PLA2R1 ELISA Kit for Human(Homo sapiens) | EIAab.comPLA2R1 ELISA Kit for Human(Homo sapiens)

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Index > Protein center > PLA2R1(Gene name) > Human

PLA2R1 (Gene name),

Secretory phospholipase A2 receptor (Protein name ), PLA2R_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

PLA2R1(CLEC13C);

Protein name:

Secretory phospholipase A2 receptor(PLA2-R;PLA2R);

Alternative:

C-type lectin domain family 13 member C;180 kDa secretory phospholipase A2 receptor;M-type receptor;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

N/A

Function:

Receptor for secretory phospholipase A2 (sPLA2). Acts as a receptor for phosholipase sPLA2-IB/PLA2G1B but not sPLA2-IIA/PLA2G2A. Also able to bind to snake PA2-like toxins. Although its precise function remains unclear, binding of sPLA2 to its receptor participates in both positive and negative regulation of sPLA2 functions as well as clearance of sPLA2. Binding of sPLA2-IB/PLA2G1B induces various effects depending on the cell type, such as activation of the mitogen-activated protein kinase (MAPK) cascade to induce cell proliferation, the production of lipid mediators, selective release of arachidonic acid in bone marrow-derived mast cells. In neutrophils, binding of sPLA2-IB/PLA2G1B can activate p38 MAPK to stimulate elastase release and cell adhesion. May be involved in responses in proinflammatory cytokine productions during endotoxic shock. Also has endocytic properties and rapidly internalizes sPLA2 ligands, which is particularly important for the clearance of extracellular sPLA2s to protect their potent enzymatic activities. The soluble secretory phospholipase A2 receptor form is circulating and acts as a negative regulator of sPLA2 functions by blocking the biological functions of sPLA2-IB/PLA2G1B.

Subcellular Location:

Isoform 2 Secreted

Protein Attributes:

Sequence length:

1463

Sequence:

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1450:

1463:

ENILISDLEK | SDQ

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

Q13018

MIM:

604939

UniGene:

Hs.410477

STRING:

9606.ENSP00000283243

KEGG:

hsa:22925

SMR:

Q13018

Pfam:

PF00040

Uniprot:

Q13018

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ELISA Kit for Human PLA2-R

Cat.:

E2020h

Price:

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Manual:

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MSDS:

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Packing:

96T

Range:

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ELISA Kit for Human PLA2-R

Cat.:

E2020m

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MSDS:

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Packing:

96T

ELISA Kit for Human PLA2-R

Cat.:

E2020b

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MSDS:

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Packing:

96T

ELISA Kit for Human PLA2-R

MSDS:

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CLIA Kit for Human PLA2-R

Cat.:

U2020b

Price:

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MSDS:

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Packing:

96T

CLIA Kit for Human PLA2-R

Cat.:

U2020h

Price:

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Manual:

Looking for manual.

MSDS:

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Packing:

96T

Range:

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CLIA Kit for Human PLA2-R

MSDS:

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CLIA Kit for Human PLA2-R

Cat.:

U2020m

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MSDS:

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Packing:

96T

Polyclonal Antibody for Human PLA2-R

Cat.:

P2020Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human PLA2-R

Cat.:

P2020Rb-h

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human PLA2-R

Protein for Human PLA2-R

Cat.:

R2020h

Price:

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Packing:

1mg

Purity:

>90%

Protein for Human PLA2-R

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"The human 180-kDa receptor for secretory phospholipases A2. Molecular cloning, identification of a secreted soluble form, expression, and chromosomal localization."
Ancian P. , Lambeau G. , Mattei M.-G. , Lazdunski M.
J. Biol. Chem.270:8963-8970(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2);FUNCTION;TISSUE SPECIFICITY;VARIANTS VAL-292 AND ASP-300
tissue: Kidney.
2.

"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W. , Graves T.A. , Fulton R.S. , Fulton L.A. , Pepin K.H. , Minx P. , Wagner-McPherson C. , Layman D. , Wylie K. , Sekhon M. , Becker M.C. , Fewell G.A. , Delehaunty K.D. , Miner T.L. , Nash W.E. , Kremitzki C. , Oddy L. , Du H. , more...
Nature434:724-731(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
3.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
4.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue: Brain.
5.

"Structural comparison of phospholipase-A2-binding regions in phospholipase-A2 receptors from various mammals."
Higashino K. , Ishizaki J. , Kishino J. , Ohara O. , Arita H.
Eur. J. Biochem.225:375-382(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 532-942;TISSUE SPECIFICITY
tissue: Placenta.
6.

"Distribution of the phospholipase A2 receptor messenger RNA in human gestational tissues."
Moses E.K. , Freed K.A. , Brennecke S.P. , Rice G.E.
Placenta19:35-40(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
7.

"Activation of cytokine production by secreted phospholipase A2 in human lung macrophages expressing the M-type receptor."
Granata F. , Petraroli A. , Boilard E. , Bezzine S. , Bollinger J. , Del Vecchio L. , Gelb M.H. , Lambeau G. , Marone G. , Triggiani M.
J. Immunol.174:464-474(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY

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