Gene name:
OLR1 (CLEC8A;LOX1) ;
Protein name:
Oxidized low-density lipoprotein receptor 1 (Ox-LDL receptor 1) ;
Alternative:
Lectin-like oxidized LDL receptor 1 (LOX-1;Lectin-like oxLDL receptor 1;hLOX-1) ;C-type lectin domain family 8 member A ;Lectin-type oxidized LDL receptor 1 ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Homodimer; disulfide-linked. May form a hexamer composed of 3 homodimers. Interacts with HSP70.
Function:
Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. In addition to binding oxLDL, it acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. Also involved in inflammatory process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation. Also acts as a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells and both Gram-negative and Gram-positive bacteria.
Subcellular Location:
Cell membrane
Single-pass type II membrane protein
Secreted
A secreted form also exists.
Protein Attributes:
50:
MTFDDLKIQT | VKDQPDEKSN | GKKAKGLQFL | YSPWWCLAAA | TLGVLCLGLV |
100:
VTIMVLGMQL | SQVSDLLTQE | QANLTHQKKK | LEGQISARQQ | AEEASQESEN |
150:
ELKEMIETLA | RKLNEKSKEQ | MELHHQNLNL | QETLKRVANC | SAPCPQDWIW |
200:
HGENCYLFSS | GSFNWEKSQE | KCLSLDAKLL | KINSTADLDF | IQQAISYSSF |
250:
PFWMGLSRRN | PSYPWLWEDG | SPLMPHLFRV | RGAVSQTYPS | GTCAYIQRGA |
273:
VYAENCILAA | FSICQKKANL | RAQ
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Rat
Mouse
Bovine
Pig
Rabbit
ELISA Kit for Human Ox-LDL receptor 1
ELISA Kit for Human Ox-LDL receptor 1
ELISA Kit for Human Ox-LDL receptor 1
ELISA Kit for Human Ox-LDL receptor 1
ELISA Kit for Human Ox-LDL receptor 1
ELISA Kit for Human Ox-LDL receptor 1
CLIA Kit for Human Ox-LDL receptor 1
CLIA Kit for Human Ox-LDL receptor 1
CLIA Kit for Human Ox-LDL receptor 1
CLIA Kit for Human Ox-LDL receptor 1
CLIA Kit for Human Ox-LDL receptor 1
CLIA Kit for Human Ox-LDL receptor 1
Polyclonal Antibody for Human Ox-LDL receptor 1
Polyclonal Antibody for Human Ox-LDL receptor 1
Polyclonal Antibody for Human Ox-LDL receptor 1
Polyclonal Antibody for Human Ox-LDL receptor 1
Polyclonal Antibody for Human Ox-LDL receptor 1
Polyclonal Antibody for Human Ox-LDL receptor 1
Monoclonal Antibody for Human Ox-LDL receptor 1
Monoclonal Antibody for Human Ox-LDL receptor 1
Monoclonal Antibody for Human Ox-LDL receptor 1
Monoclonal Antibody for Human Ox-LDL receptor 1
Monoclonal Antibody for Human Ox-LDL receptor 1
Monoclonal Antibody for Human Ox-LDL receptor 1
Protein for Human Ox-LDL receptor 1
Protein for Human Ox-LDL receptor 1
Protein for Human Ox-LDL receptor 1
Protein for Human Ox-LDL receptor 1
Protein for Human Ox-LDL receptor 1
Protein for Human Ox-LDL receptor 1
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
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"An endothelial receptor for oxidized low-density lipoprotein."
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PubMed ]
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[
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION;TISSUE SPECIFICITY
tissue :
Lung .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);DOMAIN;DISULFIDE BONDS;GLYCOSYLATION;MUTAGENESIS OF CYS-144; CYS-155; CYS-172; ASN-183; 209-ARG-ASN-210; HIS-226; ARG-229; ARG-231; 235-SER-GLN-236; SER-240; CYS-243; CYS-256; CYS-264 AND 267-LYS--GLN-273
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA];TISSUE SPECIFICITY;INDUCTION
5.
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Biochem. Biophys. Res. Commun.303:247-250(2003)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);INVOLVEMENT IN MYOCARDIAL INFARCTION;VARIANT ASN-167
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Submitted (1999-02) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA]
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3)
tissue :
Placenta .
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[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2);VARIANT ASN-167
tissue :
Corpus callosum .
tissue :
Synovial cell .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA]
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Nature440:346-351(2006)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
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Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
11.
Mural R.J.
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Istrail S.
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Sutton G.
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Florea L.
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Halpern A.L.
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Mobarry C.M.
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Turner R.
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Myers E.W.
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more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases
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Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
12.
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Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue :
Placenta .
13.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION
14.
"Involvement of LOX-1 in dendritic cell-mediated antigen cross-presentation."
Delneste Y.
,
Magistrelli G.
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Gauchat J.-F.
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Haeuw J.-P.
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Aubry J.-F.
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Nakamura K.
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Kawakami-Honda N.
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Goetsch L.
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Sawamura T.
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Bonnefoy J.-Y.
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Jeannin P.
Immunity17:353-362(2002)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;TISSUE SPECIFICITY
15.
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Cited for : INVOLVEMENT IN ALZHEIMER DISEASE
16.
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Cited for : INDUCTION
17.
"Genetic variation in lectin-like oxidized low-density lipoprotein receptor 1 (LOX1) gene and the risk of coronary artery disease."
Chen Q.
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Reis S.E.
,
Kammerer C.
,
Craig W.Y.
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LaPierre S.E.
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Zimmer E.L.
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Sopko G.
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Bontempo F.
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Kamboh M.I.
Circulation107:3146-3151(2003)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INVOLVEMENT IN MYOCARDIAL INFARCTION
18.
"Association of 3'-UTR polymorphisms of the oxidised LDL receptor 1 (OLR1) gene with Alzheimer's disease."
Lambert J.-C.
,
Luedecking-Zimmer E.
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Merrot S.
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Hayes A.
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Thaker U.
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Desai P.
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Houzet A.
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Hermant X.
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Kamboh M.I.
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more...
J. Med. Genet.40:424-430(2003)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INVOLVEMENT IN ALZHEIMER DISEASE
19.
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Cited for : HOMODIMERIZATION;INTERCHAIN DISULFIDE BOND;MUTAGENESIS OF CYS-140
20.
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Cited for : LACK OF INVOLVEMENT IN ALZHEIMER DISEASE
21.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : LACK OF INVOLVEMENT IN ALZHEIMER DISEASE
22.
"In vivo and in vitro studies support that a new splicing isoform of OLR1 gene is protective against acute myocardial infarction."
Mango R.
,
Biocca S.
,
del Vecchio F.
,
Clementi F.
,
Sangiuolo F.
,
Amati F.
,
Filareto A.
,
Grelli S.
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Spitalieri P.
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Filesi I.
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Favalli C.
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Lauro R.
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Mehta J.L.
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Romeo F.
,
Novelli G.
Circ. Res.97:152-158(2005)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INVOLVEMENT IN MYOCARDIAL INFARCTION
23.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INVOLVEMENT IN ALZHEIMER DISEASE
24.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : DOMAIN;SUBCELLULAR LOCATION;MUTAGENESIS OF 22-LYS--LYS-25 AND GLU-70
25.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : GLYCOSYLATION AT ASN-139
26.
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Cited for : PALMITOYLATION AT CYS-36 AND CYS-46;SUBCELLULAR LOCATION
27.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (1.4 ANGSTROMS) OF 136-270;SUBUNIT;DISULFIDE BONDS
28.
"Crystal structure of human lectin-like, oxidized low-density lipoprotein receptor 1 ligand binding domain and its ligand recognition mode to oxLDL."
Ohki I.
,
Ishigaki T.
,
Oyama T.
,
Matsunaga S.
,
Xie Q.
,
Ohnishi-Kameyama M.
,
Murata T.
,
Tsuchiya D.
,
Machida S.
,
Morikawa K.
,
Tate S.
Structure13:905-917(2005)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 143-271;SUBUNIT;DISULFIDE BONDS;MUTAGENESIS OF TRP-150; ARG-208; ARG-209; HIS-226; ARG-229; ARG-231 AND ARG-248