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Index > Protein center > SPP1(Gene name) > Human
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  • SPP1 (Gene name),
  • Osteopontin (Protein name ),  OSTP_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Related Databases
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  • Citations  (5)
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  • Gene name:
    SPP1(PSEC0156;BNSP;OPN);
    Protein name:
    Osteopontin;
    Alternative:
    Uropontin;Urinary stone protein;Secreted phosphoprotein 1(SPP-1);Bone sialoprotein 1;Nephropontin;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Ligand for integrin alpha-V/beta-3.
    Function:
    Acts as a cytokine involved in enhancing production of interferon-gamma and interleukin-12 and reducing production of interleukin-10 and is essential in the pathway that leads to type I immunity.
    Subcellular Location:
    Secreted
    Protein Attributes:
    Sequence length:
    314
    Sequence:
    50:
    MRIAVICFCL | LGITCAIPVK | QADSGSSEEK | QLYNKYPDAV | ATWLNPDPSQ | 
    100:
    KQNLLAPQNA | VSSEETNDFK | QETLPSKSNE | SHDHMDDMDD | EDDDDHVDSQ | 
    150:
    DSIDSNDSDD | VDDTDDSHQS | DESHHSDESD | ELVTDFPTDL | PATEVFTPVV | 
    200:
    PTVDTYDGRG | DSVVYGLRSK | SKKFRRPDIQ | YPDATDEDIT | SHMESEELNG | 
    250:
    AYKAIPVAQD | LNAPSDWDSR | GKDSYETSQL | DDQSAETHSH | KQSRLYKRKA | 
    300:
    NDESNEHSDV | IDSQELSKVS | REFHSHEFHS | HEDMLVVDPK | SKEEDKHLKF | 
    314:
    RISHELDSAS | SEVN
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    Pfam:
    KEGG:
    String:
    MIM:
    Uniprot:
     
    FOR
    ELISA Kit for Human Osteopontin
    Cat.:
    E0899h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human Osteopontin
    MSDS:
    Please sign in first.
    ELISA Kit for Human Osteopontin
    Cat.:
    E0899m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human Osteopontin
    Cat.:
    E0899r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human Osteopontin
    Cat.:
    E0899b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human Osteopontin
    Cat.:
    E0899c
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Human Osteopontin
    Cat.:
    E0899p
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Osteopontin
    Cat.:
    U0899c
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Osteopontin
    Cat.:
    U0899b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Osteopontin
    Cat.:
    U0899p
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Osteopontin
    Cat.:
    U0899r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Osteopontin
    Cat.:
    U0899m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Osteopontin
    MSDS:
    Please sign in first.
    CLIA Kit for Human Osteopontin
    Cat.:
    U0899h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    Polyclonal Antibody for Human Osteopontin
    Cat.:
    P0899Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Osteopontin
    Polyclonal Antibody for Human Osteopontin
    Polyclonal Antibody for Human Osteopontin
    Polyclonal Antibody for Human Osteopontin
    Cat.:
    P0899Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Osteopontin
    Cat.:
    P0899Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Osteopontin
    Monoclonal Antibody for Human Osteopontin
    Monoclonal Antibody for Human Osteopontin
    Monoclonal Antibody for Human Osteopontin
    Monoclonal Antibody for Human Osteopontin
    Monoclonal Antibody for Human Osteopontin
    Monoclonal Antibody for Human Osteopontin
    Monoclonal Antibody for Human Osteopontin
    Protein for Human Osteopontin
    Protein for Human Osteopontin
    Protein for Human Osteopontin
    Protein for Human Osteopontin
    Protein for Human Osteopontin
    Protein for Human Osteopontin
    Protein for Human Osteopontin

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    References
    1. 1.
      "The cDNA and derived amino acid sequence for human osteopontin."
      Kiefer M.C. , Bauer D.M. , Barr P.J.
      Nucleic Acids Res.17:3306-3306(1989) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A)
    2. 2.
      "cDNA cloning, mRNA distribution and heterogeneity, chromosomal location, and RFLP analysis of human osteopontin (OPN)."
      Young M.F. , Kerr J.M. , Termine J.D. , Wewer U.M. , Wang M.G. , McBride O.W. , Fisher L.W.
      Genomics7:491-502(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM B)
    3. 3.
      "Inhibition of calcium oxalate crystal growth in vitro by uropontin: another member of the aspartic acid-rich protein superfamily."
      Shiraga H. , Min W. , VanDusen W.J. , Clayman M.D. , Miner D. , Terrell C.H. , Sherbotie J.R. , Foreman J.W. , Przysiecki C. , Neilson E.G. , Hoyer J.R.
      Proc. Natl. Acad. Sci. U.S.A.89:426-430(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A)
    4. 4.
      "Genomic organization of the human osteopontin gene: exclusion of the locus from a causative role in the pathogenesis of dentinogenesis imperfecta type II."
      Crosby A.H. , Edwards S.J. , Murray J.C. , Dixon M.J.
      Genomics27:155-160(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM A)
    5. 5.
      "Cloning and characterization of the human osteopontin gene and its promoter."
      Hijiya N. , Setoguchi M. , Matsuura K. , Higuchi Y. , Akizuki S. , Yamamoto S.
      Biochem. J.303:255-262(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM A)
      tissue: Liver.
    6. 6.
      "Expression of osteopontin in human glioma. Its correlation with the malignancy."
      Saitoh Y. , Kuratsu J. , Takeshima H. , Yamamoto S. , Ushio Y.
      Lab. Invest.72:55-63(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A; B AND C)
    7. 7.
      Yu W. , Sarginson J. , Gibbs R.A.
      Submitted (1998-03) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM B)
      tissue: Brain.
    8. 8.
      "Osteopontin splice variants in Indian breast cancer patients as biomarker."
      Sivakumar S. , Niranjali Devaraj S.
      Submitted (2011-02) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM C)
    9. 9.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS A; C AND 5)
      tissue: Kidney.
      tissue: Subthalamic nucleus.
    10. 10.
      "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
      Otsuki T. , Ota T. , Nishikawa T. , Hayashi K. , Suzuki Y. , Yamamoto J. , Wakamatsu A. , Kimura K. , Sakamoto K. , Hatano N. , Kawai Y. , Ishii S. , Saito K. , Kojima S. , Sugiyama T. , Ono T. , Okano K. , Yoshikawa Y. , more...
      DNA Res.12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM D)
      tissue: Placenta.
    11. 11.
      "A computer system platform used to predict novel genes."
      Yu Z. , Zheng Z. , Tang T. , Fu Y.
      Submitted (2006-07) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A)
    12. 12.
      "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W. , Graves T.A. , Fulton R.S. , Fulton L.A. , Pepin K.H. , Minx P. , Wagner-McPherson C. , Layman D. , Wylie K. , Sekhon M. , Becker M.C. , Fewell G.A. , Delehaunty K.D. , Miner T.L. , Nash W.E. , Kremitzki C. , Oddy L. , Du H. , more...
      Nature434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    13. 13.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    14. 14.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS A; B AND C)
      tissue: Brain.
      tissue: Kidney.
    15. 15.
      "Molecular cloning and sequencing of cDNA encoding urinary stone protein, which is identical to osteopontin."
      Kohri K. , Suzuki Y. , Yoshida K. , Yamamoto K. , Amasaki N. , Yamate T. , Umekawa T. , Iguchi M. , Sinohara H. , Kurita T.
      Biochem. Biophys. Res. Commun.184:859-864(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 67-278
      tissue: Kidney.
    16. 16.
      "Purification of a human milk protein closely similar to tumor-secreted phosphoproteins and osteopontin."
      Senger D.R. , Perruzzi C.A. , Papadopoulos A. , Tenen D.G.
      Biochim. Biophys. Acta996:43-48(1989) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 17-23 AND 169-182
      tissue: Milk.
    17. 17.
      "Post-translationally modified residues of native human osteopontin are located in clusters: identification of 36 phosphorylation and five O-glycosylation sites and their biological implications."
      Christensen B. , Nielsen M.S. , Haselmann K.F. , Petersen T.E. , Sorensen E.S.
      Biochem. J.390:285-292(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-24; SER-26; SER-27; SER-62; SER-63; THR-66; SER-76; SER-81; SER-99; SER-102; SER-108; SER-117; SER-120; SER-123; SER-129; THR-185; SER-191; SER-195; SER-215; SER-219; SER-224; SER-228; SER-234; SER-254; SER-263; SER-267; SER-275; SER-280; SER-303; SER-308; SER-310; SER-105 AND SER-126;GLYCOSYLATION AT ASN-79; ASN-106; THR-134; THR-138; THR-143; THR-147 AND THR-152
      tissue: Milk.
    18. 18.
      "Phosphoproteomic analysis of the human pituitary."
      Beranova-Giorgianni S. , Zhao Y. , Desiderio D.M. , Giorgianni F.
      Pituitary9:109-120(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-81;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Pituitary.
    19. 19.
      "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
      Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    20. 20.
      "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T. , Prokhorova T.A. , Akimov V. , Henningsen J. , Johansen P.T. , Kratchmarova I. , Kassem M. , Mann M. , Olsen J.V. , Blagoev B.
      Sci. Signal.4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-219; SER-224; SER-234 AND SER-254;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    21. 21.
      "Secreted kinase phosphorylates extracellular proteins that regulate biomineralization."
      Tagliabracci V.S. , Engel J.L. , Wen J. , Wiley S.E. , Worby C.A. , Kinch L.N. , Xiao J. , Grishin N.V. , Dixon J.E.
      Science336:1150-1153(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION BY FAM20C
    22. 22.
      "LC-MS/MS characterization of O-glycosylation sites and glycan structures of human cerebrospinal fluid glycoproteins."
      Halim A. , Ruetschi U. , Larson G. , Nilsson J.
      J. Proteome Res.12:573-584(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION;IDENTIFICATION BY MASS SPECTROMETRY
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