Protein name:
Serine/threonine-protein kinase PAK 6 ;
Alternative:
p21-activated kinase 6 (PAK-6) ;PAK-5 ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Interacts tightly with GTP-bound but not GDP-bound CDC42/p21 and RAC1 (By similarity). Interacts with the androgen receptor AR and the estrogen receptor ESR1. Interacts with IQGAP1 and PPM1B.
Function:
Serine/threonine protein kinase that plays a role in the regulation of gene transcription. The kinase activity is induced by various effectors including AR or MAP2K6/MAPKK6. Phosphorylates the DNA-binding domain of androgen receptor/AR and thereby inhibits AR-mediated transcription. Inhibits also ESR1-mediated transcription. May play a role in cytoskeleton regulation by interacting with IQGAP1. May protect cells from apoptosis through phosphorylation of BAD.
Subcellular Location:
Cytoplasm
Nucleus
Cotranslocates into nucleus with AR in response to androgen induction.
Protein Attributes:
50:
MFRKKKKKRP | EISAPQNFQH | RVHTSFDPKE | GKFVGLPPQW | QNILDTLRRP |
100:
KPVVDPSRIT | RVQLQPMKTV | VRGSAMPVDG | YISGLLNDIQ | KLSVISSNTL |
150:
RGRSPTSRRR | AQSLGLLGDE | HWATDPDMYL | QSPQSERTDP | HGLYLSCNGG |
200:
TPAGHKQMPW | PEPQSPRVLP | NGLAAKAQSL | GPAEFQGASQ | RCLQLGACLQ |
250:
SSPPGASPPT | GTNRHGMKAA | KHGSEEARPQ | SCLVGSATGR | PGGEGSPSPK |
300:
TRESSLKRRL | FRSMFLSTAA | TAPPSSSKPG | PPPQSKPNSS | FRPPQKDNPP |
350:
SLVAKAQSLP | SDQPVGTFSP | LTTSDTSSPQ | KSLRTAPATG | QLPGRSSPAG |
400:
SPRTWHAQIS | TSNLYLPQDP | TVAKGALAGE | DTGVVTHEQF | KAALRMVVDQ |
450:
GDPRLLLDSY | VKIGEGSTGI | VCLAREKHSG | RQVAVKMMDL | RKQQRRELLF |
500:
NEVVIMRDYQ | HFNVVEMYKS | YLVGEELWVL | MEFLQGGALT | DIVSQVRLNE |
550:
EQIATVCEAV | LQALAYLHAQ | GVIHRDIKSD | SILLTLDGRV | KLSDFGFCAQ |
600:
ISKDVPKRKS | LVGTPYWMAP | EVISRSLYAT | EVDIWSLGIM | VIEMVDGEPP |
650:
YFSDSPVQAM | KRLRDSPPPK | LKNSHKVSPV | LRDFLERMLV | RDPQERATAQ |
681:
ELLDHPFLLQ | TGLPECLVPL | IQLYRKQTST | C
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
ELISA Kit for Human Serine/threonine-protein kinase PAK 6
ELISA Kit for Human Serine/threonine-protein kinase PAK 6
CLIA Kit for Human Serine/threonine-protein kinase PAK 6
CLIA Kit for Human Serine/threonine-protein kinase PAK 6
Polyclonal Antibody for Human Serine/threonine-protein kinase PAK 6
Polyclonal Antibody for Human Serine/threonine-protein kinase PAK 6
Monoclonal Antibody for Human Serine/threonine-protein kinase PAK 6
Monoclonal Antibody for Human Serine/threonine-protein kinase PAK 6
Protein for Human Serine/threonine-protein kinase PAK 6
Protein for Human Serine/threonine-protein kinase PAK 6
R&D Technical Data
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Precision
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Recovery
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Linearity
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