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Index > Protein center > Acan(Gene name) > Mouse
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  • Acan (Gene name),
  • Aggrecan core protein (Protein name ),  PGCA_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    Acan(Agc;Agc1);
    Protein name:
    Aggrecan core protein;
    Alternative:
    Cartilage-specific proteoglycan core protein(CSPCP);
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Interacts with COMP (By similarity). Interacts with FBLN1.
    Function:
    This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.
    Subcellular Location:
    Secreted extracellular space extracellular matrix
    Protein Attributes:
    Sequence length:
    2132
    Sequence:
    50:
    MTTLLLVFVT | LRVIAAVISE | EVPDHDNSLS | VSIPQPSPLK | VLLGSSLTIP | 
    100:
    CYFIDPMHPV | TTAPSTAPLT | PRIKWSRVSK | EKEVVLLVAT | EGQVRVNSIY | 
    150:
    QDKVSLPNYP | AIPSDATLEI | QNLRSNDSGI | YRCEVMHGIE | DSEATLEVIV | 
    200:
    KGIVFHYRAI | STRYTLDFDR | AQRACLQNSA | IIATPEQLQA | AYEDGFHQCD | 
    250:
    AGWLADQTVR | YPIHTPREGC | YGDKDEFPGV | RTYGIRDTNE | TYDVYCFAEE | 
    300:
    MEGEVFYATS | PEKFTFQEAA | NECRRLGARL | ATTGQLYLAW | QGGMDMCSAG | 
    350:
    WLADRSVRYP | ISKARPNCGG | NLLGVRTVYL | HANQTGYPDP | SSRYDAICYT | 
    400:
    GEDFVDIPEN | FFGVGGEDDI | TIQTVTWPDL | ELPLPRNVTE | GEALGSVILT | 
    450:
    AKPIFDLSPT | ISEPGEALTL | APEVGSTAFP | EAEERTGEAT | RPWGFPAEVT | 
    500:
    RGPDSATAFA | SEDLVVRVTI | SPGAAEVPGQ | PRLPGGVVFH | YRPGSTRYSL | 
    550:
    TFEEAQQACM | HTGAVIASPE | QLQAAYEAGY | EQCDAGWLQD | QTVRYPIVSP | 
    600:
    RTPCVGDKDS | SPGVRTYGVR | PSSETYDVYC | YVDKLEGEVF | FATRLEQFTF | 
    650:
    QEARAFCAAQ | NATLASTGQL | YAAWSQGLDK | CYAGWLADGT | LRYPIITPRP | 
    700:
    ACGGDKPGVR | TVYLYPNQTG | LPDPLSKHHA | FCFRGVSVAP | SPGEEGGSTP | 
    750:
    TSPSDIEDWI | VTQVGPGVDA | VPLEPKTTEV | PYFTTEPRKQ | TEWEPAYTPV | 
    800:
    GTSPQPGIPP | TWLPTLPAAE | EHTESPSASE | EPSASAVPST | SEEPYTSSFA | 
    850:
    VPSMTELPGS | GEASGAPDLS | GDFTGSGDAS | GRLDSSGQPS | GGIESGLPSG | 
    900:
    DLDSSGLSPT | VSSGLPVESG | SASGDGEVPW | SHTPTVGRLP | SGGESPEGSA | 
    950:
    SASGTGDLSG | LPSGGEITET | STSGAEETSG | LPSGGDGLET | STSGVDDVSG | 
    1000:
    IPTGREGLET | SASGVEDLSG | LPSGEEGSET | STSGIEDISV | LPTGGESLET | 
    1050:
    SASGVGDLSG | LPSGGESLET | SASGAEDVTQ | LPTERGGLET | SASGVEDITV | 
    1100:
    LPTGRESLET | SASGVEDVSG | LPSGREGLET | SASGIEDISV | FPTEAEGLDT | 
    1150:
    SASGGYVSGI | PSGGDGTETS | ASGVEDVSGL | PSGGEGLETS | ASGVEDLGPS | 
    1200:
    TRDSLETSAS | GVDVTGFPSG | RGDPETSVSG | VGDDFSGLPS | GKEGLETSAS | 
    1250:
    GAEDLSGLPS | GKEDLVGSAS | GALDFGKLPP | GTLGSGQTPE | VNGFPSGFSG | 
    1300:
    EYSGADIGSG | PSSGLPDFSG | LPSGFPTVSL | VDSTLVEVIT | ATTSSELEGR | 
    1350:
    GTIGISGSGE | VSGLPLGELD | SSADISGLPS | GTELSGQASG | SPDSSGETSG | 
    1400:
    FFDVSGQPFG | SSGVSEETSG | IPEISGQPSG | TPDTTATSGV | TELNELSSGQ | 
    1450:
    PDVSGDGSGI | LFGSGQSSGI | TSVSGETSGI | SDLSGQPSGF | PVFSGTATRT | 
    1500:
    PDLASGTISG | SGESSGITFV | DTSFVEVTPT | TFREEEGLGS | VELSGFPSGE | 
    1550:
    TELSGTSGTV | DVSEQSSGAI | DSSGLTSPTP | EFSGLPSGVA | EVSGEFSGVE | 
    1600:
    TGSSLPSGAF | DGSGLVSGFP | TVSLVDRTLV | ESITQAPTAQ | EAGEGPSGIL | 
    1650:
    EFSGAHSGTP | DISGELSGSL | DLSTLQSGQM | ETSTETPSSP | YFSGDFSSTT | 
    1700:
    DVSGESIAAT | TGSGESSGLP | EVTLNTSELV | EGVTEPTVSQ | ELGHGPSMTY | 
    1750:
    TPRLFEASGD | ASASGDLGGA | VTNFPGSGIE | ASVPEASSDL | SAYPEAGVGV | 
    1800:
    SAAPEASSKL | SEFPDLHGIT | SAFHETDLEM | TTPSTEVNSN | PWTFQEGTRE | 
    1850:
    GSAAPEVSGE | SSTTSDIDTG | TSGVPSATPM | ASGDRTEISG | EWSDHTSEVN | 
    1900:
    VAISSTITES | EWAQPTRYPT | ETLQEIESPN | PSYSGEETQT | AETTMSLTDA | 
    1950:
    PTLSSSEGSG | ETESTVADQE | QCEEGWTKFQ | GHCYRHFHDR | ETWVDAERRC | 
    2000:
    REQQSHLSSI | VTPEEQEFVN | KNAQDYQWIG | LNDRTIEGDF | RWSDGHSLQF | 
    2050:
    EKWRPNQPDN | FFATGEDCVV | MIWHERGEWN | DVPCNYQLPF | TCKKGTVACG | 
    2100:
    DPPVVEHART | LGQKKDRYEI | SSLVRYQCTE | GFVQRHVPTI | RCQPSGHWEE | 
    2132:
    PRITCTDPNT | YKHRLQKRSM | RPTRRSRPSM | AH
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    SMR:
    Pfam:
    String:
    KEGG:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse Aggrecan core protein
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    E1908h
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    96T
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    ELISA Kit for Mouse Aggrecan core protein
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    ELISA Kit for Mouse Aggrecan core protein
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    E1908d
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    ELISA Kit for Mouse Aggrecan core protein
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    E1908m
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    ELISA Kit for Mouse Aggrecan core protein
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    E1908c
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    96T
    ELISA Kit for Mouse Aggrecan core protein
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    E1908b
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    ELISA Kit for Mouse Aggrecan core protein
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    E1908p
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    ELISA Kit for Mouse Aggrecan core protein
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    CLIA Kit for Mouse Aggrecan core protein
    Cat.:
    U1908r
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    96T
    CLIA Kit for Mouse Aggrecan core protein
    Cat.:
    U1908p
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Mouse Aggrecan core protein
    Cat.:
    U1908c
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Mouse Aggrecan core protein
    MSDS:
    Please sign in first.
    CLIA Kit for Mouse Aggrecan core protein
    Cat.:
    U1908m
    Price:
    Please sign in first.
    MSDS:
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    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Mouse Aggrecan core protein
    Cat.:
    U1908d
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    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Mouse Aggrecan core protein
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    U1908h
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    MSDS:
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    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Mouse Aggrecan core protein
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    U1908b
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    Packing:
    96T
    Polyclonal Antibody for Mouse Aggrecan core protein
    Polyclonal Antibody for Mouse Aggrecan core protein
    Cat.:
    P1908Rb-r
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse Aggrecan core protein
    Polyclonal Antibody for Mouse Aggrecan core protein
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    P1908Rb-h
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    Packing:
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    Polyclonal Antibody for Mouse Aggrecan core protein
    Polyclonal Antibody for Mouse Aggrecan core protein
    Cat.:
    P1908Rb-m
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    Packing:
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    Polyclonal Antibody for Mouse Aggrecan core protein
    Polyclonal Antibody for Mouse Aggrecan core protein
    Monoclonal Antibody for Mouse Aggrecan core protein
    Monoclonal Antibody for Mouse Aggrecan core protein
    Monoclonal Antibody for Mouse Aggrecan core protein
    Monoclonal Antibody for Mouse Aggrecan core protein
    Monoclonal Antibody for Mouse Aggrecan core protein
    Monoclonal Antibody for Mouse Aggrecan core protein
    Monoclonal Antibody for Mouse Aggrecan core protein
    Monoclonal Antibody for Mouse Aggrecan core protein
    Protein for Mouse Aggrecan core protein
    Protein for Mouse Aggrecan core protein
    Protein for Mouse Aggrecan core protein
    Protein for Mouse Aggrecan core protein
    Protein for Mouse Aggrecan core protein
    Protein for Mouse Aggrecan core protein
    Protein for Mouse Aggrecan core protein
    Protein for Mouse Aggrecan core protein

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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    References
    1. 1.
      "Complete coding sequence, deduced primary structure, chromosomal localization, and structural analysis of murine aggrecan."
      Walcz E. , Deak F. , Erhardt P. , Coulter S.N. , Fueloep C. , Horvath P. , Doege K.J. , Glant T.T.
      Genomics22:364-371(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      strain: BALB/c.
      tissue: Cartilage.
    2. 2.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
      strain: C57BL/6J.
    3. 3.
      "Mouse cartilage matrix deficiency (cmd) caused by a 7 bp deletion in the aggrecan gene."
      Watanabe H. , Kimata K. , Line S. , Strong D. , Gao L.-Y. , Kozak C.A. , Yamada Y.
      Nat. Genet.7:154-157(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 211-326
      strain: 129/Sv.
    4. 4.
      "Fibulin-1 is a ligand for the C-type lectin domains of aggrecan and versican."
      Aspberg A. , Adam S. , Kostka G. , Timpl R. , Heinegaard D.
      J. Biol. Chem.274:20444-20449(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH FBLN1
    5. 5.
      "Analysis of aggrecan and tenascin gene expression in mouse skeletal tissues by northern and in situ hybridization using species specific cDNA probes."
      Glumoff V. , Savontaus M. , Vehanen J. , Vuorio E.
      Biochim. Biophys. Acta1219:613-622(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY;DEVELOPMENTAL STAGE
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