PARP2 ELISA Kit for Human(Homo sapiens) | EIAab.comPARP2 ELISA Kit for Human(Homo sapiens)

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PARP2 (Gene name),

Poly [ADP-ribose] polymerase 2 (Protein name ), PARP2_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

PARP2(ADPRT2;ADPRTL2);

Protein name:

Poly [ADP-ribose] polymerase 2(PARP-2;hPARP-2);

Alternative:

Poly[ADP-ribose] synthase 2(pADPRT-2);NAD(+) ADP-ribosyltransferase 2(ADPRT-2);Poly[ADP-ribose] synthase 2(pADPRT-2);

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Component of a base excision repair (BER) complex, containing at least XRCC1, PARP1, POLB and LRIG3. Homo- and heterodimer with PARP1.

Function:

Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks.

Subcellular Location:

Nucleus

Protein Attributes:

Sequence length:

583

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

583:

GYTLNYNEYI | VYNPNQVRMR | YLLKVQFNFL | QLW

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

KEGG:

hsa:10038

STRING:

9606.ENSP00000250416

UniGene:

Hs.409412

String:

Q9UGN5

Pfam:

PF00644

MIM:

607725

SMR:

Q9UGN5

Uniprot:

Q9UGN5

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ELISA Kit for Human PARP-2

Cat.:

E9945h

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Packing:

96T

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ELISA Kit for Human PARP-2

Cat.:

E9945m

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Packing:

96T

CLIA Kit for Human PARP-2

Cat.:

U9945h

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96T

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CLIA Kit for Human PARP-2

Cat.:

U9945m

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Packing:

96T

Polyclonal Antibody for Human PARP-2

Cat.:

P9945Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human PARP-2

Cat.:

P9945Rb-h

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human PARP-2

Protein for Human PARP-2

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

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References

1.

"PARP-2, a novel mammalian DNA damage-dependent poly(ADP-ribose) polymerase."
Ame J.-C. , Rolli V. , Schreiber V. , Niedergang C. , Apiou F. , Decker P. , Muller S. , Hoeger T. , Menissier-de Murcia J. , de Murcia G.M.
J. Biol. Chem.274:17860-17868(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
tissue: Fetal brain.
2.

"A human poly(ADP-ribose) polymerase gene family (ADPRTL): cDNA cloning of two novel poly(ADP-ribose) polymerase homologues."
Johansson M.
Genomics57:442-445(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 2-583 (ISOFORM 1)
tissue: Fetal brain.
3.

"pADPRT-2: a novel mammalian polymerizing(ADP-ribosyl)transferase gene related to truncated pADPRT homologues in plants and Caenorhabditis elegans."
Berghammer H. , Ebner M. , Marksteiner R. , Auer B.
FEBS Lett.449:259-263(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 22-583 (ISOFORM 1)
tissue: Fibroblast.
4.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue: Placenta.
5.

NIEHS SNPs program
Submitted (2002-02) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS ASN-161; SER-168; GLY-235; VAL-285 AND GLN-296
6.

"Poly(ADP-ribose) polymerase-2 (PARP-2) is required for efficient base excision DNA repair in association with PARP-1 and XRCC1."
Schreiber V. , Ame J.-C. , Dolle P. , Schultz I. , Rinaldi B. , Fraulob V. , Menissier-de Murcia J. , de Murcia G.M.
J. Biol. Chem.277:23028-23036(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PARP1; XRCC1; POLB AND LRIG3
7.

"Toward a unified nomenclature for mammalian ADP-ribosyltransferases."
Hottiger M.O. , Hassa P.O. , Luscher B. , Schuler H. , Koch-Nolte F.
Trends Biochem. Sci.35:208-219(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NOMENCLATURE
8.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
9.

"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T. , Prokhorova T.A. , Akimov V. , Henningsen J. , Johansen P.T. , Kratchmarova I. , Kassem M. , Mann M. , Olsen J.V. , Blagoev B.
Sci. Signal.4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-226 AND SER-232;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
10.

"Crystal structure of the catalytic domain of human PARP2 in complex with PARP inhibitor ABT-888."
Karlberg T. , Hammarstrom M. , Schutz P. , Svensson L. , Schuler H.
Biochemistry49:1056-1058(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.95 ANGSTROMS) OF 235-579 IN COMPLEX WITH PARP INHIBITORS;SUBUNIT

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