Gene name:
Opn4 (Mop;Mopn) ;
Protein name:
Melanopsin ;
Alternative:
Opsin-4 ;
Organism:
Mouse (Mus musculus).
General Annotation
Function:
Photoreceptor required for regulation of circadian rhythm. Contributes to pupillar reflex and other non-image forming responses to light. May be able to isomerize covalently bound all-trans retinal back to 11-cis retinal.
Subcellular Location:
Membrane
Multi-pass membrane protein
Found in soma, dendrites and proximal part of axons of certain retinal ganglion cells.
Protein Attributes:
50:
MDSPSGPRVL | SSLTQDPSFT | TSPALQGIWN | GTQNVSVRAQ | LLSVSPTTSA |
100:
HQAAAWVPFP | TVDVPDHAHY | TLGTVILLVG | LTGMLGNLTV | IYTFCRNRGL |
150:
RTPANMFIIN | LAVSDFLMSV | TQAPVFFASS | LYKKWLFGET | GCEFYAFCGA |
200:
VFGITSMITL | TAIAMDRYLV | ITRPLATIGR | GSKRRTALVL | LGVWLYALAW |
250:
SLPPFFGWSA | YVPEGLLTSC | SWDYMTFTPQ | VRAYTMLLFC | FVFFLPLLII |
300:
IFCYIFIFRA | IRETGRACEG | CGESPLRQRR | QWQRLQSEWK | MAKVALIVIL |
350:
LFVLSWAPYS | TVALVAFAGY | SHILTPYMSS | VPAVIAKASA | IHNPIIYAIT |
400:
HPKYRVAIAQ | HLPCLGVLLG | VSGQRSHPSL | SYRSTHRSTL | SSQSSDLSWI |
450:
SGRKRQESLG | SESEVGWTDT | ETTAAWGAAQ | QASGQSFCSQ | NLEDGELKAS |
500:
SSPQVQRSKT | PKVPGPSTCR | PMKGQGARPS | SLRGDQKGRL | AVCTGLSECP |
521:
HPHTSQFPLA | FLEDDVTLRH | L
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
Rat
ELISA Kit for Mouse Melanopsin
ELISA Kit for Mouse Melanopsin
ELISA Kit for Mouse Melanopsin
CLIA Kit for Mouse Melanopsin
CLIA Kit for Mouse Melanopsin
CLIA Kit for Mouse Melanopsin
Polyclonal Antibody for Mouse Melanopsin
Polyclonal Antibody for Mouse Melanopsin
Polyclonal Antibody for Mouse Melanopsin
Monoclonal Antibody for Mouse Melanopsin
Monoclonal Antibody for Mouse Melanopsin
Monoclonal Antibody for Mouse Melanopsin
Protein for Mouse Melanopsin
Protein for Mouse Melanopsin
Protein for Mouse Melanopsin
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION;TISSUE SPECIFICITY
tissue :
Retina .
2.
"Differential expression of two distinct functional isoforms of melanopsin (Opn4) in the mammalian retina."
Pires S.S.
,
Hughes S.
,
Turton M.
,
Melyan Z.
,
Peirson S.N.
,
Zheng L.
,
Kosmaoglou M.
,
Bellingham J.
,
Cheetham M.E.
,
Lucas R.J.
,
Foster R.G.
,
Hankins M.W.
,
Halford S.
J. Neurosci.29:12332-12342(2009)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2);SYNTHESIS OF 1-15 AND 500-514;FUNCTION;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
strain :
C3H/He .
tissue :
Retina .
3.
"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M.
,
Goodstadt L.
,
Hillier L.W.
,
Zody M.C.
,
Goldstein S.
,
She X.
,
Bult C.J.
,
Agarwala R.
,
Cherry J.L.
,
DiCuccio M.
,
Hlavina W.
,
Kapustin Y.
,
Meric P.
,
Maglott D.
,
Birtle Z.
,
Marques A.C.
,
Graves T.
,
Zhou S.
,
Teague B.
,
Potamousis K.
,
Churas C.
,
Place M.
,
Herschleb J.
,
Runnheim R.
,
Forrest D.
,
Amos-Landgraf J.
,
Schwartz D.C.
,
Cheng Z.
,
Lindblad-Toh K.
,
Eichler E.E.
,
Ponting C.P.
more...
PLoS Biol.7:E1000112-E1000112(2009)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain :
C57BL/6J .
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
5.
"Melanopsin and rod-cone photoreceptive systems account for all major accessory visual functions in mice."
Hattar S.
,
Lucas R.J.
,
Mrosovsky N.
,
Thompson S.
,
Douglas R.H.
,
Hankins M.W.
,
Lem J.
,
Biel M.
,
Hofmann F.
,
Foster R.G.
,
Yau K.-W.
Nature424:76-81(2003)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;DISRUPTION PHENOTYPE