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Index > Protein center > ADCYAP1R1(Gene name) > Human
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  • ADCYAP1R1 (Gene name),
  • Pituitary adenylate cyclase-activating polypeptide type I receptor (Protein name ),  PACR_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    ADCYAP1R1;
    Protein name:
    Pituitary adenylate cyclase-activating polypeptide type I receptor(PACAP type I receptor;PACAP-R-1;PACAP-R1);
    Alternative:

    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts (via N-terminal extracellular domain) with ADCYAP1.
    Function:
    This is a receptor for PACAP-27 and PACAP-38. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. May regulate the release of adrenocorticotropin, luteinizing hormone, growth hormone, prolactin, epinephrine, and catecholamine. May play a role in spermatogenesis and sperm motility. Causes smooth muscle relaxation and secretion in the gastrointestinal tract.
    Subcellular Location:
    Cell membrane Multi-pass membrane protein
    Protein Attributes:
    Sequence length:
    468
    Sequence:
    50:
    MAGVVHVSLA | ALLLLPMAPA | MHSDCIFKKE | QAMCLEKIQR | ANELMGFNDS | 
    100:
    SPGCPGMWDN | ITCWKPAHVG | EMVLVSCPEL | FRIFNPDQVW | ETETIGESDF | 
    150:
    GDSNSLDLSD | MGVVSRNCTE | DGWSEPFPHY | FDACGFDEYE | SETGDQDYYY | 
    200:
    LSVKALYTVG | YSTSLVTLTT | AMVILCRFRK | LHCTRNFIHM | NLFVSFMLRA | 
    250:
    ISVFIKDWIL | YAEQDSNHCF | ISTVECKAVM | VFFHYCVVSN | YFWLFIEGLY | 
    300:
    LFTLLVETFF | PERRYFYWYT | IIGWGTPTVC | VTVWATLRLY | FDDTGCWDMN | 
    350:
    DSTALWWVIK | GPVVGSIMVN | FVLFIGIIVI | LVQKLQSPDM | GGNESSIYLR | 
    400:
    LARSTLLLIP | LFGIHYTVFA | FSPENVSKRE | RLVFELGLGS | FQGFVVAVLY | 
    450:
    CFLNGEVQAE | IKRKWRSWKV | NRYFAVDFKH | RHPSLASSGV | NGGTQLSILS | 
    468:
    KSSSQIRMSG | LPADNLAT
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    MIM:
    SMR:
    KEGG:
    String:
    Pfam:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Human PACAP type I receptor
    Cat.:
    E15100h
    Price:
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    MSDS:
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    Packing:
    96T
    Range:
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    ELISA Kit for Human PACAP type I receptor
    MSDS:
    Please sign in first.
    ELISA Kit for Human PACAP type I receptor
    MSDS:
    Please sign in first.
    ELISA Kit for Human PACAP type I receptor
    Cat.:
    E15100m
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human PACAP type I receptor
    MSDS:
    Please sign in first.
    CLIA Kit for Human PACAP type I receptor
    MSDS:
    Please sign in first.
    CLIA Kit for Human PACAP type I receptor
    MSDS:
    Please sign in first.
    CLIA Kit for Human PACAP type I receptor
    Cat.:
    U15100h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human PACAP type I receptor
    Polyclonal Antibody for Human PACAP type I receptor
    Polyclonal Antibody for Human PACAP type I receptor
    Polyclonal Antibody for Human PACAP type I receptor
    Monoclonal Antibody for Human PACAP type I receptor
    Monoclonal Antibody for Human PACAP type I receptor
    Monoclonal Antibody for Human PACAP type I receptor
    Monoclonal Antibody for Human PACAP type I receptor
    Protein for Human PACAP type I receptor
    Protein for Human PACAP type I receptor
    Protein for Human PACAP type I receptor
    Protein for Human PACAP type I receptor

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Molecular cloning and functional expression of a cDNA encoding a human pituitary adenylate cyclase activating polypeptide receptor."
      Ogi K. , Miyamoto Y. , Masuda Y. , Habata Y. , Hosoya M. , Ohtaki T. , Masuo Y. , Onda H. , Fujino M.
      Biochem. Biophys. Res. Commun.196:1511-1521(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM N)
      tissue: Pituitary.
    2. 2.
      "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
      Suwa M. , Sato T. , Okouchi I. , Arita M. , Futami K. , Matsumoto S. , Tsutsumi S. , Aburatani H. , Asai K. , Akiyama Y.
      Submitted (2001-07) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    3. 3.
      "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
      King M. , Aronstam R.S. , Sharma S.V.
      Submitted (2003-08) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM N)
      tissue: Brain.
    4. 4.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM N)
      tissue: Hippocampus.
    5. 5.
      "The DNA sequence of human chromosome 7."
      Hillier L.W. , Fulton R.S. , Fulton L.A. , Graves T.A. , Pepin K.H. , Wagner-McPherson C. , Layman D. , Maas J. , Jaeger S. , Walker R. , Wylie K. , Sekhon M. , Becker M.C. , O'Laughlin M.D. , Schaller M.E. , Fewell G.A. , Delehaunty K.D. , Miner T.L. , more...
      Nature424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 6.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    7. 7.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM N-HOP1)
      tissue: Brain.
      tissue: Testis.
    8. 8.
      "Human type I pituitary adenylate cyclase activating polypeptide receptor (ADCYAP1R): localization to chromosome band 7p14 and integration into the cytogenetic, physical and genetic map of chromosome 7."
      Stoffel M. , Espinosa R. , Trabb J.B. , le Beau M.M. , Bell G.I.
      Genomics23:697-699(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 418-468
      tissue: Placenta.
    9. 9.
      "N-terminal splice variants of the type I PACAP receptor: isolation, characterization and ligand binding/selectivity determinants."
      Dautzenberg F.M. , Mevenkamp G. , Wille S. , Hauger R.L.
      J. Neuroendocrinol.11:941-949(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ALTERNATIVE SPLICING
    10. 10.
      "Solution structure and mutational analysis of pituitary adenylate cyclase-activating polypeptide binding to the extracellular domain of PAC1-RS."
      Sun C. , Song D. , Davis-Taber R.A. , Barrett L.W. , Scott V.E. , Richardson P.L. , Pereda-Lopez A. , Uchic M.E. , Solomon L.R. , Lake M.R. , Walter K.A. , Hajduk P.J. , Olejniczak E.T.
      Proc. Natl. Acad. Sci. U.S.A.104:7875-7880(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 22-143 IN COMPLEX WITH ADCYAP1;MUTAGENESIS OF VAL-114; GLU-125; PRO-128; GLU-138 AND TYR-139;DISULFIDE BONDS
    11. 11.
      "Crystal structure of the PAC1R extracellular domain unifies a consensus fold for hormone recognition by class B G-protein coupled receptors."
      Kumar S. , Pioszak A. , Zhang C. , Swaminathan K. , Xu H.E.
      PLoS ONE6:E19682-E19682(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 26-140;MUTAGENESIS OF GLU-125;DISULFIDE BONDS
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