Gene name:
EPX (EPER;EPO;EPP) ;
Protein name:
Eosinophil peroxidase (EPO) ;
Alternative:
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Tetramer of two light chains and two heavy chains.
Function:
Mediates tyrosine nitration of secondary granule proteins in mature resting eosinophils. Shows significant inhibitory activity towards Mycobacterium tuberculosis H37Rv by inducing bacterial fragmentation and lysis.
Subcellular Location:
Cytoplasmic granule
Cytoplasmic granules of eosinophils.
Protein Attributes:
50:
MHLLPALAGV | LATLVLAQPC | EGTDPASPGA | VETSVLRDCI | AEAKLLVDAA |
100:
YNWTQKSIKQ | RLRSGSASPM | DLLSYFKQPV | AATRTVVRAA | DYMHVALGLL |
150:
EEKLQPQRSG | PFNVTDVLTE | PQLRLLSQAS | GCALRDQAER | CSDKYRTITG |
200:
RCNNKRRPLL | GASNQALARW | LPAEYEDGLS | LPFGWTPSRR | RNGFLLPLVR |
250:
AVSNQIVRFP | NERLTSDRGR | ALMFMQWGQF | IDHDLDFSPE | SPARVAFTAG |
300:
VDCERTCAQL | PPCFPIKIPP | NDPRIKNQRD | CIPFFRSAPS | CPQNKNRVRN |
350:
QINALTSFVD | ASMVYGSEVS | LSLRLRNRTN | YLGLLAINQR | FQDNGRALLP |
400:
FDNLHDDPCL | LTNRSARIPC | FLAGDTRSTE | TPKLAAMHTL | FMREHNRLAT |
450:
ELRRLNPRWN | GDKLYNEARK | IMGAMVQIIT | YRDFLPLVLG | KARARRTLGH |
500:
YRGYCSNVDP | RVANVFTLAF | RFGHTMLQPF | MFRLDSQYRA | SAPNSHVPLS |
550:
SAFFASWRIV | YEGGIDPILR | GLMATPAKLN | RQDAMLVDEL | RDRLFRQVRR |
600:
IGLDLAALNM | QRSRDHGLPG | YNAWRRFCGL | SQPRNLAQLS | RVLKNQDLAR |
650:
KFLNLYGTPD | NIDIWIGAIA | EPLLPGARVG | PLLACLFENQ | FRRARDGDRF |
700:
WWQKRGVFTK | RQRKALSRIS | LSRIICDNTG | ITTVSRDIFR | ANIYPRGFVN |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Pig
Mouse
Polyclonal Antibody for Human EPO
Polyclonal Antibody for Human EPO
Polyclonal Antibody for Human EPO
Monoclonal Antibody for Human EPO
Monoclonal Antibody for Human EPO
Monoclonal Antibody for Human EPO
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA]
tissue :
Placenta .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS MET-40; HIS-122; GLU-249; ARG-276; LEU-292; PRO-326; LEU-358; HIS-364; THR-441; GLN-496 AND TYR-572
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 13-715;PROTEIN SEQUENCE OF 140-187 AND 251-288
tissue :
Blood .
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : COVALENT HEME ATTACHMENT;PARTIAL PROTEIN SEQUENCE
tissue :
Blood .
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION
6.
"Post-translational tyrosine nitration of eosinophil granule toxins mediated by eosinophil peroxidase."
Ulrich M.
,
Petre A.
,
Youhnovski N.
,
Proemm F.
,
Schirle M.
,
Schumm M.
,
Pero R.S.
,
Doyle A.
,
Checkel J.
,
Kita H.
,
Thiyagarajan N.
,
Acharya K.R.
,
Schmid-Grendelmeier P.
,
Simon H.-U.
,
Schwarz H.
,
Tsutsui M.
,
Shimokawa H.
,
Bellon G.
,
Lee J.J.
,
Przybylski M.
,
Doering G.
more...
J. Biol. Chem.283:28629-28640(2008)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;NITRATION AT TYR-488
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT EPXD HIS-286
8.
"High contribution contrast between the genes of eosinophil peroxidase and IL-4 receptor alpha-chain in Japanese cedar pollinosis."
Nakamura H.
,
Miyagawa K.
,
Ogino K.
,
Endo T.
,
Imai T.
,
Ozasa K.
,
Motohashi Y.
,
Matsuzaki I.
,
Sasahara S.
,
Hatta K.
,
Eboshida A.
J. Allergy Clin. Immunol.112:1127-1131(2003)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANTS HIS-326; LEU-326 AND LEU-358;POLYMORPHISM