Protein name:
Parkin coregulated gene protein ;
Alternative:
PARK2 coregulated gene protein ;Molecular chaperone/chaperonin-binding protein ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Forms a large molecular chaperone complex containing heat shock proteins 70 and 90 and chaperonin components. Interacts with STIP1, PARK2, GPR37, HSPA8, TCP1/CCT1, CCT2, CCT3, CCT4, CCT5, CCT6A, CCT7, CCT8.
Function:
Suppresses cell death induced by accumulation of unfolded Pael receptor (Pael-R, a substrate of Parkin). Facilitates the formation of inclusions consisting of Pael-R, molecular chaperones, protein degradation molecules and itself when proteasome is inhibited. May play an important role in the formation of Lewy bodies and protection of dopaminergic neurons against Parkinson disease.
Subcellular Location:
N/A
Protein Attributes:
50:
MVAEKETLSL | NKCPDKMPKR | TKLLAQQPLP | VHQPHSLVSE | GFTVKAMMKN |
100:
SVVRGPPAAG | AFKERPTKPT | AFRKFYERGD | FPIALEHDSK | GNKIAWKVEI |
150:
EKLDYHHYLP | LFFDGLCEMT | FPYEFFARQG | IHDMLEHGGN | KILPVLPQLI |
200:
IPIKNALNLR | NRQVICVTLK | VLQHLVVSAE | MVGKALVPYY | RQILPVLNIF |
250:
KNMNGSYSLP | RLECSGAIMA | RCNLDHLGSS | DPPTSASQVA | EIIVNSGDGI |
296:
DYSQQKRENI | GDLIQETLEA | FERYGGENAF | INIKYVVPTY | ESCLLN
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
ELISA Kit for Human Parkin coregulated gene protein
ELISA Kit for Human Parkin coregulated gene protein
CLIA Kit for Human Parkin coregulated gene protein
CLIA Kit for Human Parkin coregulated gene protein
Polyclonal Antibody for Human Parkin coregulated gene protein
Polyclonal Antibody for Human Parkin coregulated gene protein
Monoclonal Antibody for Human Parkin coregulated gene protein
Monoclonal Antibody for Human Parkin coregulated gene protein
Protein for Human Parkin coregulated gene protein
Protein for Human Parkin coregulated gene protein
R&D Technical Data
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Precision
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Recovery
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Linearity
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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Submitted (2005-09) to the EMBL/GenBank/DDBJ databases
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
tissue :
Testis .
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION;FUNCTION;INTERACTION WITH STIP1; PARK2; GPR37; HSPA8; TCP1; CCT2; CCT3; CCT4; CCT5; CCT6A; CCT7 AND CCT8
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : TISSUE SPECIFICITY;INVOLVEMENT IN SUSCEPTIBILITY TO LEPROSY