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Index > Protein center > PACRG(Gene name) > Human
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  • PACRG (Gene name),
  • Parkin coregulated gene protein (Protein name ),  PACRG_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    PACRG(GLUP);
    Protein name:
    Parkin coregulated gene protein;
    Alternative:
    PARK2 coregulated gene protein;Molecular chaperone/chaperonin-binding protein;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Forms a large molecular chaperone complex containing heat shock proteins 70 and 90 and chaperonin components. Interacts with STIP1, PARK2, GPR37, HSPA8, TCP1/CCT1, CCT2, CCT3, CCT4, CCT5, CCT6A, CCT7, CCT8.
    Function:
    Suppresses cell death induced by accumulation of unfolded Pael receptor (Pael-R, a substrate of Parkin). Facilitates the formation of inclusions consisting of Pael-R, molecular chaperones, protein degradation molecules and itself when proteasome is inhibited. May play an important role in the formation of Lewy bodies and protection of dopaminergic neurons against Parkinson disease.
    Subcellular Location:
    N/A
    Protein Attributes:
    Sequence length:
    296
    Sequence:
    50:
    MVAEKETLSL | NKCPDKMPKR | TKLLAQQPLP | VHQPHSLVSE | GFTVKAMMKN | 
    100:
    SVVRGPPAAG | AFKERPTKPT | AFRKFYERGD | FPIALEHDSK | GNKIAWKVEI | 
    150:
    EKLDYHHYLP | LFFDGLCEMT | FPYEFFARQG | IHDMLEHGGN | KILPVLPQLI | 
    200:
    IPIKNALNLR | NRQVICVTLK | VLQHLVVSAE | MVGKALVPYY | RQILPVLNIF | 
    250:
    KNMNGSYSLP | RLECSGAIMA | RCNLDHLGSS | DPPTSASQVA | EIIVNSGDGI | 
    296:
    DYSQQKRENI | GDLIQETLEA | FERYGGENAF | INIKYVVPTY | ESCLLN
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    MIM:
    Pfam:
    UniGene:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Human Parkin coregulated gene protein
    Cat.:
    E1522h
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    MSDS:
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    Packing:
    96T
    Range:
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    ELISA Kit for Human Parkin coregulated gene protein
    Cat.:
    E1522m
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human Parkin coregulated gene protein
    Cat.:
    U1522h
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Parkin coregulated gene protein
    Cat.:
    U1522m
    Price:
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    MSDS:
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    Packing:
    96T
    Polyclonal Antibody for Human Parkin coregulated gene protein
    Cat.:
    P1522Rb-m
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Parkin coregulated gene protein
    Cat.:
    P1522Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Parkin coregulated gene protein
    Monoclonal Antibody for Human Parkin coregulated gene protein
    Protein for Human Parkin coregulated gene protein
    Protein for Human Parkin coregulated gene protein

    R&D Technical Data
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    Precision
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    Recovery
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    References
    1. 1.
      "Identification of a novel gene linked to parkin via a bi-directional promoter."
      West A.B. , Lockhart P.J. , O'Farell C. , Farrer M.J.
      J. Mol. Biol.326:11-19(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
    2. 2.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Testis.
    3. 3.
      "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J. , Palmer S.A. , Sims S.K. , Edwards C.A. , Ashurst J.L. , Wilming L. , Jones M.C. , Horton R. , Hunt S.E. , Scott C.E. , Gilbert J.G.R. , Clamp M.E. , Bethel G. , Milne S. , Ainscough R. , Almeida J.P. , Ambrose K.D. , Andrews T.D. , more...
      Nature425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    4. 4.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
      tissue: Testis.
    6. 6.
      "A product of the human gene adjacent to parkin is a component of Lewy bodies and suppresses Pael receptor-induced cell death."
      Imai Y. , Soda M. , Murakami T. , Shoji M. , Abe K. , Takahashi R.
      J. Biol. Chem.278:51901-51910(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION;FUNCTION;INTERACTION WITH STIP1; PARK2; GPR37; HSPA8; TCP1; CCT2; CCT3; CCT4; CCT5; CCT6A; CCT7 AND CCT8
    7. 7.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY;INVOLVEMENT IN SUSCEPTIBILITY TO LEPROSY
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