Oprm1 ELISA Kit for Rat(Rattus norvegicus) | EIAab.comOprm1 ELISA Kit for Rat(Rattus norvegicus)

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Oprm1 (Gene name),

Mu-type opioid receptor (Protein name ), OPRM_RAT from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Oprm1(Ror-b);

Protein name:

Mu-type opioid receptor(M-OR-1;MOR-1);

Alternative:

Opioid receptor B;

Organism:

Rat (Rattus norvegicus).

General Annotation

Sub Unit:

Forms a complex with G(alpha)z/i2 subunits and the RGSZ proteins, RGSZ17 and RGSZ20. The formation of this complex results in mu-opioid receptor desensitization. Interacts with RGSZ17 and RGSZ20.

Function:

Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Receptor for beta-endorphin.

Subcellular Location:

Cell membrane Multi-pass membrane protein

Protein Attributes:

Sequence length:

398

Sequence:

50:

100:

150:

200:

250:

300:

350:

398:

CIPTSSTIEQ | QNSTRVRQNT | REHPSTANTV | DRTNHQLENL | EAETAPLP

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

Pfam:

PF00001

STRING:

10116.ENSRNOP00000057371

UniGene:

Rn.10118

String:

P33535

KEGG:

rno:25601

Uniprot:

P33535

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ELISA Kit for Rat M-OR-1

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E0714h

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ELISA Kit for Rat M-OR-1

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E0714r

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ELISA Kit for Rat M-OR-1

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E0714p

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ELISA Kit for Rat M-OR-1

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E0714m

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ELISA Kit for Rat M-OR-1

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E0714b

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CLIA Kit for Rat M-OR-1

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U0714r

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96T

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CLIA Kit for Rat M-OR-1

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U0714h

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CLIA Kit for Rat M-OR-1

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U0714m

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96T

CLIA Kit for Rat M-OR-1

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U0714p

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96T

CLIA Kit for Rat M-OR-1

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U0714b

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Polyclonal Antibody for Rat M-OR-1

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P0714Rb-r

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40ug/0.2ml

Polyclonal Antibody for Rat M-OR-1

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P0714Rb-h

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Polyclonal Antibody for Rat M-OR-1

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P0714Rb-m

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40ug/0.2ml

Monoclonal Antibody for Rat M-OR-1

Protein for Rat M-OR-1

R&D Technical Data

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Precision

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Recovery

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Linearity

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References

1.

"Primary structures and expression from cDNAs of rat opioid receptor delta- and mu-subtypes."
Fukuda K. , Kato S. , Mori K. , Nishi M. , Takeshima H.
FEBS Lett.327:311-314(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue: Brain.
2.

"Mu opiate receptor: cDNA cloning and expression."
Wang J.-B. , Imai Y. , Epler M.C. , Gregor P. , Spivak C. , Uhl G.R.
Proc. Natl. Acad. Sci. U.S.A.90:10230-10234(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue: Brain.
3.

"Molecular cloning and functional expression of a mu-opioid receptor from rat brain."
Chen Y. , Mestek A. , Liu J. , Hurley J.A. , Yu L.
Mol. Pharmacol.44:8-12(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue: Brain.
4.

Bunzow J.R. , Grandy D.K. , Kelly M.
Submitted (1993-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
strain: Sprague-Dawley.
tissue: Brain.
5.

"Cloning and pharmacological characterization of a rat mu opioid receptor."
Thompson R.C. , Mansour A. , Akil H. , Watson S.J.
Neuron11:903-913(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
strain: Sprague-Dawley.
tissue: Olfactory bulb.
6.

"Cloning, characterization, and distribution of a mu-opioid receptor in rat brain."
Zastawny R.L. , George S.R. , Nguyen T. , Cheng R. , Tsatsos J. , Briones-Urbina R. , O'Dowd B.F.
J. Neurochem.62:2099-2105(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue: Brain.
7.

"Identification and characterization of two new alternatively spliced variants from the rat mu opioid receptor gene, Oprm."
Pan Y.-X. , Xu J. , Pasternak G.W.
Submitted (2003-05) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 3 AND 5)
strain: Sprague-Dawley.
8.

"Identification of three new alternatively spliced variants of the rat mu opioid receptor gene: dissociation of affinity and efficacy."
Pasternak D.A. , Pan L. , Xu J. , Yu R. , Xu M.M. , Pasternak G.W. , Pan Y.X.
J. Neurochem.91:881-890(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2; 6; 7 AND 8)
strain: Sprague-Dawley.
9.

"Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
Gibbs R.A. , Weinstock G.M. , Metzker M.L. , Muzny D.M. , Sodergren E.J. , Scherer S. , Scott G. , Steffen D. , Worley K.C. , Burch P.E. , Okwuonu G. , Hines S. , Lewis L. , Deramo C. , Delgado O. , Dugan-Rocha S. , Miner G. , Morgan M. , more...
Nature428:493-521(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain: Brown Norway.
10.

"Complementary DNA cloning of a mu-opioid receptor from rat peritoneal macrophages."
Sedqi M. , Roy S. , Ramakrishnan S. , Elde R. , Loh H.H.
Biochem. Biophys. Res. Commun.209:563-574(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 101-340
tissue: Macrophage.
11.

"Cloning and expression of an isoform of the rat mu opioid receptor (rMOR1B) which differs in agonist induced desensitization from rMOR1."
Zimprich A. , Simon T. , Hoellt V.
FEBS Lett.359:142-146(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 356-398 (ISOFORM 4)
12.

"Activation of mu opioid receptors inhibits transient high- and low-threshold Ca2+ currents, but spares a sustained current."
Schroeder J.E. , Fischbach P.S. , Zheng D. , McCleskey E.W.
Neuron6:13-20(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
13.

"Inhibition of Ca2+ currents by a mu-opioid in a defined subset of rat sensory neurons."
Schroeder J.E. , McCleskey E.W.
J. Neurosci.13:867-873(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
14.

"-mu opiate receptor. Charged transmembrane domain amino acids are critical for agonist recognition and intrinsic activity."
Surratt C.K. , Johnson P.S. , Moriwaki A. , Seidleck B.K. , Blaschak C.J. , Wang J.B. , Uhl G.R.
J. Biol. Chem.269:20548-20553(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;MUTAGENESIS OF ASP-114; ASP-147 AND HIS-297
15.

"Activation of type II adenylyl cyclase by the cloned mu-opioid receptor: coupling to multiple G proteins."
Chan J.S. , Chiu T.T. , Wong Y.H.
J. Neurochem.65:2682-2689(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;COUPLING TO G-PROTEINS
16.

"The mu-opioid receptor down-regulates differently from the delta-opioid receptor: requirement of a high affinity receptor/G protein complex formation."
Chakrabarti S. , Yang W. , Law P.Y. , Loh H.H.
Mol. Pharmacol.52:105-113(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;MUTAGENESIS OF ASP-114
17.

"Palmitoylation of the rat mu opioid receptor."
Chen C. , Shahabi V. , Xu W. , Liu-Chen L.Y.
FEBS Lett.441:148-152(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PALMITOYLATION;MUTAGENESIS OF CYS-346 AND CYS-351
18.

"Differential coupling of mu-, delta-, and kappa-opioid receptors to G alpha16-mediated stimulation of phospholipase C."
Lee J.W. , Joshi S. , Chan J.S. , Wong Y.H.
J. Neurochem.70:2203-2211(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: COUPLING TO GNA15
19.

"Agonist-induced, G protein-dependent and -independent down-regulation of the mu opioid receptor. The receptor is a direct substrate for protein-tyrosine kinase."
Pak Y. , O'Dowd B.F. , Wang J.B. , George S.R.
J. Biol. Chem.274:27610-27616(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION;MUTAGENESIS OF TYR-91; TYR-96; TYR-166; TYR-336 AND THR-394
20.

"Role for the C-terminus in agonist-induced mu opioid receptor phosphorylation and desensitization."
Deng H.B. , Yu Y. , Pak Y. , O'Dowd B.F. , George S.R. , Surratt C.K. , Uhl G.R. , Wang J.B.
Biochemistry39:5492-5499(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT THR-394;MUTAGENESIS OF THR-394
21.

"Oligomerization of mu- and delta-opioid receptors. Generation of novel functional properties."
George S.R. , Fan T. , Xie Z. , Tse R. , Tam V. , Varghese G. , O'Dowd B.F.
J. Biol. Chem.275:26128-26135(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: RECEPTOR HETEROOLIGOMERIZATION;INTERACTION WITH OPRD1
22.

"Mutational analysis of Gbetagamma and phospholipid interaction with G protein-coupled receptor kinase 2."
Carman C.V. , Barak L.S. , Chen C. , Liu-Chen L.Y. , Onorato J.J. , Kennedy S.P. , Caron M.G. , Benovic J.L.
J. Biol. Chem.275:10443-10452(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION BY ADRBK1
23.

"Constitutive activation of the mu opioid receptor by mutation of D3.49(164), but not D3.32(147): D3.49(164) is critical for stabilization of the inactive form of the receptor and for its expression."
Li J. , Huang P. , Chen C. , de Riel J.K. , Weinstein H. , Liu-Chen L.Y.
Biochemistry40:12039-12050(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF ASP-147 AND ASP-164
24.

"Functional role of a conserved motif in TM6 of the rat mu opioid receptor: constitutively active and inactive receptors result from substitutions of Thr6.34(279) with Lys and Asp."
Huang P. , Li J. , Chen C. , Visiers I. , Weinstein H. , Liu-Chen L.Y.
Biochemistry40:13501-13509(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF THR-279
25.

"Threonine 180 is required for G-protein-coupled receptor kinase 3- and beta-arrestin 2-mediated desensitization of the mu-opioid receptor in Xenopus oocytes."
Celver J.P. , Lowe J. , Kovoor A. , Gurevich V.V. , Chavkin C.
J. Biol. Chem.276:4894-4900(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF THR-180
26.

"Phosphorylation of Ser363, Thr370, and Ser375 residues within the carboxyl tail differentially regulates mu-opioid receptor internalization."
El Kouhen R. , Burd A.L. , Erickson-Herbrandson L.J. , Chang C.Y. , Law P.Y. , Loh H.H.
J. Biol. Chem.276:12774-12780(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-363; THR-370 AND SER-375;MUTAGENESIS OF SER-363; THR-370 AND SER-375
27.

"The local environment at the cytoplasmic end of TM6 of the mu opioid receptor differs from those of rhodopsin and monoamine receptors: introduction of an ionic lock between the cytoplasmic ends of helices 3 and 6 by a L6.30(275)E mutation inactivates the mu opioid receptor and reduces the constitutive activity of its T6.34(279)K mutant."
Huang P. , Visiers I. , Weinstein H. , Liu-Chen L.Y.
Biochemistry41:11972-11980(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF LEU-275 AND THR-279
28.

"Heterodimerization of somatostatin and opioid receptors cross-modulates phosphorylation, internalization, and desensitization."
Pfeiffer M. , Koch T. , Schroder H. , Laugsch M. , Hollt V. , Schulz S.
J. Biol. Chem.277:19762-19772(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: RECEPTOR HETEROOLIGOMERIZATION;INTERACTION WITH SSTR2
29.

"ADP-ribosylation factor-dependent phospholipase D2 activation is required for agonist-induced mu-opioid receptor endocytosis."
Koch T. , Brandenburg L.O. , Schulz S. , Liang Y. , Klein J. , Hollt V.
J. Biol. Chem.278:9979-9985(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PLD2
30.

"Functional interactions between mu opioid and alpha 2A-adrenergic receptors."
Jordan B.A. , Gomes I. , Rios C. , Filipovska J. , Devi L.A.
Mol. Pharmacol.64:1317-1324(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: RECEPTOR HETEROOLIGOMERIZATION;INTERACTION WITH ADRA2A
31.

"Heterodimerization and cross-desensitization between the mu-opioid receptor and the chemokine CCR5 receptor."
Chen C. , Li J. , Bot G. , Szabo I. , Rogers T.J. , Liu-Chen L.Y.
Eur. J. Pharmacol.483:175-186(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: RECEPTOR HETEROOLIGOMERIZATION;INTERACTION WITH CCR5
32.

"Biochemical demonstration of mu-opioid receptor association with Gsalpha: enhancement following morphine exposure."
Chakrabarti S. , Regec A. , Gintzler A.R.
Brain Res. Mol. Brain Res.135:217-224(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH GNAS
33.

"Mu and kappa opioid receptors activate ERK/MAPK via different protein kinase C isoforms and secondary messengers in astrocytes."
Belcheva M.M. , Clark A.L. , Haas P.D. , Serna J.S. , Hahn J.W. , Kiss A. , Coscia C.J.
J. Biol. Chem.280:27662-27669(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
34.

"Receptor heterodimerization leads to a switch in signaling: beta-arrestin2-mediated ERK activation by mu-delta opioid receptor heterodimers."
Rozenfeld R. , Devi L.A.
FASEB J.21:2455-2465(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: RECEPTOR HETEROOLIGOMERIZATION;INTERACTION WITH OPRD1
35.

"Membrane glycoprotein M6a interacts with the micro-opioid receptor and facilitates receptor endocytosis and recycling."
Wu D.F. , Koch T. , Liang Y.J. , Stumm R. , Schulz S. , Schroder H. , Hollt V.
J. Biol. Chem.282:22239-22247(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH GPM6A
36.

"Interaction of the mu-opioid receptor with synaptophysin influences receptor trafficking and signaling."
Liang Y.J. , Wu D.F. , Yang L.Q. , Hollt V. , Koch T.
Mol. Pharmacol.71:123-131(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SYP
37.

"mu opioid and CB1 cannabinoid receptor interactions: reciprocal inhibition of receptor signaling and neuritogenesis."
Rios C. , Gomes I. , Devi L.A.
Br. J. Pharmacol.148:387-395(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;RECEPTOR HETEROOLIGOMERIZATION;INTERACTION WITH CNR1
38.

"Morphine-induced mu-opioid receptor rapid desensitization is independent of receptor phosphorylation and beta-arrestins."
Chu J. , Zheng H. , Loh H.H. , Law P.Y.
Cell. Signal.20:1616-1624(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF SER-363; THR-370 AND SER-375
39.

"Beta-arrestin-dependent mu-opioid receptor-activated extracellular signal-regulated kinases (ERKs) Translocate to Nucleus in Contrast to G protein-dependent ERK activation."
Zheng H. , Loh H.H. , Law P.Y.
Mol. Pharmacol.73:178-190(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
40.

"Regulator of G protein signaling 4 confers selectivity to specific G proteins to modulate mu- and delta-opioid receptor signaling."
Leontiadis L.J. , Papakonstantinou M.P. , Georgoussi Z.
Cell. Signal.21:1218-1228(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH RGS4
41.

"Phosphorylation of the mu-opioid receptor at tyrosine 166 (Tyr3.51) in the DRY motif reduces agonist efficacy."
Clayton C.C. , Bruchas M.R. , Lee M.L. , Chavkin C.
Mol. Pharmacol.77:339-347(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT TYR-166;MUTAGENESIS OF TYR-166
42.

"Modulating micro-opioid receptor phosphorylation switches agonist-dependent signaling as reflected in PKCepsilon activation and dendritic spine stability."
Zheng H. , Chu J. , Zhang Y. , Loh H.H. , Law P.Y.
J. Biol. Chem.286:12724-12733(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;MUTAGENESIS OF SER-375

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