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Index > Protein center > PLA2G4A(Gene name) > Human
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  • PLA2G4A (Gene name),
  • Cytosolic phospholipase A2 (Protein name ),  PA24A_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    PLA2G4A(CPLA2;PLA2G4);
    Protein name:
    Cytosolic phospholipase A2(cPLA2);
    Alternative:
    Phospholipase A2 group IVA;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with KAT5.
    Function:
    Selectively hydrolyzes arachidonyl phospholipids in the sn-2 position releasing arachidonic acid. Together with its lysophospholipid activity, it is implicated in the initiation of the inflammatory response.
    Subcellular Location:
    Cytoplasm Cytoplasmic vesicle Translocates to membrane vesicles in a calcium-dependent fashion.
    Protein Attributes:
    Sequence length:
    749
    Sequence:
    50:
    MSFIDPYQHI | IVEHQYSHKF | TVVVLRATKV | TKGAFGDMLD | TPDPYVELFI | 
    100:
    STTPDSRKRT | RHFNNDINPV | WNETFEFILD | PNQENVLEIT | LMDANYVMDE | 
    150:
    TLGTATFTVS | SMKVGEKKEV | PFIFNQVTEM | VLEMSLEVCS | CPDLRFSMAL | 
    200:
    CDQEKTFRQQ | RKEHIRESMK | KLLGPKNSEG | LHSARDVPVV | AILGSGGGFR | 
    250:
    AMVGFSGVMK | ALYESGILDC | ATYVAGLSGS | TWYMSTLYSH | PDFPEKGPEE | 
    300:
    INEELMKNVS | HNPLLLLTPQ | KVKRYVESLW | KKKSSGQPVT | FTDIFGMLIG | 
    350:
    ETLIHNRMNT | TLSSLKEKVN | TAQCPLPLFT | CLHVKPDVSE | LMFADWVEFS | 
    400:
    PYEIGMAKYG | TFMAPDLFGS | KFFMGTVVKK | YEENPLHFLM | GVWGSAFSIL | 
    450:
    FNRVLGVSGS | QSRGSTMEEE | LENITTKHIV | SNDSSDSDDE | SHEPKGTENE | 
    500:
    DAGSDYQSDN | QASWIHRMIM | ALVSDSALFN | TREGRAGKVH | NFMLGLNLNT | 
    550:
    SYPLSPLSDF | ATQDSFDDDE | LDAAVADPDE | FERIYEPLDV | KSKKIHVVDS | 
    600:
    GLTFNLPYPL | ILRPQRGVDL | IISFDFSARP | SDSSPPFKEL | LLAEKWAKMN | 
    650:
    KLPFPKIDPY | VFDREGLKEC | YVFKPKNPDM | EKDCPTIIHF | VLANINFRKY | 
    700:
    RAPGVPRETE | EEKEIADFDI | FDDPESPFST | FNFQYPNQAF | KRLHDLMHFN | 
    749:
    TLNNIDVIKE | AMVESIEYRR | QNPSRCSVSL | SNVEARRFFN | KEFLSKPKA
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    SMR:
    KEGG:
    UniGene:
    MIM:
    Pfam:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Human cPLA2
    Cat.:
    E1624r
    Price:
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    MSDS:
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    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human cPLA2
    Cat.:
    E1624h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human cPLA2
    Cat.:
    E1624m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
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    ELISA Kit for Human cPLA2
    Cat.:
    E1624b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Human cPLA2
    Cat.:
    E1624c
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Human cPLA2
    MSDS:
    Please sign in first.
    CLIA Kit for Human cPLA2
    Cat.:
    U1624b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human cPLA2
    MSDS:
    Please sign in first.
    CLIA Kit for Human cPLA2
    Cat.:
    U1624m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human cPLA2
    Cat.:
    U1624r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human cPLA2
    Cat.:
    U1624h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human cPLA2
    Cat.:
    U1624c
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human cPLA2
    Cat.:
    P1624Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human cPLA2
    Polyclonal Antibody for Human cPLA2
    Cat.:
    P1624Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human cPLA2
    Cat.:
    P1624Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human cPLA2
    Polyclonal Antibody for Human cPLA2
    Monoclonal Antibody for Human cPLA2
    Monoclonal Antibody for Human cPLA2
    Monoclonal Antibody for Human cPLA2
    Monoclonal Antibody for Human cPLA2
    Monoclonal Antibody for Human cPLA2
    Monoclonal Antibody for Human cPLA2
    Protein for Human cPLA2
    Protein for Human cPLA2
    Protein for Human cPLA2
    Protein for Human cPLA2
    Protein for Human cPLA2
    Protein for Human cPLA2

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "A novel arachidonic acid-selective cytosolic PLA2 contains a Ca(2+)-dependent translocation domain with homology to PKC and GAP."
      Clark J.D. , Lin L.-L. , Kriz R.W. , Ramesha C.S. , Sultzman L.A. , Lin A.Y. , Milona N. , Knopf J.L.
      Cell65:1043-1051(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];PARTIAL PROTEIN SEQUENCE;VARIANT LYS-651
    2. 2.
      "Molecular cloning and expression of human Ca(2+)-sensitive cytosolic phospholipase A2."
      Sharp J. , White D. , Chiou G. , Goodson T. , Gamboa G. , McClure D. , Burgett S. , Hoskins J. , Skatrud P. , Sportsman J. , Becker G. , Kang L. , Roberts E. , Kramer R.
      J. Biol. Chem.266:14850-14853(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANT LYS-651
    3. 3.
      NIEHS SNPs program
      Submitted (2004-02) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS ILE-224 AND LYS-651
    4. 4.
      "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G. , Barlow K.F. , McLay K.E. , Kaul R. , Swarbreck D. , Dunham A. , Scott C.E. , Howe K.L. , Woodfine K. , Spencer C.C.A. , Jones M.C. , Gillson C. , Searle S. , Zhou Y. , Kokocinski F. , McDonald L. , Evans R. , Phillips K. , more...
      Nature441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANT LYS-651
    6. 6.
      "cPLA2 is phosphorylated and activated by MAP kinase."
      Lin L.-L. , Wartmann M. , Lin A.Y. , Knopf J.L. , Seth A. , Davis R.J.
      Cell72:269-278(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF SER-505;PHOSPHORYLATION AT SER-505
    7. 7.
      "Serine 228 is essential for catalytic activities of 85-kDa cytosolic phospholipase A2."
      Sharp J.D. , Pickard R.T. , Chiou X.G. , Manetta J.V. , Kovacevic S. , Miller J.R. , Varshavsky A.D. , Roberts E.F. , Strifler B.A. , Brems D.N. , Kramer R.M.
      J. Biol. Chem.269:23250-23254(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACTIVE SITE;MUTAGENESIS OF CYS-139; CYS-141; CYS-151; SER-195; SER-215; CYS-220; SER-228; CYS-324; CYS-331; SER-577; CYS-620; CYS-634 AND CYS-726;BIOPHYSICOCHEMICAL PROPERTIES
    8. 8.
      "Functional identification of the active-site nucleophile of the human 85-kDa cytosolic phospholipase A2."
      Huang Z. , Payette P. , Abdullah K. , Cromlish W.A. , Kennedy B.P.
      Biochemistry35:3712-3721(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CATALYTIC ACTIVITY;SUBCELLULAR LOCATION;ACTIVE SITE;MUTAGENESIS OF SER-228
    9. 9.
      "Identification of essential residues for the catalytic function of 85-kDa cytosolic phospholipase A2. Probing the role of histidine, aspartic acid, cysteine, and arginine."
      Pickard R.T. , Chiou X.G. , Strifler B.A. , DeFelippis M.R. , Hyslop P.A. , Tebbe A.L. , Yee Y.K. , Reynolds L.J. , Dennis E.A. , Kramer R.M. , Sharp J.D.
      J. Biol. Chem.271:19225-19231(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACTIVE SITE;CATALYTIC ACTIVITY;MUTAGENESIS OF ARG-200; SER-228 AND ASP-549
    10. 10.
      "Identification of the phosphorylation sites of cytosolic phospholipase A2 in agonist-stimulated human platelets and HeLa cells."
      Boersch-Haubold A.G. , Bartoli F. , Asselin J. , Dudler T. , Kramer R.M. , Apitz-Castro R. , Watson S.P. , Gelb M.H.
      J. Biol. Chem.273:4449-4458(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-505 AND SER-727
    11. 11.
      "PLIP, a novel splice variant of Tip60, interacts with group IV cytosolic phospholipase A(2), induces apoptosis, and potentiates prostaglandin production."
      Sheridan A.M. , Force T. , Yoon H.J. , O'Leary E. , Choukroun G. , Taheri M.R. , Bonventre J.V.
      Mol. Cell. Biol.21:4470-4481(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH KAT5
    12. 12.
      "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V. , Blagoev B. , Gnad F. , Macek B. , Kumar C. , Mortensen P. , Mann M.
      Cell127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    13. 13.
      "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
      Beausoleil S.A. , Villen J. , Gerber S.A. , Rush J. , Gygi S.P.
      Nat. Biotechnol.24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-729;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    14. 14.
      "Inherited human cPLA(2alpha) deficiency is associated with impaired eicosanoid biosynthesis, small intestinal ulceration, and platelet dysfunction."
      Adler D.H. , Cogan J.D. , Phillips J.A. , Schnetz-Boutaud N. , Milne G.L. , Iverson T. , Stein J.A. , Brenner D.A. , Morrow J.D. , Boutaud O. , Oates J.A.
      J. Clin. Invest.118:2121-2131(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN PHOSPHOLIPASE A2 DEFICIENCY;VARIANTS PRO-111; HIS-485 AND LYS-651
    15. 15.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Platelet.
    16. 16.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-268; SER-437; SER-727 AND SER-729;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    17. 17.
      "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
      Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-268; SER-437 AND SER-729;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    18. 18.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    19. 19.
      "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T. , Prokhorova T.A. , Akimov V. , Henningsen J. , Johansen P.T. , Kratchmarova I. , Kassem M. , Mann M. , Olsen J.V. , Blagoev B.
      Sci. Signal.4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-437;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    20. 20.
      "Crystal structure of a calcium-phospholipid binding domain from cytosolic phospholipase A2."
      Perisic O. , Fong S. , Lynch D.E. , Bycroft M. , Williams R.L.
      J. Biol. Chem.273:1596-1604(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 16-141 IN COMPLEX WITH CALCIUM IONS;DOMAIN
    21. 21.
      "Solution structure and membrane interactions of the C2 domain of cytosolic phospholipase A2."
      Xu G.-Y. , McDonagh T. , Yu H.-A. , Nalefski E.A. , Clark J.D. , Cumming D.A.
      J. Mol. Biol.280:485-500(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 1-138 IN COMPLEX WITH CALCIUM IONS;DOMAIN;SUBCELLULAR LOCATION
    22. 22.
      "Crystal structure of human cytosolic phospholipase A2 reveals a novel topology and catalytic mechanism."
      Dessen A. , Tang J. , Schmidt H. , Stahl M. , Clark J.D. , Seehra J. , Somers W.S.
      Cell97:349-360(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) IN COMPLEX WITH CALCIUM IONS;ACTIVE SITE
    23. 23.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT [LARGE SCALE ANALYSIS] GLN-442
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