Protein name:
Pituitary adenylate cyclase-activating polypeptide type I receptor (PACAP type I receptor;PACAP-R-1;PACAP-R1) ;
Alternative:
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Interacts (via N-terminal extracellular domain) with ADCYAP1.
Function:
This is a receptor for PACAP-27 and PACAP-38. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. May regulate the release of adrenocorticotropin, luteinizing hormone, growth hormone, prolactin, epinephrine, and catecholamine. May play a role in spermatogenesis and sperm motility. Causes smooth muscle relaxation and secretion in the gastrointestinal tract.
Subcellular Location:
Cell membrane
Multi-pass membrane protein
Protein Attributes:
50:
MAGVVHVSLA | ALLLLPMAPA | MHSDCIFKKE | QAMCLEKIQR | ANELMGFNDS |
100:
SPGCPGMWDN | ITCWKPAHVG | EMVLVSCPEL | FRIFNPDQVW | ETETIGESDF |
150:
GDSNSLDLSD | MGVVSRNCTE | DGWSEPFPHY | FDACGFDEYE | SETGDQDYYY |
200:
LSVKALYTVG | YSTSLVTLTT | AMVILCRFRK | LHCTRNFIHM | NLFVSFMLRA |
250:
ISVFIKDWIL | YAEQDSNHCF | ISTVECKAVM | VFFHYCVVSN | YFWLFIEGLY |
300:
LFTLLVETFF | PERRYFYWYT | IIGWGTPTVC | VTVWATLRLY | FDDTGCWDMN |
350:
DSTALWWVIK | GPVVGSIMVN | FVLFIGIIVI | LVQKLQSPDM | GGNESSIYLR |
400:
LARSTLLLIP | LFGIHYTVFA | FSPENVSKRE | RLVFELGLGS | FQGFVVAVLY |
450:
CFLNGEVQAE | IKRKWRSWKV | NRYFAVDFKH | RHPSLASSGV | NGGTQLSILS |
468:
KSSSQIRMSG | LPADNLAT
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Bovine
Rat
Mouse
ELISA Kit for Human PACAP type I receptor
ELISA Kit for Human PACAP type I receptor
ELISA Kit for Human PACAP type I receptor
ELISA Kit for Human PACAP type I receptor
CLIA Kit for Human PACAP type I receptor
CLIA Kit for Human PACAP type I receptor
CLIA Kit for Human PACAP type I receptor
CLIA Kit for Human PACAP type I receptor
Polyclonal Antibody for Human PACAP type I receptor
Polyclonal Antibody for Human PACAP type I receptor
Polyclonal Antibody for Human PACAP type I receptor
Polyclonal Antibody for Human PACAP type I receptor
Monoclonal Antibody for Human PACAP type I receptor
Monoclonal Antibody for Human PACAP type I receptor
Monoclonal Antibody for Human PACAP type I receptor
Monoclonal Antibody for Human PACAP type I receptor
Protein for Human PACAP type I receptor
Protein for Human PACAP type I receptor
Protein for Human PACAP type I receptor
Protein for Human PACAP type I receptor
R&D Technical Data
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
Precision
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
Recovery
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
Linearity
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM N)
tissue :
Pituitary .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA]
3.
"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
King M.
,
Aronstam R.S.
,
Sharma S.V.
Submitted (2003-08) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM N)
tissue :
Brain .
4.
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T.
,
Suzuki Y.
,
Nishikawa T.
,
Otsuki T.
,
Sugiyama T.
,
Irie R.
,
Wakamatsu A.
,
Hayashi K.
,
Sato H.
,
Nagai K.
,
Kimura K.
,
Makita H.
,
Sekine M.
,
Obayashi M.
,
Nishi T.
,
Shibahara T.
,
Tanaka T.
,
Ishii S.
,
Yamamoto J.
,
Saito K.
,
Kawai Y.
,
Isono Y.
,
Nakamura Y.
,
Nagahari K.
,
Murakami K.
,
Yasuda T.
,
Iwayanagi T.
,
Wagatsuma M.
,
Shiratori A.
,
Sudo H.
,
Hosoiri T.
,
Kaku Y.
,
Kodaira H.
,
Kondo H.
,
Sugawara M.
,
Takahashi M.
,
Kanda K.
,
Yokoi T.
,
Furuya T.
,
Kikkawa E.
,
Omura Y.
,
Abe K.
,
Kamihara K.
,
Katsuta N.
,
Sato K.
,
Tanikawa M.
,
Yamazaki M.
,
Ninomiya K.
,
Ishibashi T.
,
Yamashita H.
,
Murakawa K.
,
Fujimori K.
,
Tanai H.
,
Kimata M.
,
Watanabe M.
,
Hiraoka S.
,
Chiba Y.
,
Ishida S.
,
Ono Y.
,
Takiguchi S.
,
Watanabe S.
,
Yosida M.
,
Hotuta T.
,
Kusano J.
,
Kanehori K.
,
Takahashi-Fujii A.
,
Hara H.
,
Tanase T.-O.
,
Nomura Y.
,
Togiya S.
,
Komai F.
,
Hara R.
,
Takeuchi K.
,
Arita M.
,
Imose N.
,
Musashino K.
,
Yuuki H.
,
Oshima A.
,
Sasaki N.
,
Aotsuka S.
,
Yoshikawa Y.
,
Matsunawa H.
,
Ichihara T.
,
Shiohata N.
,
Sano S.
,
Moriya S.
,
Momiyama H.
,
Satoh N.
,
Takami S.
,
Terashima Y.
,
Suzuki O.
,
Nakagawa S.
,
Senoh A.
,
Mizoguchi H.
,
Goto Y.
,
Shimizu F.
,
Wakebe H.
,
Hishigaki H.
,
Watanabe T.
,
Sugiyama A.
,
Takemoto M.
,
Kawakami B.
,
Yamazaki M.
,
Watanabe K.
,
Kumagai A.
,
Itakura S.
,
Fukuzumi Y.
,
Fujimori Y.
,
Komiyama M.
,
Tashiro H.
,
Tanigami A.
,
Fujiwara T.
,
Ono T.
,
Yamada K.
,
Fujii Y.
,
Ozaki K.
,
Hirao M.
,
Ohmori Y.
,
Kawabata A.
,
Hikiji T.
,
Kobatake N.
,
Inagaki H.
,
Ikema Y.
,
Okamoto S.
,
Okitani R.
,
Kawakami T.
,
Noguchi S.
,
Itoh T.
,
Shigeta K.
,
Senba T.
,
Matsumura K.
,
Nakajima Y.
,
Mizuno T.
,
Morinaga M.
,
Sasaki M.
,
Togashi T.
,
Oyama M.
,
Hata H.
,
Watanabe M.
,
Komatsu T.
,
Mizushima-Sugano J.
,
Satoh T.
,
Shirai Y.
,
Takahashi Y.
,
Nakagawa K.
,
Okumura K.
,
Nagase T.
,
Nomura N.
,
Kikuchi H.
,
Masuho Y.
,
Yamashita R.
,
Nakai K.
,
Yada T.
,
Nakamura Y.
,
Ohara O.
,
Isogai T.
,
Sugano S.
more...
Nat. Genet.36:40-45(2004)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM N)
tissue :
Hippocampus .
5.
"The DNA sequence of human chromosome 7."
Hillier L.W.
,
Fulton R.S.
,
Fulton L.A.
,
Graves T.A.
,
Pepin K.H.
,
Wagner-McPherson C.
,
Layman D.
,
Maas J.
,
Jaeger S.
,
Walker R.
,
Wylie K.
,
Sekhon M.
,
Becker M.C.
,
O'Laughlin M.D.
,
Schaller M.E.
,
Fewell G.A.
,
Delehaunty K.D.
,
Miner T.L.
,
Nash W.E.
,
Cordes M.
,
Du H.
,
Sun H.
,
Edwards J.
,
Bradshaw-Cordum H.
,
Ali J.
,
Andrews S.
,
Isak A.
,
Vanbrunt A.
,
Nguyen C.
,
Du F.
,
Lamar B.
,
Courtney L.
,
Kalicki J.
,
Ozersky P.
,
Bielicki L.
,
Scott K.
,
Holmes A.
,
Harkins R.
,
Harris A.
,
Strong C.M.
,
Hou S.
,
Tomlinson C.
,
Dauphin-Kohlberg S.
,
Kozlowicz-Reilly A.
,
Leonard S.
,
Rohlfing T.
,
Rock S.M.
,
Tin-Wollam A.-M.
,
Abbott A.
,
Minx P.
,
Maupin R.
,
Strowmatt C.
,
Latreille P.
,
Miller N.
,
Johnson D.
,
Murray J.
,
Woessner J.P.
,
Wendl M.C.
,
Yang S.-P.
,
Schultz B.R.
,
Wallis J.W.
,
Spieth J.
,
Bieri T.A.
,
Nelson J.O.
,
Berkowicz N.
,
Wohldmann P.E.
,
Cook L.L.
,
Hickenbotham M.T.
,
Eldred J.
,
Williams D.
,
Bedell J.A.
,
Mardis E.R.
,
Clifton S.W.
,
Chissoe S.L.
,
Marra M.A.
,
Raymond C.
,
Haugen E.
,
Gillett W.
,
Zhou Y.
,
James R.
,
Phelps K.
,
Iadanoto S.
,
Bubb K.
,
Simms E.
,
Levy R.
,
Clendenning J.
,
Kaul R.
,
Kent W.J.
,
Furey T.S.
,
Baertsch R.A.
,
Brent M.R.
,
Keibler E.
,
Flicek P.
,
Bork P.
,
Suyama M.
,
Bailey J.A.
,
Portnoy M.E.
,
Torrents D.
,
Chinwalla A.T.
,
Gish W.R.
,
Eddy S.R.
,
McPherson J.D.
,
Olson M.V.
,
Eichler E.E.
,
Green E.D.
,
Waterston R.H.
,
Wilson R.K.
more...
Nature424:157-164(2003)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.
Mural R.J.
,
Istrail S.
,
Sutton G.G.
,
Florea L.
,
Halpern A.L.
,
Mobarry C.M.
,
Lippert R.
,
Walenz B.
,
Shatkay H.
,
Dew I.
,
Miller J.R.
,
Flanigan M.J.
,
Edwards N.J.
,
Bolanos R.
,
Fasulo D.
,
Halldorsson B.V.
,
Hannenhalli S.
,
Turner R.
,
Yooseph S.
,
Lu F.
,
Nusskern D.R.
,
Shue B.C.
,
Zheng X.H.
,
Zhong F.
,
Delcher A.L.
,
Huson D.H.
,
Kravitz S.A.
,
Mouchard L.
,
Reinert K.
,
Remington K.A.
,
Clark A.G.
,
Waterman M.S.
,
Eichler E.E.
,
Adams M.D.
,
Hunkapiller M.W.
,
Myers E.W.
,
Venter J.C.
more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM N-HOP1)
tissue :
Brain .
tissue :
Testis .
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 418-468
tissue :
Placenta .
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ALTERNATIVE SPLICING
10.
"Solution structure and mutational analysis of pituitary adenylate cyclase-activating polypeptide binding to the extracellular domain of PAC1-RS."
Sun C.
,
Song D.
,
Davis-Taber R.A.
,
Barrett L.W.
,
Scott V.E.
,
Richardson P.L.
,
Pereda-Lopez A.
,
Uchic M.E.
,
Solomon L.R.
,
Lake M.R.
,
Walter K.A.
,
Hajduk P.J.
,
Olejniczak E.T.
Proc. Natl. Acad. Sci. U.S.A.104:7875-7880(2007)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : STRUCTURE BY NMR OF 22-143 IN COMPLEX WITH ADCYAP1;MUTAGENESIS OF VAL-114; GLU-125; PRO-128; GLU-138 AND TYR-139;DISULFIDE BONDS
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 26-140;MUTAGENESIS OF GLU-125;DISULFIDE BONDS