Protein name:
Gamma-secretase subunit PEN-2 ;
Alternative:
Presenilin enhancer protein 2 ;
Organism:
Bovine (Bos taurus).
General Annotation
Sub Unit:
Component of the gamma-secretase complex, a complex composed of a presenilin homodimer (PSEN1 or PSEN2), nicastrin (NCSTN), APH1 (APH1A or APH1B) and PSENEN/PEN2. Such minimal complex is sufficient for secretase activity, although other components may exist.
Function:
Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Probably represents the last step of maturation of gamma-secretase, facilitating endoproteolysis of presenilin and conferring gamma-secretase activity.
Subcellular Location:
Endoplasmic reticulum membrane
Multi-pass membrane protein
Golgi apparatus
cis-Golgi network membrane
Multi-pass membrane protein
Predominantly located in the endoplasmic reticulum and in the cis-Golgi.
Protein Attributes:
50:
MNLERVSNEE | KLNLCRKYYL | GGFAFLPFLW | LVNIFWFFRE | AFIVPAYTEQ |
100:
SQIKGYVWRS | AVGFFLWVIV | LSTWITIFQI | YRPRWGALGD | YLSFTIPLGT |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
Rat
Bovine
ELISA Kit for Bovine Gamma-secretase subunit PEN-2
ELISA Kit for Bovine Gamma-secretase subunit PEN-2
ELISA Kit for Bovine Gamma-secretase subunit PEN-2
ELISA Kit for Bovine Gamma-secretase subunit PEN-2
CLIA Kit for Bovine Gamma-secretase subunit PEN-2
CLIA Kit for Bovine Gamma-secretase subunit PEN-2
CLIA Kit for Bovine Gamma-secretase subunit PEN-2
CLIA Kit for Bovine Gamma-secretase subunit PEN-2
Polyclonal Antibody for Bovine Gamma-secretase subunit PEN-2
Polyclonal Antibody for Bovine Gamma-secretase subunit PEN-2
Polyclonal Antibody for Bovine Gamma-secretase subunit PEN-2
Polyclonal Antibody for Bovine Gamma-secretase subunit PEN-2
Monoclonal Antibody for Bovine Gamma-secretase subunit PEN-2
Monoclonal Antibody for Bovine Gamma-secretase subunit PEN-2
Monoclonal Antibody for Bovine Gamma-secretase subunit PEN-2
Monoclonal Antibody for Bovine Gamma-secretase subunit PEN-2
Protein for Bovine Gamma-secretase subunit PEN-2
Protein for Bovine Gamma-secretase subunit PEN-2
Protein for Bovine Gamma-secretase subunit PEN-2
Protein for Bovine Gamma-secretase subunit PEN-2
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
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Cited for : NUCLEOTIDE SEQUENCE [MRNA]
2.
"Estimating probability of parentage in U.S. beef and dairy cattle with single nucleotide polymorphisms."
Heaton M.P.
,
Clawson M.L.
,
Snelling W.M.
,
Keele J.W.
,
Harhay G.P.
,
Wiedmann R.T.
,
Bennett G.L.
,
Smith T.P.L.
,
Stone R.T.
,
Freking B.A.
,
Van Tassell C.P.
,
Sonstegard T.S.
,
Gasbarre L.C.
,
Carr J.
,
DiBello P.
,
Kumar M.
,
Lee M.S.
,
Murthy J.
,
Otto J.
,
Salisbury B.
,
Schulz V.
,
Tracy R.
,
Hawk D.A.
,
Kalbfleisch T.
,
Laegreid W.W.
more...
Submitted (2004-12) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA]
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain :
Crossbred X Angus .
tissue :
Ileum .