PIN1 ELISA Kit for Human(Homo sapiens) | EIAab.comPIN1 ELISA Kit for Human(Homo sapiens)

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Index > Protein center > PIN1(Gene name) > Human

PIN1 (Gene name),

Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (Protein name ), PIN1_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

PIN1;

Protein name:

Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1;

Alternative:

Rotamase Pin1;Peptidyl-prolyl cis-trans isomerase Pin1(PPIase Pin1);

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts with STIL (By similarity). Interacts with KIF20B. Interacts with NEK6. Interacts (via WW domain) with PRKX. Interacts with BTK.

Function:

Essential PPIase that regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Displays a preference for an acidic residue N-terminal to the isomerized proline bond. Catalyzing pSer/Thr-Pro cis/trans isomerizations. Down-regulates kinase activity of BTK.

Subcellular Location:

Nucleus Co-localizes with NEK6 in the nucleus.

Protein Attributes:

Sequence length:

163

Sequence:

50:

100:

150:

163:

FTDSGIHIIL | RTE

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

MIM:

601052

STRING:

9606.ENSP00000247970

String:

Q13526

UniGene:

Hs.465849

SMR:

Q13526

KEGG:

hsa:5300

Pfam:

PF00639

Uniprot:

Q13526

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ELISA Kit for Human Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

Cat.:

E7189m

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Packing:

96T

ELISA Kit for Human Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

Cat.:

E7189h

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96T

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ELISA Kit for Human Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

Cat.:

E7189b

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Packing:

96T

CLIA Kit for Human Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

Cat.:

U7189h

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Manual:

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96T

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CLIA Kit for Human Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

Cat.:

U7189b

Price:

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MSDS:

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Packing:

96T

CLIA Kit for Human Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

Cat.:

U7189m

Price:

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MSDS:

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Packing:

96T

Polyclonal Antibody for Human Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

Cat.:

P7189Rb-m

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40ug/0.2ml

Polyclonal Antibody for Human Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

Cat.:

P7189Rb-h

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Packing:

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Monoclonal Antibody for Human Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

Protein for Human Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"A human peptidyl-prolyl isomerase essential for regulation of mitosis."
Lu K.P. , Hanes S.D. , Hunter T.
Nature380:544-547(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
2.

"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Ebert L. , Schick M. , Neubert P. , Schatten R. , Henze S. , Korn B.
Submitted (2004-05) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
3.

"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
Submitted (2004-10) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
4.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
5.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Lung.
7.

"Identification of a novel kinesin-related protein, KRMP1, as a target for mitotic peptidyl-prolyl isomerase Pin1."
Kamimoto T. , Zama T. , Aoki R. , Muro Y. , Hagiwara M.
J. Biol. Chem.276:37520-37528(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH KIF20B;MUTAGENESIS OF TYR-23
8.

"Regulation of Raf-1 by direct feedback phosphorylation."
Dougherty M.K. , Muller J. , Ritt D.A. , Zhou M. , Zhou X.Z. , Copeland T.D. , Conrads T.P. , Veenstra T.D. , Lu K.P. , Morrison D.K.
Mol. Cell17:215-224(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH RAF1
9.

"Interaction of Pin1 with Nek6 and characterization of their expression correlation in Chinese hepatocellular carcinoma patients."
Chen J. , Li L. , Zhang Y. , Yang H. , Wei Y. , Zhang L. , Liu X. , Yu L.
Biochem. Biophys. Res. Commun.341:1059-1065(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;INTERACTION WITH NEK6
10.

"Regulation of Bruton tyrosine kinase by the peptidylprolyl isomerase Pin1."
Yu L. , Mohamed A.J. , Vargas L. , Berglof A. , Finn G. , Lu K.P. , Smith C.I.
J. Biol. Chem.281:18201-18207(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH BTX;FUNCTION
11.

"Genotoxic stress regulates expression of the proto-oncogene Bcl6 in germinal center B cells."
Phan R.T. , Saito M. , Kitagawa Y. , Means A.R. , Dalla-Favera R.
Nat. Immunol.8:1132-1139(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN BCL6 STABILITY REGULATION;INTERACTION WITH BCL6;TISSUE SPECIFICITY
12.

"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."
Matsuoka S. , Ballif B.A. , Smogorzewska A. , McDonald E.R. III , Hurov K.E. , Luo J. , Bakalarski C.E. , Zhao Z. , Solimini N. , Lerenthal Y. , Shiloh Y. , Gygi S.P. , Elledge S.J.
Science316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-108;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Embryonic kidney.
13.

"Nerve growth factor stimulates interaction of Cayman ataxia protein BNIP-H/Caytaxin with peptidyl-prolyl isomerase Pin1 in differentiating neurons."
Buschdorf J.P. , Chew L.L. , Soh U.J. , Liou Y.C. , Low B.C.
PLoS ONE3:E2686-E2686(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ATCAY
14.

"Protein kinase-X interacts with Pin-1 and Polycystin-1 during mouse kidney development."
Li X. , Hyink D.P. , Radbill B. , Sudol M. , Zhang H. , Zheleznova N.N. , Wilson P.D.
Kidney Int.76:54-62(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PRKX
15.

"Lysine acetylation targets protein complexes and co-regulates major cellular functions."
Choudhary C. , Kumar C. , Gnad F. , Nielsen M.L. , Rehman M. , Walther T.C. , Olsen J.V. , Mann M.
Science325:834-840(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-46;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
16.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
17.

"Mitogen-activated protein kinase extracellular signal-regulated kinase 2 phosphorylates and promotes Pin1 protein-dependent promyelocytic leukemia protein turnover."
Lim J.H. , Liu Y. , Reineke E. , Kao H.Y.
J. Biol. Chem.286:44403-44411(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH PML
18.

"Death-associated protein kinase 1 phosphorylates Pin1 and inhibits its prolyl isomerase activity and cellular function."
Lee T.H. , Chen C.H. , Suizu F. , Huang P. , Schiene-Fischer C. , Daum S. , Zhang Y.J. , Goate A. , Chen R.H. , Zhou X.Z. , Lu K.P.
Mol. Cell42:147-159(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;PHOSPHORYLATION AT SER-71;INTERACTION WITH DAPK1;SUBCELLULAR LOCATION;MUTAGENESIS OF SER-71;TISSUE SPECIFICITY
19.

"Structural and functional analysis of the mitotic rotamase Pin1 suggests substrate recognition is phosphorylation dependent."
Ranganathan R. , Lu K.P. , Hunter T. , Noel J.P.
Cell89:875-886(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.35 ANGSTROMS)

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