PHF1 ELISA Kit for Human(Homo sapiens) | EIAab.comPHF1 ELISA Kit for Human(Homo sapiens)

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PHF1 (Gene name),

PHD finger protein 1 (Protein name ), PHF1_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

PHF1(PCL1);

Protein name:

PHD finger protein 1(Protein PHF1);

Alternative:

Polycomb-like protein 1(hPCl1);

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts with CHMP1 (By similarity). Interacts with the PRC2 complex.

Function:

Transcriptional repressor. May promote methylation of histone H3 on 'Lys-27' by the PRC2/EED-EZH2 complex.

Subcellular Location:

Nucleus Cytoplasm cytoskeleton centrosome Localizes specifically to the promoters of numerous target genes. Co-localizes with NEK6 in the centrosome.

Protein Attributes:

Sequence length:

567

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

567:

PDGSVQYLVE | WGGGGIF

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

Pfam:

PF14061

String:

O43189

KEGG:

hsa:5252

UniGene:

Hs.166204

SMR:

O43189

MIM:

602881

Pfam:

PF00628

Uniprot:

O43189

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ELISA Kit for Human Protein PHF1

Cat.:

E13279m

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Packing:

96T

ELISA Kit for Human Protein PHF1

Cat.:

E13279h

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Manual:

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96T

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CLIA Kit for Human Protein PHF1

Cat.:

U13279m

Price:

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MSDS:

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Packing:

96T

CLIA Kit for Human Protein PHF1

Cat.:

U13279h

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

Polyclonal Antibody for Human Protein PHF1

Monoclonal Antibody for Human Protein PHF1

Protein for Human Protein PHF1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"The identification and localization of a human gene with sequence similarity to Polycomblike of Drosophila melanogaster."
Coulson M. , Robert S. , Eyre H.J. , Saint R.
Genomics48:381-383(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANT LYS-304
tissue: Placenta.
2.

Wang J.H. , Du G.W. , Zhou Y. , Yuan J.G. , Qiang B.Q.
Submitted (1998-03) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);VARIANT LYS-304
3.

"The DNA sequence and analysis of human chromosome 6."
Mungall A.J. , Palmer S.A. , Sims S.K. , Edwards C.A. , Ashurst J.L. , Wilming L. , Jones M.C. , Horton R. , Hunt S.E. , Scott C.E. , Gilbert J.G.R. , Clamp M.E. , Bethel G. , Milne S. , Ainscough R. , Almeida J.P. , Ambrose K.D. , Andrews T.D. , more...
Nature425:805-811(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA];VARIANT LYS-304
4.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA];VARIANT LYS-304
5.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2);VARIANT LYS-304
tissue: Uterus.
6.

"Consistent rearrangement of chromosomal band 6p21 with generation of fusion genes JAZF1/PHF1 and EPC1/PHF1 in endometrial stromal sarcoma."
Micci F. , Panagopoulos I. , Bjerkehagen B. , Heim S.
Cancer Res.66:107-112(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISEASE;CHROMOSOMAL TRANSLOCATION WITH JAZF1
7.

"Role of hPHF1 in H3K27 methylation and Hox gene silencing."
Cao R. , Wang H. , He J. , Erdjument-Bromage H. , Tempst P. , Zhang Y.
Mol. Cell. Biol.28:1862-1872(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;IDENTIFICATION BY MASS SPECTROMETRY;INTERACTION WITH THE PRC2 COMPLEX
8.

"Ezh2 requires PHF1 to efficiently catalyze H3 lysine 27 trimethylation in vivo."
Sarma K. , Margueron R. , Ivanov A. , Pirrotta V. , Reinberg D.
Mol. Cell. Biol.28:2718-2731(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH THE PRC2 COMPLEX;SUBCELLULAR LOCATION
9.

"A polycomb group protein, PHF1, is involved in the response to DNA double-strand breaks in human cell."
Hong Z. , Jiang J. , Lan L. , Nakajima S. , Kanno S. , Koseki H. , Yasui A.
Nucleic Acids Res.36:2939-2947(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION
10.

"A quantitative atlas of mitotic phosphorylation."
Dephoure N. , Zhou C. , Villen J. , Beausoleil S.A. , Bakalarski C.E. , Elledge S.J. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-360 (ISOFORM 1);IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
11.

"Characterization of hNek6 interactome reveals an important role for its short N-terminal domain and colocalization with proteins at the centrosome."
Vaz Meirelles G. , Ferreira Lanza D.C. , da Silva J.C. , Santana Bernachi J. , Paes Leme A.F. , Kobarg J.
J. Proteome Res.9:6298-6316(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
12.

"Novel fusion of MYST/Esa1-associated factor 6 and PHF1 in endometrial stromal sarcoma."
Panagopoulos I. , Micci F. , Thorsen J. , Gorunova L. , Eibak A.M. , Bjerkehagen B. , Davidson B. , Heim S.
PLoS ONE7:E39354-E39354(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISEASE;CHROMOSOMAL TRANSLOCATION WITH MEAF6
13.

"Tudor domains of the PRC2 components PHF1 and PHF19 selectively bind to histone H3K36me3."
Qin S. , Guo Y. , Xu C. , Bian C. , Fu M. , Gong S. , Min J.
Biochem. Biophys. Res. Commun.430:547-553(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: H3K36ME3-BINDING
14.

"Polycomb group protein PHF1 regulates p53-dependent cell growth arrest and apoptosis."
Yang Y. , Wang C. , Zhang P. , Gao K. , Wang D. , Yu H. , Zhang T. , Jiang S. , Hexige S. , Hong Z. , Yasui A. , Liu J.O. , Huang H. , Yu L.
J. Biol. Chem.288:529-539(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH TP53;SUBCELLULAR LOCATION
15.

"Solution structure of the Tudor domain of PHD finger protein 1 (PHF1 protein)."
RIKEN structural genomics initiative (RSGI)
Submitted (2007-06) to the PDB data bank

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 29-85
16.

"An H3K36 methylation-engaging Tudor motif of Polycomb-like proteins mediates PRC2 complex targeting."
Cai L. , Rothbart S.B. , Lu R. , Xu B. , Chen W.Y. , Tripathy A. , Rockowitz S. , Zheng D. , Patel D.J. , Allis C.D. , Strahl B.D. , Song J. , Wang G.G.
Mol. Cell49:571-582(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 6-83;FUNCTION;H3K36ME3-BINDING;SUBCELLULAR LOCATION;MUTAGENESIS OF TRP-41; TYR-47; PHE-65; GLU-66 AND PHE-71
17.

"Molecular basis for H3K36me3 recognition by the Tudor domain of PHF1."
Musselman C.A. , Avvakumov N. , Watanabe R. , Abraham C.G. , Lalonde M.E. , Hong Z. , Allen C. , Roy S. , Nunez J.K. , Nickoloff J. , Kulesza C.A. , Yasui A. , Cote J. , Kutateladze T.G.
Nat. Struct. Mol. Biol.19:1266-1272(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.85 ANGSTROMS) OF 28-85;FUNCTION;H3K36ME3-BINDING;SUBCELLULAR LOCATION;MUTAGENESIS OF TRP-41 AND TYR-47

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