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Index > Protein center > Pja1(Gene name) > Mouse
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  • Pja1 (Gene name),
  • E3 ubiquitin-protein ligase Praja-1 (Protein name ),  PJA1_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    Pja1;
    Protein name:
    E3 ubiquitin-protein ligase Praja-1(Praja1);
    Alternative:

    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Binds ubiquitin-conjugating enzymes (E2s). Binds, in vitro and in vivo, the MAGE conserved domain of MAGED1. Binds weakly Necdin, in vitro.
    Function:
    Has E2-dependent E3 ubiquitin-protein ligase activity. Ubiquitinates MAGED1 antigen leading to its subsequent degradation by proteasome. May be involved in protein sorting.
    Subcellular Location:
    N/A
    Protein Attributes:
    Sequence length:
    578
    Sequence:
    50:
    MSHQERIASQ | RRTTAEVPMH | RSTANQSKRS | RSPFASTRRR | WDDSESSGAS | 
    100:
    LAVESEDYSR | YPPREYRASG | SRRGLAYGHI | DTVVARDSEE | EGAGPVDRLP | 
    150:
    VRGKAGKFKD | DPEKGARSSR | FTSVNHDAKE | ECGKVESPPA | ARCSARRAEL | 
    200:
    SKQNGSSASQ | ISSAEGRAAA | KGNNSLERER | QNLPARPSRA | PVSICGGGEN | 
    250:
    TPKSAEEPVV | RPKVRNVATP | NCMKPKVFFD | TDDDDDVPHS | TSRWRDAADA | 
    300:
    EEAHAEGLAR | RGRGEAASSS | EPRYAEDQDA | RSEQAKADKV | PRRRRTMADP | 
    350:
    DFWAYTDDYY | RYYEEDSDSD | KEWMAALRRK | YRSREQPQSS | SGESWELLPG | 
    400:
    KEELERQQAG | AGSLASAGSN | GSGYPEEVQD | PSLQEEEQAS | LEEGEIPWLR | 
    450:
    YNENESSSEG | DNESTHELIQ | PGMFMLDGNN | NLEDDSSVSE | DLEVDWSLFD | 
    500:
    GFADGLGVAE | AISYVDPQFL | TYMALEERLA | QAMETALAHL | ESLAVDVEVA | 
    550:
    NPPASKESID | ALPEILVTED | HGAVGQEMCC | PICCSEYVKG | EVATELPCHH | 
    578:
    YFHKPCVSIW | LQKSGTCPVC | RCMFPPPL
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    String:
    Pfam:
    UniGene:
    KEGG:
    SMR:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse Praja1
    ELISA Kit for Mouse Praja1
    CLIA Kit for Mouse Praja1
    CLIA Kit for Mouse Praja1
    Polyclonal Antibody for Mouse Praja1
    Polyclonal Antibody for Mouse Praja1
    Monoclonal Antibody for Mouse Praja1
    Monoclonal Antibody for Mouse Praja1
    Protein for Mouse Praja1
    Protein for Mouse Praja1

    R&D Technical Data
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Precision
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Recovery
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    References
    1. 1.
      "Praja1, a novel gene encoding a RING-H2 motif in mouse development."
      Mishra L. , Tully R.E. , Monga S.P.S. , Yu P. , Cai T. , Makalowski W. , Mezey E. , Pavan W.J. , Mishra B.
      Oncogene15:2361-2368(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
      strain: C57BL/6.
      tissue: Embryo.
    2. 2.
      Mishra L.
      Submitted (2004-07) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SEQUENCE REVISION
    3. 3.
      "Identification of genes expressed in the amygdala during the formation of fear memory."
      Stork O. , Stork S. , Pape H.-C. , Obata K.
      Learn. Memory8:209-219(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 3 AND 4)
      strain: C57BL/6.
      tissue: Amygdala.
    4. 4.
      Stork O. , Stork S.
      Submitted (2006-08) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SEQUENCE REVISION TO C-TERMINUS (ISOFORMS 1 AND 3)
    5. 5.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      strain: C57BL/6J.
      tissue: Cerebellum.
    6. 6.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Eye.
    7. 7.
      "RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination."
      Lorick K.L. , Jensen J.P. , Fang S. , Ong A.M. , Hatakeyama S. , Weissman A.M.
      Proc. Natl. Acad. Sci. U.S.A.96:11364-11369(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION AS A UBIQUITATION LIGASE;MUTAGENESIS OF HIS-553
    8. 8.
      "PJA1, encoding a RING-H2 finger ubiquitin ligase, is a novel human X chromosome gene abundantly expressed in brain."
      Yu P. , Chen Y. , Tagle D.A. , Cai T.
      Genomics79:869-874(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH UBE2D2
    9. 9.
      "A RING finger protein Praja1 regulates Dlx5-dependent transcription through its ubiquitin ligase activity for the Dlx/Msx-interacting MAGE/Necdin family protein, Dlxin-1."
      Sasaki A. , Masuda Y. , Iwai K. , Ikeda K. , Watanabe K.
      J. Biol. Chem.277:22541-22546(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MAGED1;MUTAGENESIS OF CYS-533
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