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Index > Protein center > Smpd3(Gene name) > Mouse
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  • Smpd3 (Gene name),
  • Sphingomyelin phosphodiesterase 3 (Protein name ),  NSMA2_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    Smpd3;
    Protein name:
    Sphingomyelin phosphodiesterase 3;
    Alternative:
    Neutral sphingomyelinase II;Neutral sphingomyelinase 2(nSMase-2;nSMase2);
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Catalyzes the hydrolysis of sphingomyelin to form ceramide and phosphocholine. Ceramide mediates numerous cellular functions, such as apoptosis and growth arrest, and is capable of regulating these 2 cellular events independently. Also hydrolyzes sphingosylphosphocholine. Regulates the cell cycle by acting as a growth suppressor in confluent cells. Acts as a regulator of postnatal development and participates in bone and dentin mineralization. Overexpression enhances cell death, suggesting that it may be involved in apoptosis control.
    Subcellular Location:
    Golgi apparatus membrane Multi-pass membrane protein May localize to detergent-resistant subdomains of Golgi membranes of hypothalamic neurosecretory neurons.
    Protein Attributes:
    Sequence length:
    655
    Sequence:
    50:
    MVLYTTPFPN | SCLSALHAVS | WALIFPCYWL | VDRLLASFIP | TTYEKRQRAD | 
    100:
    DPCCLQLFCT | VLFTPVYLAL | LVAALPFAFL | GFIFWSPLQS | ARRPYSYSRL | 
    150:
    EDKNPAGGAA | LLSEWKGTGA | GKSFCFATAN | VCLLPDSLAR | LNNVFNTQAR | 
    200:
    AKEIGQRIRN | GAARPQIKIY | IDSPTNTSIS | AASFSSLVSP | QGGDGSRAVP | 
    250:
    GSIKRTASVE | YKGDGGRHPS | DEAANGPASG | EQADGSLEDS | CIVRIGGEEG | 
    300:
    GRPQEADDPA | AGSQARNGAG | GTPKGQTPNH | NQRDGDSGSL | GSPSASRESL | 
    350:
    VKARAGQDSG | GSGEPGANSK | LLYKTSVVKK | AAARRRRHPD | EAFDHEVSAF | 
    400:
    FPANLDFLCL | QEVFDKRAAA | KLKEQLHGYF | EYILYDVGVY | GCHGCCNFKC | 
    450:
    LNSGLFFASR | YPVMDVAYHC | YPNGCSFDAL | ASKGALFLKV | QVGSTPQDQR | 
    500:
    IVGYIACTHL | HAPPEDSAVR | CEQLDLLQDW | LADFRKSTSS | TSTANPEELV | 
    550:
    VFDVICGDLN | FDNCSSDDKL | EQQHSLFTRY | KDPCRLGPGE | EKPWAIGTLL | 
    600:
    DTNGLYDEDV | CTPDNLQKVL | ESEEGRREYL | AFPTSKSPGA | GQKGRKDLLK | 
    650:
    GNGRRIDYML | HAEEGLCPDW | KAEVEEFSFI | TQLSGLTDHL | PVAMRLMVSA | 
    655:
    GEEEA
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    Pfam:
    KEGG:
    UniGene:
    SMR:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse Sphingomyelin phosphodiesterase 3
    ELISA Kit for Mouse Sphingomyelin phosphodiesterase 3
    ELISA Kit for Mouse Sphingomyelin phosphodiesterase 3
    CLIA Kit for Mouse Sphingomyelin phosphodiesterase 3
    CLIA Kit for Mouse Sphingomyelin phosphodiesterase 3
    CLIA Kit for Mouse Sphingomyelin phosphodiesterase 3
    Polyclonal Antibody for Mouse Sphingomyelin phosphodiesterase 3
    Polyclonal Antibody for Mouse Sphingomyelin phosphodiesterase 3
    Polyclonal Antibody for Mouse Sphingomyelin phosphodiesterase 3
    Monoclonal Antibody for Mouse Sphingomyelin phosphodiesterase 3
    Monoclonal Antibody for Mouse Sphingomyelin phosphodiesterase 3
    Monoclonal Antibody for Mouse Sphingomyelin phosphodiesterase 3
    Protein for Mouse Sphingomyelin phosphodiesterase 3
    Protein for Mouse Sphingomyelin phosphodiesterase 3
    Protein for Mouse Sphingomyelin phosphodiesterase 3

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Cloning and characterization of the mammalian brain-specific, Mg2+-dependent neutral sphingomyelinase."
      Hofmann K. , Tomiuk S. , Wolff G. , Stoffel W.
      Proc. Natl. Acad. Sci. U.S.A.97:5895-5900(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];TISSUE SPECIFICITY
    2. 2.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: C57BL/6J.
      tissue: Cerebellum.
      tissue: Skin.
    3. 3.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: C57BL/6.
      strain: FVB/N.
      tissue: Brain.
      tissue: Colon.
    4. 4.
      "Biochemical properties of mammalian neutral sphingomyelinase 2 and its role in sphingolipid metabolism."
      Marchesini N. , Luberto C. , Hannun Y.A.
      J. Biol. Chem.278:13775-13783(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CATALYTIC ACTIVITY;COFACTOR;ENZYME REGULATION
    5. 5.
      "Role for mammalian neutral sphingomyelinase 2 in confluence-induced growth arrest of MCF7 cells."
      Marchesini N. , Osta W. , Bielawski J. , Luberto C. , Obeid L.M. , Hannun Y.A.
      J. Biol. Chem.279:25101-25111(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    6. 6.
      "Differential regulation of ceramide in lipid-rich microdomains (rafts): antagonistic role of palmitoyl:protein thioesterase and neutral sphingomyelinase 2."
      Goswami R. , Ahmed M. , Kilkus J. , Han T. , Dawson S.A. , Dawson G.
      J. Neurosci. Res.81:208-217(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    7. 7.
      "A deletion in the gene encoding sphingomyelin phosphodiesterase 3 (Smpd3) results in osteogenesis and dentinogenesis imperfecta in the mouse."
      Aubin I. , Adams C.P. , Opsahl S. , Septier D. , Bishop C.E. , Auge N. , Salvayre R. , Negre-Salvayre A. , Goldberg M. , Guenet J.-L. , Poirier C.
      Nat. Genet.37:803-805(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    8. 8.
      "Neutral sphingomyelinase 2 (smpd3) in the control of postnatal growth and development."
      Stoffel W. , Jenke B. , Bloeck B. , Zumbansen M. , Koebke J.
      Proc. Natl. Acad. Sci. U.S.A.102:4554-4559(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DISRUPTION PHENOTYPE;SUBCELLULAR LOCATION
    9. 9.
      "Neutral sphingomyelinase 2 is palmitoylated on multiple cysteine residues. Role of palmitoylation in subcellular localization."
      Tani M. , Hannun Y.A.
      J. Biol. Chem.282:10047-10056(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;PALMITOYLATION AT CYS-53; CYS-54; CYS-59; CYS-395 AND CYS-396
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