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Index > Protein center > PHF1(Gene name) > Human
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  • PHF1 (Gene name),
  • PHD finger protein 1 (Protein name ),  PHF1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    PHF1(PCL1);
    Protein name:
    PHD finger protein 1(Protein PHF1);
    Alternative:
    Polycomb-like protein 1(hPCl1);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with CHMP1 (By similarity). Interacts with the PRC2 complex.
    Function:
    Transcriptional repressor. May promote methylation of histone H3 on 'Lys-27' by the PRC2/EED-EZH2 complex.
    Subcellular Location:
    Nucleus Cytoplasm cytoskeleton centrosome Localizes specifically to the promoters of numerous target genes. Co-localizes with NEK6 in the centrosome.
    Protein Attributes:
    Sequence length:
    567
    Sequence:
    50:
    MAQPPRLSRS | GASSLWDPAS | PAPTSGPRPR | LWEGQDVLAR | WTDGLLYLGT | 
    100:
    IKKVDSAREV | CLVQFEDDSQ | FLVLWKDISP | AALPGEELLC | CVCRSETVVP | 
    150:
    GNRLVSCEKC | RHAYHQDCHV | PRAPAPGEGE | GTSWVCRQCV | FAIATKRGGA | 
    200:
    LKKGPYARAM | LGMKLSLPYG | LKGLDWDAGH | LSNRQQSYCY | CGGPGEWNLK | 
    250:
    MLQCRSCLQW | FHEACTQCLS | KPLLYGDRFY | EFECCVCRGG | PEKVRRLQLR | 
    300:
    WVDVAHLVLY | HLSVCCKKKY | FDFDREILPF | TSENWDSLLL | GELSDTPKGE | 
    350:
    RSSRLLSALN | SHKDRFISGR | EIKKRKCLFG | LHARMPPPVE | PPTGDGALTS | 
    400:
    FPSGQGPGGG | VSRPLGKRRR | PEPEPLRRRQ | KGKVEELGPP | SAVRNQPEPQ | 
    450:
    EQRERAHLQR | ALQASVSPPS | PSPNQSYQGS | SGYNFRPTDA | RCLPSSPIRM | 
    500:
    FASFHPSAST | AGTSGDSGPP | DRSPLELHIG | FPTDIPKSAP | HSMTASSSSV | 
    550:
    SSPSPGLPRR | SAPPSPLCRS | LSPGTGGGVR | GGVGYLSRGD | PVRVLARRVR | 
    567:
    PDGSVQYLVE | WGGGGIF
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    Pfam:
    SMR:
    MIM:
    KEGG:
    UniGene:
    Pfam:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Human Protein PHF1
    Cat.:
    E13279m
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Human Protein PHF1
    Cat.:
    E13279h
    Price:
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    MSDS:
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    Packing:
    96T
    Range:
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    CLIA Kit for Human Protein PHF1
    Cat.:
    U13279m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Protein PHF1
    Cat.:
    U13279h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human Protein PHF1
    Polyclonal Antibody for Human Protein PHF1
    Monoclonal Antibody for Human Protein PHF1
    Monoclonal Antibody for Human Protein PHF1
    Protein for Human Protein PHF1
    Protein for Human Protein PHF1

    R&D Technical Data
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    Precision
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    Recovery
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    References
    1. 1.
      "The identification and localization of a human gene with sequence similarity to Polycomblike of Drosophila melanogaster."
      Coulson M. , Robert S. , Eyre H.J. , Saint R.
      Genomics48:381-383(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANT LYS-304
      tissue: Placenta.
    2. 2.
      Wang J.H. , Du G.W. , Zhou Y. , Yuan J.G. , Qiang B.Q.
      Submitted (1998-03) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);VARIANT LYS-304
    3. 3.
      "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J. , Palmer S.A. , Sims S.K. , Edwards C.A. , Ashurst J.L. , Wilming L. , Jones M.C. , Horton R. , Hunt S.E. , Scott C.E. , Gilbert J.G.R. , Clamp M.E. , Bethel G. , Milne S. , Ainscough R. , Almeida J.P. , Ambrose K.D. , Andrews T.D. , more...
      Nature425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA];VARIANT LYS-304
    4. 4.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA];VARIANT LYS-304
    5. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2);VARIANT LYS-304
      tissue: Uterus.
    6. 6.
      "Consistent rearrangement of chromosomal band 6p21 with generation of fusion genes JAZF1/PHF1 and EPC1/PHF1 in endometrial stromal sarcoma."
      Micci F. , Panagopoulos I. , Bjerkehagen B. , Heim S.
      Cancer Res.66:107-112(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISEASE;CHROMOSOMAL TRANSLOCATION WITH JAZF1
    7. 7.
      "Role of hPHF1 in H3K27 methylation and Hox gene silencing."
      Cao R. , Wang H. , He J. , Erdjument-Bromage H. , Tempst P. , Zhang Y.
      Mol. Cell. Biol.28:1862-1872(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;IDENTIFICATION BY MASS SPECTROMETRY;INTERACTION WITH THE PRC2 COMPLEX
    8. 8.
      "Ezh2 requires PHF1 to efficiently catalyze H3 lysine 27 trimethylation in vivo."
      Sarma K. , Margueron R. , Ivanov A. , Pirrotta V. , Reinberg D.
      Mol. Cell. Biol.28:2718-2731(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH THE PRC2 COMPLEX;SUBCELLULAR LOCATION
    9. 9.
      "A polycomb group protein, PHF1, is involved in the response to DNA double-strand breaks in human cell."
      Hong Z. , Jiang J. , Lan L. , Nakajima S. , Kanno S. , Koseki H. , Yasui A.
      Nucleic Acids Res.36:2939-2947(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION
    10. 10.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-360 (ISOFORM 1);IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    11. 11.
      "Characterization of hNek6 interactome reveals an important role for its short N-terminal domain and colocalization with proteins at the centrosome."
      Vaz Meirelles G. , Ferreira Lanza D.C. , da Silva J.C. , Santana Bernachi J. , Paes Leme A.F. , Kobarg J.
      J. Proteome Res.9:6298-6316(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
    12. 12.
      "Novel fusion of MYST/Esa1-associated factor 6 and PHF1 in endometrial stromal sarcoma."
      Panagopoulos I. , Micci F. , Thorsen J. , Gorunova L. , Eibak A.M. , Bjerkehagen B. , Davidson B. , Heim S.
      PLoS ONE7:E39354-E39354(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISEASE;CHROMOSOMAL TRANSLOCATION WITH MEAF6
    13. 13.
      "Tudor domains of the PRC2 components PHF1 and PHF19 selectively bind to histone H3K36me3."
      Qin S. , Guo Y. , Xu C. , Bian C. , Fu M. , Gong S. , Min J.
      Biochem. Biophys. Res. Commun.430:547-553(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: H3K36ME3-BINDING
    14. 14.
      "Polycomb group protein PHF1 regulates p53-dependent cell growth arrest and apoptosis."
      Yang Y. , Wang C. , Zhang P. , Gao K. , Wang D. , Yu H. , Zhang T. , Jiang S. , Hexige S. , Hong Z. , Yasui A. , Liu J.O. , Huang H. , Yu L.
      J. Biol. Chem.288:529-539(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH TP53;SUBCELLULAR LOCATION
    15. 15.
      "Solution structure of the Tudor domain of PHD finger protein 1 (PHF1 protein)."
      RIKEN structural genomics initiative (RSGI)
      Submitted (2007-06) to the PDB data bank
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 29-85
    16. 16.
      "An H3K36 methylation-engaging Tudor motif of Polycomb-like proteins mediates PRC2 complex targeting."
      Cai L. , Rothbart S.B. , Lu R. , Xu B. , Chen W.Y. , Tripathy A. , Rockowitz S. , Zheng D. , Patel D.J. , Allis C.D. , Strahl B.D. , Song J. , Wang G.G.
      Mol. Cell49:571-582(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 6-83;FUNCTION;H3K36ME3-BINDING;SUBCELLULAR LOCATION;MUTAGENESIS OF TRP-41; TYR-47; PHE-65; GLU-66 AND PHE-71
    17. 17.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.85 ANGSTROMS) OF 28-85;FUNCTION;H3K36ME3-BINDING;SUBCELLULAR LOCATION;MUTAGENESIS OF TRP-41 AND TYR-47
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