Protein name:
Cellular tumor antigen p53 ;
Alternative:
Tumor suppressor p53 ;
Organism:
Rabbit (Oryctolagus cuniculus).
General Annotation
Sub Unit:
Binds DNA as a homotetramer. Found in a complex with CABLES1 and TP73. Interacts with histone acetyltransferases EP300 and methyltransferases HRMT1L2 and CARM1, and recruits them to promoters. The C-terminus interacts with TAF1, when TAF1 is part of the TFIID complex. Interacts with HIPK1, HIPK2, AXIN1, and P53DINP1. Part of a complex consisting of TP53, HIPK2 and AXIN1. Interacts with WWOX. Interacts with USP7 and SYVN1. Interacts with HSP90AB1. Interacts with ARMD10, BANP, CDKN2AIP, NUAK1, STK11/LKB1 and E4F1. Interacts with CHD8, leading to recruit histone H1 and prevent transactivation activity. Interacts with YWHAZ; the interaction enhances TP53 transcriptional activity. Phosphorylation of YWHAZ on 'Ser-58' inhibits this interaction. Directly interacts with FBXO42; leading to ubiquination and degradation of TP53. Interacts with AURKA, DAXX, BRD7 and TRIM24. Interacts (when monomethylated at Lys-380) with L3MBTL1. Binds to the CAK complex (CDK7, cyclin H and MAT1) in response to DNA damage. Interacts with CDK5 in neurons.
Function:
Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression (By similarity). Interacts with GRK5.
Subcellular Location:
Cytoplasm
Nucleus
Endoplasmic reticulum
Interaction with BANP promotes nuclear localization.
Protein Attributes:
50:
MEESQSDLSL | EPPLSQETFS | DLWKLLPENN | LLTTSLNPPV | DDLLSAEDVA |
100:
NWLNEDPEEG | LRVPAAPAPE | APAPAAPALA | APAPATSWPL | SSSVPSQKTY |
150:
HGNYGFRLGF | LHSGTAKSVT | CTYSPCLNKL | FCQLAKTCPV | QLWVDSTPPP |
200:
GTRVRAMAIY | KKSQHMTEVV | RRCPHHERCS | DSDGLAPPQH | LIRVEGNLRA |
250:
EYLDDRNTFR | HSVVVPYEPP | EVGSDCTTIH | YNYMCNSSCM | GGMNRRPILT |
300:
IITLEDSSGN | LLGRNSFEVR | VCACPGRDRR | TEEENFRKKG | EPCPELPPGS |
350:
SKRALPTTTT | DSSPQTKKKP | LDGEYFILKI | RGRERFEMFR | ELNEALELKD |
391:
AQAEKEPGGS | RAHSSYLKAK | KGQSTSRHKK | PMFKREGPDS | D
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Rat
Human
Bovine
Mouse
Pig
Rabbit
Chicken
Dog
ELISA Kit for Rabbit Cellular tumor antigen p53
ELISA Kit for Rabbit Cellular tumor antigen p53
ELISA Kit for Rabbit Cellular tumor antigen p53
ELISA Kit for Rabbit Cellular tumor antigen p53
ELISA Kit for Rabbit Cellular tumor antigen p53
ELISA Kit for Rabbit Cellular tumor antigen p53
ELISA Kit for Rabbit Cellular tumor antigen p53
ELISA Kit for Rabbit Cellular tumor antigen p53
CLIA Kit for Rabbit Cellular tumor antigen p53
CLIA Kit for Rabbit Cellular tumor antigen p53
CLIA Kit for Rabbit Cellular tumor antigen p53
CLIA Kit for Rabbit Cellular tumor antigen p53
CLIA Kit for Rabbit Cellular tumor antigen p53
CLIA Kit for Rabbit Cellular tumor antigen p53
CLIA Kit for Rabbit Cellular tumor antigen p53
CLIA Kit for Rabbit Cellular tumor antigen p53
Polyclonal Antibody for Rabbit Cellular tumor antigen p53
Polyclonal Antibody for Rabbit Cellular tumor antigen p53
Polyclonal Antibody for Rabbit Cellular tumor antigen p53
Polyclonal Antibody for Rabbit Cellular tumor antigen p53
Polyclonal Antibody for Rabbit Cellular tumor antigen p53
Polyclonal Antibody for Rabbit Cellular tumor antigen p53
Polyclonal Antibody for Rabbit Cellular tumor antigen p53
Polyclonal Antibody for Rabbit Cellular tumor antigen p53
Monoclonal Antibody for Rabbit Cellular tumor antigen p53
Monoclonal Antibody for Rabbit Cellular tumor antigen p53
Monoclonal Antibody for Rabbit Cellular tumor antigen p53
Monoclonal Antibody for Rabbit Cellular tumor antigen p53
Monoclonal Antibody for Rabbit Cellular tumor antigen p53
Monoclonal Antibody for Rabbit Cellular tumor antigen p53
Monoclonal Antibody for Rabbit Cellular tumor antigen p53
Monoclonal Antibody for Rabbit Cellular tumor antigen p53
Protein for Rabbit Cellular tumor antigen p53
Protein for Rabbit Cellular tumor antigen p53
Protein for Rabbit Cellular tumor antigen p53
Protein for Rabbit Cellular tumor antigen p53
Protein for Rabbit Cellular tumor antigen p53
Protein for Rabbit Cellular tumor antigen p53
Protein for Rabbit Cellular tumor antigen p53
Protein for Rabbit Cellular tumor antigen p53
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
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Cited for : NUCLEOTIDE SEQUENCE [MRNA]
strain :
New Zealand .