PIAS4 ELISA Kit for Human(Homo sapiens) | EIAab.comPIAS4 ELISA Kit for Human(Homo sapiens)

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PIAS4 (Gene name),

E3 SUMO-protein ligase PIAS4 (Protein name ), PIAS4_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

PIAS4(PIASG);

Protein name:

E3 SUMO-protein ligase PIAS4;

Alternative:

Protein inhibitor of activated STAT protein 4;PIASy;Protein inhibitor of activated STAT protein gamma(PIAS-gamma);

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts with AR, AXIN1, GATA2, LEF1, TP53 and STAT1 (IFNG-induced). Binds to AT-rich DNA sequences, known as matrix or scaffold attachment regions (MARs/SARs) (By similarity). Interacts with TICAM1. Interacts with KLF8; the interaction results in SUMO ligation and repression of KLF8 transcriptional activity and of its cell cycle progression into G(1) phase.

Function:

Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53 pathway, the Wnt pathway and the steroid hormone signaling pathway. Involved in gene silencing. Promotes PARK7 sumoylation. In Wnt signaling, represses LEF1 and enhances TCF4 transcriptional activities through promoting their sumoylations.

Subcellular Location:

Nucleus PML body Colocalizes with SUMO1 and TCF7L2/TCF4 and LEF1 in a subset of PML (promyelocytic leukemia) nuclear bodies.

Protein Attributes:

Sequence length:

510

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

510:

PFQKGLVPAC |

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

Q8N2W9

UniGene:

Hs.105779

MIM:

605989

KEGG:

hsa:51588

STRING:

9606.ENSP00000262971

Pfam:

PF14324

Pfam:

PF02891

String:

Q8N2W9

Uniprot:

Q8N2W9

FOR

ELISA Kit for Human E3 SUMO-protein ligase PIAS4

CLIA Kit for Human E3 SUMO-protein ligase PIAS4

Polyclonal Antibody for Human E3 SUMO-protein ligase PIAS4

Monoclonal Antibody for Human E3 SUMO-protein ligase PIAS4

Protein for Human E3 SUMO-protein ligase PIAS4

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Inhibition of Stat1-mediated gene activation by PIAS1."
Liu B. , Liao J. , Rao X. , Kushner S.A. , Chung C.D. , Chang D.D. , Shuai K.
Proc. Natl. Acad. Sci. U.S.A.95:10626-10631(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
tissue: B-cell.
2.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Brain.
tissue: Lung.
tissue: Skin.
3.

"A putative protein inhibitor of activated STAT (PIASy) interacts with p53 and inhibits p53-mediated transactivation but not apoptosis."
Nelson V. , Davis G.E. , Maxwell S.A.
Apoptosis6:221-234(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 10-510;INTERACTION WITH TP53
4.

"A transcriptional corepressor of Stat1 with an essential LXXLL signature motif."
Liu B. , Gross M. , ten Hoeve J. , Shuai K.
Proc. Natl. Acad. Sci. U.S.A.98:3203-3207(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH STAT1;SUBCELLULAR LOCATION;MUTAGENESIS OF 23-LEU-LEU-24
5.

"Distinct effects of PIAS proteins on androgen-mediated gene activation in prostate cancer cells."
Gross M. , Liu B. , Tan J.-A. , French F.S. , Carey M. , Shuai K.
Oncogene20:3880-3887(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH AR;TISSUE SPECIFICITY;MUTAGENESIS OF 23-LEU-LEU-24
6.

"SUMO-1 modification of the C-terminal KVEKVD of Axin is required for JNK activation but has no effect on Wnt signaling."
Rui H.L. , Fan E. , Zhou H.M. , Xu Z. , Zhang Y. , Lin S.C.
J. Biol. Chem.277:42981-42986(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH AXIN1
7.

"Modification of GATA-2 transcriptional activity in endothelial cells by the SUMO E3 ligase PIASy."
Chun T.-H. , Itoh H. , Subramanian L. , Iniguez-Lluhi J.A. , Nakao K.
Circ. Res.92:1201-1208(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH GATA2
8.

"Sumoylation is involved in beta-catenin-dependent activation of Tcf-4."
Yamamoto H. , Ihara M. , Matsuura Y. , Kikuchi A.
EMBO J.22:2047-2059(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN SUMOYLATION OF TCF4;SUBCELLULAR LOCATION;MUTAGENESIS OF LYS-35 AND LYS-128
9.

"Transactivation properties of c-Myb are critically dependent on two SUMO-1 acceptor sites that are conjugated in a PIASy enhanced manner."
Dahle O. , Andersen T.O. , Nordgaard O. , Matre V. , Del Sal G. , Gabrielsen O.S.
Eur. J. Biochem.270:1338-1348(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN SUMOYLATION OF MYB
10.

"A synergy control motif within the attenuator domain of CCAAT/enhancer-binding protein alpha inhibits transcriptional synergy through its PIASy-enhanced modification by SUMO-1 or SUMO-3."
Subramanian L. , Benson M.D. , Iniguez-Lluhi J.A.
J. Biol. Chem.278:9134-9141(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN SUMOYLATION OF CEBPA
11.

"PIASy represses TRIF-induced ISRE and NF-kappaB activation but not apoptosis."
Zhang J. , Xu L.G. , Han K.J. , Wei X. , Shu H.B.
FEBS Lett.570:97-101(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TICAM1
12.

"SUMO-1 modification of PIASy, an E3 ligase, is necessary for PIASy-dependent activation of Tcf-4."
Ihara M. , Yamamoto H. , Kikuchi A.
Mol. Cell. Biol.25:3506-3518(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUMOYLATION AT LYS-35 AND LYS-128;FUNCTION IN SUMOYLATION OF TCF4;SUBCELLULAR LOCATION;MUTAGENESIS OF LYS-35 AND LYS-128
13.

"Proper SUMO-1 conjugation is essential to DJ-1 to exert its full activities."
Shinbo Y. , Niki T. , Taira T. , Ooe H. , Takahashi-Niki K. , Maita C. , Seino C. , Iguchi-Ariga S.M.M. , Ariga H.
Cell Death Differ.13:96-108(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN SUMOYLATION OF PARK7
14.

"Sumoylation delimits KLF8 transcriptional activity associated with the cell cycle regulation."
Wei H. , Wang X. , Gan B. , Urvalek A.M. , Melkoumian Z.K. , Guan J.-L. , Zhao J.
J. Biol. Chem.281:16664-16671(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH KLF8
15.

"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S. , Helbig A.O. , Slijper M. , Krijgsveld J. , Heck A.J. , Mohammed S.
Anal. Chem.81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS];CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS]
16.

"Lysine acetylation targets protein complexes and co-regulates major cellular functions."
Choudhary C. , Kumar C. , Gnad F. , Nielsen M.L. , Rehman M. , Walther T.C. , Olsen J.V. , Mann M.
Science325:834-840(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-114;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
17.

"SUMOylation and SUMO-interacting motif (SIM) of metastasis tumor antigen 1 (MTA1) synergistically regulate its transcriptional repressor function."
Cong L. , Pakala S.B. , Ohshiro K. , Li D.Q. , Kumar R.
J. Biol. Chem.286:43793-43808(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH MTA1
18.

"DNA damage-inducible SUMOylation of HERC2 promotes RNF8 binding via a novel SUMO-binding Zinc finger."
Danielsen J.R. , Povlsen L.K. , Villumsen B.H. , Streicher W. , Nilsson J. , Wikstrom M. , Bekker-Jensen S. , Mailand N.
J. Cell Biol.197:179-187(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN SUMOYLATION OF HERC2 AND RNF168

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