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Index > Protein center > PDE10A(Gene name) > Human
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  • PDE10A (Gene name),
  • cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Protein name ),  PDE10_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    PDE10A;
    Protein name:
    cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A;
    Alternative:

    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Homodimer.
    Function:
    Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate.
    Subcellular Location:
    Cytoplasm Located mostly to soluble cellular fractions.
    Protein Attributes:
    Sequence length:
    779
    Sequence:
    50:
    MRIEERKSQH | LTGLTDEKVK | AYLSLHPQVL | DEFVSESVSA | ETVEKWLKRK | 
    100:
    NNKSEDESAP | KEVSRYQDTN | MQGVVYELNS | YIEQRLDTGG | DNQLLLYELS | 
    150:
    SIIKIATKAD | GFALYFLGEC | NNSLCIFTPP | GIKEGKPRLI | PAGPITQGTT | 
    200:
    VSAYVAKSRK | TLLVEDILGD | ERFPRGTGLE | SGTRIQSVLC | LPIVTAIGDL | 
    250:
    IGILELYRHW | GKEAFCLSHQ | EVATANLAWA | SVAIHQVQVC | RGLAKQTELN | 
    300:
    DFLLDVSKTY | FDNIVAIDSL | LEHIMIYAKN | LVNADRCALF | QVDHKNKELY | 
    350:
    SDLFDIGEEK | EGKPVFKKTK | EIRFSIEKGI | AGQVARTGEV | LNIPDAYADP | 
    400:
    RFNREVDLYT | GYTTRNILCM | PIVSRGSVIG | VVQMVNKISG | SAFSKTDENN | 
    450:
    FKMFAVFCAL | ALHCANMYHR | IRHSECIYRV | TMEKLSYHSI | CTSEEWQGLM | 
    500:
    QFTLPVRLCK | EIELFHFDIG | PFENMWPGIF | VYMVHRSCGT | SCFELEKLCR | 
    550:
    FIMSVKKNYR | RVPYHNWKHA | VTVAHCMYAI | LQNNHTLFTD | LERKGLLIAC | 
    600:
    LCHDLDHRGF | SNSYLQKFDH | PLAALYSTST | MEQHHFSQTV | SILQLEGHNI | 
    650:
    FSTLSSSEYE | QVLEIIRKAI | IATDLALYFG | NRKQLEEMYQ | TGSLNLNNQS | 
    700:
    HRDRVIGLMM | TACDLCSVTK | LWPVTKLTAN | DIYAEFWAEG | DEMKKLGIQP | 
    750:
    IPMMDRDKKD | EVPQGQLGFY | NAVAIPCYTT | LTQILPPTEP | LLKACRDNLS | 
    779:
    QWEKVIRGEE | TATWISSPSV | AQKAAASED
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    SMR:
    Pfam:
    UniGene:
    String:
    KEGG:
    MIM:
    Uniprot:
     
    FOR
    ELISA Kit for Human cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
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    Packing:
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    ELISA Kit for Human cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
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    E1158m
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    Packing:
    96T
    CLIA Kit for Human cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
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    MSDS:
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    Packing:
    96T
    Range:
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    CLIA Kit for Human cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
    Cat.:
    U1158m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
    Cat.:
    U1158r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
    Cat.:
    P1158Rb-m
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
    Cat.:
    P1158Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
    Cat.:
    P1158Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
    Monoclonal Antibody for Human cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
    Monoclonal Antibody for Human cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
    Protein for Human cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
    Protein for Human cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
    Protein for Human cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A

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    Precision
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    Linearity
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    References
    1. 1.
      "Characterization and phosphorylation of PDE10A2, a novel alternative splice variant of human phosphodiesterase that hydrolyzes cAMP and cGMP."
      Kotera J. , Fujishige K. , Yuasa K. , Omori K.
      Biochem. Biophys. Res. Commun.261:551-557(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM PDE10A2);PHOSPHORYLATION AT THR-16 (ISOFORM PDE10A2) BY PKA
      tissue: Fetal lung.
    2. 2.
      "Cloning and characterization of a novel human phosphodiesterase that hydrolyzes both cAMP and cGMP (PDE10A)."
      Fujishige K. , Kotera J. , Michibata H. , Yuasa K. , Takebayashi S. , Okumura K. , Omori K.
      J. Biol. Chem.274:18438-18445(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM PDE10A1)
      tissue: Fetal lung.
    3. 3.
      "Isolation and characterization of PDE10A, a novel human 3',5'-cyclic nucleotide phosphodiesterase."
      Loughney K. , Snyder P.B. , Uher L. , Rosman G.J. , Ferguson K. , Florio V.A.
      Gene234:109-117(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS PDE10A1 AND PDE10A2)
      tissue: Fetal brain.
    4. 4.
      "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L. , Schick M. , Neubert P. , Schatten R. , Henze S. , Korn B.
      Submitted (2004-06) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM PDE10A1)
    5. 5.
      "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J. , Palmer S.A. , Sims S.K. , Edwards C.A. , Ashurst J.L. , Wilming L. , Jones M.C. , Horton R. , Hunt S.E. , Scott C.E. , Gilbert J.G.R. , Clamp M.E. , Bethel G. , Milne S. , Ainscough R. , Almeida J.P. , Ambrose K.D. , Andrews T.D. , more...
      Nature425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 6.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM PDE10A1)
      tissue: Colon.
    7. 7.
      "The human phosphodiesterase PDE10A gene genomic organization and evolutionary relatedness with other PDEs containing GAF domains."
      Fujishige K. , Kotera J. , Yuasa K. , Omori K.
      Eur. J. Biochem.267:5943-5951(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 66-779;ALTERNATIVE SPLICING
    8. 8.
      "cAMP is a ligand for the tandem GAF domain of human phosphodiesterase 10 and cGMP for the tandem GAF domain of phosphodiesterase 11."
      Gross-Langenhoff M. , Hofbauer K. , Weber J. , Schultz A. , Schultz J.E.
      J. Biol. Chem.281:2841-2846(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DOMAIN;ENZYME REGULATION
    9. 9.
      "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H. , Olsen J.V. , Bairlein M. , Gnad F. , Oppermann F.S. , Korner R. , Greff Z. , Keri G. , Stemmann O. , Mann M.
      Mol. Cell31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    10. 10.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    11. 11.
      "Structural insight into substrate specificity of phosphodiesterase 10."
      Wang H. , Liu Y. , Hou J. , Zheng M. , Robinson H. , Ke H.
      Proc. Natl. Acad. Sci. U.S.A.104:5782-5787(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.45 ANGSTROMS) OF 436-766 IN COMPLEXES WITH AMP; CAMP; GMP; CGMP AND MAGNESIUM;MUTAGENESIS OF ASP-554;FUNCTION;COFACTOR;BIOPHYSICOCHEMICAL PROPERTIES
    12. 12.
      "Crystal structure of the GAF-B domain from human phosphodiesterase 10A complexed with its ligand, cAMP."
      Handa N. , Mizohata E. , Kishishita S. , Toyama M. , Morita S. , Uchikubo-Kamo T. , Akasaka R. , Omori K. , Kotera J. , Terada T. , Shirouzu M. , Yokoyama S.
      J. Biol. Chem.283:19657-19664(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 242-427 IN COMPLEX WITH CAMP;DOMAIN;SUBUNIT
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