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Index > Protein center > PLCB1(Gene name) > Human
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  • PLCB1 (Gene name),
  • 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-1 (Protein name ),  PLCB1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    PLCB1(KIAA0581);
    Protein name:
    1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-1;
    Alternative:
    Phosphoinositide phospholipase C-beta-1;PLC-154;Phospholipase C-beta-1(PLC-beta-1);Phospholipase C-I(PLC-I);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with DGKQ.
    Function:
    The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.
    Subcellular Location:
    N/A
    Protein Attributes:
    Sequence length:
    1216
    Sequence:
    50:
    MAGAQPGVHA | LQLKPVCVSD | SLKKGTKFVK | WDDDSTIVTP | IILRTDPQGF | 
    100:
    FFYWTDQNKE | TELLDLSLVK | DARCGRHAKA | PKDPKLRELL | DVGNIGRLEQ | 
    150:
    RMITVVYGPD | LVNISHLNLV | AFQEEVAKEW | TNEVFSLATN | LLAQNMSRDA | 
    200:
    FLEKAYTKLK | LQVTPEGRIP | LKNIYRLFSA | DRKRVETALE | ACSLPSSRND | 
    250:
    SIPQEDFTPE | VYRVFLNNLC | PRPEIDNIFS | EFGAKSKPYL | TVDQMMDFIN | 
    300:
    LKQRDPRLNE | ILYPPLKQEQ | VQVLIEKYEP | NNSLARKGQI | SVDGFMRYLS | 
    350:
    GEENGVVSPE | KLDLNEDMSQ | PLSHYFINSS | HNTYLTAGQL | AGNSSVEMYR | 
    400:
    QVLLSGCRCV | ELDCWKGRTA | EEEPVITHGF | TMTTEISFKE | VIEAIAECAF | 
    450:
    KTSPFPILLS | FENHVDSPKQ | QAKMAEYCRL | IFGDALLMEP | LEKYPLESGV | 
    500:
    PLPSPMDLMY | KILVKNKKKS | HKSSEGSGKK | KLSEQASNTY | SDSSSMFEPS | 
    550:
    SPGAGEADTE | SDDDDDDDDC | KKSSMDEGTA | GSEAMATEEM | SNLVNYIQPV | 
    600:
    KFESFEISKK | RNKSFEMSSF | VETKGLEQLT | KSPVEFVEYN | KMQLSRIYPK | 
    650:
    GTRVDSSNYM | PQLFWNAGCQ | MVALNFQTMD | LAMQINMGMY | EYNGKSGYRL | 
    700:
    KPEFMRRPDK | HFDPFTEGIV | DGIVANTLSV | KIISGQFLSD | KKVGTYVEVD | 
    750:
    MFGLPVDTRR | KAFKTKTSQG | NAVNPVWEEE | PIVFKKVVLP | TLACLRIAVY | 
    800:
    EEGGKFIGHR | ILPVQAIRPG | YHYICLRNER | NQPLTLPAVF | VYIEVKDYVP | 
    850:
    DTYADVIEAL | SNPIRYVNLM | EQRAKQLAAL | TLEDEEEVKK | EADPGETPSE | 
    900:
    APSEARTTPA | ENGVNHTTTL | TPKPPSQALH | SQPAPGSVKA | PAKTEDLIQS | 
    950:
    VLTEVEAQTI | EELKQQKSFV | KLQKKHYKEM | KDLVKRHHKK | TTDLIKEHTT | 
    1000:
    KYNEIQNDYL | RRRAALEKSA | KKDSKKKSEP | SSPDHGSSTI | EQDLAALDAE | 
    1050:
    MTQKLIDLKD | KQQQQLLNLR | QEQYYSEKYQ | KREHIKLLIQ | KLTDVAEECQ | 
    1100:
    NNQLKKLKEI | CEKEKKELKK | KMDKKRQEKI | TEAKSKDKSQ | MEEEKTEMIR | 
    1150:
    SYIQEVVQYI | KRLEEAQSKR | QEKLVEKHKE | IRQQILDEKP | KLQVELEQEY | 
    1200:
    QDKFKRLPLE | ILEFVQEAMK | GKISEDSNHG | SAPLSLSSDP | GKVNHKTPSS | 
    1216:
    EELGGDIPGK | EFDTPL
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    KEGG:
    MIM:
    SMR:
    UniGene:
    Pfam:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Human 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-1
    Cat.:
    E1605b
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Human 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-1
    Cat.:
    E1605r
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    ELISA Kit for Human 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-1
    Cat.:
    E1605h
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    Packing:
    96T
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    ELISA Kit for Human 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-1
    Cat.:
    E1605m
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-1
    Cat.:
    U1605h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-1
    Cat.:
    U1605b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-1
    Cat.:
    U1605m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-1
    Cat.:
    U1605r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-1
    Polyclonal Antibody for Human 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-1
    Cat.:
    P1605Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-1
    Cat.:
    P1605Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-1
    Cat.:
    P1605Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-1
    Monoclonal Antibody for Human 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-1
    Monoclonal Antibody for Human 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-1
    Monoclonal Antibody for Human 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-1
    Protein for Human 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-1
    Protein for Human 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-1
    Protein for Human 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-1
    Protein for Human 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-1

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    References
    1. 1.
      "Cloning and characterization of the human phosphoinositide-specific phospholipase C-beta 1 (PLCbeta1)."
      Caricasole A. , Sala C. , Roncarati R. , Formenti E. , Terstappen G.C.
      Biochim. Biophys. Acta1517:63-72(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A AND B)
      tissue: Brain.
    2. 2.
      "Identification and chromosomal localisation by fluorescence in situ hybridisation of human gene of phosphoinositide-specific phospholipase C beta 1."
      Peruzzi D. , Calabrese G. , Faenza I. , Manzoli L. , Matteucci A. , Gianfrancesco F. , Billi A.M. , Stuppia L. , Palka G. , Cocco L.
      Biochim. Biophys. Acta1484:175-182(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A)
      tissue: Brain.
    3. 3.
      "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
      Nagase T. , Ishikawa K. , Miyajima N. , Tanaka A. , Kotani H. , Nomura N. , Ohara O.
      DNA Res.5:31-39(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A)
      tissue: Brain.
    4. 4.
      "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
      Nakajima D. , Okazaki N. , Yamakawa H. , Kikuno R. , Ohara O. , Nagase T.
      DNA Res.9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SEQUENCE REVISION
    5. 5.
      "The DNA sequence and comparative analysis of human chromosome 20."
      Deloukas P. , Matthews L.H. , Ashurst J.L. , Burton J. , Gilbert J.G.R. , Jones M. , Stavrides G. , Almeida J.P. , Babbage A.K. , Bagguley C.L. , Bailey J. , Barlow K.F. , Bates K.N. , Beard L.M. , Beare D.M. , Beasley O.P. , Bird C.P. , Blakey S.E. , more...
      Nature414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 6.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    7. 7.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS A AND B)
      tissue: Brain.
    8. 8.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 261-1216 (ISOFORM B)
      tissue: Testis.
    9. 9.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 417-1062 (ISOFORMS A AND B)
      tissue: Placenta.
    10. 10.
      "Diacylglycerol kinase-theta is localized in the speckle domains of the nucleus."
      Tabellini G. , Bortul R. , Santi S. , Riccio M. , Baldini G. , Cappellini A. , Billi A.M. , Berezney R. , Ruggeri A. , Cocco L. , Martelli A.M.
      Exp. Cell Res.287:143-154(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH DGKQ
    11. 11.
      "Phospholipase C beta 1 deficiency is associated with early-onset epileptic encephalopathy."
      Kurian M.A. , Meyer E. , Vassallo G. , Morgan N.V. , Prakash N. , Pasha S. , Hai N.A. , Shuib S. , Rahman F. , Wassmer E. , Cross J.H. , O'Callaghan F.J. , Osborne J.P. , Scheffer I.E. , Gissen P. , Maher E.R.
      Brain133:2964-2970(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN EIEE12
    12. 12.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT [LARGE SCALE ANALYSIS] PRO-907
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