Protein name:
1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1 ;
Alternative:
Phosphoinositide phospholipase C-gamma-1 ;PLC-148 ;Phospholipase C-gamma-1 (PLC-gamma-1) ;Phospholipase C-II (PLC-II) ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Interacts with AGAP2 via its SH3 domain. Interacts (via SH2 domain) with RET (By similarity). Interacts (via SH2 domain) with FGFR1, FGFR2, FGFR3 and FGFR4 (phosphorylated). Interacts with LAT (phosphorylated) upon TCR activation. Interacts (via SH3 domain) with the Pro-rich domain of TNK1. Associates with BLNK, VAV1, GRB2 and NCK1 in a B-cell antigen receptor-dependent fashion. Interacts with CBLB in activated T-cells; which inhibits phosphorylation. Interacts with SHB. Interacts (via SH3 domain) with the Arg/Gly-rich-flanked Pro-rich domains of KHDRBS1/SAM68. This interaction is selectively regulated by arginine methylation of KHDRBS1/SAM68. Interacts with INPP5D/SHIP1, THEMIS and CLNK (By similarity). Interacts with AXL and KIT. Interacts with RALGPS1. Interacts (via SH3 domain) with HEV ORF3 protein. Interacts (via the SH2 domains) with VIL1 (phosphorylated at C-terminus tyrosine phosphorylation sites).
Function:
Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand-mediated activation of receptor-type tyrosine kinases, such as fibroblast growth factor receptors. Plays a role in actin reorganization and cell migration.
Subcellular Location:
Cell projection
lamellipodium
Cell projection
ruffle
Rapidly redistributed to ruffles and lamellipodia structures in response to epidermal growth factor (EGF) treatment.
Protein Attributes:
50:
MAGAASPCAN | GCGPGAPSDA | EVLHLCRSLE | VGTVMTLFYS | KKSQRPERKT |
100:
FQVKLETRQI | TWSRGADKIE | GAIDIREIKE | IRPGKTSRDF | DRYQEDPAFR |
150:
PDQSHCFVIL | YGMEFRLKTL | SLQATSEDEV | NMWIKGLTWL | MEDTLQAPTP |
200:
LQIERWLRKQ | FYSVDRNRED | RISAKDLKNM | LSQVNYRVPN | MRFLRERLTD |
250:
LEQRSGDITY | GQFAQLYRSL | MYSAQKTMDL | PFLEASTLRA | GERPELCRVS |
300:
LPEFQQFLLD | YQGELWAVDR | LQVQEFMLSF | LRDPLREIEE | PYFFLDEFVT |
350:
FLFSKENSVW | NSQLDAVCPD | TMNNPLSHYW | ISSSHNTYLT | GDQFSSESSL |
400:
EAYARCLRMG | CRCIELDCWD | GPDGMPVIYH | GHTLTTKIKF | SDVLHTIKEH |
450:
AFVASEYPVI | LSIEDHCSIA | QQRNMAQYFK | KVLGDTLLTK | PVEISADGLP |
500:
SPNQLKRKIL | IKHKKLAEGS | AYEEVPTSMM | YSENDISNSI | KNGILYLEDP |
550:
VNHEWYPHYF | VLTSSKIYYS | EETSSDQGNE | DEEEPKEVSS | STELHSNEKW |
600:
FHGKLGAGRD | GRHIAERLLT | EYCIETGAPD | GSFLVRESET | FVGDYTLSFW |
650:
RNGKVQHCRI | HSRQDAGTPK | FFLTDNLVFD | SLYDLITHYQ | QVPLRCNEFE |
700:
MRLSEPVPQT | NAHESKEWYH | ASLTRAQAEH | MLMRVPRDGA | FLVRKRNEPN |
750:
SYAISFRAEG | KIKHCRVQQE | GQTVMLGNSE | FDSLVDLISY | YEKHPLYRKM |
800:
KLRYPINEEA | LEKIGTAEPD | YGALYEGRNP | GFYVEANPMP | TFKCAVKALF |
850:
DYKAQREDEL | TFIKSAIIQN | VEKQEGGWWR | GDYGGKKQLW | FPSNYVEEMV |
900:
NPVALEPERE | HLDENSPLGD | LLRGVLDVPA | CQIAIRPEGK | NNRLFVFSIS |
950:
MASVAHWSLD | VAADSQEELQ | DWVKKIREVA | QTADARLTEG | KIMERRKKIA |
1000:
LELSELVVYC | RPVPFDEEKI | GTERACYRDM | SSFPETKAEK | YVNKAKGKKF |
1050:
LQYNRLQLSR | IYPKGQRLDS | SNYDPLPMWI | CGSQLVALNF | QTPDKPMQMN |
1100:
QALFMTGRHC | GYVLQPSTMR | DEAFDPFDKS | SLRGLEPCAI | SIEVLGARHL |
1150:
PKNGRGIVCP | FVEIEVAGAE | YDSTKQKTEF | VVDNGLNPVW | PAKPFHFQIS |
1200:
NPEFAFLRFV | VYEEDMFSDQ | NFLAQATFPV | KGLKTGYRAV | PLKNNYSEDL |
1250:
ELASLLIKID | IFPAKENGDL | SPFSGTSLRE | RGSDASGQLF | HGRAREGSFE |
1290:
SRYQQPFEDF | RISQEHLADH | FDSRERRAPR | RTRVNGDNRL |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
Bovine
Rat
ELISA Kit for Human 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1
ELISA Kit for Human 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1
ELISA Kit for Human 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1
ELISA Kit for Human 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1
CLIA Kit for Human 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1
CLIA Kit for Human 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1
CLIA Kit for Human 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1
CLIA Kit for Human 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1
Polyclonal Antibody for Human 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1
Polyclonal Antibody for Human 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1
Polyclonal Antibody for Human 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1
Polyclonal Antibody for Human 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1
Monoclonal Antibody for Human 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1
Monoclonal Antibody for Human 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1
Monoclonal Antibody for Human 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1
Monoclonal Antibody for Human 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1
Protein for Human 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1
Protein for Human 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1
Protein for Human 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1
Protein for Human 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);PHOSPHORYLATION
tissue :
Brain .
tissue :
Vein .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS ASN-209; GLY-279; THR-739 AND THR-813
3.
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Nature414:865-871(2001)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
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more...
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2);VARIANT THR-813
tissue :
Brain .
tissue :
Testis .
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH FGFR1
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION AT SER-1248
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH FGFR4
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION AT TYR-771 AND TYR-783 BY SYK;INTERACTION WITH SYK
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH KIT
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH AXL
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH LAT
13.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH SHB
14.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION BY KDR
15.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH TNK1
16.
"The ORF3 protein of hepatitis E virus binds to Src homology 3 domains and activates MAPK."
Korkaya H.
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J. Biol. Chem.276:42389-42400(2001)
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PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH HEV ORF3 PROTEIN
17.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH RALGPS1
18.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROBABLE DEPHOSPHORYLATION BY PTPRJ
19.
"Membrane raft-dependent regulation of phospholipase Cgamma-1 activation in T lymphocytes."
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Mol. Cell. Biol.21:6939-6950(2001)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION AT TYR-783;SUBCELLULAR LOCATION
20.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROBABLE DEPHOSPHORYLATION BY PTPRJ
21.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-771 AND TYR-1253;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Leukemic T-cell .
22.
"TrkA alternative splicing: a regulated tumor-promoting switch in human neuroblastoma."
Tacconelli A.
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,
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Cancer Cell6:347-360(2004)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH NTRK1
23.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : REVIEW ON INTERACTION WITH KIT AND ROLE IN KIT SIGNALING
24.
"Deficiency of BLNK hampers PLC-gamma2 phosphorylation and Ca2+ influx induced by the pre-B-cell receptor in human pre-B cells."
Taguchi T.
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Kiyokawa N.
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Takenouch H.
,
Matsui J.
,
Tang W.-R.
,
Nakajima H.
,
Suzuki K.
,
Shiozawa Y.
,
Saito M.
,
Katagiri Y.U.
,
Takahashi T.
,
Karasuyama H.
,
Matsuo Y.
,
Okita H.
,
Fujimoto J.
Immunology112:575-582(2004)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH BLNK; VAV1; GRB2 AND NCK1
25.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH FLT4
26.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION AT TYR-783 IN RESPONSE TO KDR ACTIVATION
27.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION BY ITK
28.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH FGFR2;PHOSPHORYLATION
29.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;INTERACTION WITH VIL1;SUBCELLULAR LOCATION
30.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION BY FGFR3
31.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH PDGFRB
32.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1221;PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1222 (ISOFORM 2);IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
33.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS];CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS]
34.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH FGFR3
35.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-771; TYR-775; TYR-783 AND SER-1221;PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1222 (ISOFORM 2);IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Leukemic T-cell .
36.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH PDGFRB;PHOSPHORYLATION AT TYR-771
37.
"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V.
,
Vermeulen M.
,
Santamaria A.
,
Kumar C.
,
Miller M.L.
,
Jensen L.J.
,
Gnad F.
,
Cox J.
,
Jensen T.S.
,
Nigg E.A.
,
Brunak S.
,
Mann M.
Sci. Signal.3:RA3-RA3(2010)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1221 AND TYR-1253;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
38.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
39.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH FGFR1;PHOSPHORYLATION BY FGFR1
40.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1222 (ISOFORM 2);IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
41.
"Tespa1 is involved in late thymocyte development through the regulation of TCR-mediated signaling."
Wang D.
,
Zheng M.
,
Lei L.
,
Ji J.
,
Yao Y.
,
Qiu Y.
,
Ma L.
,
Lou J.
,
Ouyang C.
,
Zhang X.
,
He Y.
,
Chi J.
,
Wang L.
,
Kuang Y.
,
Wang J.
,
Cao X.
,
Lu L.
Nat. Immunol.13:560-568(2012)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH TESPA1
tissue :
Thymocyte .
42.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : REVIEW ON ROLE IN FGF-ACTIVATED SIGNALING PATHWAYS
43.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : STRUCTURE BY NMR OF SH3 DOMAIN