Pappa ELISA Kit for Mouse(Mus musculus) | EIAab.comPappa ELISA Kit for Mouse(Mus musculus)

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Pappa (Gene name),

Pappalysin-1 (Protein name ), PAPP1_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Pappa;

Protein name:

Pappalysin-1;

Alternative:

Pregnancy-associated plasma protein A(PAPP-A);Insulin-like growth factor-dependent IGF-binding protein 4 protease(IGF-dependent IGFBP-4 protease;IGFBP-4ase);

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Homodimer; disulfide-linked. In pregnancy serum, predominantly found as a disulfide-linked 2:2 heterotetramer with the proform of PRG2.

Function:

Metalloproteinase which specifically cleaves IGFBP-4 and IGFBP-5, resulting in release of bound IGF. Cleavage of IGFBP-4 is dramatically enhanced by the presence of IGF, whereas cleavage of IGFBP-5 is slightly inhibited by the presence of IGF. Isoform 2 cleaves IGFBP-4 very slowly compared to PAPP-A, but its ability to cleave IGFBP-5 is unaffected.

Subcellular Location:

Secreted

Protein Attributes:

Sequence length:

1624

Sequence:

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1624:

NDCACRDPEA | QEHNRKDLRG | YSHG

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

Q8R4K8

KEGG:

mmu:18491

SMR:

Q8R4K8

Pfam:

PF00066

UniGene:

Mm.317854

Uniprot:

Q8R4K8

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ELISA Kit for Mouse Pappalysin-1

Cat.:

E0800m

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Packing:

96T

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ELISA Kit for Mouse Pappalysin-1

Cat.:

E0800h

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96T

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CLIA Kit for Mouse Pappalysin-1

Cat.:

U0800h

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Manual:

Looking for manual.

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Packing:

96T

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CLIA Kit for Mouse Pappalysin-1

Cat.:

U0800m

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MSDS:

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Packing:

96T

Polyclonal Antibody for Mouse Pappalysin-1

Cat.:

P0800Rb-m

Price:

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Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse Pappalysin-1

Cat.:

P0800Rb-h

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Mouse Pappalysin-1

Protein for Mouse Pappalysin-1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

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References

1.

"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M. , Goodstadt L. , Hillier L.W. , Zody M.C. , Goldstein S. , She X. , Bult C.J. , Agarwala R. , Cherry J.L. , DiCuccio M. , Hlavina W. , Kapustin Y. , Meric P. , Maglott D. , Birtle Z. , Marques A.C. , Graves T. , Zhou S. , more...
PLoS Biol.7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain: C57BL/6J.
2.

"Expression of recombinant murine pregnancy-associated plasma protein-A (PAPP-A) and a novel variant (PAPP-Ai) with differential proteolytic activity."
Soe R. , Overgaard M.T. , Thomsen A.R. , Laursen L.S. , Olsen I.M. , Sottrup-Jensen L. , Haaning J. , Giudice L.C. , Conover C.A. , Oxvig C.
Eur. J. Biochem.269:2247-2256(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 80-1624 (ISOFORMS 1 AND 2);FUNCTION;TISSUE SPECIFICITY
3.

"Differential regulation of pregnancy associated plasma protein (PAPP)-A during pregnancy in human and mouse."
Qin X. , Sexton C. , Byun D. , Strong D.D. , Baylink D.J. , Mohan S.
Growth Horm. IGF Res.12:359-366(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 136-489 (ISOFORM 1)
strain: 129/SvJ.
4.

"The regulated expression of the pregnancy-associated plasma protein-A in the rodent ovary: a proposed role in the development of dominant follicles and of corpora lutea."
Hourvitz A. , Kuwahara A. , Hennebold J.D. , Tavares A.B. , Negishi H. , Lee T.H. , Erickson G.F. , Adashi E.Y.
Endocrinology143:1833-1844(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 258-1624 (ISOFORM 1);TISSUE SPECIFICITY
strain: C57BL/6J.
5.

"Partial sequence of Mus musculus Mus musculus pregnancy-associated plasma protein A (Pappa)."
Olesen C. , Hansen C. , Hayashizaki Y. , Byskov A. , Tommerup N.
Submitted (2000-04) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1157-1624 (ISOFORM 1)
strain: C57BL/6J.
tissue: Embryo.

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