OGT ELISA Kit for Human(Homo sapiens) | EIAab.comOGT ELISA Kit for Human(Homo sapiens)

Search Protein-oriented Product center.

For antibodies, ELISA/CLIA, proteins... Product center

Tips

Index > Protein center > OGT(Gene name) > Human

OGT (Gene name),

UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit (Protein name ), OGT1_HUMAN from NCBI database.

top

General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

Feedback

Gene name:

OGT;

Protein name:

UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit;

Alternative:

O-linked N-acetylglucosamine transferase 110 kDa subunit(OGT);O-GlcNAc transferase subunit p110;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Heterotrimer of two 110 kDa and one 70 kDa subunits. It is not known if the 70 kDa subunit is encoded by a separate gene or is the product of either of a proteolytic degradation or an alternative initiation of the 110 kDa subunit (By similarity). Interacts with ATXN10 (By similarity). Component of the MLL5-L complex, at least composed of MLL5, STK38, PPP1CA, PPP1CB, PPP1CC, HCFC1, ACTB and OGT. Interacts directly with HCFC1.

Function:

Addition of nucleotide-activated sugars directly onto the polypeptide through O-glycosidic linkage with the hydroxyl of serine or threonine. Mediates the O-glycosylation of MLL5 and HCFC1. Promotes proteolytic maturation of HCFC1.

Subcellular Location:

Cytoplasm Nucleus Mostly in the nucleus.

Protein Attributes:

Sequence length:

1046

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

700:

750:

800:

850:

900:

950:

1000:

1046:

RISSPLFNTK | QYTMELERLY | LQMWEHYAAG | NKPDHMIKPV | EVTESA

3D Structure:

N/A

Predicted Eptitope:

Please Sign in.

Vaild Sequence:

Please Sign in.

Related Databases

UniGene:

Hs.405410

String:

O15294

Pfam:

PF00515

STRING:

9606.ENSP00000362824

KEGG:

hsa:8473

MIM:

300255

SMR:

O15294

Uniprot:

O15294

FOR

ELISA Kit for Human UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

CLIA Kit for Human UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

Polyclonal Antibody for Human UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

Monoclonal Antibody for Human UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

Protein for Human UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"O-linked GlcNAc transferase is a conserved nucleocytoplasmic protein containing tetratricopeptide repeats."
Lubas W.A. , Frank D.W. , Krause M. , Hanover J.A.
J. Biol. Chem.272:9316-9324(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);PROTEIN SEQUENCE OF 227-236 AND 955-971;TISSUE SPECIFICITY
tissue: Liver.
2.

"Human O-GlcNAc transferase (OGT): genomic structure, analysis of splice variants, fine mapping in Xq13.1."
Nolte D. , Muller U.
Mamm. Genome13:62-64(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS 1; 2 AND 3)
3.

"The full-ORF clone resource of the German cDNA consortium."
Bechtel S. , Rosenfelder H. , Duda A. , Schmidt C.P. , Ernst U. , Wellenreuther R. , Mehrle A. , Schuster C. , Bahr A. , Bloecker H. , Heubner D. , Hoerlein A. , Michel G. , Wedler H. , Koehrer K. , Ottenwaelder B. , Poustka A. , Wiemann S. , more...
BMC Genomics8:399-399(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 4)
tissue: Endometrium.
tissue: Fetal brain.
tissue: Spinal cord.
4.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3)
tissue: Colon.
tissue: Pancreas.
5.

Bienvenut W.V. , Dhillon A.S. , Kolch W.
Submitted (2008-02) to the UniProtKB

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 2-17; 31-42; 161-168; 244-250; 339-348; 734-752; 868-877 AND 1002-1010;CLEAVAGE OF INITIATOR METHIONINE;ACETYLATION AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY
tissue: Hepatoma.
6.

"Recruitment of O-GlcNAc transferase to promoters by corepressor mSin3A: coupling protein O-GlcNAcylation to transcriptional repression."
Yang X. , Zhang F. , Kudlow J.E.
Cell110:69-80(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SIN3A;FUNCTION
7.

"Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1."
Wysocka J. , Myers M.P. , Laherty C.D. , Eisenman R.N. , Herr W.
Genes Dev.17:896-911(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH HCFC1
8.

"Phosphoinositide signalling links O-GlcNAc transferase to insulin resistance."
Yang X. , Ongusaha P.P. , Miles P.D. , Havstad J.C. , Zhang F. , So W.V. , Kudlow J.E. , Michell R.H. , Olefsky J.M. , Field S.J. , Evans R.M.
Nature451:964-969(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;FUNCTION;PHOSPHATIDYLINOSITOL-BINDING;MUTAGENESIS OF 991-LYS-LYS-992; ARG-994; LYS-996; LYS-999; ARG-1001 AND LYS-1010
9.

"A quantitative atlas of mitotic phosphorylation."
Dephoure N. , Zhou C. , Villen J. , Beausoleil S.A. , Bakalarski C.E. , Elledge S.J. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
10.

"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S. , Helbig A.O. , Slijper M. , Krijgsveld J. , Heck A.J. , Mohammed S.
Anal. Chem.81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
11.

"Reduced O-GlcNAcylation links lower brain glucose metabolism and tau pathology in Alzheimer's disease."
Liu F. , Shi J. , Tanimukai H. , Gu J. , Gu J. , Grundke-Iqbal I. , Iqbal K. , Gong C.X.
Brain132:1820-1832(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;ASSOCIATION WITH ALZHEIMER DISEASE
12.

"Up-regulation of O-GlcNAc transferase with glucose deprivation in HepG2 cells is mediated by decreased hexosamine pathway flux."
Taylor R.P. , Geisler T.S. , Chambers J.H. , McClain D.A.
J. Biol. Chem.284:3425-3432(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION
13.

"GlcNAcylation of a histone methyltransferase in retinoic-acid-induced granulopoiesis."
Fujiki R. , Chikanishi T. , Hashiba W. , Ito H. , Takada I. , Roeder R.G. , Kitagawa H. , Kato S.
Nature459:455-459(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;CATALYTIC ACTIVITY;IDENTIFICATION IN THE MLL5-L COMPLEX
14.

"Subunit composition and substrate specificity of a MOF-containing histone acetyltransferase distinct from the male-specific lethal (MSL) complex."
Cai Y. , Jin J. , Swanson S.K. , Cole M.D. , Choi S.H. , Florens L. , Washburn M.P. , Conaway J.W. , Conaway R.C.
J. Biol. Chem.285:4268-4272(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN HISTONE H4 ACETYLATION;IDENTIFICATION IN NSL COMPLEX;SUBCELLULAR LOCATION
15.

"Regulation of insulin receptor substrate 1 (IRS-1)/AKT kinase-mediated insulin signaling by O-Linked beta-N-acetylglucosamine in 3T3-L1 adipocytes."
Whelan S.A. , Dias W.B. , Thiruneelakantapillai L. , Lane M.D. , Hart G.W.
J. Biol. Chem.285:5204-5211(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;POSSIBLE ASSOCIATION WITH DIABETES
16.

"The THAP-zinc finger protein THAP1 associates with coactivator HCF-1 and O-GlcNAc transferase: a link between DYT6 and DYT3 dystonias."
Mazars R. , Gonzalez-de-Peredo A. , Cayrol C. , Lavigne A.C. , Vogel J.L. , Ortega N. , Lacroix C. , Gautier V. , Huet G. , Ray A. , Monsarrat B. , Kristie T.M. , Girard J.P.
J. Biol. Chem.285:13364-13371(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY IN A THAP1/THAP3-HCFC1-OGT COMPLEX;INTERACTION WITH HCFC1; THAP1 AND THAP3;FUNCTION
17.

"Elevated O-GlcNAc-dependent signaling through inducible mOGT expression selectively triggers apoptosis."
Shin S.H. , Love D.C. , Hanover J.A.
Amino Acids40:885-893(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION (ISOFORM 2)
18.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
19.

"Crosstalk between O-GlcNAcylation and proteolytic cleavage regulates the host cell factor-1 maturation pathway."
Daou S. , Mashtalir N. , Hammond-Martel I. , Pak H. , Yu H. , Sui G. , Vogel J.L. , Kristie T.M. , Affar E.B.
Proc. Natl. Acad. Sci. U.S.A.108:2747-2752(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;CATALYTIC ACTIVITY;SUBCELLULAR LOCATION;UBIQUITINATION;INTERACTION WITH HCFC1
20.

"GlcNAcylation of histone H2B facilitates its monoubiquitination."
Fujiki R. , Hashiba W. , Sekine H. , Yokoyama A. , Chikanishi T. , Ito S. , Imai Y. , Kim J. , He H.H. , Igarashi K. , Kanno J. , Ohtake F. , Kitagawa H. , Roeder R.G. , Brown M. , Kato S.
Nature480:557-560(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH H2B
21.

"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P. , Lasa M. , Polevoda B. , Gazquez C. , Elosegui-Artola A. , Kim D.S. , De Juan-Pardo E. , Demeyer K. , Hole K. , Larrea E. , Timmerman E. , Prieto J. , Arnesen T. , Sherman F. , Gevaert K. , Aldabe R.
Proc. Natl. Acad. Sci. U.S.A.109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
22.

"Phosphofructokinase 1 glycosylation regulates cell growth and metabolism."
Yi W. , Clark P.M. , Mason D.E. , Keenan M.C. , Hill C. , Goddard W.A. III , Peters E.C. , Driggers E.M. , Hsieh-Wilson L.C.
Science337:975-980(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
23.

"TET2 and TET3 regulate GlcNAcylation and H3K4 methylation through OGT and SET1/COMPASS."
Deplus R. , Delatte B. , Schwinn M.K. , Defrance M. , Mendez J. , Murphy N. , Dawson M.A. , Volkmar M. , Putmans P. , Calonne E. , Shih A.H. , Levine R.L. , Bernard O. , Mercher T. , Solary E. , Urh M. , Daniels D.L. , Fuks F.
EMBO J.32:645-655(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH HCFC1; TET2 AND TET3
24.

"TET2 promotes histone O-GlcNAcylation during gene transcription."
Chen Q. , Chen Y. , Bian C. , Fujiki R. , Yu X.
Nature493:561-564(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH TET2 AND TET3
25.

"O-GlcNAcylation regulates EZH2 protein stability and function."
Chu C.S. , Lo P.W. , Yeh Y.H. , Hsu P.H. , Peng S.H. , Teng Y.C. , Kang M.L. , Wong C.H. , Juan L.J.
Proc. Natl. Acad. Sci. U.S.A.111:1355-1360(2014) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
26.

"The superhelical TPR-repeat domain of O-linked GlcNAc transferase exhibits structural similarities to importin alpha."
Jinek M. , Rehwinkel J. , Lazarus B.D. , Izaurralde E. , Hanover J.A. , Conti E.
Nat. Struct. Mol. Biol.11:1001-1007(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.85 ANGSTROMS) OF 26-400;FUNCTION;CATALYTIC ACTIVITY;DOMAIN;MUTAGENESIS OF TRP-208 AND ILE-211
27.

"Structure of human O-GlcNAc transferase and its complex with a peptide substrate."
Lazarus M.B. , Nam Y. , Jiang J. , Sliz P. , Walker S.
Nature469:564-567(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.95 ANGSTROMS) OF 323-1041 IN COMPLEXES WITH UDP AND PEPTIDE SUBSTRATE;FUNCTION;CATALYTIC ACTIVITY;ENZYME REGULATION;BIOPHYSICOCHEMICAL PROPERTIES;ACTIVE SITE;MUTAGENESIS OF HIS-508; HIS-568 AND HIS-911

Product Feedback Wall

* Email:
*Comments: