TPO ELISA Kit for Human(Homo sapiens) | EIAab.comTPO ELISA Kit for Human(Homo sapiens) | EIAab.com

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TPO (Gene name),

Thyroid peroxidase (Protein name ), PERT_HUMAN from NCBI database.

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General Annotation

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Antigen Annotation

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3D

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Predicted Eptitope

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Vaild Sequence

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Related Databases

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Citations (1)

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Gene name:

TPO;

Protein name:

Thyroid peroxidase(TPO);

Alternative:

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts with DUOX1, DUOX2 and CYBA.

Function:

Iodination and coupling of the hormonogenic tyrosines in thyroglobulin to yield the thyroid hormones T(3) and T(4).

Subcellular Location:

Isoform 3 Cell surface

Protein Attributes:

Sequence length:

933

Sequence:

50:

MRALAVLSVT | LVMACTEAFF | PFISRGKELL | WGKPEESRVS | SVLEESKRLV |

100:

DTAMYATMQR | NLKKRGILSP | AQLLSFSKLP | EPTSGVIARA | AEIMETSIQA |

150:

MKRKVNLKTQ | QSQHPTDALS | EDLLSIIANM | SGCLPYMLPP | KCPNTCLANK |

200:

YRPITGACNN | RDHPRWGASN | TALARWLPPV | YEDGFSQPRG | WNPGFLYNGF |

250:

PLPPVREVTR | HVIQVSNEVV | TDDDRYSDLL | MAWGQYIDHD | IAFTPQSTSK |

300:

AAFGGGADCQ | MTCENQNPCF | PIQLPEEARP | AAGTACLPFY | RSSAACGTGD |

350:

QGALFGNLST | ANPRQQMNGL | TSFLDASTVY | GSSPALERQL | RNWTSAEGLL |

400:

RVHARLRDSG | RAYLPFVPPR | APAACAPEPG | IPGETRGPCF | LAGDGRASEV |

450:

PSLTALHTLW | LREHNRLAAA | LKALNAHWSA | DAVYQEARKV | VGALHQIITL |

500:

RDYIPRILGP | EAFQQYVGPY | EGYDSTANPT | VSNVFSTAAF | RFGHATIHPL |

550:

VRRLDASFQE | HPDLPGLWLH | QAFFSPWTLL | RGGGLDPLIR | GLLARPAKLQ |

600:

VQDQLMNEEL | TERLFVLSNS | STLDLASINL | QRGRDHGLPG | YNEWREFCGL |

650:

PRLETPADLS | TAIASRSVAD | KILDLYKHPD | NIDVWLGGLA | ENFLPRARTG |

700:

PLFACLIGKQ | MKALRDGDWF | WWENSHVFTD | AQRRELEKHS | LSRVICDNTG |

750:

LTRVPMDAFQ | VGKFPEDFES | CDSITGMNLE | AWRETFPQDD | KCGFPESVEN |

800:

GDFVHCEESG | RRVLVYSCRH | GYELQGREQL | TCTQEGWDFQ | PPLCKDVNEC |

850:

ADGAHPPCHA | SARCRNTKGG | FQCLCADPYE | LGDDGRTCVD | SGRLPRVTWI |

900:

SMSLAALLIG | GFAGLTSTVI | CRWTRTGTKS | TLPISETGGG | TPELRCGKHQ |

933:

AVGTSPQRAA | AQDSEQESAG | MEGRDTHRLP | RAL

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

MIM:

UniGene:

SMR:

KEGG:

String:

Pfam:

Uniprot:

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ELISA Kit for Human TPO

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ELISA Kit for Human TPO

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ELISA Kit for Human TPO

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ELISA Kit for Human TPO

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ELISA Kit for Human TPO

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E0557m

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CLIA Kit for Human TPO

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U0557p

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CLIA Kit for Human TPO

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CLIA Kit for Human TPO

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CLIA Kit for Human TPO

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CLIA Kit for Human TPO

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Polyclonal Antibody for Human TPO

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Polyclonal Antibody for Human TPO

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Polyclonal Antibody for Human TPO

Polyclonal Antibody for Human TPO

Monoclonal Antibody for Human TPO

Monoclonal Antibody for Human TPO

Monoclonal Antibody for Human TPO

Monoclonal Antibody for Human TPO

Monoclonal Antibody for Human TPO

Protein for Human TPO

Protein for Human TPO

Protein for Human TPO

Protein for Human TPO

Protein for Human TPO

R&D Technical Data

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12% SDS-PAGE Analysis

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Precision

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Recovery

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Linearity

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Citations

[1].

"MATERNAL IODINE DISORDER, OXIDATIVE STRESS STATUS AND THYROID FUNCTION AMONG PREGNANT SAUDI WOMEN"

HA El-Beshbishy, IM Taha, AY Shaheen, et al.

From:International Journal of Pharmaceutical Applications

References

1.

"Human thyroid peroxidase: complete cDNA and protein sequence, chromosome mapping, and identification of two alternately spliced mRNAs."
Kimura S. , Kotani T. , McBride O.W. , Umeki K. , Hirai K. , Nakayama T. , Ohtaki S.
Proc. Natl. Acad. Sci. U.S.A.84:5555-5559(1987) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2);VARIANTS PRO-725 AND ALA-847
2.

"Complete nucleotide sequence of the human thyroperoxidase-microsomal antigen cDNA."
Libert F. , Ruel J. , Ludgate M. , Swillens S. , Alexander N. , Vassart G. , Dinsart C.
Nucleic Acids Res.15:6735-6735(1987) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANTS PRO-725 AND ALA-847
tissue: Thyroid.
3.

"Structure of the human thyroid peroxidase gene: comparison and relationship to the human myeloperoxidase gene."
Kimura S. , Hong Y.S. , Kotani T. , Ohtaki S. , Kikkawa F.
Biochemistry28:4481-4489(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1)
4.

"Nucleotide sequence of the alternatively spliced human thyroid peroxidase cDNA, TPO-2."
Barnett P.S. , Banga J.P. , Watkins J. , Huang G.C. , Gluckman D.R.B. , Page M.J. , McGregor A.M.
Nucleic Acids Res.18:670-670(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
tissue: Thyroid.
5.

Rapoport B.
Submitted (1999-04) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANT SER-257
tissue: Thyroid.
6.

"Homo sapiens thyroid peroxidase (TPO) variant mRNA, alternatively spliced sequence."
Hennen G.P. , Igout A. , Melen L.B.
Submitted (2002-01) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5);VARIANTS SER-257; PRO-725 AND ALA-847
tissue: Thyroid.
7.

"Increasing diversity of human thyroperoxidase generated by alternative splicing. Characterization by molecular cloning of new transcripts with single- and multispliced mRNAs."
Ferrand M. , Le Fourn V. , Franc J.-L.
J. Biol. Chem.278:3793-3800(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PARTIAL NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 4; 5; 6; 2-3 AND 2-4);VARIANTS PRO-725 AND ALA-847
tissue: Thyroid.
8.

"Isolation of a complementary DNA clone for thyroid microsomal antigen. Homology with the gene for thyroid peroxidase."
Seto P. , Hirayu H. , Magnusson R.P. , Gestautas J. , Portmann L. , Degroot L.J. , Rapoport B.
J. Clin. Invest.80:1205-1208(1987) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 217-496
9.

"Evidence for an alternate splicing in the thyroperoxidase messenger from patients with Graves' disease."
Zanelli E. , Henry M. , Charvet B. , Malthiery Y.
Biochem. Biophys. Res. Commun.170:735-741(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 670-933 (ISOFORM 3);ALTERNATIVE SPLICING IN GRAVES' DISEASE
tissue: Thyroid.
10.

"Identification of a novel partner of duox: EFP1, a thioredoxin-related protein."
Wang D. , De Deken X. , Milenkovic M. , Song Y. , Pirson I. , Dumont J.E. , Miot F.
J. Biol. Chem.280:3096-3103(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH DUOX1; DUOX2 AND CYBA
11.

"Identification of five novel inactivating mutations in the human thyroid peroxidase gene by denaturing gradient gel electrophoresis."
Bikker H. , Vulsma T. , Baas F. , de Vijlder J.J.M.
Hum. Mutat.6:9-16(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS TDH2A ASP-453; SER-590 AND LYS-799;VARIANTS SER-257; SER-373; THR-398 AND PRO-725
12.

"Molecular analysis of mutated thyroid peroxidase detected in patients with total iodide organification defects."
Bikker H. , Baas F. , De Vijlder J.J.M.
J. Clin. Endocrinol. Metab.82:649-653(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT TDH2A PHE-447
13.

"A novel mutation in the TPO gene in goitrous hypothyroid patients with iodide organification defect."
Santos C.L.S. , Bikker H. , Rego K.G.M. , Nascimento A.C. , Tambascia M. , De Vijlder J.J.M. , Medeiros-Neto G.
Clin. Endocrinol. (Oxf.)51:165-172(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT TDH2A GLU-660
14.

"Two different mutations in the thyroid peroxidase gene of a large inbred Amish kindred: power and limits of homozygosity mapping."
Pannain S. , Weiss R.E. , Jackson C.E. , Dian D. , Beck J.C. , Sheffield V.C. , Cox N. , Refetoff S.
J. Clin. Endocrinol. Metab.84:1061-1071(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS TDH2A GLN-648 AND LYS-799
15.

"A novel mutation in the human thyroid peroxidase gene resulting in a total iodide organification defect."
Kotani T. , Umeki K. , Yamamoto I. , Maesaka H. , Tachibana K. , Ohtaki S.
J. Endocrinol.160:267-273(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT TDH2A ASN-240;CHARACTERIZATION OF VARIANT TDH2A ASN-240
16.

"Two decades of screening for congenital hypothyroidism in The Netherlands: TPO gene mutations in total iodide organification defects (an update)."
Bakker B. , Bikker H. , Vulsma T. , de Randamie J.S.E. , Wiedijk B.M. , De Vijlder J.J.M.
J. Clin. Endocrinol. Metab.85:3708-3712(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS TDH2A THR-326; PHE-447; ASP-453; CYS-527; TRP-693 AND LYS-799
17.

"Novel mutations of the thyroid peroxidase gene in patients with permanent congenital hypothyroidism."
Ambrugger P. , Stoeva I. , Biebermann H. , Torresani T. , Leitner C. , Grueters A.
Eur. J. Endocrinol.145:19-24(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS TDH2A PRO-458 AND HIS-491
18.

"Two novel missense mutations in the thyroid peroxidase gene, R665W and G771R, result in a localization defect and cause congenital hypothyroidism."
Umeki K. , Kotani T. , Kawano J. , Suganuma T. , Yamamoto I. , Aratake Y. , Furujo M. , Ichiba Y.
Eur. J. Endocrinol.146:491-498(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS TDH2A TRP-665 AND ARG-771;CHARACTERIZATION OF VARIANTS TDH2A TRP-665 AND ARG-771
19.

"High prevalence of a novel mutation (2268 insT) of the thyroid peroxidase gene in Taiwanese patients with total iodide organification defect, and evidence for a founder effect."
Niu D.-M. , Hwang B. , Chu Y.-K. , Liao C.-J. , Wang P.-L. , Lin C.-Y.
J. Clin. Endocrinol. Metab.87:4208-4212(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT TDH2A PRO-53
20.

"Mutation analysis of thyroid peroxidase gene in Chinese patients with total iodide organification defect: identification of five novel mutations."
Wu J.-Y. , Shu S.-G. , Yang C.-F. , Lee C.-C. , Tsai F.-J.
J. Endocrinol.172:627-635(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS TDH2A SER-493 AND TYR-796
21.

"Genetics of specific phenotypes of congenital hypothyroidism: a population-based approach."
Calaciura F. , Miscio G. , Coco A. , Leonardi D. , Cisternino C. , Regalbuto C. , Bozzali M. , Maiorana R. , Ranieri A. , Carta A. , Buscema M. , Trischitta V. , Sava L. , Tassi V.
Thyroid12:945-951(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT TDH2A ILE-839
22.

"Partial iodide organification defect caused by a novel mutation of the thyroid peroxidase gene in three siblings."
Kotani T. , Umeki K. , Kawano J. , Suganuma T. , Hishinuma A. , Ieiri T. , Harada S.
Clin. Endocrinol. (Oxf.)59:198-206(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS TDH2A CYS-533 AND ASP-574-575-LEU DEL;CHARACTERIZATION OF VARIANTS TDH2A CYS-533 AND ASP-574-575-LEU DEL
23.

"Five novel inactivating mutations in the thyroid peroxidase gene responsible for congenital goiter and iodide organification defect."
Rivolta C.M. , Esperante S.A. , Gruneiro-Papendieck L. , Chiesa A. , Moya C.M. , Domene S. , Varela V. , Targovnik H.M.
Hum. Mutat.22:259-259(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS TDH2A THR-307; MET-433; LEU-499 AND ARG-808
24.

"Monoallelic expression of mutant thyroid peroxidase allele causing total iodide organification defect."
Fugazzola L. , Cerutti N. , Mannavola D. , Vannucchi G. , Fallini C. , Persani L. , Beck-Peccoz P.
J. Clin. Endocrinol. Metab.88:3264-3271(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT TDH2A TRP-693
25.

"Two novel mutations in the thyroid peroxidase gene with goitrous hypothyroidism."
Tajima T. , Tsubaki J. , Fujieda K.
Endocr. J.52:643-645(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT TDH2A LYS-378
26.

"Goitrous congenital hypothyroidism and hearing impairment associated with mutations in the TPO and SLC26A4/PDS genes."
Pfarr N. , Borck G. , Turk A. , Napiontek U. , Keilmann A. , Mueller-Forell W. , Kopp P. , Pohlenz J.
J. Clin. Endocrinol. Metab.91:2678-2681(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT TDH2A ASP-453

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