Protein name:
Ubiquitin thioesterase OTU1 ;
Alternative:
Organism:
Bovine (Bos taurus).
General Annotation
Sub Unit:
Interacts with VCP; the interaction is direct. Interacts with FAF2/UBXD8. Interacts with DERL1; however interaction is dependent on the UBAX-like region, suggesting that it may be indirect.
Function:
Hydrolase that can remove conjugated ubiquitin from proteins and participates in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by triming the ubiquitin chain on the associated substrate to facilitate their threading through the VCP/p97 pore. Ubiquitin moieties on substrates may present a steric impediment to the threading process when the substrate is transferred to the VCP pore and threaded through VCP's axial channel. Mediates deubiquitination of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Able to cleave both polyubiquitin and di-ubiquitin.
Subcellular Location:
N/A
Protein Attributes:
50:
MFGPAKGGHF | GVHPAAGCPG | GVSQPAAGTK | AGPAGVCPVG | GRTNAMWRLR |
100:
CKAKEGTHVL | QGLSSRTRVR | ELQGQIAAIT | GISPGCQRIL | VGYPPECLDL |
150:
SNGDTILEDL | PIQSGDMLIV | EEDQNRPKTS | PAFTKYGAPS | YVRETLPVLA |
200:
RMAVPADNSC | LFTSVYYVVE | GGVLNPACAP | EMRRFIAQIV | ASDPDFYSEA |
250:
ILGKTNEEYC | DWIKRDDTWG | GAIEISILSK | FYQCEICVVD | TQTVRIDRFG |
300:
EDAGYTKRVL | LIYDGIHYDP | LHLVFPDPDT | PPLTIFSSYD | DIVLVQALEL |
348:
ADEARKKRQF | TDVNRFTLRC | MVCQKGLTGQ | AEARDHAKET | GHTNFGEV
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
Rat
Bovine
Chicken
ELISA Kit for Bovine Ubiquitin thioesterase OTU1
ELISA Kit for Bovine Ubiquitin thioesterase OTU1
ELISA Kit for Bovine Ubiquitin thioesterase OTU1
ELISA Kit for Bovine Ubiquitin thioesterase OTU1
ELISA Kit for Bovine Ubiquitin thioesterase OTU1
CLIA Kit for Bovine Ubiquitin thioesterase OTU1
CLIA Kit for Bovine Ubiquitin thioesterase OTU1
CLIA Kit for Bovine Ubiquitin thioesterase OTU1
CLIA Kit for Bovine Ubiquitin thioesterase OTU1
CLIA Kit for Bovine Ubiquitin thioesterase OTU1
Polyclonal Antibody for Bovine Ubiquitin thioesterase OTU1
Polyclonal Antibody for Bovine Ubiquitin thioesterase OTU1
Polyclonal Antibody for Bovine Ubiquitin thioesterase OTU1
Polyclonal Antibody for Bovine Ubiquitin thioesterase OTU1
Polyclonal Antibody for Bovine Ubiquitin thioesterase OTU1
Monoclonal Antibody for Bovine Ubiquitin thioesterase OTU1
Monoclonal Antibody for Bovine Ubiquitin thioesterase OTU1
Monoclonal Antibody for Bovine Ubiquitin thioesterase OTU1
Monoclonal Antibody for Bovine Ubiquitin thioesterase OTU1
Monoclonal Antibody for Bovine Ubiquitin thioesterase OTU1
Protein for Bovine Ubiquitin thioesterase OTU1
Protein for Bovine Ubiquitin thioesterase OTU1
Protein for Bovine Ubiquitin thioesterase OTU1
Protein for Bovine Ubiquitin thioesterase OTU1
Protein for Bovine Ubiquitin thioesterase OTU1
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
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Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain :
Crossbred X Angus .
tissue :
Liver .