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Index > Protein center > PGK1(Gene name) > Human
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  • PGK1 (Gene name),
  • Phosphoglycerate kinase 1 (Protein name ),  PGK1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    PGK1(MIG10;OK/SW-cl.110;PGKA);
    Protein name:
    Phosphoglycerate kinase 1;
    Alternative:
    Primer recognition protein 2(PRP 2);Cell migration-inducing gene 10 protein;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Monomer.
    Function:
    In addition to its role as a glycolytic enzyme, it seems that PGK-1 acts as a polymerase alpha cofactor protein (primer recognition protein).
    Subcellular Location:
    Cytoplasm
    Protein Attributes:
    Sequence length:
    417
    Sequence:
    50:
    MSLSNKLTLD | KLDVKGKRVV | MRVDFNVPMK | NNQITNNQRI | KAAVPSIKFC | 
    100:
    LDNGAKSVVL | MSHLGRPDGV | PMPDKYSLEP | VAVELKSLLG | KDVLFLKDCV | 
    150:
    GPEVEKACAN | PAAGSVILLE | NLRFHVEEEG | KGKDASGNKV | KAEPAKIEAF | 
    200:
    RASLSKLGDV | YVNDAFGTAH | RAHSSMVGVN | LPQKAGGFLM | KKELNYFAKA | 
    250:
    LESPERPFLA | ILGGAKVADK | IQLINNMLDK | VNEMIIGGGM | AFTFLKVLNN | 
    300:
    MEIGTSLFDE | EGAKIVKDLM | SKAEKNGVKI | TLPVDFVTAD | KFDENAKTGQ | 
    350:
    ATVASGIPAG | WMGLDCGPES | SKKYAEAVTR | AKQIVWNGPV | GVFEWEAFAR | 
    400:
    GTKALMDEVV | KATSRGCITI | IGGGDTATCC | AKWNTEDKVS | HVSTGGGASL | 
    417:
    ELLEGKVLPG | VDALSNI
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    MIM:
    KEGG:
    String:
    Pfam:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Human Phosphoglycerate kinase 1
    Cat.:
    E12522h
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Human Phosphoglycerate kinase 1
    Cat.:
    E12522r
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    Packing:
    96T
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    ELISA Kit for Human Phosphoglycerate kinase 1
    MSDS:
    Please sign in first.
    ELISA Kit for Human Phosphoglycerate kinase 1
    MSDS:
    Please sign in first.
    ELISA Kit for Human Phosphoglycerate kinase 1
    Cat.:
    E12522m
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    MSDS:
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    Packing:
    96T
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    CLIA Kit for Human Phosphoglycerate kinase 1
    Cat.:
    U12522r
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human Phosphoglycerate kinase 1
    Cat.:
    U12522m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Phosphoglycerate kinase 1
    MSDS:
    Please sign in first.
    CLIA Kit for Human Phosphoglycerate kinase 1
    MSDS:
    Please sign in first.
    CLIA Kit for Human Phosphoglycerate kinase 1
    Cat.:
    U12522h
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
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    Polyclonal Antibody for Human Phosphoglycerate kinase 1
    Polyclonal Antibody for Human Phosphoglycerate kinase 1
    Polyclonal Antibody for Human Phosphoglycerate kinase 1
    Polyclonal Antibody for Human Phosphoglycerate kinase 1
    Polyclonal Antibody for Human Phosphoglycerate kinase 1
    Cat.:
    P12522Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Phosphoglycerate kinase 1
    Monoclonal Antibody for Human Phosphoglycerate kinase 1
    Monoclonal Antibody for Human Phosphoglycerate kinase 1
    Monoclonal Antibody for Human Phosphoglycerate kinase 1
    Monoclonal Antibody for Human Phosphoglycerate kinase 1
    Protein for Human Phosphoglycerate kinase 1
    Protein for Human Phosphoglycerate kinase 1
    Protein for Human Phosphoglycerate kinase 1
    Protein for Human Phosphoglycerate kinase 1
    Protein for Human Phosphoglycerate kinase 1

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Isolation and DNA sequence of a full-length cDNA clone for human X chromosome-encoded phosphoglycerate kinase."
      Michelson A.M. , Markham A.F. , Orkin S.H.
      Proc. Natl. Acad. Sci. U.S.A.80:472-476(1983) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      tissue: Liver.
    2. 2.
      "Structure of the human phosphoglycerate kinase gene and the intron-mediated evolution and dispersal of the nucleotide-binding domain."
      Michelson A.M. , Blake C.C. , Evans S.T. , Orkin S.H.
      Proc. Natl. Acad. Sci. U.S.A.82:6965-6969(1985) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    3. 3.
      "Identification of a human migration-inducing gene 10 (MIG10)."
      Kim J.W.
      Submitted (2003-09) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
    4. 4.
      "Identification of immuno-peptidmics that are recognized by tumor-reactive CTL generated from TIL of colon cancer patients."
      Shichijo S. , Itoh K.
      Submitted (2001-05) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Colon adenocarcinoma.
    5. 5.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
      tissue: Cerebellum.
      tissue: Testis.
    6. 6.
      "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L. , Schick M. , Neubert P. , Schatten R. , Henze S. , Korn B.
      Submitted (2004-06) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
    7. 7.
      "The DNA sequence of the human X chromosome."
      Ross M.T. , Grafham D.V. , Coffey A.J. , Scherer S. , McLay K. , Muzny D. , Platzer M. , Howell G.R. , Burrows C. , Bird C.P. , Frankish A. , Lovell F.L. , Howe K.L. , Ashurst J.L. , Fulton R.S. , Sudbrak R. , Wen G. , Jones M.C. , more...
      Nature434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    8. 8.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    9. 9.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Brain.
      tissue: Skin.
      tissue: Uterus.
    10. 10.
      "Sequence of the promoter region of the gene for human X-linked 3-phosphoglycerate kinase]."
      Singer-Sam J. , Keith D.H. , Tani K. , Simmer R.L. , Shively L. , Lindsay S. , Yoshida A. , Riggs A.D.
      Gene32:409-417(1984) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-21
    11. 11.
      "Genomic sequencing and methylation analysis by ligation mediated PCR."
      Pfeifer G.P. , Steigerwald S.D. , Mueller P.R. , Wold B. , Riggs A.D.
      Science246:810-813(1989) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-14
    12. 12.
      "Complete amino acid sequence of human phosphoglycerate kinase. Cyanogen bromide peptides and complete amino acid sequence."
      Huang I.-Y. , Welch C.D. , Yoshida A.
      J. Biol. Chem.255:6412-6420(1980) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 2-417
      tissue: Erythrocyte.
    13. 13.
      Lubec G. , Vishwanath V. , Chen W.-Q. , Sun Y.
      Submitted (2008-12) to the UniProtKB
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 23-30; 76-86; 107-123; 157-171; 200-216; 221-264; 280-297; 333-350; 366-382 AND 389-417;IDENTIFICATION BY MASS SPECTROMETRY
      tissue: Brain.
      tissue: Cajal-Retzius cell.
      tissue: Fetal brain cortex.
    14. 14.
      "Functional identity of a primer recognition protein as phosphoglycerate kinase."
      Jindal H.K. , Vishwanatha J.K.
      J. Biol. Chem.265:6540-6543(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PARTIAL PROTEIN SEQUENCE
      tissue: Placenta.
    15. 15.
      "Hematologically important mutations: molecular abnormalities of phosphoglycerate kinase."
      Yoshida A.
      Blood Cells Mol. Dis.22:265-267(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON VARIANTS
    16. 16.
      "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."
      Rush J. , Moritz A. , Lee K.A. , Guo A. , Goss V.L. , Spek E.J. , Zhang H. , Zha X.-M. , Polakiewicz R.D. , Comb M.J.
      Nat. Biotechnol.23:94-101(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-196;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    17. 17.
      "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V. , Blagoev B. , Gnad F. , Macek B. , Kumar C. , Mortensen P. , Mann M.
      Cell127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-203;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    18. 18.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    19. 19.
      "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C. , Kumar C. , Gnad F. , Nielsen M.L. , Rehman M. , Walther T.C. , Olsen J.V. , Mann M.
      Science325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-11; LYS-48; LYS-75; LYS-86; LYS-97; LYS-131; LYS-146; LYS-199; LYS-267 AND LYS-291;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    20. 20.
      "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
      Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-203;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    21. 21.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    22. 22.
      "The first identification of lysine malonylation substrates and its regulatory enzyme."
      Peng C. , Lu Z. , Xie Z. , Cheng Z. , Chen Y. , Tan M. , Luo H. , Zhang Y. , He W. , Yang K. , Zwaans B.M. , Tishkoff D. , Ho L. , Lombard D. , He T.C. , Dai J. , Verdin E. , Ye Y. , more...
      Mol. Cell. Proteomics10:M111.012658.01-M111.012658.12(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MALONYLATION AT LYS-131
    23. 23.
      "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T. , Prokhorova T.A. , Akimov V. , Henningsen J. , Johansen P.T. , Kratchmarova I. , Kassem M. , Mann M. , Olsen J.V. , Blagoev B.
      Sci. Signal.4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-203;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    24. 24.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS];CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS]
    25. 25.
      "Molecular basis for the lack of enantioselectivity of human 3-phosphoglycerate kinase."
      Gondeau C. , Chaloin L. , Lallemand P. , Roy B. , Perigaud C. , Barman T. , Varga A. , Vas M. , Lionne C. , Arold S.T.
      Nucleic Acids Res.36:3620-3629(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) IN COMPLEX WITH PHOSPHOGLYCERATE; L-ADP; D-ADP; L-CDP AND D-CDP;SUBSTRATE-BINDING SITES
    26. 26.
      "Molecular abnormality of a phosphoglycerate kinase variant (PGK-Alabama)."
      Yoshida A. , Twele T.W. , Dave V. , Beutler E.
      Blood Cells Mol. Dis.21:179-181(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT PGK1D LYS-191 DEL
    27. 27.
      "Identification of new mutations in two phosphoglycerate kinase (PGK) variants expressing different clinical syndromes: PGK Creteil and PGK Amiens."
      Cohen-Solal M. , Valentin C. , Plassa F. , Guillemin G. , Danze F. , Jaisson F. , Rosa R.
      Blood84:898-903(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS PGK1D VAL-164 AND ASN-315
    28. 28.
      "Retarded and aberrant splicings caused by single exon mutation in a phosphoglycerate kinase variant."
      Ookawara T. , Dave V. , Willems P. , Martin J.J. , de Barsy T. , Matthys E. , Yoshida A.
      Arch. Biochem. Biophys.327:35-40(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT PGK1D ALA-252
    29. 29.
      "A phosphoglycerate kinase mutant (PGK Herlev; D285V) in a Danish patient with isolated chronic hemolytic anemia: mechanism of mutation and structure-function relationships."
      Valentin C. , Birgens H. , Craescu C.T. , Broedum-Nielsen K. , Cohen-Solal M.
      Hum. Mutat.12:280-287(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT PGK1D VAL-285
    30. 30.
      "Molecular defect of a phosphoglycerate kinase variant (PGK-Matsue) associated with hemolytic anemia: Leu-->Pro substitution caused by T/A-->C/G transition in exon 3."
      Maeda M. , Yoshida A.
      Blood77:1348-1352(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT PGK1D PRO-88
    31. 31.
      "Molecular abnormalities of a phosphoglycerate kinase variant generated by spontaneous mutation."
      Maeda M. , Bawle E.V. , Kulkarni R. , Beutler E. , Yoshida A.
      Blood79:2759-2762(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT PGK1D ARG-316
    32. 32.
      "A single amino acid substitution (Asp leads to Asn) in a phosphoglycerate kinase variant (PGK Munchen) associated with enzyme deficiency."
      Fujii H. , Krietsch W.K.G. , Yoshida A.
      J. Biol. Chem.255:6421-6423(1980) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT MUNCHEN ASN-268
    33. 33.
      "Structure and function of normal and variant human phosphoglycerate kinase."
      Huang I.-Y. , Fujii H. , Yoshida A.
      Hemoglobin4:601-609(1980) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT MUNCHEN ASN-268;VARIANT ASN-352
    34. 34.
      "A single amino acid substitution (157 Gly-->Val) in a phosphoglycerate kinase variant (PGK Shizuoka) associated with chronic hemolysis and myoglobinuria."
      Fujii H. , Kanno H. , Hirono A. , Shiomura T. , Miwa S.
      Blood79:1582-1585(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT PGK1D VAL-158
    35. 35.
      "Use of cultured lymphoblastoid cells for the study of abnormal enzymes: molecular abnormality of a phosphoglycerate kinase variant associated with hemolytic anemia."
      Fujii H. , Chen S.-H. , Akatsuka J. , Miwa S. , Yoshida A.
      Proc. Natl. Acad. Sci. U.S.A.78:2587-2590(1981) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT PGK1D MET-266
    36. 36.
      "Molecular abnormality of phosphoglycerate kinase-Uppsala associated with chronic nonspherocytic hemolytic anemia."
      Fujii H. , Yoshida A.
      Proc. Natl. Acad. Sci. U.S.A.77:5461-5465(1980) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT PGK1D PRO-206
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