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Index > Protein center > POFUT1(Gene name) > Human
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  • POFUT1 (Gene name),
  • GDP-fucose protein O-fucosyltransferase 1 (Protein name ),  OFUT1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    POFUT1(FUT12;KIAA0180);
    Protein name:
    GDP-fucose protein O-fucosyltransferase 1;
    Alternative:
    Peptide-O-fucosyltransferase 1(O-FucT-1);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Catalyzes the reaction that attaches fucose through an O-glycosidic linkage to a conserved serine or threonine residue in EGF domains. Plays a crucial role in Notch signaling.
    Subcellular Location:
    Endoplasmic reticulum
    Protein Attributes:
    Sequence length:
    388
    Sequence:
    50:
    MGAAAWARPL | SVSFLLLLLP | LPGMPAGSWD | PAGYLLYCPC | MGRFGNQADH | 
    100:
    FLGSLAFAKL | LNRTLAVPPW | IEYQHHKPPF | TNLHVSYQKY | FKLEPLQAYH | 
    150:
    RVISLEDFME | KLAPTHWPPE | KRVAYCFEVA | AQRSPDKKTC | PMKEGNPFGP | 
    200:
    FWDQFHVSFN | KSELFTGISF | SASYREQWSQ | RFSPKEHPVL | ALPGAPAQFP | 
    250:
    VLEEHRPLQK | YMVWSDEMVK | TGEAQIHAHL | VRPYVGIHLR | IGSDWKNACA | 
    300:
    MLKDGTAGSH | FMASPQCVGY | SRSTAAPLTM | TMCLPDLKEI | QRAVKLWVRS | 
    350:
    LDAQSVYVAT | DSESYVPELQ | QLFKGKVKVV | SLKPEVAQVD | LYILGQADHF | 
    388:
    IGNCVSSFTA | FVKRERDLQG | RPSSFFGMDR | PPKLRDEF
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    KEGG:
    MIM:
    SMR:
    String:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Human GDP-fucose protein O-fucosyltransferase 1
    ELISA Kit for Human GDP-fucose protein O-fucosyltransferase 1
    ELISA Kit for Human GDP-fucose protein O-fucosyltransferase 1
    CLIA Kit for Human GDP-fucose protein O-fucosyltransferase 1
    CLIA Kit for Human GDP-fucose protein O-fucosyltransferase 1
    CLIA Kit for Human GDP-fucose protein O-fucosyltransferase 1
    Polyclonal Antibody for Human GDP-fucose protein O-fucosyltransferase 1
    Polyclonal Antibody for Human GDP-fucose protein O-fucosyltransferase 1
    Polyclonal Antibody for Human GDP-fucose protein O-fucosyltransferase 1
    Monoclonal Antibody for Human GDP-fucose protein O-fucosyltransferase 1
    Monoclonal Antibody for Human GDP-fucose protein O-fucosyltransferase 1
    Monoclonal Antibody for Human GDP-fucose protein O-fucosyltransferase 1
    Protein for Human GDP-fucose protein O-fucosyltransferase 1
    Protein for Human GDP-fucose protein O-fucosyltransferase 1
    Protein for Human GDP-fucose protein O-fucosyltransferase 1

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Modification of epidermal growth factor-like repeats with O-fucose: molecular cloning and expression of a novel GDP-fucose protein O-fucosyltransferase."
      Wang Y. , Shao L. , Shi S. , Harris R.J. , Spellman M.W. , Stanley P. , Haltiwanger R.S.
      J. Biol. Chem.276:40338-40345(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION;BIOPHYSICOCHEMICAL PROPERTIES;TISSUE SPECIFICITY
      tissue: Heart.
    2. 2.
      "Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1."
      Nagase T. , Seki N. , Ishikawa K. , Tanaka A. , Nomura N.
      DNA Res.3:17-24(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Bone marrow.
    3. 3.
      "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
      Nakajima D. , Okazaki N. , Yamakawa H. , Kikuno R. , Ohara O. , Nagase T.
      DNA Res.9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SEQUENCE REVISION
    4. 4.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
    5. 5.
      "The DNA sequence and comparative analysis of human chromosome 20."
      Deloukas P. , Matthews L.H. , Ashurst J.L. , Burton J. , Gilbert J.G.R. , Jones M. , Stavrides G. , Almeida J.P. , Babbage A.K. , Bagguley C.L. , Bailey J. , Barlow K.F. , Bates K.N. , Beard L.M. , Beare D.M. , Beasley O.P. , Bird C.P. , Blakey S.E. , more...
      Nature414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 6.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    7. 7.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
      tissue: Brain.
    8. 8.
      "O-linked fucose and other post-translational modifications unique to EGF modules."
      Harris R.J. , Spellman M.W.
      Glycobiology3:219-224(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    9. 9.
      "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
      Chen R. , Jiang X. , Sun D. , Han G. , Wang F. , Ye M. , Wang L. , Zou H.
      J. Proteome Res.8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-160
      tissue: Liver.
    10. 10.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    11. 11.
      "Mutations in POFUT1, encoding protein O-fucosyltransferase 1, cause generalized Dowling-Degos disease."
      Li M. , Cheng R. , Liang J. , Yan H. , Zhang H. , Yang L. , Li C. , Jiao Q. , Lu Z. , He J. , Ji J. , Shen Z. , Li C. , Hao F. , Yu H. , Yao Z.
      Am. J. Hum. Genet.92:895-903(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN DDD2
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