMYFVVVYVR | 
    550:
    DLGHVALYVV | AAVVSVAYLG | FVFYLGWQCL | IALGMSFLDC | GHTCHLGLTA | 
    568:
    QPELYLLNTM | DADSLVSR
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    KEGG:
    Pfam:
    MIM:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Human NRAMP 2
    Cat.:
    E0316r
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human NRAMP 2
    Cat.:
    E0316h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
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    ELISA Kit for Human NRAMP 2
    Cat.:
    E0316m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human NRAMP 2
    Cat.:
    U0316m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human NRAMP 2
    Cat.:
    U0316h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human NRAMP 2
    Cat.:
    U0316r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    Polyclonal Antibody for Human NRAMP 2
    Cat.:
    P0316Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human NRAMP 2
    Cat.:
    P0316Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human NRAMP 2
    Cat.:
    P0316Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human NRAMP 2
    Monoclonal Antibody for Human NRAMP 2
    Monoclonal Antibody for Human NRAMP 2
    Protein for Human NRAMP 2
    Protein for Human NRAMP 2
    Protein for Human NRAMP 2

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Complete nucleotide sequence of human NRAMP2 cDNA."
      Kishi F. , Tabuchi M.
      Mol. Immunol.34:839-842(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      tissue: Brain.
    2. 2.
      "Human natural resistance-associated macrophage protein 2: gene cloning and protein identification."
      Kishi F. , Tabuchi M.
      Biochem. Biophys. Res. Commun.251:775-783(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
      tissue: Placenta.
    3. 3.
      "The human Nramp2 gene: characterization of the gene structure, alternative splicing, promoter region and polymorphisms."
      Lee P.L. , Gelbart T. , West C. , Halloran C. , Beutler E.
      Blood Cells Mol. Dis.24:199-215(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 1 AND 2);TISSUE SPECIFICITY;VARIANT ILE-435
    4. 4.
      "Previously uncharacterized isoforms of divalent metal transporter (DMT)-1: implications for regulation and cellular function."
      Hubert N. , Hentze M.W.
      Proc. Natl. Acad. Sci. U.S.A.99:12345-12350(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);NUCLEOTIDE SEQUENCE [MRNA] OF 1-583 (ISOFORM 3);ALTERNATIVE SPLICING (ISOFORMS 2 AND 4);TISSUE SPECIFICITY
    5. 5.
      "Cloning and functional expression of the full length human NRAMP2 iron transporter."
      Worthington M.T. , Battle E. , Luo R.Q.
      Submitted (1998-02) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE (ISOFORM 1)
    6. 6.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 5)
      tissue: Brain.
      tissue: Thalamus.
      tissue: Trachea.
    7. 7.
      "Identification of immuno-peptidmics that are recognized by tumor-reactive CTL generated from TIL of colon cancer patients."
      Shichijo S. , Itoh K.
      Submitted (2001-05) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
      tissue: Colon adenocarcinoma.
    8. 8.
      "The finished DNA sequence of human chromosome 12."
      Scherer S.E. , Muzny D.M. , Buhay C.J. , Chen R. , Cree A. , Ding Y. , Dugan-Rocha S. , Gill R. , Gunaratne P. , Harris R.A. , Hawes A.C. , Hernandez J. , Hodgson A.V. , Hume J. , Jackson A. , Khan Z.M. , Kovar-Smith C. , Lewis L.R. , more...
      Nature440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    9. 9.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    10. 10.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3)
      tissue: Hypothalamus.
      tissue: Neuroblastoma.
    11. 11.
      "Cloning and characterization of a second human NRAMP gene on chromosome 12q13."
      Vidal S. , Belouchi A.-M. , Cellier M. , Beatty B. , Gros P.
      Mamm. Genome6:224-230(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 58-568 (ISOFORM 1)
      tissue: Liver.
    12. 12.
      "Functional properties of multiple isoforms of human divalent metal-ion transporter 1 (DMT1)."
      Mackenzie B. , Takanaga H. , Hubert N. , Rolfs A. , Hediger M.A.
      Biochem. J.403:59-69(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    13. 13.
      "Ca2+ channel blockers reverse iron overload by a new mechanism via divalent metal transporter-1."
      Ludwiczek S. , Theurl I. , Muckenthaler M.U. , Jakab M. , Mair S.M. , Theurl M. , Kiss J. , Paulmichl M. , Hentze M.W. , Ritter M. , Weiss G.
      Nat. Med.13:448-454(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: BIOPHYSICOCHEMICAL PROPERTIES;NIFEDIPINE TREATMENT
    14. 14.
      "Regulation of the divalent metal ion transporter DMT1 and iron homeostasis by a ubiquitin-dependent mechanism involving Ndfips and WWP2."
      Foot N.J. , Dalton H.E. , Shearwin-Whyatt L.M. , Dorstyn L. , Tan S.S. , Yang B. , Kumar S.
      Blood112:4268-4275(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH NDFIP1; NDFIP2 AND WWP2;SUBCELLULAR LOCATION
    15. 15.
      "Divalent metal transporter 1 (DMT1) regulation by Ndfip1 prevents metal toxicity in human neurons."
      Howitt J. , Putz U. , Lackovic J. , Doan A. , Dorstyn L. , Cheng H. , Yang B. , Chan-Ling T. , Silke J. , Kumar S. , Tan S.S.
      Proc. Natl. Acad. Sci. U.S.A.106:15489-15494(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH NDFIP1 AND NEDD4L
    16. 16.
      "Evidence for mitochondrial localization of divalent metal transporter 1 (DMT1)."
      Wolff N.A. , Ghio A.J. , Garrick L.M. , Garrick M.D. , Zhao L. , Fenton R.A. , Thevenod F.
      FASEB J.28:2134-2145(2014) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;FUNCTION;INTERACTION WITH COX2 AND TOM6
    17. 17.
      "Identification of a human mutation of DMT1 in a patient with microcytic anemia and iron overload."
      Mims M.P. , Guan Y. , Pospisilova D. , Priwitzerova M. , Indrak K. , Ponka P. , Divoky V. , Prchal J.T.
      Blood105:1337-1342(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT AHMIO1 ASP-399
    18. 18.
      "Microcytic anemia and hepatic iron overload in a child with compound heterozygous mutations in DMT1 (SCL11A2)."
      Iolascon A. , d'Apolito M. , Servedio V. , Cimmino F. , Piga A. , Camaschella C.
      Blood107:349-354(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT AHMIO1 CYS-416
    19. 19.
      "Two new human DMT1 gene mutations in a patient with microcytic anemia, low ferritinemia, and liver iron overload."
      Beaumont C. , Delaunay J. , Hetet G. , Grandchamp B. , de Montalembert M. , Tchernia G.
      Blood107:4168-4170(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS AHMIO1 VAL-114 DEL AND VAL-212
    20. 20.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT [LARGE SCALE ANALYSIS] THR-48
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