PLA2G4A ELISA Kit for Human(Homo sapiens) | EIAab.comPLA2G4A ELISA Kit for Human(Homo sapiens)

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Index > Protein center > PLA2G4A(Gene name) > Human

PLA2G4A (Gene name),

Cytosolic phospholipase A2 (Protein name ), PA24A_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

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Gene name:

PLA2G4A(CPLA2;PLA2G4);

Protein name:

Cytosolic phospholipase A2(cPLA2);

Alternative:

Phospholipase A2 group IVA;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts with KAT5.

Function:

Selectively hydrolyzes arachidonyl phospholipids in the sn-2 position releasing arachidonic acid. Together with its lysophospholipid activity, it is implicated in the initiation of the inflammatory response.

Subcellular Location:

Cytoplasm Cytoplasmic vesicle Translocates to membrane vesicles in a calcium-dependent fashion.

Protein Attributes:

Sequence length:

749

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

700:

749:

TLNNIDVIKE | AMVESIEYRR | QNPSRCSVSL | SNVEARRFFN | KEFLSKPKA

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

STRING:

9606.ENSP00000356436

SMR:

P47712

KEGG:

hsa:5321

UniGene:

Hs.497200

MIM:

600522

Pfam:

PF00168

String:

P47712

Uniprot:

P47712

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ELISA Kit for Human cPLA2

Cat.:

E1624r

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Manual:

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Packing:

96T

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ELISA Kit for Human cPLA2

Cat.:

E1624h

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Packing:

96T

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ELISA Kit for Human cPLA2

Cat.:

E1624m

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Manual:

Looking for manual.

MSDS:

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Packing:

96T

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ELISA Kit for Human cPLA2

Cat.:

E1624b

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96T

ELISA Kit for Human cPLA2

Cat.:

E1624c

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Packing:

96T

ELISA Kit for Human cPLA2

MSDS:

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CLIA Kit for Human cPLA2

Cat.:

U1624b

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Packing:

96T

CLIA Kit for Human cPLA2

MSDS:

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CLIA Kit for Human cPLA2

Cat.:

U1624m

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MSDS:

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Packing:

96T

CLIA Kit for Human cPLA2

Cat.:

U1624r

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Packing:

96T

CLIA Kit for Human cPLA2

Cat.:

U1624h

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Packing:

96T

CLIA Kit for Human cPLA2

Cat.:

U1624c

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96T

Polyclonal Antibody for Human cPLA2

Cat.:

P1624Rb-r

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human cPLA2

Cat.:

P1624Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human cPLA2

Cat.:

P1624Rb-h

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human cPLA2

Monoclonal Antibody for Human cPLA2

Protein for Human cPLA2

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"A novel arachidonic acid-selective cytosolic PLA2 contains a Ca(2+)-dependent translocation domain with homology to PKC and GAP."
Clark J.D. , Lin L.-L. , Kriz R.W. , Ramesha C.S. , Sultzman L.A. , Lin A.Y. , Milona N. , Knopf J.L.
Cell65:1043-1051(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];PARTIAL PROTEIN SEQUENCE;VARIANT LYS-651
2.

"Molecular cloning and expression of human Ca(2+)-sensitive cytosolic phospholipase A2."
Sharp J. , White D. , Chiou G. , Goodson T. , Gamboa G. , McClure D. , Burgett S. , Hoskins J. , Skatrud P. , Sportsman J. , Becker G. , Kang L. , Roberts E. , Kramer R.
J. Biol. Chem.266:14850-14853(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANT LYS-651
3.

NIEHS SNPs program
Submitted (2004-02) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS ILE-224 AND LYS-651
4.

"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G. , Barlow K.F. , McLay K.E. , Kaul R. , Swarbreck D. , Dunham A. , Scott C.E. , Howe K.L. , Woodfine K. , Spencer C.C.A. , Jones M.C. , Gillson C. , Searle S. , Zhou Y. , Kokocinski F. , McDonald L. , Evans R. , Phillips K. , more...
Nature441:315-321(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
5.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANT LYS-651
6.

"cPLA2 is phosphorylated and activated by MAP kinase."
Lin L.-L. , Wartmann M. , Lin A.Y. , Knopf J.L. , Seth A. , Davis R.J.
Cell72:269-278(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF SER-505;PHOSPHORYLATION AT SER-505
7.

"Serine 228 is essential for catalytic activities of 85-kDa cytosolic phospholipase A2."
Sharp J.D. , Pickard R.T. , Chiou X.G. , Manetta J.V. , Kovacevic S. , Miller J.R. , Varshavsky A.D. , Roberts E.F. , Strifler B.A. , Brems D.N. , Kramer R.M.
J. Biol. Chem.269:23250-23254(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACTIVE SITE;MUTAGENESIS OF CYS-139; CYS-141; CYS-151; SER-195; SER-215; CYS-220; SER-228; CYS-324; CYS-331; SER-577; CYS-620; CYS-634 AND CYS-726;BIOPHYSICOCHEMICAL PROPERTIES
8.

"Functional identification of the active-site nucleophile of the human 85-kDa cytosolic phospholipase A2."
Huang Z. , Payette P. , Abdullah K. , Cromlish W.A. , Kennedy B.P.
Biochemistry35:3712-3721(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CATALYTIC ACTIVITY;SUBCELLULAR LOCATION;ACTIVE SITE;MUTAGENESIS OF SER-228
9.

"Identification of essential residues for the catalytic function of 85-kDa cytosolic phospholipase A2. Probing the role of histidine, aspartic acid, cysteine, and arginine."
Pickard R.T. , Chiou X.G. , Strifler B.A. , DeFelippis M.R. , Hyslop P.A. , Tebbe A.L. , Yee Y.K. , Reynolds L.J. , Dennis E.A. , Kramer R.M. , Sharp J.D.
J. Biol. Chem.271:19225-19231(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACTIVE SITE;CATALYTIC ACTIVITY;MUTAGENESIS OF ARG-200; SER-228 AND ASP-549
10.

"Identification of the phosphorylation sites of cytosolic phospholipase A2 in agonist-stimulated human platelets and HeLa cells."
Boersch-Haubold A.G. , Bartoli F. , Asselin J. , Dudler T. , Kramer R.M. , Apitz-Castro R. , Watson S.P. , Gelb M.H.
J. Biol. Chem.273:4449-4458(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-505 AND SER-727
11.

"PLIP, a novel splice variant of Tip60, interacts with group IV cytosolic phospholipase A(2), induces apoptosis, and potentiates prostaglandin production."
Sheridan A.M. , Force T. , Yoon H.J. , O'Leary E. , Choukroun G. , Taheri M.R. , Bonventre J.V.
Mol. Cell. Biol.21:4470-4481(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH KAT5
12.

"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
Olsen J.V. , Blagoev B. , Gnad F. , Macek B. , Kumar C. , Mortensen P. , Mann M.
Cell127:635-648(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
13.

"A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
Beausoleil S.A. , Villen J. , Gerber S.A. , Rush J. , Gygi S.P.
Nat. Biotechnol.24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-729;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
14.

"Inherited human cPLA(2alpha) deficiency is associated with impaired eicosanoid biosynthesis, small intestinal ulceration, and platelet dysfunction."
Adler D.H. , Cogan J.D. , Phillips J.A. , Schnetz-Boutaud N. , Milne G.L. , Iverson T. , Stein J.A. , Brenner D.A. , Morrow J.D. , Boutaud O. , Oates J.A.
J. Clin. Invest.118:2121-2131(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN PHOSPHOLIPASE A2 DEFICIENCY;VARIANTS PRO-111; HIS-485 AND LYS-651
15.

"Phosphoproteome of resting human platelets."
Zahedi R.P. , Lewandrowski U. , Wiesner J. , Wortelkamp S. , Moebius J. , Schuetz C. , Walter U. , Gambaryan S. , Sickmann A.
J. Proteome Res.7:526-534(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Platelet.
16.

"A quantitative atlas of mitotic phosphorylation."
Dephoure N. , Zhou C. , Villen J. , Beausoleil S.A. , Bakalarski C.E. , Elledge S.J. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-268; SER-437; SER-727 AND SER-729;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
17.

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-268; SER-437 AND SER-729;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
18.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
19.

"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T. , Prokhorova T.A. , Akimov V. , Henningsen J. , Johansen P.T. , Kratchmarova I. , Kassem M. , Mann M. , Olsen J.V. , Blagoev B.
Sci. Signal.4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-437;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
20.

"Crystal structure of a calcium-phospholipid binding domain from cytosolic phospholipase A2."
Perisic O. , Fong S. , Lynch D.E. , Bycroft M. , Williams R.L.
J. Biol. Chem.273:1596-1604(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 16-141 IN COMPLEX WITH CALCIUM IONS;DOMAIN
21.

"Solution structure and membrane interactions of the C2 domain of cytosolic phospholipase A2."
Xu G.-Y. , McDonagh T. , Yu H.-A. , Nalefski E.A. , Clark J.D. , Cumming D.A.
J. Mol. Biol.280:485-500(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 1-138 IN COMPLEX WITH CALCIUM IONS;DOMAIN;SUBCELLULAR LOCATION
22.

"Crystal structure of human cytosolic phospholipase A2 reveals a novel topology and catalytic mechanism."
Dessen A. , Tang J. , Schmidt H. , Stahl M. , Clark J.D. , Seehra J. , Somers W.S.
Cell97:349-360(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) IN COMPLEX WITH CALCIUM IONS;ACTIVE SITE
23.

"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T. , Jones S. , Wood L.D. , Parsons D.W. , Lin J. , Barber T.D. , Mandelker D. , Leary R.J. , Ptak J. , Silliman N. , Szabo S. , Buckhaults P. , Farrell C. , Meeh P. , Markowitz S.D. , Willis J. , Dawson D. , Willson J.K.V. , more...
Science314:268-274(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT [LARGE SCALE ANALYSIS] GLN-442

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