OPRM1 ELISA Kit for Human(Homo sapiens) | EIAab.comOPRM1 ELISA Kit for Human(Homo sapiens)

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Index > Protein center > OPRM1(Gene name) > Human

OPRM1 (Gene name),

Mu-type opioid receptor (Protein name ), OPRM_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

OPRM1(MOR1);

Protein name:

Mu-type opioid receptor(M-OR-1;MOR-1);

Alternative:

Mu opioid receptor(MOP;hMOP);Mu opiate receptor;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Forms a complex with G(alpha)z/i2 subunits and the RGSZ proteins, RGSZ17 and RGSZ20. The formation of this complex results in mu-opioid receptor desensitization. Interacts with RGSZ17 and RGSZ20 (By similarity). The C-terminal tail interacts with the C-terminal section of DNAJB4.

Function:

Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Receptor for beta-endorphin.

Subcellular Location:

Cell membrane Multi-pass membrane protein

Protein Attributes:

Sequence length:

400

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

P35372

MIM:

600018

Pfam:

PF00001

SMR:

P35372

UniGene:

Hs.2353

KEGG:

hsa:4988

Uniprot:

P35372

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ELISA Kit for Human M-OR-1

Cat.:

E0714h

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96T

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ELISA Kit for Human M-OR-1

Cat.:

E0714r

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96T

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ELISA Kit for Human M-OR-1

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E0714p

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96T

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ELISA Kit for Human M-OR-1

Cat.:

E0714m

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96T

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ELISA Kit for Human M-OR-1

Cat.:

E0714b

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96T

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CLIA Kit for Human M-OR-1

Cat.:

U0714r

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96T

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CLIA Kit for Human M-OR-1

Cat.:

U0714h

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Looking for manual.

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Packing:

96T

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CLIA Kit for Human M-OR-1

Cat.:

U0714m

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MSDS:

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Packing:

96T

CLIA Kit for Human M-OR-1

Cat.:

U0714p

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MSDS:

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Packing:

96T

CLIA Kit for Human M-OR-1

Cat.:

U0714b

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96T

Polyclonal Antibody for Human M-OR-1

Cat.:

P0714Rb-r

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40ug/0.2ml

Polyclonal Antibody for Human M-OR-1

Cat.:

P0714Rb-h

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40ug/0.2ml

Polyclonal Antibody for Human M-OR-1

Cat.:

P0714Rb-m

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human M-OR-1

Protein for Human M-OR-1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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Linearity

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References

1.

NIEHS SNPs program
Submitted (2006-11) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS VAL-6; ASP-40; CYS-147; ASP-152; CYS-265 AND ASN-274
2.

"Isolation and characterization of two alternatively spliced variants from the human mu opioid receptor, OPRM1, gene."
Xu J. , Xu M. , Pasternak G.W. , Pan Y.
Submitted (2008-08) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 6 AND 10)
3.

"The DNA sequence and analysis of human chromosome 6."
Mungall A.J. , Palmer S.A. , Sims S.K. , Edwards C.A. , Ashurst J.L. , Wilming L. , Jones M.C. , Horton R. , Hunt S.E. , Scott C.E. , Gilbert J.G.R. , Clamp M.E. , Bethel G. , Milne S. , Ainscough R. , Almeida J.P. , Ambrose K.D. , Andrews T.D. , more...
Nature425:805-811(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
4.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
5.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
6.

"An homozygous Ala 6 Val (GCC->GTC) mutation was detected on human mu opioid receptor gene of an African American individual with sickle cell anemia."
Metha S. , Glendenning M. , Kutlar A. , Kutlar F.
Submitted (2003-05) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-20;VARIANT VAL-6
tissue: Blood.
7.

"The mu opiate receptor as a candidate gene for pain: polymorphisms, variations in expression, nociception, and opiate responses."
Uhl G.R. , Sora I. , Wang Z.
Proc. Natl. Acad. Sci. U.S.A.96:7752-7755(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-47
8.

"Mu opioid receptor gene expression in immune cells."
Chuang T.K. , Killam K.F. Jr. , Chuang L.F. , Kung H.F. , Sheng W.S. , Chao C.C. , Yu L. , Chuang R.Y.
Biochem. Biophys. Res. Commun.216:922-930(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 229-374
9.

"ADP-ribosylation factor-dependent phospholipase D2 activation is required for agonist-induced mu-opioid receptor endocytosis."
Koch T. , Brandenburg L.O. , Schulz S. , Liang Y. , Klein J. , Hollt V.
J. Biol. Chem.278:9979-9985(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PLD2
10.

"Mutation of human mu opioid receptor extracellular 'disulfide cysteine' residues alters ligand binding but does not prevent receptor targeting to the cell plasma membrane."
Zhang P. , Johnson P.S. , Zollner C. , Wang W. , Wang Z. , Montes A.E. , Seidleck B.K. , Blaschak C.J. , Surratt C.K.
Brain Res. Mol. Brain Res.72:195-204(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF CYS-142 AND CYS-219
11.

"Calmodulin binding to G protein-coupling domain of opioid receptors."
Wang D. , Sadee W. , Quillan J.M.
J. Biol. Chem.274:22081-22088(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CALMODULIN;MUTAGENESIS OF LYS-273
12.

"Molecular mechanisms and regulation of opioid receptor signaling."
Law P.Y. , Wong Y.H. , Loh H.H.
Annu. Rev. Pharmacol. Toxicol.40:389-430(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
13.

"Calmodulin regulation of basal and agonist-stimulated G protein coupling by the mu-opioid receptor (OP(3)) in morphine-pretreated cell."
Wang D. , Surratt C.K. , Sadee W.
J. Neurochem.75:763-771(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CALMODULIN;MUTAGENESIS OF LYS-273 AND ARG-275
14.

"Interactions of opioid and chemokine receptors: oligomerization of mu, kappa, and delta with CCR5 on immune cells."
Suzuki S. , Chuang L.F. , Yau P. , Doi R.H. , Chuang R.Y.
Exp. Cell Res.280:192-200(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: RECEPTOR HETEROOLIGOMERIZATION;INTERACTION WITH CCR5
15.

"Agonists activate Gi1 alpha or Gi2 alpha fused to the human mu opioid receptor differently."
Massotte D. , Brillet K. , Kieffer B. , Milligan G.
J. Neurochem.81:1372-1382(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: COUPLING TO GNAI1 AND GNAI2
16.

"Selective interactions between helix VIII of the human mu-opioid receptors and the C terminus of periplakin disrupt G protein activation."
Feng G.J. , Kellett E. , Scorer C.A. , Wilde J. , White J.H. , Milligan G.
J. Biol. Chem.278:33400-33407(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PPL
17.

"Human mu opiate receptor. cDNA and genomic clones, pharmacologic characterization and chromosomal assignment."
Wang J.-B. , Johnson P.S. , Persico A.M. , Hawkins A.L. , Griffin C.A. , Uhl G.R.
FEBS Lett.338:217-222(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue: Brain.
18.

"Expression of two variants of the human mu opioid receptor mRNA in SK-N-SH cells and human brain."
Bare L.A. , Mansson E. , Yang D.
FEBS Lett.354:213-216(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);VARIANT ASP-40
tissue: Brain.
19.

"The human mu opioid receptor: modulation of functional desensitization by calcium/calmodulin-dependent protein kinase and protein kinase C."
Mestek A. Jr. , Hurley J.H. , Bye L.S. , Campbell A.D. , Chen Y. , Tian M. , Liu J. , Schulman H. , Yu L.
J. Neurosci.15:2396-2406(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue: Brain.
20.

"Identification and characterization of two new human mu opioid receptor splice variants, hMOR-1O and hMOR-1X."
Pan Y.X. , Xu J. , Mahurter L. , Xu M. , Gilbert A.K. , Pasternak G.W.
Biochem. Biophys. Res. Commun.301:1057-1061(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 3 AND 5)
21.

"Molecular identification and functional expression of mu 3, a novel alternatively spliced variant of the human mu opiate receptor gene."
Cadet P. , Mantione K.J. , Stefano G.B.
J. Immunol.170:5118-5123(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 14)
22.

"Identification and characterization of six new alternatively spliced variants of the human mu opioid receptor gene, Oprm."
Pan L. , Xu J. , Yu R. , Xu M.-M. , Pan Y.-X. , Pasternak G.W.
Neuroscience133:209-220(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2; 4; 6; 7; 8; 9 AND 11)
23.

"Isolation and characterization of new exon 11-associated N-terminal splice variants of the human mu opioid receptor gene."
Xu J. , Xu M. , Hurd Y.L. , Pasternak G.W. , Pan Y.X.
J. Neurochem.108:962-972(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 10; 12 AND 13)
24.

"Novel variants of the human mu opioid receptor are generated by alternative splicing and transcription from different positions in the OPRM1 gene."
Baar C. , Kvam T.-M. , Rakvag T.T. , Kaasa S. , Skorpen F.
Submitted (2003-08) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 6 AND 15)
tissue: Brain.
25.

"Isolation and expression of alternatively spliced variants encoding proteins with single transmembrane domain in mu opioid receptor genes."
Xu J. , Pasternak G.W. , Pan Y.
Submitted (2010-12) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 18)
26.

"Expansion of the human mu-opioid receptor gene architecture: novel functional variants."
Shabalina S.A. , Zaykin D.V. , Gris P. , Ogurtsov A.Y. , Gauthier J. , Shibata K. , Tchivileva I.E. , Belfer I. , Mishra B. , Kiselycznyk C. , Wallace M.R. , Staud R. , Spiridonov N.A. , Max M.B. , Goldman D. , Fillingim R.B. , Maixner W. , Diatchenko L.
Hum. Mol. Genet.18:1037-1051(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 12)
tissue: Brain.
27.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue: Brain.
28.

"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
Kopatz S.A. , Aronstam R.S. , Sharma S.V.
Submitted (2004-01) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue: Brain.
29.

"Interaction between the mu opioid receptor and filamin A is involved in receptor regulation and trafficking."
Onoprishvili I. , Andria M.L. , Kramer H.K. , Ancevska-Taneva N. , Hiller J.M. , Simon E.J.
Mol. Pharmacol.64:1092-1100(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH FLNA
30.

"Opioid receptor homo- and heterodimerization in living cells by quantitative bioluminescence resonance energy transfer."
Wang D. , Sun X. , Bohn L.M. , Sadee W.
Mol. Pharmacol.67:2173-2184(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: HOMOOLIGOMERIZATION;RECEPTOR HETEROOLIGOMERIZATION;INTERACTION WITH OPRD1 AND OPRK1
31.

"Functional complementation and the analysis of opioid receptor homodimerization."
Pascal G. , Milligan G.
Mol. Pharmacol.68:905-915(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: HOMOOLIGOMERIZATION
32.

"The opioid ligand binding of human mu-opioid receptor is modulated by novel splice variants of the receptor."
Choi H.S. , Kim C.S. , Hwang C.K. , Song K.Y. , Wang W. , Qiu Y. , Law P.Y. , Wei L.N. , Loh H.H.
Biochem. Biophys. Res. Commun.343:1132-1140(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ALTERNATIVE SPLICING (ISOFORMS 16 AND 17);FUNCTION (ISOFORMS 16 AND 17);SUBCELLULAR LOCATION;TISSUE SPECIFICITY;SUBUNIT
33.

"A member of the heat shock protein 40 family, hlj1, binds to the carboxyl tail of the human mu opioid receptor."
Ancevska-Taneva N. , Onoprishvili I. , Andria M.L. , Hiller J.M. , Simon E.J.
Brain Res.1081:28-33(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH DNAJB4
34.

"Physical association between neuropeptide FF and micro-opioid receptors as a possible molecular basis for anti-opioid activity."
Roumy M. , Lorenzo C. , Mazeres S. , Bouchet S. , Zajac J.M. , Mollereau C.
J. Biol. Chem.282:8332-8342(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: RECEPTOR HETEROOLIGOMERIZATION;INTERACTION WITH NPFFR2
35.

"Membrane functional organisation and dynamic of mu-opioid receptors."
Lopez A. , Salome L.
Cell. Mol. Life Sci.66:2093-2108(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
36.

"Regulation of mu opioid receptor internalization by the scaffold protein RanBPM."
Talbot J.N. , Skifter D.A. , Bianchi E. , Monaghan D.T. , Toews M.L. , Murrin L.C.
Neurosci. Lett.466:154-158(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH RANBP9
37.

"Interaction of the mu-opioid receptor with GPR177 (Wntless) inhibits Wnt secretion: potential implications for opioid dependence."
Jin J. , Kittanakom S. , Wong V. , Reyes B.A. , Van Bockstaele E.J. , Stagljar I. , Berrettini W. , Levenson R.
BMC Neurosci.11:33-33(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH WLS
38.

"A novel alternatively spliced isoform of the mu-opioid receptor: functional antagonism."
Gris P. , Gauthier J. , Cheng P. , Gibson D.G. , Gris D. , Laur O. , Pierson J. , Wentworth S. , Nackley A.G. , Maixner W. , Diatchenko L.
Mol. Pain6:33-33(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION (ISOFORM 12);SUBCELLULAR LOCATION (ISOFORM 12)
39.

"Mu opioid receptor gene variants: lack of association with alcohol dependence."
Bergen A.W. , Kokoszka J. , Peterson R. , Long J.C. , Virkkunen M. , Linnoila M. , Goldman D.
Mol. Psychiatry2:490-494(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS VAL-6; ASP-40 AND CYS-147
40.

"Single-nucleotide polymorphism in the human mu opioid receptor gene alters beta-endorphin binding and activity: possible implications for opiate addiction."
Bond C. , LaForge K.S. , Tian M. , Melia D. , Zhang S. , Borg L. , Gong J. , Schluger J. , Strong J.A. , Leal S.M. , Tischfield J.A. , Kreek M.J. , Yu L.
Proc. Natl. Acad. Sci. U.S.A.95:9608-9613(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS VAL-6; ASP-40 AND HIS-260

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