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Index > Protein center > OAS3(Gene name) > Human
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  • OAS3 (Gene name),
  • 2'-5'-oligoadenylate synthase 3 (Protein name ),  OAS3_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    OAS3(P/OKcl.4);
    Protein name:
    2'-5'-oligoadenylate synthase 3((2-5')oligo(A) synthase 3;2-5A synthase 3);
    Alternative:
    p100 OAS(p100OAS);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Monomer.
    Function:
    May play a role in mediating resistance to virus infection, control of cell growth, differentiation, and apoptosis. OAS3 synthesizes preferentially dimeric 2',5'-oligoadenylate molecules. GTP can be an alternative substrate.
    Subcellular Location:
    Protein Attributes:
    Sequence length:
    1087
    Sequence:
    50:
    MDLYSTPAAA | LDRFVARRLQ | PRKEFVEKAR | RALGALAAAL | RERGGRLGAA | 
    100:
    APRVLKTVKG | GSSGRGTALK | GGCDSELVIF | LDCFKSYVDQ | RARRAEILSE | 
    150:
    MRASLESWWQ | NPVPGLRLTF | PEQSVPGALQ | FRLTSVDLED | WMDVSLVPAF | 
    200:
    NVLGQAGSGV | KPKPQVYSTL | LNSGCQGGEH | AACFTELRRN | FVNIRPAKLK | 
    250:
    NLILLVKHWY | HQVCLQGLWK | ETLPPVYALE | LLTIFAWEQG | CKKDAFSLAE | 
    300:
    GLRTVLGLIQ | QHQHLCVFWT | VNYGFEDPAV | GQFLQRQLKR | PRPVILDPAD | 
    350:
    PTWDLGNGAA | WHWDLLAQEA | ASCYDHPCFL | RGMGDPVQSW | KGPGLPRAGC | 
    400:
    SGLGHPIQLD | PNQKTPENSK | SLNAVYPRAG | SKPPSCPAPG | PTGAASIVPS | 
    450:
    VPGMALDLSQ | IPTKELDRFI | QDHLKPSPQF | QEQVKKAIDI | ILRCLHENCV | 
    500:
    HKASRVSKGG | SFGRGTDLRD | GCDVELIIFL | NCFTDYKDQG | PRRAEILDEM | 
    550:
    RAQLESWWQD | QVPSLSLQFP | EQNVPEALQF | QLVSTALKSW | TDVSLLPAFD | 
    600:
    AVGQLSSGTK | PNPQVYSRLL | TSGCQEGEHK | ACFAELRRNF | MNIRPVKLKN | 
    650:
    LILLVKHWYR | QVAAQNKGKG | PAPASLPPAY | ALELLTIFAW | EQGCRQDCFN | 
    700:
    MAQGFRTVLG | LVQQHQQLCV | YWTVNYSTED | PAMRMHLLGQ | LRKPRPLVLD | 
    750:
    PADPTWNVGH | GSWELLAQEA | AALGMQACFL | SRDGTSVQPW | DVMPALLYQT | 
    800:
    PAGDLDKFIS | EFLQPNRQFL | AQVNKAVDTI | CSFLKENCFR | NSPIKVIKVV | 
    850:
    KGGSSAKGTA | LRGRSDADLV | VFLSCFSQFT | EQGNKRAEII | SEIRAQLEAC | 
    900:
    QQERQFEVKF | EVSKWENPRV | LSFSLTSQTM | LDQSVDFDVL | PAFDALGQLV | 
    950:
    SGSRPSSQVY | VDLIHSYSNA | GEYSTCFTEL | QRDFIISRPT | KLKSLIRLVK | 
    1000:
    HWYQQCTKIS | KGRGSLPPQH | GLELLTVYAW | EQGGKDSQFN | MAEGFRTVLE | 
    1050:
    LVTQYRQLCI | YWTINYNAKD | KTVGDFLKQQ | LQKPRPIILD | PADPTGNLGH | 
    1087:
    NARWDLLAKE | AAACTSALCC | MGRNGIPIQP | WPVKAAV
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    MIM:
    UniGene:
    KEGG:
    String:
    Pfam:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Human (2-5')oligo(A) synthase 3
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    E1715h
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    ELISA Kit for Human (2-5')oligo(A) synthase 3
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    ELISA Kit for Human (2-5')oligo(A) synthase 3
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    E1715r
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human (2-5')oligo(A) synthase 3
    Cat.:
    U1715h
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human (2-5')oligo(A) synthase 3
    Cat.:
    U1715m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human (2-5')oligo(A) synthase 3
    Cat.:
    U1715r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human (2-5')oligo(A) synthase 3
    Cat.:
    P1715Rb-m
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    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human (2-5')oligo(A) synthase 3
    Cat.:
    P1715Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human (2-5')oligo(A) synthase 3
    Cat.:
    P1715Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human (2-5')oligo(A) synthase 3
    Monoclonal Antibody for Human (2-5')oligo(A) synthase 3
    Monoclonal Antibody for Human (2-5')oligo(A) synthase 3
    Protein for Human (2-5')oligo(A) synthase 3
    Protein for Human (2-5')oligo(A) synthase 3
    Protein for Human (2-5')oligo(A) synthase 3

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "The 100-kDa 2',5'-oligoadenylate synthetase catalyzing preferentially the synthesis of dimeric pppA2'p5'A molecules is composed of three homologous domains."
      Rebouillat D. , Hovnanian A. , Marie I. , Hovanessian A.G.
      J. Biol. Chem.274:1557-1565(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];PARTIAL PROTEIN SEQUENCE;FUNCTION;SUBCELLULAR LOCATION
    2. 2.
      "Molecular basis of T cell-mediated recognition of pancreatic cancer cells."
      Ito M. , Shichijo S. , Tsuda N. , Ochi M. , Harashima N. , Saito N. , Itoh K.
      Cancer Res.61:2038-2046(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANT LYS-18
      tissue: Pancreatic cancer.
    3. 3.
      "The finished DNA sequence of human chromosome 12."
      Scherer S.E. , Muzny D.M. , Buhay C.J. , Chen R. , Cree A. , Ding Y. , Dugan-Rocha S. , Gill R. , Gunaratne P. , Harris R.A. , Hawes A.C. , Hernandez J. , Hodgson A.V. , Hume J. , Jackson A. , Khan Z.M. , Kovar-Smith C. , Lewis L.R. , more...
      Nature440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    4. 4.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANT ARG-381
      tissue: Brain.
    5. 5.
      "Characterization of the gene encoding the 100-kDa form of human 2', 5'oligoadenylate synthetase."
      Rebouillat D. , Hovnanian A. , David G. , Hovanessian A.G. , Williams B.R.
      Genomics70:232-240(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-59
      tissue: Monocyte.
    6. 6.
      Bienvenut W.V. , Gao M. , Leug H.
      Submitted (2009-06) to the UniProtKB
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 1-17; 118-132; 244-253 AND 371-378;ACETYLATION AT MET-1;IDENTIFICATION BY MASS SPECTROMETRY
      tissue: Prostatic carcinoma.
    7. 7.
      "The human 2'-5'oligoadenylate synthetase family: unique interferon-inducible enzymes catalyzing 2'-5' instead of 3'-5' phosphodiester bond formation."
      Hovanessian A.G. , Justesen J.
      Biochimie89:779-788(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON FUNCTION
    8. 8.
      "Distinct antiviral roles for human 2',5'-oligoadenylate synthetase family members against dengue virus infection."
      Lin R.J. , Yu H.P. , Chang B.L. , Tang W.C. , Liao C.L. , Lin Y.L.
      J. Immunol.183:8035-8043(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION
    9. 9.
      "Evolution of the 2'-5'-oligoadenylate synthetase family in eukaryotes and bacteria."
      Kjaer K.H. , Poulsen J.B. , Reintamm T. , Saby E. , Martensen P.M. , Kelve M. , Justesen J.
      J. Mol. Evol.69:612-624(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
    10. 10.
      "The large form of human 2',5'-Oligoadenylate Synthetase (OAS3) exerts antiviral effect against Chikungunya virus."
      Brehin A.C. , Casademont I. , Frenkiel M.P. , Julier C. , Sakuntabhai A. , Despres P.
      Virology384:216-222(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    11. 11.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    12. 12.
      "The oligoadenylate synthetase family: an ancient protein family with multiple antiviral activities."
      Kristiansen H. , Gad H.H. , Eskildsen-Larsen S. , Despres P. , Hartmann R.
      J. Interferon Cytokine Res.31:41-47(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON FUNCTION
    13. 13.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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