Gene name:
Acan (Agc;Agc1) ;
Protein name:
Aggrecan core protein ;
Alternative:
Cartilage-specific proteoglycan core protein (CSPCP) ;
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Interacts with COMP (By similarity). Interacts with FBLN1.
Function:
This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.
Subcellular Location:
Secreted
extracellular space
extracellular matrix
Protein Attributes:
50:
MTTLLLVFVT | LRVIAAVISE | EVPDHDNSLS | VSIPQPSPLK | VLLGSSLTIP |
100:
CYFIDPMHPV | TTAPSTAPLT | PRIKWSRVSK | EKEVVLLVAT | EGQVRVNSIY |
150:
QDKVSLPNYP | AIPSDATLEI | QNLRSNDSGI | YRCEVMHGIE | DSEATLEVIV |
200:
KGIVFHYRAI | STRYTLDFDR | AQRACLQNSA | IIATPEQLQA | AYEDGFHQCD |
250:
AGWLADQTVR | YPIHTPREGC | YGDKDEFPGV | RTYGIRDTNE | TYDVYCFAEE |
300:
MEGEVFYATS | PEKFTFQEAA | NECRRLGARL | ATTGQLYLAW | QGGMDMCSAG |
350:
WLADRSVRYP | ISKARPNCGG | NLLGVRTVYL | HANQTGYPDP | SSRYDAICYT |
400:
GEDFVDIPEN | FFGVGGEDDI | TIQTVTWPDL | ELPLPRNVTE | GEALGSVILT |
450:
AKPIFDLSPT | ISEPGEALTL | APEVGSTAFP | EAEERTGEAT | RPWGFPAEVT |
500:
RGPDSATAFA | SEDLVVRVTI | SPGAAEVPGQ | PRLPGGVVFH | YRPGSTRYSL |
550:
TFEEAQQACM | HTGAVIASPE | QLQAAYEAGY | EQCDAGWLQD | QTVRYPIVSP |
600:
RTPCVGDKDS | SPGVRTYGVR | PSSETYDVYC | YVDKLEGEVF | FATRLEQFTF |
650:
QEARAFCAAQ | NATLASTGQL | YAAWSQGLDK | CYAGWLADGT | LRYPIITPRP |
700:
ACGGDKPGVR | TVYLYPNQTG | LPDPLSKHHA | FCFRGVSVAP | SPGEEGGSTP |
750:
TSPSDIEDWI | VTQVGPGVDA | VPLEPKTTEV | PYFTTEPRKQ | TEWEPAYTPV |
800:
GTSPQPGIPP | TWLPTLPAAE | EHTESPSASE | EPSASAVPST | SEEPYTSSFA |
850:
VPSMTELPGS | GEASGAPDLS | GDFTGSGDAS | GRLDSSGQPS | GGIESGLPSG |
900:
DLDSSGLSPT | VSSGLPVESG | SASGDGEVPW | SHTPTVGRLP | SGGESPEGSA |
950:
SASGTGDLSG | LPSGGEITET | STSGAEETSG | LPSGGDGLET | STSGVDDVSG |
1000:
IPTGREGLET | SASGVEDLSG | LPSGEEGSET | STSGIEDISV | LPTGGESLET |
1050:
SASGVGDLSG | LPSGGESLET | SASGAEDVTQ | LPTERGGLET | SASGVEDITV |
1100:
LPTGRESLET | SASGVEDVSG | LPSGREGLET | SASGIEDISV | FPTEAEGLDT |
1150:
SASGGYVSGI | PSGGDGTETS | ASGVEDVSGL | PSGGEGLETS | ASGVEDLGPS |
1200:
TRDSLETSAS | GVDVTGFPSG | RGDPETSVSG | VGDDFSGLPS | GKEGLETSAS |
1250:
GAEDLSGLPS | GKEDLVGSAS | GALDFGKLPP | GTLGSGQTPE | VNGFPSGFSG |
1300:
EYSGADIGSG | PSSGLPDFSG | LPSGFPTVSL | VDSTLVEVIT | ATTSSELEGR |
1350:
GTIGISGSGE | VSGLPLGELD | SSADISGLPS | GTELSGQASG | SPDSSGETSG |
1400:
FFDVSGQPFG | SSGVSEETSG | IPEISGQPSG | TPDTTATSGV | TELNELSSGQ |
1450:
PDVSGDGSGI | LFGSGQSSGI | TSVSGETSGI | SDLSGQPSGF | PVFSGTATRT |
1500:
PDLASGTISG | SGESSGITFV | DTSFVEVTPT | TFREEEGLGS | VELSGFPSGE |
1550:
TELSGTSGTV | DVSEQSSGAI | DSSGLTSPTP | EFSGLPSGVA | EVSGEFSGVE |
1600:
TGSSLPSGAF | DGSGLVSGFP | TVSLVDRTLV | ESITQAPTAQ | EAGEGPSGIL |
1650:
EFSGAHSGTP | DISGELSGSL | DLSTLQSGQM | ETSTETPSSP | YFSGDFSSTT |
1700:
DVSGESIAAT | TGSGESSGLP | EVTLNTSELV | EGVTEPTVSQ | ELGHGPSMTY |
1750:
TPRLFEASGD | ASASGDLGGA | VTNFPGSGIE | ASVPEASSDL | SAYPEAGVGV |
1800:
SAAPEASSKL | SEFPDLHGIT | SAFHETDLEM | TTPSTEVNSN | PWTFQEGTRE |
1850:
GSAAPEVSGE | SSTTSDIDTG | TSGVPSATPM | ASGDRTEISG | EWSDHTSEVN |
1900:
VAISSTITES | EWAQPTRYPT | ETLQEIESPN | PSYSGEETQT | AETTMSLTDA |
1950:
PTLSSSEGSG | ETESTVADQE | QCEEGWTKFQ | GHCYRHFHDR | ETWVDAERRC |
2000:
REQQSHLSSI | VTPEEQEFVN | KNAQDYQWIG | LNDRTIEGDF | RWSDGHSLQF |
2050:
EKWRPNQPDN | FFATGEDCVV | MIWHERGEWN | DVPCNYQLPF | TCKKGTVACG |
2100:
DPPVVEHART | LGQKKDRYEI | SSLVRYQCTE | GFVQRHVPTI | RCQPSGHWEE |
2132:
PRITCTDPNT | YKHRLQKRSM | RPTRRSRPSM | AH
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Rat
Dog
Mouse
Chicken
Bovine
Pig
Rabbit
ELISA Kit for Mouse Aggrecan core protein
ELISA Kit for Mouse Aggrecan core protein
ELISA Kit for Mouse Aggrecan core protein
ELISA Kit for Mouse Aggrecan core protein
ELISA Kit for Mouse Aggrecan core protein
ELISA Kit for Mouse Aggrecan core protein
ELISA Kit for Mouse Aggrecan core protein
ELISA Kit for Mouse Aggrecan core protein
CLIA Kit for Mouse Aggrecan core protein
CLIA Kit for Mouse Aggrecan core protein
CLIA Kit for Mouse Aggrecan core protein
CLIA Kit for Mouse Aggrecan core protein
CLIA Kit for Mouse Aggrecan core protein
CLIA Kit for Mouse Aggrecan core protein
CLIA Kit for Mouse Aggrecan core protein
CLIA Kit for Mouse Aggrecan core protein
Polyclonal Antibody for Mouse Aggrecan core protein
Polyclonal Antibody for Mouse Aggrecan core protein
Polyclonal Antibody for Mouse Aggrecan core protein
Polyclonal Antibody for Mouse Aggrecan core protein
Polyclonal Antibody for Mouse Aggrecan core protein
Polyclonal Antibody for Mouse Aggrecan core protein
Polyclonal Antibody for Mouse Aggrecan core protein
Polyclonal Antibody for Mouse Aggrecan core protein
Monoclonal Antibody for Mouse Aggrecan core protein
Monoclonal Antibody for Mouse Aggrecan core protein
Monoclonal Antibody for Mouse Aggrecan core protein
Monoclonal Antibody for Mouse Aggrecan core protein
Monoclonal Antibody for Mouse Aggrecan core protein
Monoclonal Antibody for Mouse Aggrecan core protein
Monoclonal Antibody for Mouse Aggrecan core protein
Monoclonal Antibody for Mouse Aggrecan core protein
Protein for Mouse Aggrecan core protein
Protein for Mouse Aggrecan core protein
Protein for Mouse Aggrecan core protein
Protein for Mouse Aggrecan core protein
Protein for Mouse Aggrecan core protein
Protein for Mouse Aggrecan core protein
Protein for Mouse Aggrecan core protein
Protein for Mouse Aggrecan core protein
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
"Complete coding sequence, deduced primary structure, chromosomal localization, and structural analysis of murine aggrecan."
Walcz E.
,
Deak F.
,
Erhardt P.
,
Coulter S.N.
,
Fueloep C.
,
Horvath P.
,
Doege K.J.
,
Glant T.T.
Genomics22:364-371(1994)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
strain :
BALB/c .
tissue :
Cartilage .
2.
"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M.
,
Goodstadt L.
,
Hillier L.W.
,
Zody M.C.
,
Goldstein S.
,
She X.
,
Bult C.J.
,
Agarwala R.
,
Cherry J.L.
,
DiCuccio M.
,
Hlavina W.
,
Kapustin Y.
,
Meric P.
,
Maglott D.
,
Birtle Z.
,
Marques A.C.
,
Graves T.
,
Zhou S.
,
Teague B.
,
Potamousis K.
,
Churas C.
,
Place M.
,
Herschleb J.
,
Runnheim R.
,
Forrest D.
,
Amos-Landgraf J.
,
Schwartz D.C.
,
Cheng Z.
,
Lindblad-Toh K.
,
Eichler E.E.
,
Ponting C.P.
more...
PLoS Biol.7:E1000112-E1000112(2009)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain :
C57BL/6J .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 211-326
strain :
129/Sv .
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH FBLN1
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : TISSUE SPECIFICITY;DEVELOPMENTAL STAGE